PureBulk

Click to Enlarge Unit Weight: 100 grams Unit Volume: 200 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is Grape Seed Extract?

Who would believe the benefits of grape seed extract eclipse the advantages of eating grapes? Surprising but grape seed extract may be better for you than the grapes from which it comes. For centuries, people from many different cultures around the world have enjoyed a fine glass of wine, but it is only now that scientists learned it might be beneficial for us, too. In fact, one of the unexpected advantages for millions of consumers enjoying the fruits of the wine industry is that its by-products can be turned into some really useful health supplements, with grape seeds, for example. Grape seed extract is treated as waste product of the winery and grape juice industry, because it is a by-product of the wine and juice making process and they don't go into the finished drinks.

Grape Seed Extract is a natural plant product taken from the grape seed (or pip). Grape Seed Extract is rich in procyanidins, a special type of water-soluble bioflavonoids which are outstanding free radical binders. As one might expect, grape seed extract is extracted from the seeds, and sometimes the skins as well, of red grapes. These are the same kind of red grapes used to make wine, and the same grapes believed to provide the health benefits that enabled the French to eat a fatty diet without the rampant heart disease experienced by Americans and other westerners. Grape Seed Extract is rich in polyphenols, a compound that's high in antioxidants. It is known to be a rich source of flavonoids, those phytochemicals whose antioxidant properties may exceed those of the more well known sources like vitamin A, C, E, and beta-carotene. These anti-oxidants assist in protecting cells from damages caused by free radicals, and also promotes healthy circulation. Some people call these polyphenols nature's biological response modifiers because of their ability to help the body fight viruses, allergens, and carcinogens. That means together with their many benefits, Grape Seed Extract also exhibits anti-inflammatory, anti-allergic, anti-cancerous and anti-microbial capailities.

Grape seed extracts also have compounds called procyanidolic oligomers (PCOs), or otherwise known as oligomeric proanthocyanidins (OPCs). Other sources of OPCs are berries, green and black teas, and red wine. Aside from being powerful antioxidants, OPCs also inhibit a number of enzymes that degrade connective tissue such as elastase, collagenase, and hyaluronidase. As strong antioxidants, they are also thought to help improve blood flow and strengthen the blood vessels. This improved blood circulation can significantly help strengthen and protect the heart. This positive effect on blood flow makes supplementation with grape seed extract an excellent idea for anyone who is likely to benefit from better circulation. Those with leg cramps, diabetes, varicose veins and numbness of the legs and arms stand to benefit the most from this supplement. The increased blood flow can also help aid erectile dysfunction. On top of the benefits already mentioned, eye diseases common to the elderly, like cataracts and macular degeneration, may be prevented by grape seed extract. Grape seed extract is also believed to help fight minor eye problems such as eye strain.

Before Grape seed extract was discovered, antioxidants were derived from consuming food and supplements containing vitamin C, E, and beta-carotene, which were the best sources then; however, these sources were not powerful enough to fight the free radicals and are also excreted by the body within a short time of ingestion. Grape seed extract, in contrast, has been shown to remain available in the body for as long as 3 whole days, and is 20 times more potent than vitamin C, and 50 times stronger than Vitamin E. The research done on Grape Seed Extract first came about in late 20th century from what is more popularly known as the "French paradox." It is aptly named as such because the French had very low rates of heart disease, considering their fatty diet should have contributed to higher incidence of heart diseases. Scientists believed this is because the French frequently consumed red wine. Further research has shown the OPC present in their red wine promotes cardiovascular health, and now, grape seed extract has been found to contain the richest sources of OPCs. It can be said without a doubt that grape seed extract is one of the most powerful antioxidants available.

What is IN Grape Seed Extract?

What many people do not know is that grape seed extract contains a vast array of health-giving ingredients, such as protein, lipids, carbohydrates and polyphenols (which come mainly in the form of flavonoids, also known as bioflavonoids). One specific class of phenol available in grape seed is called procyanidin. It was first found in 1936 by Professor Jacques Masquelier, who named it Vitamin P, (although the name didn't really stick, and has since fallen out of usage). Aside from the the disease prevention and health benefits mentioned above, procyanidins are believed to protect the body from premature ageing. Scientists say GSE does this by increasing vitamin C levels in the cells, which in turn scavenges for toxins so the organs can be free of them. Procyanidins also bond and work well with collagen, a key component of skin, gums, bones, teeth, hair and body tissues. This bonding leads to cell health and skin elasticity, making a person's appearance seem more youthful, in a process that works close to a natural face-lift. Procyanidins also help protect the body from the sun's harmful rays, which can also cause premature ageing of the skin.

Far more important to your body than vanity and looking good, is the fact that procyanidins can enhance your vision, your joint's flexibility, the health of your heart and arteries, and also bolster and build up your capilliaries and veins to improve your overall circulatory system. This is important because the health of your circulatory system directly affects the health of your heart. It appears grape seed extract is able to delay the oxidation of low density lipoproteins, the fats that are responsible for bad cholesterol. The more time it takes for LDL to oxidize, the less susceptible it is for your veins and arteries to start clogging up. People who drink purple grape juice have been shown to gain an increase in oxidation lag time of 27%.

Also, procyanidins present in grape seeds have been clinically proven to exert anti-inflammatory, anti-arthritic and anti-allergic activities, to prevent skin aging, to scavenge oxygen free radicals and to inhibit the damaging effects of UV radiation from sunlight. Since most of these processes are related to cancer, it follows that grape seeds are strong anti-carcinogenic and/or anti-tumor-promoting agents. Studies show they may have particular application against colorectal cancer, and scientists are dedicating more than just a fair amount of resources, time, and new research to grape seed because they're pretty confident about its abilities.

One other of the grape's hidden health weapons is also worth a mention: it's called resveratrol. This chemical is found primarily in the skin and seeds, particularly in muscadine grapes, and it provides numerous health benefits to the body. They include all those mentioned above, but resveratrol also has an ability to help the brain and its processes work efficiently i.e. they have neuroprotective attributes. In rats, this has life-prolonging effects, so it's reasonable to assume it may do the same for other animals, humans included.

What is Grape Seed Extract used for?

Today, there are two main aspects of grape seed: as an antioxidant, and to prevent heart disease. A recent study of volunteers that are generally healthy discovered that grape seed supplementation drastically increased the levels of antioxidants found within the blood. Antioxidants are helpful because they fight and destroy free radicals, items found in the body that damage cell membranes, tamper with DNA, and can even possibly cause unwanted and damaging forms of cellular death. Free radicals can take place without outside interference and can naturally occur within the body. Free radicals hasten the aging process, as well as heart disease and cancer. Antioxidants that are found within grape seeds can lower or avert a type of damage that free radicals can cause.

The other main benefit of grape seed stems from the flavonoids it contains. Red wine containing flavonoids has been proven in studies to assist in protecting the heart as they can possibly interrupt or foil the oxidation of LDL, or the bad kind of cholesterol. This bad type of cholesterol, when oxidized, can harden the arteries which could take a turn for the worse possibly in the form of atherosclerosis. In countries such as America, where heart disease is prevalent, there's a great deal of need for products that prevent such illnesses. Grape seed extract is excellent in its ability to maintain healthy heart performance, due to its ability to hinder and stave off the development of plaque, which is known to clog the arteries and endanger those who suffer from this condition. Stroke can also be inhibited through the ongoing use of this particular food supplement, for the same reasons. Other studies have shown that a lower risk of death from coronary disease and the consumption of flavonoids are directly correlated to each other. Grape seed extract is effective for conditions pertaining to the heart and blood vessels, such as atherosclerosis (hardening of the arteries), high blood pressure, high cholesterol, and poor circulation. Other uses of grape seed extract in medicine include complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); and swelling after an injury or surgery. Grape seed extract is also beneficial for cancer prevention and wound healing.

Grapeseed helps alleviate symptoms from damages caused by free radicals and poor circulation, including chronic venous insufficiency (CVS), varicose veins, macular degeneration, and diabetic retinopathy. Grape seed extract also helps to reduce or eliminate the symptoms of leg cramps, varicose veins, diabetes, numbness in the extremities an even the effects of impotence, since this food supplement is designed to improve the body's blood flow. OPCs in grapeseed extract (GSE) also tone the capillaries and increase blood supply to the skin, which helps intercept and restrain the breakdown of collagen. For those who are keen in retaining a youthful appearance, the benefits of grape seed extract can come in handy as well. When applied topically, grape seed extract acts as an alpha-hydroxy acid. With its ability to help maintain the elasticity of the skin, Grapeseed has become a popular ingredient of many facial and skin creams designed to improve skin tone and diminish fine wrinkles. Grapeseed also contains significant amounts of resveratrol, a substance that acts as an anti-inflammatory and has demonstrated an ability to lower cholesterol and triglyceride levels and provide antioxidant protection. Some studies have shown that resveratrol may even help slow tumor growth.

Who uses Grape Seed Extract?

Healthy adults, as well as those that are sick, may benefit from supplementing with grape seed due to its ability to help fight free radicals. Regardless of gender, age, and medical condition, free radicals are a danger to everybody's body and holding them off is never a bad idea.

Those likely to benefit from increased blood flow, including people who suffer from leg cramps, Type 2 diabetes, varicose veins, and leg and arm numbness can experience relief by taking grape seed extract. The increased blood flow may even help to treat erectile dysfunction and eye diseases common in senior citizens, such as cataracts and macular degeneration. Those suffering from fibromyalgia, a disorder characterized by chronic muscle pain and stiffness, may also find the regular ingestion of grape seed extract an effective treatment for their symptoms. Those concerned about the effects of aging on skin elasticity enjoy many healthy benefits when taking grape seed extract as it promotes healthy cell growth and skin elasticity. The procyanidins contained in grape seed extract bond with collagen, the most abundant protein in the human body and a key component of skin, bone, teeth, hair, and gum tissues. Procyanidins protect the body from sun damage, which also causes premature aging of the skin.

How pure is your Grape Seed Extract?

Our high-quality, food grade grape seed extract powder is 97.3% Oligomeric Proantocyanidins, or OPCs. It is delivered in a sealed, labeled, heavy-duty 4 mil polyethylene bag of slightly red-brown powder. It contains no fillers, taste additives, or anti-caking agents. Luckily, you don't have to drink liters of wine or grape juice, or eat sacks of grape seeds to get these helpful chemicals into your body. Thanks to modern technology, we now have high-quality grape seed extract in the form of supplements. That means you can enjoy all the health-giving properties of grape seed simply by taking a food grade grape seed extract powder. Next time you toast your good health, you might like to spare a thought for the humble grape seed and all the wonders it can offer your body.

What kind of results do people anticipate while taking Grape Seed Extract?

The common effects of regularly taking grape seed extract are healthier looking skin, reduced pain as a result of arthritis, greater flexibility of the joins, and improved vision. Over the long-term, many regular takers of grape seed extract experience a reduction in the lipoproteins, or the fats that cause the 'bad' cholesterol. Because grape seed extract delays the oxidation of low density lipoproteins, those are less likely to cause plaque which hardens the veins and arteries and can clog. Additional effects include reduction of fat in the blood, lowered blood pressure, reduction of blood vessel scleroses and reduction of blood viscidity all of which are signs of a healthy cardiovascular system more likely to avoid heart disease.

What is the daily suggested or recommended dose of Grape Seed Extract?

Grape seed extract is typically taken orally with a standard dose containing 50mg to 100mg. Doses higher than 500mg per day should not be taken with out the direct care and supervision of a licensed physician or health practice professional. You can see the full bulk density/volumetric conversion chart for Grape Seed Extract here. Debasis Bagchi, a leading grape seed extract researcher suggests daily dose of 50mg for ages 30 to 40 years, 100mg for ages 40 to 50 years, and 200mg for adults older than 50 years.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of Grape Seed Extract

Currently, there are no side effects reported with taking grape seed extract, and no drug interactions have been reported either. In some cases, people consuming more than 300mg at a single time have reported mild nausea, but reducing the single dose to multiple doses taken throughout the day has shown to quickly eliminate the problem. Naturally, do not take grape seed extract if you're allergic to grapes.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

How does Grape Seed Extract taste and how should I take it?

In its powder form Grape Seed Extract is relatively simple to stir into a small glass of juice or water and drink. Alternatively it can be sprinkled on your food prior to consuming it, e.g. oats, etc. Depending on whether you have a sensitive stomach taking your dose with food may help some individuals combat feelings of nausea that may accompany larger doses. For doses larger than about 100mg Grape Seed Extract in its powder form will likely be too bitter for most individuals to tolerate regardless of whether it is taken with juice or food. Encapsulation for doses larger than 100mg may therefore the best option for taste sensitive people.

Given that Grape Seed Extract is 95% or higher OPCs and these OPCs have a half-life of approximately 72 hours in systemic circulation, it is not necessary to take Grape Seed Extract every day. Taking it every other day will maintain blood levels sufficiently constant. If you consider that a double ought (00) capsule such as the size we sell here on our website has an available volume of 0.95ml, it is typical that a uniformly packed double ought capsule will hold approximately 500mg to 600mg grape seen extract. At this dose it would really only be necessary to consume one capsule every other day. A dose of 600mg may not be practical for all individuals owing to the potential for the nausea that some may experience in doses above about 250mg. But when taken with a meal the the nausea will likely be reduced or unnoticeable for most individuals.

Therefore, if you find that the bitter taste of grape seed extract is objectionable for you in its bulk powder form you might want to consider taking your every other day dose filled within a double ought (00) capsule. We do sell 500mg capsules of Grape Seed Extract on our website and you may want to consider this product instead of the bulk powder if you are not prepared to encapsulate this product yourself. Although most researchers don't recommend higher OPC doses some researchers are recommending doses as high as 600mg (one double ought (00) capsule) per day. You should do your own research and come to your own conclusions before entertaining doses above 300mg per day (600mg every other day).

Grape Seed Extract is used in the following Proprietary Formulas

Source Naturals Grape Seed Extract, GNC Herbal Plus Standardized® Grape Seed Extract, Vitamin Shoppe Grape Seed Extract, Natrol ActiVin Grape Seed Extract, Country Life Grape Seed Extract, Now Foods Grape Seed Standardized, Optimum Opti-Men, Universal Animal Pump, Optimum Opti-Women, NOW ADAM, Gaspari Nutrition Mitotropin, Enzymatic Therapy Grape Seed Extract, Healthy Origins MegaNatural-BP Grape Seed Extract, MRM Grape Seed Extract, Nature's Science Grape Seed Extract, NOW Grapefruit Pectin, Olympian Labs Grape Seed Extra Strength, Olympian Labs Grape Seed Extract, Twinlab Grape Seed Extract,

References and Further Research on Grape Seed Extract

Grapeseed Extract Kills 76% of Leukemia Cancer Cells in 24 Hours
January 06, 2009; Mike Adams, the Health Ranger, NaturalNews Editor
A new study conducted at the University of Kentucky in the United States, and published in the journal Clinical Cancer Research, found that leukemia cancer cells exposed to grapeseed extract (GSE) were rapidly killed through a process of cell suicide known as "apoptosis."

Oral Grape Seed Extract Inhibits Prostate Tumor Growth and Progression in TRAMP Mice
This study has identified, for the first time, that oral GSE inhibits prostate cancer growth and progression in TRAMP mice, which could be mediated via a strong suppression of cell cycle progression and cell proliferation and an increase in apoptosis

Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells
Accumulating evidences suggest the beneficial effects of fruit-and-vegetable consumption in lowering the risk of various cancers, including colorectal cancer. In this study, the in vitro and in vivo anticancer effects of grape seed extract (GSE), a rich source of proanthocyanidins, as well as its associated mechanisms against colorectal cancer was investigated.

Grape Seed Extract for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying Grape Seed Extract Bulk or Wholesale

If you need Grape Seed Extract in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!