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What is Dehydroepiandrosterone (DHEA)?

DHEA, or dehydroepiandrosterone, is a steroid hormone produced by the adrenal glands and it is the adrenal hormone precursor for numerous hormones such as testosterone and estrogen. DHEA is sometimes called the “mother hormone” because the body is able to synthesize estrogen and testosterone from it, two other well-known steroid hormones, DHEA is the most abundant naturally occurring hormone precursor in the human body and is not water soluble. However, this micronized form has an extremely small particle size of 50 microns that facilitates assimilation and absorption when taken internally or sublingually. DHEA supplements are available in tablets, capsules, and creams. It is also incorporated in many formulas and supplements that claim to increase muscle mass, longevity, libido, etc. As with other hormones, DHEA decreases as we age. In normal adults, natural DHEA levels peak around the age of twenty, and then decrease steadily. The lower the level becomes, the more susceptible a person is to sickness. If you think you have low DHEA levels, a simple blood or saliva test at your physician’s office is the best way to confirm this.

Aside from being a hormone produced by the adrenal glands, DHEA is also produced in the gonads, adipose tissue and the brain. Since cholesterol is the precursor to DHEA, this natural steroid hormone is produced from cholesterol by the adrenal glands found atop of the kidneys in the human body, and is synthesized in the adrenal cortex in the region known as the zona reticularis. DHEA is then produced in the adrenal glands and is converted on command to specific hormones the body needs to maintain bodily functions, such as the sex hormones estrogen and testosterone. Because DHEA levels are lower than normal in people with kidney disease, type 2 diabetes, anorexia, Addison’s disease, and AIDS, it is thought that certain prescription medications such as insulin, corticosteroids, opiates, and danazol used to treat these disorders may suppress the production of DHEA in the body. Existing research indicates that DHEA may indeed help treat or prevent these diseases. People currently taking these medications may want to supplement DHEA, but not without first consulting their physicians.

As the most abundant steroid in the bloodstream and as the precursor for the production and synthesis of many other hormones, such as estrogen, testosterone, progesterone, cortisone, and others, DHEA is the most naturally-occurring hormone or the most common steroid in the human body. Depending on the body’s needs for specific functions, DHEA can be transformed into testosterone (the primary male sex hormone), estrogen (an important female sex hormone), or other steroids. Optimal levels of DHEA are directly linked to increased energy, healthy immune and cardiovascular function, improved memory and elevated mood. Adequate DHEA levels give the body the building blocks necessary to synthesize these hormones. Taking DHEA may increase IGF-1 levels and improve the sense of well-being. Conversely, low levels of DHEA have been linked with coronary artery disease. DHEA is also responsible for producing hormones that regulate fat and mineral metabolism, as well as stress.

What is Dehydroepiandrosterone (DHEA) used for and who uses it?

DHEA plays an integral part in the regulation and production of other hormones such as testosterone and estrogen. DHEA also facilitates the improvement of cholesterol profiles, loss of body fat, increase in muscle mass, etc. DHEA is absorbed and taken from the small intestine and is transferred to the liver, where it is processed primarily to DHEAS by the action of the enzyme sulfotransferase. DHEA and DHEAS are then transported to the various tissues in the body where metabolites, including androstenedione, testosterone, estrogens (estrone and estradiol), androstenediol and 7-oxo-DHEA, are synthesized. AN increase in DHEA levels have been linked to an improved sense of well being, significant body fat reduction, noticeable improvements in skin tone and moisture, increase sex drive, better immune functions, enhanced memory, and increased bone density. DHEA indeed may one day be proven to be a wonder drug, as there have already been numerous studies carried out that indicate DHEA may help treat numerous other disorders as well, including Crohn’s disease, depression, menopause, myotonic dystrophy, irregular menstrual cycle, schizophrenia, and erectile dysfunction, to name a few.

DHEA has been used for around thirty years to help treat conditions including obesity, diabetes, and lupus, and since then it has been found out that people with various diseases have levels of DHEA that are unusually low. Since DHEA levels decline with age, the lack of it increases the incidence or risk of killer diseases. When the human body is about twenty years old DHEA levels are at its peak. But by the age of eighty or so, DHEA levels recede to about ten to twenty percent of the amount at twenty years of age. This is when supplementation with DHEA is most beneficial. It has also been found to enhance and provide a more restful sleep, resulting in increased energy levels and an improved sense of well being, as reported by those who have used DHEA. Maintaining proper levels of DHEA is also claimed to have a positive effect on a person's appearance. DHEA may also be intimately involved in protecting brain neurons from senility-associated degenerative conditions, like Alzheimer's disease.

DHEA is also beneficial in cancer prevention. Low levels of DHEA in the blood have been linked to a higher incidence rate of breast cancer in women. As a naturally occurring steroid synthesized in the adrenal cortex, gonads, brain, and gastrointestinal tract, DHEA is known to have chemopreventive and anti-proliferative actions on tumors. These effects are considered to be the direct result of the inhibition of glucose-6-phosphate dehydrogenase (G6PD) and/or HMG-CoA reductase (HMGR) functions. DHEA may also play a crucial part in protecting against depression. As a cholesterol metabolite, DHEA aids in the relief of stress. Stress triggers the body to secrete cortisol and DHEA, thus increasing the risk of getting infectious diseases. DHEA works with serum cortisol to strike a balance between them, because an imbalance between the two can lead to stress disorders. During highly stressful conditions, such as critical illness, cortisol is increased, and DHEA is suppressed. DHEA has an anxiolytic or a tranquilizing effect on stress, thus relieving anxiety, and reducing tension and irritability. These effects demonstrate that DHEA works to terminate the stress response, depending on the amount of DHEA. DHEA also aids in weight control, as hormones produced from DHEA such as testosterone directly influence fat and mineral metabolism. Because of DHEA’s ability to block the G6PD enzyme, it can cause the reduction of body fat by redirecting glucose from anabolic fat-production into catabolic energy metabolism, thus creating a leaner metabolism. This makes DHEA a weight control method that is not dependent upon a person's diet.

How pure is your Dehydroepiandrosterone (DHEA)?

This ultra fine micronized (less than 50 microns particle size) Dehydroepiandrosterone (more commonly referred to as DHEA) is assayed by the manufacturer as 99.31% pure product (99% minimum). You will receive a double sealed and labeled bulk polyethylene bag containing this white nutritional powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 0.69% by weight are inactive byproducts of the extraction.

DHEA is a steroid hormone precursor nutritional supplement product. Every year after the age of 30, the DHEA produced by the body becomes less and less. Since DHEA plays a crucial role in the production of male and female sex hormones, it has developed a reputation as a veritable fountain of youth. DHEA supplements are believed to help make muscles bigger, speed up the metabolism, increase libido, and to prevent a variety of conditions associated with aging, including osteoporosis, arthritis, hardening of the arteries, and cancer. DHEA is also currently being looked at for its possible role in treating autoimmune diseases, such as chronic fatigue syndrome and lupus. Existing studies seem to substantiate the notion that DHEA can significantly strengthen the immune system. For these reasons, it makes sense to consider taking a supplement.

What is the daily suggested dose of Dehydroepiandrosterone (DHEA)?

DHEA can be taken internally from as little to 25 mg to as high as 200 milligrams per day. Daily doses higher than 200 milligrams of this micronized DHEA and DHEA alcohol solutions are generally considered to be extreme and should only be taken under the direct supervision and advice of a physician or health practice professional. You can see the full bulk density/volumetric conversion chart for DHEA here. When used in the correct dosages, DHEA is great, but just like with other types of hormone or compound, when used incorrectly it can cause problems. The exact right dosage may vary with each individual, so consulting a physician is a good idea. Women and men over 60 are typically advised to take 50mg and 100mg respectively. Since the younger you are the more DHEA you can produce naturally, younger people should take less. Pregnant or nursing women should not take it.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

What kind of results do people anticipate while taking Dehydroepiandrosterone (DHEA)?

Because DHEA levels decrease with age, people above middle age can have incredible results as studies have shown. Bodybuilders or athletes can have some of the greatest beneficial results as they can use it to help build strong muscles and lower body fat. It is also said to help keep the brain clear and the skin smooth as well.

Precautions, Interactions, and Potential side effects of Dehydroepiandrosterone (DHEA)

Few side effects have been reported when DHEA is used at recommended doses. Side effects at high intakes appear to be acne, increased facial hair, and increased perspiration. Various androgenic effects, including acne, deepening of the voice, hirsutism and hair loss have been reported in women using supplemental DHEA. If it abnormally increases testosterone, then testosterone side effects may be expected, including increased risk of prostate cancer. Women taking excessive doses of DHEA have reported acne and facial hair. DHEA can also be converted into estrogen, so high levels of DHEA can lead to estrogen side effects as well, including increased risk of breast cancer and undesirable or unwanted feminine characteristics. Other side effects of DHEA may include irritability and restlessness. Some studies suggest that people with HIV and Kaposi's Sarcoma (KS) have very high levels of DHEA, so DHEA intake might be especially harmful for people with these conditions. DHEA may have additive adverse effects if used along with 4-androstenedione, 4-androstenediol, 5-androstenedione, 19-4-norandrostenedione and 19-5-norandrostenediol--all available as OTC sports supplements. DHEA may interact with certain seizure and pain medications, clofibrate and tamoxifen. Pregnant women, non-adults and people at high risk for or who have hormone-sensitive cancers should never use DHEA.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Dehydroepiandrosterone (DHEA)

This DHEA has a mildly bitter taste and should be taken with meals or sublingually for increased absorption. Many claim that DHEA dissolved in alcohol and taken sublingual may have two to four times the absorption as when ingested in capsules or powder. Topical preparations for DHEA usually involve between 5% and 10% DHEA by weight and include ethyl alcohol and an oil, like olive oil. DHEA is not water soluble but will readily dissolve in ethyl alcohol and can then be mixed or blended with an oil or oil based cream for topical administration.

Dehydroepiandrosterone (DHEA) is used in the following Proprietary Formulas

Fountain Of Youth HGH Complete, Gaspari Nutrition Halodrol Liquigels, Higher Power DHEA 200, Higher Power DHEA, Pharmaceutical Alternatives TestoRx, AST DHEA 100, Biochem DHEA, BioSynergy DHEA, Maximum Nutrients DHEA, MRM DHEA, Nutraceutics DHEA MAX, Olympian Labs DHEA 25, Ultimate Nutrition DHEA, ASN Enhanced DHEA, ASN Maxabol II, Biotab Nutraceuticals ExtenZe, Country Life DHEA Complex For Men

References & Further Research

Dehydroepiandrosterone and lupus: Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus
The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Dehydroepiandrosterone treatment increased serum levels of sulphated dehydroepiandrosterone from subnormal to normal. There were no effects on bone density or disease activity and no serious adverse events. Side effects were mild. We conclude that low dose dehydroepiandrosterone treatment improves HRQOL with regard to mental well-being and sexuality and can be offered to women with SLE where mental distress and/or impaired sexuality constitutes a problem.

Osteoporosis and bone strength: Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone
Age-related reductions in serum dehydroepiandrosterone concentrations may be involved in bone mineral density (BMD) losses. The objective was to determine whether DHEA supplementation in older adults improves BMD when co-administered with vitamin D and calcium. In year 1, a randomized trial was conducted in which men and women aged 65–75 y took 50 mg/d oral DHEA supplements or placebo. In both groups, serum concentrations of bone turnover markers decreased during year 1 and remained low during year 2, but did not differ between groups. DHEA supplementation in older women, but not in men, improves spine BMD when co-administered with vitamin D and calcium.

Very short term dehydroepiandrosterone treatment in female adrenal failure: impact on carbohydrate, lipid and protein metabolism
In female adrenal insufficiency, dehydroepiandrosterone secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological dehydroepiandrosterone substitution on substrate metabolism. We studied nine females with adrenal insufficiency after 9 days of oral dehydroepiandrosterone replacement (50 mg/day) in a double-blind, placebo-controlled crossover study. Basal and insulin-stimulated total energy expenditure and rates of protein, lipid and glucose oxidation were unaffected by dehydroepiandrosterone. Finally, the interstitial release of glycerol in adipose tissue was not significantly influenced by dehydroepiandrosterone. CONCLUSIONS: Short-term oral dehydroepiandrosterone replacement in women with adrenal insufficiency was not associated with measurable changes in total or regional substrate metabolism.

Dehydroepiandrosterone (DHEA) for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

International Shipping of DHEA:Because many countries impose restrictions on the import of DHEA or have altogether banned the import of DHEA, you need to do your own research into your own country's rules and regulations for the importation of this nutritional supplement. If DHEA is banned by your country it will likely be returned, impounded, confiscated, and or destroyed by your country's customs and you may not receive your package delivery. You may even be required to pay fines by your country's customs for attempting to import a banned product illegally. If you order DHEA from Purebulk, you agree that you will not hold us responsible or accountable should you not receive your shipment or should you suffer any financial losses as a result of your attempts to import this product. Do your own research and make sure it is legal to import DHEA into your country before you purchase this item. If you order DHEA from Purebulk, and you have us ship this item to you internationally, and you do not receive delivery of this item, our responibility to you will only extend so far as to demonstrate by USPS tracking that we did in fact mail your package. We will only issue you a refund of your purchase price for this product in the case that your package is returned to us. Shipping charges, however, will not be refunded.

Buying Dehydroepiandrosterone (DHEA) Bulk or Wholesale

If you need Dehydroepiandrosterone (DHEA) in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!