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What is Coenzyme Q10 (COQ10)?

Coenzyme Q10 is a quinone, a substance that aids in providing energy to cells in all oxygen-breathing organisms. Researchers first knew about coenzyme Q10 in 1957, and the name ubiquinone describes it precisely because it was a quinone that was found in every cell of the body (the prefix ubi means everywhere). Ubiquinones are lipophilic, water-insoluble substances that participate in electron transport and energy generation in the mitochondria. Studies conducted later on demonstrated that ubiquinone acts as a coenzyme in the body, and is of paramount importance for the enzymes that provide energy to the body so they can properly function. Coenzyme Q10 (or CoQ10), essentially a vitamin or vitamin-like substance, helps deliver electrical charges to the mitochondria, or powerhouses, of the cells, so that they can produce energy; i.e., sustain life. The heart has the highest concentration of mitochondria of any muscle in the body, so it is not surprising that CoQ10 has been proven beneficial in the treatment of cardiovascular disease. In many countries including Japan, Italy, Sweden, Denmark, Israel, and Canada, CoQ10 is widely prescribed by physicians to treat congestive heart failure because it is classified as a prescription drug. In the United States, CoQ10 is considered a natural supplement and is a main constituent of many other supplements as well that are readily available over-the-counter.

Coenzyme Q10 has a variety of critical functions within the human body, ranging from energy production to antioxidant activity. CoQ10 is crucial in the synthesis of an important molecule known as ATP, as Coenzyme Q10 helps to process food into adenosine triphosphate (ATP), the energy on which the body runs. ATP serves as the cell's major energy source and drives a number of biological processes including muscle contraction and the production of protein. Coenzyme Q10 plays an important role as the coenzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell. Oily fish, such as mackerel and tuna, organ meats, and vegetable oils are good sources of coenzyme Q10, but it’s hard to get medicinal amounts of CoQ10 from dietary sources. It is readily available over the counter in many forms, including capsules, tablets, skin creams, and combination supplements marketed as energy enhancers or anti-aging products. CoQ10 supplements are extremely safe, as no serious toxicity associated with the use of coenzyme Q10 has been reported. However, those with serious medical conditions should consult their doctor before making this part of their diet. To gain medicinal and therapeutic benefits to those with heart disease, diabetes, etc., CoQ10 must be taken in high doses. It is also important to remember that as beneficial as CoQ10 is, it should be taken in conjunction with, not in place of, prescription medications.

What is Coenzyme Q10 (COQ10) used for and who uses it?

Improved energy production is of particular importance not just to athletes and bodybuilders but for anyone who lives either an active or sedentary lifestyle. Coenzyme Q10 increases energy, strengthens the immune system, and provides the benefits of an antioxidant. It functions as a coenzyme for numerous key enzymatic steps in the energy production within the cell. CoQ10 is used by the body to convert food into adenosine triphosphate (ATP), which in turn is used by the body as its primary energy source. Coenzyme Q10 supplements, whether as a stand alone or in conjunction with other prescription medications, can be particularly effective in the treatment of several health problems, including cardiac conditions and diseases, breast cancer, diabetes mellitus, immune deficiency, muscular dystrophy, and periodontal disease. CoQ10 may lower blood pressure, while helping inhibit cholesterol from becoming harmful (oxidizing) in the body and forming plaques in the arteries (atherosclerosis).

Coenzyme Q10 can be beneficial in cardiovascular disease, specifically in congestive heart failure. CoQ10 assists in speeding up the treatment of cardiovascular disease by improving circulation throughout the body, and aiding mitochondria to process fat and cholesterol more efficiently. It heightens the levels of blood and oxygen available for the heart to use, while preventing atherosclerosis or cholesterol build-up in the arteries. Coenzyme Q10 is thought to have a protective action on the cells of the heart since the heart muscle contains the greatest concentration of Coenzyme Q10 in the body and heart disease sufferers tend to be relatively deficient in coenzyme Q10. Research have confirmed that CoQ10 also inhibits blood vessels from clumping together to form blood clots, and aids in lowering and managing the blood pressure within healthy levels. Coenzyme Q10 may be particularly beneficial for people who just had a heart attack and have been suffering from irregular heart beats (arrhythmias) since.

CoQ10 is not just good for the heart—it is also a powerful antioxidant, and protects the body from free radical damage. As we age, particularly after age 30, CoQ10 levels begin to drop leaving the body more susceptible to free radical damage. With the help of CoQ10 supplements, collagen and elastin in the skin can be increased and replenished as studies have shown, thus resulting in an anti-aging effect since damaged skin cells are repaired. CoQ10 is a major constituent in many topical products that claim to reduce and minimize the appearance of wrinkles and shield the skin from aging. CoQ10 may be more effective than its skincare treatment counterparts because it is a small molecule that can relatively easily penetrate into skin cells.

Studies also demonstrated that CoQ10 also strengthens immunity, reduces blood sugar, and can significantly slow down the growth of tumors. As an antioxidant, coenzyme Q-10 may also have potential as an anticancer and immune-stimulating agent because of Coenzyme Q10's antioxidant actions that can stop the free-radical damage believed to cause certain cancers. Coenzyme Q10 when used with conventional medical treatment and other antioxidant nutrients yielded a better survival rate and incidence of cancer regression. Also, Coenzyme Q10 supplements may improve heart health and blood sugar and help manage high cholesterol and high blood pressure in individuals with diabetes. CoQ10’s action of being able to convert food to ATP is especially beneficial for diabetics since people with diabetes cannot adequately process carbohydrates. With the help of Coenzyme Q10, or CoQ10, normal carbohydrate metabolism can be improved or made possible. Additionally, since CoQ10 enhances mitochondria function, it is thought to help improve athletic endurance and increase energy levels in the elderly and in those suffering from chronic illness, stress, and plain overwork and fatigue.

How pure is your Coenzyme Q10 (COQ10)?

This Coenzyme Q10 is a pharmaceutical grade pure bulk nutritional powder assayed by the manufacturer to be 98.55% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag of this bright yellow/orange powdered product. Although it is also possible to supplement your CoQ10 levels by dietary means, not only is it inconvenient, it may not be the most appetizing way to do it. The top three dietary sources with the highest concentration of CoQ10 are pork hearts (125-200 mcg/g), reindeer (159 mcg/g) and beef hearts (113 mcg/g). This means a gram of reindeer, in case you get one, will gain you just 159 millionths of a gram of CoQ10, when the human body should only have 0.5 to 1.5 grams all together. About a hundred different food sources can provide you with a dose of CoQ10, but it may be difficult to get a significant serving with some of the more appetizing ones. Milk, for example, has just 0.1 millionths of a gram of CoQ10 per gram of milk. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits and gains made possible with Coenzyme Q10 (COQ10), buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of Coenzyme Q10 (COQ10)?

Coenzyme Q10 can be taken internally as a nutritional supplement with benefits including anti-aging, increased energy, enhanced cognition and organ/tissue protection. Recommended internal use doses vary between 50mg and 500mg per day, depending upon individual needs. For congestive heart failure, angina, fibromyalgia, and symptoms of Alzheimer's disease, take 100 mg twice a day. For arrhythmias, high blood pressure, anti-aging actions, gum disease, and cancer prevention, take 50 mg twice a day. For supplementing conventional cancer therapy, take 200 mg every morning. For accurate dosing of this product use an accurate sub-gram (or milligram) weight scale, or consult the Bulk Density volumetric table below only if you have calibrated (verified accurate by volume) microsized measuring spoons. You can see the full bulk density/volumetric conversion chart for Coenzyme Q10 (COQ10) here. It is recommended that coenzyme Q10 be taken with a meal that contains oil to improve absorption, although people with specific health conditions may supplement with higher levels (with the advice and involvement of a physician). The assimilation and absorption of Coenzyme Q-10 may be improved if taken with a fatty substance such as oil, peanut butter, olive oil, etc. Taking at least 600–800 IU of vitamin E daily, along with the basic nutrients, including vitamin C, niacin, and other cholesterol-lowering substances, such as EPA, is probably a good idea as well for cardiovascular problems.

What kind of results do people anticipate while taking Coenzyme Q10 (COQ10)?

Coenzyme Q10 is a naturally occurring nutrient found in each cell of the body. Coenzyme Q10 is a very important antioxidant found in the fatty membranes of intracellular organelles such as mitochondria, endoplasmic reticulum, golgi complex, etc. Coenzyme Q10 was first identified by University of Wisconsin researchers in 1957. Coenzyme Q10 is found in foods, particularly in fish and meats. In addition to playing a significant role in the energy system of each of our cells, Coenzyme Q10 is a good antioxidant. Many who take Coenzyme Q10 notice that this nutrient provides energy and mental clarity. Coenzyme Q10 may be used either internally as a nutritional supplement or applied topically as a component in facial or skin creams. When taken as a nutritional supplement or as a topical agent Coenzyme Q10 may help prevent free-radical production and thereby maintain more normalized Adenosine Triphosphate (ATP) production in cellular tissues.

Potential side effects of Coenzyme Q10 (COQ10)

Coenzyme Q10 appears to be generally safe with no significant side effects. No serious toxicity associated with the use of coenzyme Q10 has been reported.

Optimal Oral Bioavailability and Topical Preparation of Coenzyme Q10 (COQ10)

Coenzyme Q10 bioavailability and absorption is dependent upon many factors. The poorest oral bioavailability for Coenzyme Q10 occurs when it is taken orally as a powder in capsules. Since Coenzyme Q10 is not water soluble when taken in capsule form very little is absorbed. Commonly, retail ready Coenzyme Q10 oral supplements are delivered in gel caps dissolved in soybean oil. Whereas Coenzyme Q10 dissolved in soybean oil is better than powder capsules, there are significant problems with this delivery method that significantly limit or reduce Coenzyme Q10's bioavailability.

Coenzyme Q10 is frequently used as an ingredient in anti-aging creams and lotions, reducing wrinkles and age spots, and improving the complexion and elasticity of body and facial skin. Topical use of Coenzyme Q10 is usually prepared in concentrations of about 1% but generally not exceeding 2% by weight. Since Coenzyme Q10 is completely insoluble in water it must first be dissolved or blended into the oil based ingredients of your topical formula prior to blending into water based components (if present).

Coenzyme Q10 and Coconut Oil recipe for increased bioavailability

1) Heat 16 fluid ounces coconut oil to between 150°F (65°C) and 158°F (70°C) in a sauce pan on the stove.
2) Add 25 grams Coenzyme Q10 powder. The powder will melt instantly and dissolve into the hot oil.
3) Stir for one minute.
4) Remove from heat and allow to cool to between 80°F (27°C) and 90°F (32°C).
5) Pour mixture into a rigid plastic or glass resealable food storage container and allow to cool to room temperature.
6) At below 76°F (24.4°C) coconut oil will turn solid, but that's alright.
7) The blended oil should be keept sealed but refrigeration is optional.
8) A level half teaspoon of this oil, liquid or solid, will net approximately 130 milligrams Coenzyme Q10, which is in the usual range of a commonly recommended daily dose for this most bioavailable form of CoQ10.
9) Do not exceed a dose of 1 level teaspoon (260 milligrams) Coenzyme Q10 per day except under the care and supervision of a physician.
10) Take your dose preferably with a fatty food at meal time. You may spread it on toast, or add it to any food like you would as if it were butter.

This 16 fluid ounce recipe will net 96 level teaspoon doses, or 192 level 1/2-teaspoon doses, enough highly bioavailable coconut oil dissolved Coenzyme-Q10 for more than a 6 month supply.

Recommended Storage of Coenzyme-Q10

As a super antioxidant, Coenzyme-Q10 in its crystalline form (as a bulk powder) is extremely susceptible to oxidation if it is allowed to be in contact with the open air. After oxidation of CoQ10 has occurred it will change from its usual bright orange color to a dark brown color. CoQ10 may only be allowed contact with air for the briefest time when you are removing your daily dose, repackaging, or transferring this bulk product to one or more resealable bags. We do not recommend keeping CoQ10 in a resealable jar because of the volume of air that will be exchanged with each opening of the container as you remove your daily doses. A good way to seal and protect CoQ10 as a bulk powder is in a resealable zip locking plastic bag that can have a minimal amount of air present inside the bag along with the CoQ10 powder. We also do not recommend that you take your daily dose from a bag that contains more than 25 grams CoQ10. When purchasing larger 100g, 250g, or 1 kilogram bulk powder quantities of CoQ10 you would do well to place about 25 grams in a resealable bag and then take your daily dose from that smaller bag so as to minimize the air exposure to the bulk of your CoQ10 supply.

The best way to keep Coenzyme-Q10 from oxidizing is to convert it from a crystalline powder state to an amorphous liquid, or solid, in a coconut oil solution (see the Coenzyme Q10 and Coconut Oil recipe above). Coconut oil usually contains up to 40% medium chain triglycerides which are natural antioxidant oils that will protect Coenzyme Q10 in solution from exposure to oxygen and oxidation.

Synonyms and Proprietary Formulas that use Coenzyme Q10 (COQ10)

Andelir®, CoenzymeQ, Co-enzyme Q10, Coenzyme Q (50), CoQ, CoQ10, CoQ(50), Co-Q10, CoQ-10, 2,3 dimethoxy-5 methyl-6-decaprenyl benzoquinone, Heartcin®, idebenone (synthetic analogue), mitoquinone, Neuquinone®, Q10, Taidecanone®, ubidecarenone, ubiquinone, ubiquinone-10, ubiquinone-Q10, Udekinon®, vitamin q10, vitamin Q10, Gaspari Nutrition SizeOn, Nutrex HEMO-RAGE Black, Beverly Int. Lean Out , Betancourt Nutrition Bullnox Androrush, Higher Power CoQ10, Cheap Supplements CoQ-10, Country Life CoQ10, Deva Nutrition Vegan Coenzyme Q10, FoodScience of Vermont Coenzyme Q10, Healthy Origins CoQ10, Jarrow Formulas Q-absorb Co-Q10, Life Extension Super Ubiquinol CoQ10, LifeTime Co-Enzyme Q10, Natrol CoQ-10, Nature's Science 100% COenzyme Q10, NOW CoQ10, NOW Ubiquinol, Olympian Labs Coenzyme Q10 Softgels, Schiff CoQ-10, Solaray BioCoQ-10, Source Naturals Coenzyme Q10, Twinlab Mega CoQ10

References & Further Research

Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension
Increasing numbers of the adult population are using alternative or complementary health resources in the treatment of chronic medical conditions. Systemic hypertension affects more than 50 million adults and is one of the most common risk factors for cardiovascular morbidity and mortality. This study evaluates the antihypertensive effectiveness of oral coenzyme Q10, an over-the-counter nutritional supplement, using 46 men and 37 women with isolated systolic hypertension. A 12-week randomized, double-blind, placebo-controlled trial was conducted with twice daily administration of 60 mg of oral coenzyme Q10 and determination of plasma coenzyme Q10 levels before and after the 12 weeks of treatment. Overall data and results suggest coenzyme Q10 may be safely offered to hypertensive patients as an alternative treatment option.

The Effects Of Coenzyme Q10 Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in Sedentary Men
The objective of this study was to determine the effects of oral coenzyme Q10 (CoQ10) supplementation on performance during repeated bouts of supramaximal exercise. This randomized, double-blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.d CoQ10 or placebo. According to the results, CoQ10 may show performance-enhancing effects during the repeated bouts of supramaximal exercises and CoQ10 might be used as ergogenic aid.

Coenzyme Q10: its biosynthesis and biological significance in animal organisms and in humans
Coenzyme Q10 (ubiquinone) is a naturally occurring compound widely distributed in animal organisms and in humans. The primary compounds involved in the biosynthesis of ubiquinone are 4-hydroxybenzoate and the polyprenyl chain. An essential role of coenzyme Q10 is as an electron carrier in the mitochondrial respiratory chain. Moreover, coenzyme Q10 is one of the most important lipophilic antioxidants, preventing the generation of free radicals as well as oxidative modifications of proteins, lipids, and DNA, it and can also regenerate the other powerful lipophilic antioxidant, alpha-tocopherol. Antioxidant action is a property of the reduced form of coenzyme Q10, ubiquinol (CoQ10H2), and the ubisemiquinone radical (CoQ10H). Decreased levels of coenzyme Q10 in humans are observed in many pathologies (e.g. cardiac disorders, neurodegenerative diseases, AIDS, cancer) associated with intensive generation of free radicals and their action on cells and tissues. In these cases, treatment involves pharmaceutical supplementation or increased consumption of coenzyme Q10 with meals as well as treatment with suitable chemical compounds (i.e. folic acid or B-group vitamins) which significantly increase ubiquinone biosynthesis in the organism.

Atorvastatin decreases the Coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke
Statins are widely used for the treatment of hypercholesterolemia and coronary heart disease and for the prevention of stroke. There have been various adverse effects, most commonly affecting muscle and ranging from myalgia to rhabdomyolysis. These adverse effects may be due to a Coenzyme Q10 deficiency because inhibition of cholesterol biosynthesis also inhibits the synthesis of Coenzyme Q10. Even brief exposure to atorvastatin causes a marked decrease in blood Coenzyme Q10 concentration. Widespread inhibition of Coenzyme Q10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria.

Coenzyme Q10 (COQ10) for International Customers

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Buying Coenzyme Q10 (COQ10) Bulk or Wholesale

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