Pure Bulk Biotin 1% Vitamin B7, Vitamin H 100g - - : Purebulk.com, Wholesale Nutritional Supplements

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Products :: Biotin 1% Vitamin B7, Vitamin H :: Biotin 1% Vitamin B7, Vitamin H 100g

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$10.50

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Unit Weight: 100 grams
Unit Volume: 200 cc

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Volumetric Equivalents

Biotin 1%, 100 grams

This pharmaceutical grade vitamin Biotin 1% is a blended product of approximately 1% Biotin USP (CAS 58-85-5) and 99% of the trituration carrier Dicalcium Phosphate USP (7757-93-9). The Biotin portion of this blended product is assayed by the manufacturer to be 1.01%. You will receive a labeled heavy-duty 4 mil polyethylene bag containing 100 grams of this as manufactured pure bulk ultrafine powder product. One hundred grams is also 100 grams, or approximately 3.527 ounces by weight. You won't receive the fancy retail packaging, but you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product. Biotin 1% has almost no taste and will not readily dissolve in water, but it will thoroughly mix and suspend with water when stirred. You can add your usual dose to water, stir and drink, or you can add your Biotin 1% dose to juice or smoothies.

Biotin is a water soluble essential vitamin that is usually considered a member of the B-complex of vitamins usually referred to a Vitamin B-7. Biotin is also commonly referred to as Vitamin-H. Biotin is necessary for physiological processes of all organisms and plants but it can only by synthesized by bacteria, yeasts and molds, algae and some plants. Biotin plays a role as a cofactor in the active sites of four important enzymes: Acetyl-CoA carboxylase catalyzes acetyl-CoA to form Malonyl-CoA which is required for the synthesis of fatty acids. Pyruvate carboxylase is an enzyme involved in gluconeogenesis (the synthesis of glucose from non-carbohydrate sources such as amino acids and fats. Methylcrotonyl-CoA carboxylase is a catalyst necessary for the metabolism of L-Leucine, an essential amino acid. Propionyl-CoA carboxylase catalyzes amino acids, cholesterol, and odd chain fatty acids.

Symptoms of biotin deficiency include hair loss, red scaly rash around the eyes, nose, mouth, and genitals. Neurologic symptoms of biotin deficiency may also include depression, lethargy, hallucinations, and numbness of the extremities. The characteristic facial rash is referred to as the " biotin deficient face " by some clinical practitioners.

The Table for Adequate Intake (AI) for Biotin established by the Food and Nutrition Board of the Institute of Medicine:

Adequate Intake (AI) for Biotin
Life Stage	Age	Males (mcg/day)	Females (mcg/day)
Infants	0-6 months	5	5
Infants	7-12 months	6	6
Children	1-3 years	8	8
Children	4-8 years	12	12
Children	9-13 years	20	20
Adolescents	14-18 years	25	25
Adults	19 years and older	30	30
Pregnancy	all ages	-	30
Breast-feeding	all ages	-	35

Biotin supplementation during pregnancy and the prevention of birth defects: Numerous research studies have show Biotin deficiency during the later stages of pregnancy to effect as many as 1/3 of all women. Research studies have shown that Biotin deficiency to cause birth defects in several animal species. Although there is not direct clinical evidence that marginal Biotin deficiency will cause birth defects in humans, the risk of biotin depletion warrants Biotin intake and supplementation so as to maintain adequate Biotin levels throughout pregnancy, according to many researchers. A common recommendation is for pregnant women to supplement with both Folic Acid (400mcg/day) and Biotin (30mcg/day) in the very earliest stages of pregnancy so as to help avoid or prevent neural tube defects.

Diabetes Mellitus is sometimes associated with Biotin deficiency owing to the impairment of glucose utilization. Some studies have shown significant improvement in the lowering of blood glucose levels in non-insulin dependent Diabetes Mellitus (also referred to as type 2 diabetes). One study showed that after one month of Biotin supplementation of 9mg per day (9 milligrams or 9000mcg or 9000 micrograms) fasting blood glucose levels were reduced by an average of 45%. However, follow-up studies involving double blind, placebo-controlled methods have failed to show similar results on the fasting glucose lowering effects of Biotin.

Brittle fingernails and hair loss in both men and women are sometimes successfully treated with Biotin supplementation in high doses (20mg to 50mg per day). Biotin supplementation is also commonly recommended for treating hoof abnormalities in horses and other hoofed animals.

Symptoms, problems, toxicity and side effects of Biotin overuse are very uncommon. Biotin doses of up to 200mg per day are well tolerated by individuals with hereditary disorders involving biotin metabolism. In individuals without such biotin disorders doses of 5 to 10 milligrams per day have not been associated with adverse effects. Owing to the lack of evidence and reports of adverse effects the Institute of Medicine elected not to establish an upper limit of intake for Biotin.

The commonly recommended dose for Biotin typically ranges between as little as the Adequate Intake (see table above) to as much as 5 milligrams or more per day. Biotin supplements capsules and tables available for purchase retail over the counter range from 1mg to 5mg per dose. Since this Biotin powder is 1% Biotin by weight a level 1/8 (one eighth) teaspoon will contain approximately 567 milligrams Biotin 1% or approximately 5.7 milligrams net Biotin.

Clinical Studies and Research References for Biotin

1. Food and Nutrition Board,, Institute of Medicine. Biotin. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy Press; 1998:374-389. (National Academy Press)
2. Mock DM. Biotin. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington, D.C.: ILSI Press; 1996:220-236.
3. Chapman-Smith A, Cronan JE, Jr. Molecular biology of biotin attachment to proteins. J Nutr. 1999;129(2S Suppl):477S-484S. (PubMed)
4. Zempleni J, Mock DM. Biotin biochemistry and human requirements. 1999; volume 10: pages 128-138. J Nutr. Biochem. 1999;10:128-138.
5. Hymes J, Wolf B. Human biotinidase isn't just for recycling biotin. J Nutr. 1999;129(2S Suppl):485S-489S. (PubMed)
6. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med. 2000;223(1):14-21. (PubMed)
7. Kothapalli N, Camporeale G, Kueh A, et al. Biological functions of biotinylated histones. J Nutr Biochem. 2005;16(7):446-448. (PubMed)
8. Mock DM. Biotin. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore: Lippincott Williams & Wilkins; 2006:482-497.
9. Mock DM. Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus. J Nutr Biochem. 2005;16(7):435-437. (PubMed)
10. Stratton SL, Bogusiewicz A, Mock MM, Mock NI, Wells AM, Mock DM. Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans. Am J Clin Nutr. 2006;84(2):384-388. (PubMed)
11. Baumgartner ER, Suormala T. Inherited defects of biotin metabolism. Biofactors. 1999;10(2-3):287-290.
12. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002;75(2):295-299. (PubMed)
13. Pabuccuoglu A, Aydogdu S, Bas M. Serum biotinidase activity in children with chronic liver disease and its clinical significance. J Pediatr Gastroenterol Nutr. 2002;34(1):59-62. (PubMed)
14. Mock DM. Biotin status: which are valid indicators and how do we know? J Nutr. 1999;129(2S Suppl):498S-503S. (PubMed)
15. Schulpis KH, Karikas GA, Tjamouranis J, Regoutas S, Tsakiris S. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001;42(10):1359-1362. (PubMed)
16. Zhang H, Osada K, Sone H, Furukawa Y. Biotin administration improves the impaired glucose tolerance of streptozotocin-induced diabetic Wistar rats. J Nutr Sci Vitaminol (Tokyo). 1997;43(3):271-280. (PubMed)
17. Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Sato T. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin dependent diabetes mellitus. J Clin Biochem Nutr. 1993;14:211-218.
18. Baez-Saldana A, Zendejas-Ruiz I, Revilla-Monsalve C, et al. Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects. Am J Clin Nutr. 2004;79(2):238-243. (PubMed)
19. Revilla-Monsalve C, Zendejas-Ruiz I, Islas-Andrade S, et al. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia. Biomed Pharmacother. 2006;60(4):182-185. (PubMed)
20. Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci. 2007;333(3):145-153. (PubMed)
21. Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial. J Cardiometab Syndr. 2007;2(2):91-97. (PubMed)
22. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006;8(6):636-643. (PubMed)
23. Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev. 2008;24(1):41-51. (PubMed)
24. Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. 2006;8(6):677-687. (PubMed)
25. Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma glucose levels in diabetics. Ann NY Acad Sci. 1985;447:389-392.
26. Romero-Navarro G, Cabrera-Valladares G, German MS, et al. Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats. Endocrinology. 1999;140(10):4595-4600. (PubMed)
27. Floersheim GL. [Treatment of brittle fingernails with biotin]. Z Hautkr. 1989;64(1):41-48. (PubMed)
28. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis. 1993;51(4):303-305. (PubMed)
29. Briggs DR, Wahlqvist ML. Food facts: the complete no-fads-plain-facts guide to healthy eating. Victoria, Australia: Penguin Books; 1988.
30. Said HM, Ortiz A, McCloud E, Dyer D, Moyer MP, Rubin S. Biotin uptake by human colonic epithelial NCM460 cells: a carrier-mediated process shared with pantothenic acid. Am J Physiol. 1998;275(5 Pt 1):C1365-1371. (PubMed)
31. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother. 1990;44(10):511-514. (PubMed)
32. Debourdeau PM, Djezzar S, Estival JL, Zammit CM, Richard RC, Castot AC. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother. 2001;35(4):424-426. (PubMed)
33. Flodin N. Pharmacology of micronutrients. New York: Alan R. Liss, Inc.; 1988.
34. Camporeale G, Zempleni J. Biotin. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition. 9th ed. Volume 1. Washington, D.C.: ILSI Press; 2006:314-326.

$10.50