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What is Collagen Hydrolyzed?

Collagen is one of the many types of protein found in skin, bone, muscles and internal organs, and it is necessary for the proper functioning of these tissues. Hydrolyzed collagen is usually made from type I collagen (the most abundant collagen of the human body)by an enzymatic hydrolysis process, and is mainly extracted from the bones and the skin from porcine, bovine and fish origin. The amino-acid content of hydrolyzed collagen is the same as collagen: 20 amino acids, including 8 out of 9 essential amino acids (except for tryptophan). It is characterized by the predominance of glycine, proline and hydroxyproline, which makes up around half of the total amino-acid content. Glycine and proline concentration is 10 to 20 times higher than in other proteins.

Hydrolyzed collagen is the end result of the process of breaking down bone and cartilage into small components that are collectively referred to as gelatin. Bone and cartilage are first crushed or ground, defatted, then its calcium content and the natural bonds in the collagen are broken down by soaking in hydrochloric acid and sodium hydroxide respectively. Once the process is complete, the remaining powder is reconstituted into gelatin (the same gelatin used in cooking and the making of empty capsules for taking medications). Among the health benefits associated with hydrolyzed collagen supplementation include muscle tone, strengthening of arteries, rebuilding of the joints and internal organs.

Collagen that has been hydrolyzed has received much emphasis and attention because this fibrous protein is broken down into short chains of amino acids (called peptides) and also into completely free amino acids. When taken internally, peptides are further broken apart into free amino acids, which are the building blocks for protein. It is generally believed that the amino acids that are present are made readily available to the body because they do not have to be broken down for the building of new collagen. This also lead to its topical application because the skin not only contains collagen, it also is porous.

Hydrolyzed collagen can now be found in nutritional supplements as a main constituent in keeping skin supple and preventing it from wrinkling and sagging. It also helps keep muscles smooth and firm, and although taken as a protein supplement by many, it should not be regarded as an adequate source of protein to replace the needed protein found in foods such as fish, beef, poultry and whey protein because it has insufficient amounts of cysteine and methionine. However, in conjunction with a balanced diet and exercise regimen, it could significantly improve muscular development, skin youthful appearance, and joint flexibility.

What is the function of Collagen and why do we need Hydrolyzed Collagen?

Collagen is the most abundant fibrous protein found in the body, but in a dietary supplement unprocessed collagen is not readily bioavailable. Many people become depleted of the important amino acids needed to make Collagen due to poor food choices in our diets, the abuse we put our bodies through everyday through strenuous activity, and aging. This can pose a significant problem for most of us, but more so for people such as athletes, bodybuilders, and construction workers because of the amount of strenuous physical activity their bodies undergo on a regular basis.

Collagen Hydrolyzed provides a more bioavailable form of collagen that contains both free amino acids as well as peptide fragments (smaller amino acid chains) that are easily absorbed through the walls of the intestine into the blood stream. These are then used by the body to form the necessary structures needed to regulate the functions of the cells. Up to 30% of all the protein in the human body is collagen, and up to 70% of the proteins in the connective tissues are made up of collagen. In the body, collagen is made by specialized cells in the skin, ligaments, bones and cartilage. Collagen Hydrolyzed also provides additional amounts of the amino acids glycine and glutamine. Glycine assists in detoxification and glutamine is crucial in helping the cells increase their levels of the energy storage molecule creatine.

Who Could Benefit from Collagen Hydrolyzed?

The body's natural ability to repair supporting connective tissue (bone, joints, cartilage, tendons, ligaments, skin, hair and nails), and maintain hydration of the cells is significantly diminished after age 25. Hydrolyzed collagen compensates for aging by providing additional amounts of amino acids like glycine, lysine, and proline which are specifically needed by the body to build connective tissue structures, and to regulate and maintain the functions of the cells. Those who could benefit from collagen supplements include smokers, people who suffer from arthritis or who have a history of arthritis, obesity or muscular skeletal or joint diseases in the family; men and women over the age of 40 (although, starting after age 25 as a preventative measure is ideal); people who work outdoors on a regular basis for long periods (to help minimize the formation of fine lines and wrinkles from sun exposure and squinting); athletes and physically active people who perform weight-bearing exercises, such as jogging, weight lifting, mountain climbing, etc; and those who experience nutritional imbalances or follow extreme diets, such as no meat or protein (to avoid protein deficiency). Taking a collagen supplement will also help maintain fuller and smoother lips and benefit bone structure support. Collagen also plays a major role in wound healing because its presence is important in all stages of the healing process.

How pure is your Collagen Hydrolyzed?

This pharmaceutical grade Collagen Hydrolyzed (more commonly referred to as Hydrolyzed Collagen) is assayed by the manufacturer as 92% pure product (normal range 90% and up). You will receive a double sealed and labeled bulk polyethylene bag containing this off-white fine powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 8% by weight are inactive byproducts of the extraction.

What are some of the common effects of Collagen Hydrolyzed?

Collagen Hydrolyzed supports rehabilitation of musculoskeletal injuries, reduces inflammation, increases hydration of the connective tissues of the body, improves joint flexibility, enhances signal induction, improves sleep, reduces pain, advances cellular calcium uptake, increases metabolic rate, and boosts the appearance and quality of hair and nails. Collagen Hydrolyzed taken as a food supplement provides the proper ratios of amino acids needed for collagen production. In addition, hydrolyzed collagen contains naturally occurring glucosamine and hyaluronic acid which supports connective tissue repair as well as boosting hydrating and volumizing effects due to the natural ability of connective tissues to hold water.

What is the daily suggested dose of Collagen Hydrolyzed?

To support bone health, numerous studies have demonstared that a total daily dose of 10g of hydrolyzed collagen for 4 to 24 weeks significantly improves bone mass density. You can see the full bulk density/volumetric conversion chart for Collagen Hydrolyzed here. Collagen supplements should be taken once per day, at night specifically before going to bed, since the skin cells and body are in repair mode. Once taken, they can be rapidly absorbed in the bloodstream in around 5-10 minutes. After the first 2-3 month period, supplementation can then be reduced and changed to every other day (approximately 2-3 times per week).

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of Collagen Hydrolyzed

To date, the FDA has ruled out any side effects or toxicity from Collagen Hydrolyzed, as well as adverse interactions with food or medications. However, they may need be taken on a case-to-case basis, especially for those who are sensitive and experience allergic reactions to products. Also, those who are not certain should check with a physician.

Women who are expecting are cautioned to consult with a medical doctor before supplementing their diet with gelatin. External use of hydrolyzed collagen is generally considered safe for those do not have sensitive skin. However, although its use is widely encouraged and accepted since hydrolyzed collagen has been added to a variety of personal care products, people with sensitive skin could still experience a condition known as contact dermatitis. If itching, swelling, or a rash develops, immediately discontinue the use of the product.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Solubility, and suggested preparation of Collagen Hydrolyzed

Collagen Hydrolyzed works best when taken on an empty stomach away from food, and then waiting 20-30 minutes before eating anything. It can be taken with juice or warm tea, and it is absorbed fastest when it's not consumed with other fluids that contain proteins or amino acids. Collagen Hydrolyzed is exceptional because it has a molecular weight less than 1000, and this makes it possible for Collagen Hydrolyzed to be rapidly absorbed from the intestinal tract.

Collagen Hydrolyzed is used in the following Proprietary Formulas

ReserveAge Collagen Booster, Olympian Labs BioCell Collagen II, Health Direct AminoSculpt, MRM Joint Performance, Health Direct AminoSculpt Supreme, Hair Regrowth For Women, NOW Joint Support Powder, Dr. Smoothie Amino Repair, Health Direct Fluid Motion, Labrada Elasti Joint, Jan Tana Moisturizing Lotion, CNP Professional ProSLAM!, Inner Armour Nitro-PEAK 50x, IDS New Whey Protein Powder, NOW Awe-Slim, Arthred Hydrolyzed Collagen Formula, NeoCell Laboratories Hydrolyzed Collagen Powder, Doctor's Best Best Collagen Types 1&3 Powder

Synonyms for Collagen Hydrolyzed

Hydrolyzed Collagen, collagen hydrolysate, collagen peptide, gelatine, gelatine hydrolysate, and hydrolyzed gelatine

References & Further Research

Effects of a hydrolyzed collagen dressing on the healing of open wounds in dogs
The objective of this study was to determine the effects of a hydrolyzed bovine collagen dressing (HBCD) on healing of open wounds in healthy dogs. Using 9 female Beagles, 2 full-thickness skin wounds were made bilaterally on the trunk of each dog. Wounds on 1 side were treated with powdered HBCD covered with a semiocclusive nonadherent bandage. Wounds on the other side (control wounds) were covered with a semiocclusive nonadherent bandage only. Wound healing was subjectively assessed, and percentage increase in tissue perfusion was assessed by use of laser Doppler perfusion imaging (LDPI). Planimetry was performed to determine the percentages of contraction, epithelialization, and total wound healing. Biopsy specimens were examined microscopically to evaluate histologic changes. Results—The HBCD did not induce a strong inflammatory reaction, as reflected by results of LDPI and histologic examination. Moreover, HBCD appeared hydrophilic and provided an environment to keep wounds clean and enhance early epithelialization. After treatment for 7 days, treated wounds had a significantly greater percentage of epithelialization than control wounds (12.13 vs 7.03%). Conclusion and Clinical Relevance—The hydrophilic property of HBCD may cleanse contaminated wounds with the body's homeostatic fluids and enhance early wound epithelialization

A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis
To assess the efficacy and safety of chicken type II collagen in rheumatoid arthritis compared with methotrexate. We conducted a prospective, 24-week, followup, multicenter, double-blind, controlled study of chicken type II collagen (0.1 mg/day) versus methotrexate (10 mg/week) in patients with active rheumatoid arthritis. In both groups there was a decrease in pain, morning stiffness, tender joint count, swollen joint count. In the methotrexate group, erythrocyte sedimentation rate and C-reactive protein level decreased. Rheumatoid factor did not change in either group. At 24 weeks, 68% of patients in the chicken type II collagen group and 83% in the methotrexate group met the American College of Rheumatology 20% improvement criteria. chicken type II collagen is effective in the treatment of rheumatoid arthritis. chicken type II collagen is well tolerated, and the incidence of adverse events of chicken type II collagen is lower than that of methotrexate.

Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial
Previous studies have shown that undenatured type II collagen (UC-II) is effective in the treatment of rheumatoid arthritis, and preliminary human and animal trials have shown it to be effective in treating osteoarthritis (OA). The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group. Thus, UC-II treated subjects showed significant enhancement in daily activities suggesting an improvement in their quality of life.

Collagen Hydrolyzed for International Customers

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