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What is Creatine Ethyl Ester Malate HCL?

Creatine is widely accepted for many years now in all fitness communities as one of the top supplements to use in developing strength and to stimulate muscle growth. Creatine Ethyl Ester Malate (CEEM in further text) is one of the latest and most effective forms of creatine in the world market. CEEM is touted as the next generation creatine and as such the most effective form of creatine available. Many bodybuilders swear by this supplement, especially for post-workout use. CEEM is a more recently derived Creatine based nutritional supplement very similar in it's effectiveness as it's predecessor, Creatine Ethyl Ester HCL.

The main distinction between the two is that CEEM tastes much better and has fewer side effects in large doses than CEE. With respect to creatine monohydrate, CEEM does not require a loading phase. This makes CEEM more cost effective, as the amount taken from start to finish is maintained. CEEM’s ethyl ester linkage greatly enhances the absorption of creatine, which improves creatine’s water-solubility, allowing it to dissolve more easily in the gut. As such even smaller doses provide greater benefit because there is less wastage, and fewer stomach upsets (bloating, cramps, etc.). Creatine is manufactured in the liver by methylation of guanidoacetate using SAM as the methyl donor. Guanidoacetate itself is synthesized in the kidney from the amino acids arginine and glycine. Creatine may also be derived from dietary sources primarily from eating meat or fish, which contains approximately four to five grams of creatine per kilogram. Following its biosynthesis, creatine is quickly taken to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine (creatine phosphate), which is a primary energy storage form in the body.

Creatine functions to increase the availability of cellular ATP, adenosine triphosphate. Creatine works by acting on mechanisms of ATP by donating a phosphate ion to increase the availability of ATP. Creatine is primarily stored in the muscle as free creatine and phosphocreatine. Creatine is used as a storage form of high energy phosphate. The phosphate of ATP is transferred to creatine, generating creatine phosphate, through the action of creatine phosphokinase. The reaction is reversible such that when energy demand is high (e.g. during muscle exertion) creatine phosphate donates its phosphate to ADP to yield ATP. hosphocreatine binds with adenosine diphosphate to convert it back to ATP (adenosine triphosphate), an important cellular energy source.

Creatine supplementation has become tremendously popular in recent years. Creatine has been clinically proven in numerous studies to increase muscle strength, and to delay fatigue, allowing athletes to train harder and achieve greater muscle gains beyond normal capacities. During high-intensity, short-duration exercise, such as lifting weights or sprinting, phosphocreatine is broken down into creatine and phosphate. The energy released in this process is used to regenerate ATP, a major source of energy within the human body that drives a number of biological processes including muscle contraction and protein production. ATP is used for all metabolic activities and is crucial for anaerobic activity such as weightlifting, sprinting and jumping that are short-term, high intensity activities the utilize fuel rapidly.

What is Creatine Ethyl Ester Malate used for and who uses it?

CEEM is used to efficiently increase overall muscular mass and strength, athletic performance, and protein synthesis. CEEM also supports optimal levels of muscle ATP for improved overall exercise performance above and beyond what can be expected from regular creatine formulations. Creatine Ethyl Ester Malate is extremely popular among strength athletes like bodybuilders and powerlifters. But it doesn’t mean they’re the only ones who can benefit from this, as anyone, from high school to professional athletes, and even elderly people who need all the help they can get to strengthen their muscles, can benefit greatly from using CEEM.

With creatine use, muscle endurance is improved, enabling users to continue with their intense and grueling training for longer periods of times. Bodybuilders and weight trainers take creatine because it has been proven effective to increase and produce faster gains in muscle mass and strength. This increase in muscle mass leads to weight gain, which is a result of creatine drawing water into the muscle cell. Depending on your goals it can either be viewed as a side effect or a benefit, but for most people who are weight training and for hard gainers, this is enough reason to use creatine. Creatine also helps alleviate muscle soreness, thus giving its users a faster recovery time thus allowing them to train more frequently.

Research on CEEM has identified a number of uses of CEEM apart from just being an aid to achieve improved muscle mass and strength and better athletic performance. CEEM can also be used to help treat neuromuscular diseases like muscular dystrophy (MD) and to alleviate the symptoms of diseases brought about by aging such as muscle atrophy, gyrate atrophy, Huntington’s disease, Parkinson’s disease, and wasting syndromes.

How pure is your Creatine Ethyl Ester Malate?

This is pure Creatine Ethyl Ester Malate, with no additives, fillers or anticaking agents included and assayed by the manufacturer to be 99.21% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag of this white powder product. Low levels of creatinine are not common and are not usually a cause for concern. However, people involved in intense physical activity, especially those limiting their intake of red meat, may have low muscle stores of creatine. Creatine deficiency in situations of strenuous muscle function results in fatigue, lessened muscle strength, compromised endurance, increased muscle soreness, and the need for frequent resting. Creatine supplements fuels and enhances short bursts of high-energy exercise, increases both total work output in a single high intensity exercise bout, and increases the peak performance during a series of repetitive bouts. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits and muscle mass gains made possible with Creatine Ethyl Ester Malate, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

Preparation of Creatine Ethyl Ester Malate prior to usage?

Take CEEM together with your favorite citrus juice or beverage. Mixing with water is not advisable because of the attached ethyl ester group loses its potency at pH levels greater than 7.2. For best results, CEEM can be consumed one hour before and/or after training together with a high glucose drink for better CEEM transport.

Potential Side Effects of Creatine Ethyl Ester Malate

No side effects have been reported in scientific literature. CEEM is completely safe and there are no known side affects found in the many studies performed on CEEM powder. As a word of advice though, it is not advisable for renal dialysis or kidney transplant patients as their body may have trouble eliminating CEEM. Compared to Creatine Ethyl Ester HCL (CEE), CEEM has fewer side effects in large doses than CEE and also results in fewer instances of gastric upset and bloating.

What is the daily suggested or recommended dose of Creatine Ethyl Ester Malate?

Many tens of thousands of performance athletes and body builders will attest to their great results using 5 to 10 grams per day. You can see the full bulk density/volumetric conversion chart for Creatine Ethyl Ester Malate here.

Methods & Recipes of ingesting Creatine Ethyl Ester Malate

CEEM powder is easily soluble in water, fruit juice or shake. The powder form of CEEM is absorbed easier into the bloodstream than the pill form. CEEM powder is mixed easily into any shake or drink that you prefer.

Taste, smell, and appearance of Creatine Ethyl Ester Malate

CEEM is an odorless white-colored crystalline powder, which appears colorless and clear in solution.

Solubility / measuring Creatine Ethyl Ester Malate

CEEM absorbs quickly. It is advisable not to mix CEEM powder too far in advance, as it will eventually separate from the liquid and break down. At this time, you may lose a lot of the effectiveness of the CEEM, so mix only the amount you need to consume at a time. For those on the go, simply measure the correct amount of powder into an empty water bottle or something similar. When you are ready to take it, fill the water bottle with your preferred method of drink.

Creatine Ethyl Ester Malate is used in the following Proprietary Formulas

BSN Creatine Ethyl Ester Malate CellMASS, Nutrabio Creatine Ethyl Ester Malate, 1Fast400 DiArginine Malate Powder, Performade from Champion Nutrition, Creatine Overload from Hi-Tech Pharmaceuticals, Assault from Muscle Pharm, Nitric Oxide/Creatine/Glutamin Powder from Xyience

References & Further Research

Kreider, R.B., 1999. Dietary supplements and the promotion of muscle growth with resistance exercise.
Creatine during resistance training have been reported to increase fat-free mass in athletic and nonathletic populations. This paper discusses rationale and effectiveness of these nutritional strategies in promoting lean tissue development during resistance training.

Becque, M.D., et al. 2000. Effects of oral creatine supplementation on muscular strength and body composition.
As the use of these nutritional supplements introduced into sport and physical fitness continues to increase, so does the need to investigate their effects on human performance. The purpose of this investigation was to examine the effects of 6 wk of oral creatine supplementation during a periodized program

Creatine Ethyl Ester Malate for International Customers

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Buying Creatine Ethyl Ester Malate Bulk or Wholesale

If you need CEEM in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!