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What is Pantothenic acid (vitamin B5)?

Pantothenic acid, also called vitamin B5 or D-Calcium Pantothenate, is a water-soluble vitamin and antioxidant necessary in break down carbohydrates, proteins, and fats and converting them to energy. Pantothenic acid comes in three forms, and it is alternately known as vitamin B5, pantethine and calcium pantothenate. Calcium pantothenate is widely used for treating ailments from stress to heartburn, while pantethine is primarily used in lowering blood cholesterol levels for those are non-responsive to other natural treatments. The primary supplemental form of pantothenic acid is calcium D-pantothenate (D-calcium pantothenate). Pantothenic acid is crucial to numerous activities of enzymes in the human body. The body utilizes pantothenic acid to convert carbohydrates, proteins and fats for energy. Pantothenic acid works as a constituent of coenzyme A and phosphopantetheine, which are involved in fatty acid metabolism. This vitamin is also responsible in synthesizing numerous enzymes and assists in maintaining precise communication between the central nervous system and the brain.

Pantothenic acid is taken from the Greek word Pantos meaning "everywhere," because it is available in almost all types of food including eggs, meats, liver, kidney, corn, peanuts, fish/shellfish, legumes, chicken, fresh vegetables and milk. It is an essential nutrient needed for human physiological synthesis of Coenzyme A (CoA), a molecule that is required so that many vital chemical reactions can occur within cells. This component is a B complex vitamin which acts as an antioxidant when involved in metabolism. It breaks down and metabolizes numerous biochemical substances including fatty acids, carbohydrates, steroids, phospholipids, heme, and amino acids. Coenzyme A (CoA) is involved in the energy production from the metabolism of macronutrients, particularly fats, from the tricarboxylic acid cycle (TCA) or Krebs cycle, metabolism of drugs and toxins in the liver, and the synthesis of lipids, acetylcholine, steroid hormones, porphyrins, hemoglobin, and melatonin. Because of the wide array of functions CoA plays in the body, and Pantothenic acid works as a constituent of coenzyme A or CoA, it follows that the utilities of supplemental pantothenic acid are many.

Common sources of pantothenic acid are cheese, corn, eggs, liver, meats, peanuts, peas soybeans, brewer's yeast, and wheat germ. Because of its wide occurrence, pantothenic acid deficiency is very rare unless specifically engineered for the purposes of biochemical investigations. The best sources of this vitamin are brewer's yeast, corn, cauliflower, kale, broccoli, tomatoes, avocado, legumes, lentils, egg yolks, beef (especially organ meats such as liver and kidney), turkey, duck, chicken, milk, split peas, peanuts, soybeans, sweet potatoes, sunflower seeds, whole-grain breads and cereals, lobster, wheat germ, and salmon. Good natural sources of pantothenic acid include yeast, liver, eggs, wheat germ, bran, peanuts, peas, meat, milk, poultry, whole grains, broccoli, mushrooms and sweet potatoes. Most vegetables and fruits contain small amounts. Heat, food processing techniques and canning destroy pantothenic acid, so in many cases, supplementation may be necessary.

What is Pantothenic acid (vitamin B5) used for and who uses it?

Vitamin B5 is of paramount importance for human growth, reproduction and many normal bodily functions. Vitamin B5 helps breakdown nutrients, synthesize antibodies, and manufacture vitamin D. It also enhances the healing of wounds by significantly lessening the time required for the entire healing process. Pantothenic acid plays an important role in numerous biological reactions, including the production of energy, the catabolism of fatty acids and amino acids, the synthesis of fatty acids, lipids, cholesterol and steroid hormones, and the production of both coenzyme A, and the cellular antioxidant glutathione. It is the most important constituent of coenzyme A, which helps in many metabolic pathways and is required for the transport of fats to and from cells. Without it, fats could not be metabolized or broken down to energy. In line with this, carbohydrates and proteins are converted to energy, glucose is manufactured in the body, fats are broken down, and cholesterol as well as certain necessary hormones are synthesized. Vitamin B5 is crucial as well to the production of red blood cells as well as sex and stress-related hormones produced in the adrenal glands, those small glands that rest above the kidneys. Aside from all those already mentioned, Vitamin B5 supplements are sometimes used to help treat symptoms of allergy and a wide range of skin conditions.

Vitamin B5 is crucial in ensuring a healthy digestive tract and it also helps the body utilize other vitamins more effectively. Pantothenic acid can also help in managing and reducing stress and adverse impact to health brought about by psychological strain, migraines, chronic fatigue syndrome, and smoking and alcohol cessation. Pantothenic acid has long been known to be necessary for reliable and optimal antibody production, for the manufacture of diphtheria toxoid and hemagglutinating antibodies, and for vaccinations against tetanus, typhoid, or Asian influenza. Adding calcium-D-pantothenate to cultured human skin cells with an artificial wound improved the number of migrating skin cells and their speed of migration, effects which indicate Pantothenic acid administration is likely to accelerate wound healing. Additionally, since the body converts pantothenic acid into a chemical called pantethine, and pantethine when taken as a supplement appears to lower the amount of lipids in the blood, a person with high cholesterol may see their level of LDL ("bad") cholesterol decrease, while at the same time increasing HDL ("good") cholesterol levels, thus lowering the chances of having cardiovascular diseases.

How pure is your Pantothenic acid (vitamin B5)?

This pure bulk Pantothenic acid nutritional raw material (more commonly referred to as vitamin B5) is assayed by the manufacturer as 99.5% pure product (normal range 98.0 to 101.0%). You will receive a double sealed and labeled bulk polyethylene bag containing this odorless ultra white powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 0.5% by weight are inactive byproducts of the extraction. Having a high level of energy is important to bodybuilders as athletes and just about anyone who is trying to get in shape. Medical professionals use this dietary supplement as a treatment in many cases like acne, hyperlipidemia, rheumatoid arthritis, and is used in burn therapy. Aside from being an integral part in the Krebs cycle of energy production, Vitamin B5 is involved in the synthesis of red blood cells and adrenal hormones. According to research, vitamin B5 may help manage and control cholesterol levels and healthy triglycerides levels in the body that are already in normal range, and can also help in the production of ATP which powers the cells. It is proven to be safe and effective as long as you do not exceed the recommended dosage. Although no one is usually deficient of Vitamin B5, supplementation can help many people. Since pantothenic acid unlike other B vitamins is not added to processed foods, and a lot of pantothenic acid is lost when foods are canned, frozen, or processed, to get the sufficient amount needed for the body, supplementation may be necessary.

What are some of the common effects of Pantothenic acid (vitamin B5)?

Pantothenic acid is both an antioxidant and a water-soluble nutrient required to metabolize and process carbohydrates, proteins, and fats. Pantothenic acid can be either in the forms of calcium pantothenate or pantethine. Vitamin B5 is needed for human growth, reproduction and many normal bodily processes, as it is beneficial in metabolizing nutrients, manufacturing antibodies and producing vitamin D. Pantothenic acid plays a key role in the synthesis of hemoglobin, neurotransmitters, and lipids. Pantothenic acid (B5) is also required for biological processes involving acetylation and energy production. Pantothenic acid also assists in acetylcholine formation, fatty acid metabolism, and the incorporation of fatty acids into cell membrane phospholipids. Pantothenic acid is also an integral part in making steroid hormones, vitamin A, vitamin D, and cholesterol.

What is the daily suggested dose of Pantothenic acid (vitamin B5)?

The recommended dosage of this vitamin is 500mg a day. It is a water-soluble vitamin so it is very easy to prepare. Just take at least 1/16 - 1/8 teaspoon per day and mix it in water or with any other beverage. One eighth level teaspoon will supply approximately 376 milligrams. You can see the full bulk density/volumetric conversion chart for Pantothenic acid here. If you need to consume more than the recommended dose, consult your doctor first just to be on the safe side. Higher doses may be recommended by a qualified practitioner for the treatment of specific conditions.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Deficiency and Potential side effects of Pantothenic acid (vitamin B5)

A deficiency of pantothenic acid in adults is rare, primarily because it is found in so many dietary sources. Even if vitamin B5 is taken in very large quantities, the worst that could happen is diarrhea. Fatigue is probably the earliest and most common indicator of pantothenic acid deficiency, though it is unlikely because of the availability of B5 in many foods, plus the fact that it is also manufactured by our intestinal bacteria. Vitamin B5 deficiency can result to depression, changes in personality, heart conditions, increased susceptibility to infections, fatigue, abdominal cramps, difficulty sleeping, numbness in the arms and legs, muscular weakness, and greater sensitivity to insulin (the hormone that lowers blood glucose levels). Pantothenic acid is not toxic in humans and no serious side effects have been reported, even at doses of up to 10,000 mg (10 grams) a day. Excessive amounts of pantothenic acid however (several grams per day) can cause diarrhea. Aside from that, no other negative reactions to high doses have been documented. Pantothenic acid works synergistically with vitamins C, vitamin B6, and vitamin B12 (which we all carry in our inventory), and can improve utilization and may correct deficiency of these vitamins.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Pantothenic acid (vitamin B5) is used in the following Proprietary Formulas

AST Multi Pro 32X, BrainQuicken BodyQuick, Dymatize Liquid L-Carnitine 1100, Palo Alto Labs Reset-A.D., SlimQuick SlimQuick Energy, NOW Pantethine, NOW Pantothenic Acid, Solaray Pantothenic Acid, Adrenal Fatigue Institute Cylapril, Anabolic Addiction MFV, ANSI Thermo Hydroxadrine, Futurebiotics StressAssist, Health Direct Nature's Optimal Nutrition, HST Thermo Fusion, Hydroxycut Maximum-Strength Cleanse System For Women, Jarrow Formulas Adrenal Optimizer, Michael's Adrenal Xtra

References & Further Research

Role of pantothenic and ascorbic acid in wound healing processes: in vitro study on fibroblasts
In order to analyze the possible role of pantothenic acid (PA) and ascorbic acid (AA) in wound healing processes, the effects of these vitamins upon the growth of fibroblasts, obtained from human fetal skin or foreskin, were studied. Cell proliferation, protein synthesis and protein release were evaluated. These results suggest that the combined use of these two vitamins might be of interest in postsurgical therapy and in wound healing.

Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit
The effect of pantothenic acid supplementation and deficiency on wound healing was investigated over a one month postoperative period in rabbits. Overall research data indicate that pantothenic acid induces an accelerating effect of the normal healing process. The mechanism responsible for this improvement seems to be an increase in cellular multiplication during the first postoperative period.

Pantothenic acid (vitamin B5) for International Customers

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