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What is D-Ribose Powder?

D-Ribose is a naturally-occurring sugar that produces energy by stimulating and triggering ATP production and maintaining normal ATP (Adenosine Triphosphate) levels in the body. It promotes fitness in athletes and improves health condition of people with cardiovascular problems and of those suffering from fibromyalgia and chronic fatigue syndrome. Adenosine triphosphate (ATP), the molecule known as the primary source of energy for all cellular processes, is considered by biologists to be the energy currency of life. It is the molecule that stores and provides the energy required in our day-to-day activities. It is present in the cytoplasm and nucleoplasm of every cell and essentially of all physiological mechanisms that require energy. Ribose is a natural sugar found in all living cells, which triggers the process by which cellular energy, or adenosine triphosphate (ATP) is synthesized and produced. As food in the cells is gradually oxidized, the released energy is used to re-form the ATP so that the cell maintains a constant supply of this essential molecule.

Healthy, active cells replace their ATP stores on a regular basis to produce the needed cellular energy. However, under debilitating conditions which can include stress, injury, or aging, vital body tissues and organs such as heart and skeletal muscles cannot replenish ATP quickly enough to perform optimally. D-ribose, a carbohydrate molecule found in every living organism, facilitates and assists in the synthesis of ATP. D-Ribose supplements and D-Ribose Powder can help speed energy recovery, increase energy reserves, and maintain healthy energy levels in heart and muscle tissue. Ribose and its related compound, deoxyribose, are the carbohydrates necessary in forming DNA and RNA (ribose is used in RNA and deoxyribose is used in DNA).

D-Ribose aids in appetite suppression, increases the body's energy level and promotes mental health. It is perfect for weight loss because it helps shorten recovery time between workouts thus, allowing those on a weight loss program to work out more often and more effectively. D-Ribose Powder supplement was initially formulated for athletes and bodybuilders but it has also been recommended for the rest of the population regardless of age, gender and fitness level. D Ribose is said to be beneficial to those who have suffered a heart attack, have fibromyalgia and for those suffering from chronic fatigue. It is also said to be good for overall muscle health.

Who uses D-Ribose and what is it used for?

Ribose provides every cell in the body with energy by its action of being able to trigger ATP synthesis and providing a constant supply of this essential molecule. Among serious athletes, just like creatine (which we also carry in our inventory) it is one of the more popular supplements to take to increase stamina and endurance and to help them recover from workouts more quickly. It is also typically taken or “stacked” with creatine, another substance that helps keep the muscles supplied with ATP, in formulas marketed to serious strength athletes like professional body builders, strongman competitors, powerlifters, etc. Ribose helps enhance strength and athletic performance by supplying cells in the muscle tissue with a continuous and dependable supply of ATP.

While there is an abundance of anecdotal evidence from body builders and other athletes concerning the positive effects of ribose, more clinical research in this area is still needed to substantiate this claim. However, laboratory studies have demonstrated that ribose is indeed able to speed up the recovery of the heart muscle and improve the well-being of people in general after suffering a massive heart attack, and can also facilitate better blood flow to the heart in those affected by ischemia. For these reasons, Ribose supplementation has been used to support heart function and rejuvenate cardiac tissue after both heart attack and heart surgery. Preliminary researches have also demonstrated that ribose may also help promote recovery in those with illnesses characterized by ATP depletion, such as Huntington’s Disease (HD) and fibromyalgia. Its effectiveness can be somewhat attributed to the fact that it is a small molecule, which enables it to easily pass through the blood brain barrier.

D-Ribose is used by athletes to reduce muscle cramps and soreness, to prevent swelling of the joints and to further enhance athletic performance. Patients suffering from fibromyalgia, chronic fatigue and muscle pain use it to reduce muscle cramps and soreness and to minimize the debilitating effects of fatigue. D-Ribose decreases blood flow through the arteries in the heart and is used to treat a genetic metabolic disorder called myoadenylate deaminase deficiency (MAD or AMPD deficiency). This supplement should be taken in large quantities initially during the loading phase while the body responds actively. During the loading phase, one should take three grams of Ribose 3-4 times a day to make the muscles strong. During the maintenance phase, Ribose should be taken about 3-6gms a day. Taking high quality Ribose supplements hastens energy recovery in all types of skeletal muscles. This means you'll be able to work out longer and rebuild muscle faster after an intense workout. Recent studies recommend a daily dose of 10-20 g of Ribose, and have targeted athletes undertaking intermittent high-intensity exercise programs like weight training and cross training.

How pure is your D-Ribose?

This D-Ribose powder is assayed by the manufacturer to be 99.2% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag of this white powder product. When you exercise, some of the ATP that your body uses for energy is lost from your cells and must be replenished. Ribose is the only substance that the body utilizes as a starting point to synthesize and restore these molecules required for energy. However, since ribose production in the heart and skeletal muscles is a slow process, and cannot always keep up and compensate with the use and loss of energy during ischemia (insufficient blood flow) or strenuous, intensive exercise, supplementation may be necessary. Under normal conditions, it may take more than just a couple of days to completely restore ATP molecules that are lost due to disease-caused ischemia, or from intensive exercise. Reduced ATP levels will also result in the poor performance of anyone engaged in exercise, from the strength and endurance athletes to fitness exercisers. The ability and efficacy of ribose to help increase muscular energy, boost endurance, and promote recovery is backed by a wide array of numerous research. As an effective source of cellular energy that is naturally occurring and found in all cells in the body, ribose supplementation is an efficient way to increase and sustain your energy levels needed for exercise, through its participation in the synthesis of ATP in the muscle cell, thus enhancing performance, and aiding in the recovery of muscle tissue after intense exercise. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits and muscle mass gains made possible with D-Ribose, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What are some of the common effects of D-Ribose?

Intense exercise results to a significant decrease ATP and energy levels in skeletal muscle, which in most cases, take 3 days or longer to be restored. To address this, recent studies have shown that supplementing with high quality ribose leads to shorter recovery time in all types of skeletal muscles. This means D-Ribose supplementation will help you get the energy you need to be able to work out longer and more frequently, and build muscle faster because you will recover sooner from intense workouts, making any fitness regimen or training program more bearable and sustainable. Additionally, research over the past 25 years has confirmed that ribose stimulates and promotes energy recovery in cardiac muscle (heart tissue) after periods of restricted blood flow. Rigorous testing in both animal and human studies have shown time and time again that supplementation of ribose restores intracellular energy levels in the cardiac muscle tissue and helps maintain healthy heart function.

What is the suggested or recommended daily dose of D-Ribose?

Recommended dosage for D-Ribose in general vary between as little as 3 grams to as much as 20 grams per day in three divided doses, depending upon individual needs. For bodybuilders and performance athletes one half level tablespoon will supply approximately 4854 milligrams, or just about 5 grams for the bulk density of this D-Ribose powder. You can see the full bulk density/volumetric conversion chart for D-Ribose here. Taking 1/2 level tablespoon 3 times per day will supply about a total daily dose of 15 grams. To have a true anabolic effect you need 5-20 grams daily. Research has shown that about 3 to 5 grams of ribose taken every day should put enough in the bloodstream to ensure that the heart and skeletal-muscle cells have an adequate supply. For people with heart or circulatory system conditions, who want to try using ribose to increase exercise tolerance or reduce post-exercise soreness or stiffness, they should do so under doctor supervision.

Precautions and Potential Side Effects of D-Ribose

Since D-Ribose is produced naturally in the body there is no reported adverse side effects with regular intake of this substance, however, overdose of this supplement can lead to diarrhea and symptoms of hypoglycemia, hyperuricemia, and hyperuricosuria. Ribose is safe when taken by mouth for short-term use, but when taken for long periods it can cause stomach discomfort, nausea, headache and low blood sugar. In insulin-dependent diabetics, D-Ribose can further lower blood glucose levels. A physician must be consulted about adjusting their medications before taking ribose supplements. Do not take ribose if you are pregnant or breast-feeding, if you have diabetes, if you have low blood sugar (hypoglycemia) or if you are scheduled for surgery in the next two weeks. It is always advisable that you take D-Ribose in a full stomach or at mealtime.

Taste, solubility, and suggested preparation of D-Ribose

This product dissolves quickly in water or fruit juice and tastes somewhat sweet like sugar. This supplement is made from the fermentation of corn syrup. It is a sugar or a carbohydrate which is used by all living cells and regarded as an important component for the body in the production of energy. The thing with Ribose is that since it is a simple sugar, it easily provides glycogen for energy storage and at the same time starts the chain reaction to make new ATP. It would be great to take in workout hyperhydration drinks, but also as a recovery supplement or a preworkout booster. It also goes well with creatine. Owing to the fact that it is a simple sugar, it can raise the insulin level in the blood and therefore facilitate the absorption of protein and creatine.

D-Ribose is used in the following Proprietary Formulas

Glycobiotics D-Ribose Powder, Bio Energy D-Ribose Powder, Best D-Ribose, Source Naturals Ribose, D-Ribose Ribopure Crystals, Supplement Direct Reps, NOW D-Ribose Powder, First Endurance Optygen, AllMax Nutrition Muscle Prime, Get Diesel NOS Ether, Cheap Supplements Ribose, Doctor's Best Best D-Ribose, Jarrow Formulas Ribose Muscle Edge, Life Extension D-Ribose Powder, Muscle-Link Ribose Size, Olympian Labs Ribose, SciFit Ribose

References & Further Research

D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHFThe administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling, a smaller left atrial dimension and a shortened E wave deceleration by echocardiography. Further, D-ribose also demonstrated a significant improvement of the patient's quality of life. In comparison, placebo did not result in any significant echocardiographic changes or in quality of life. This feasibility study in patients with coronary artery disease in CHF revealed the beneficial effects of D-ribose by improving diastolic functional parameters and enhancing quality of life.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study
This open-label uncontrolled pilot study was done to evaluate if D-ribose could improve symptoms in fibromyalgia and/or chronic fatigue syndrome patients. Forty-one patients with a diagnosis of fibromyalgia and/or chronic fatigue syndrome were given D-ribose at a dose of 5 grams three times a day for a total of 280 g. D-ribose supplements improved all five visual analog scale categories: energy; sleep; mental clarity; pain intensity; and well-being, as well as an improvement in patients' global assessment. Approximately 66% of patients experienced significant improvement while on D-ribose.

Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans
The effect of oral ribose supplementation on the resynthesis of adenine nucleotides and performance after 1 wk of intense intermittent exercise was examined. Eight subjects performed a random double-blind crossover design. The results and overall data support the hypothesis that the availability of ribose in the muscle is a limiting factor for the rate of resynthesis of ATP. Furthermore, the reduction in muscle ATP observed after intense training does not appear to be limiting for high-intensity exercise performance.

D-Ribose for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying D-Ribose Bulk or Wholesale

If you need D-Ribose in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!