PureBulk

Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2480 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Arginine?

Arginine, or L-arginine, is an amino acid that is needed to maintain the health of the liver, skin, joints, and muscles. Arginine helps strengthen the body’s immune system, regulates hormones and blood sugar, and promotes male fertility. Arginine is considered a semi-essential amino acid because, although the body can manufacture for its own needs, there are times, cases, and conditions when dietary supplementation may be a matter of necessity, such as in the case of severe wounds or diseases. People with certain conditions like protein malnutrition, excessive ammonia production, excessive lysine intake, burns, infections, peritoneal dialysis, rapid growth, urea synthesis disorders, or sepsis may not have sufficient arginine. Among the dead ringer symptoms of arginine deficiency are poor wound healing, hair loss, skin rash, constipation, and fatty liver.

Arginine stimulates and strengthens the immune system by increasing the production of T lymphocytes (T- cells) from the thymus gland. Recent studies home in on the potential of arginine as a treatment for AIDS, cancer, and other diseases linked to a weak immune system. Arginine supports in detoxifying the liver by neutralizing the effects of ammonia and other toxic substances in the body. Research has shown that this type of amino acid may significantly improve circulation and treat impotence and heart disease. Also, it is essential for the generation of urea, which is needed to remove toxic ammonia from the body during urination.

Arginine is directly involved in a myriad of hormonal processes in the body. It supports and triggers the pancreas to release insulin, is used to manufacture the pituitary hormone vasopressin, and controls the production of growth hormone, to name a few. In fact, the FDA has given the green light in using intravenous (IV) arginine to evaluate those with suspected growth hormone deficiency. Some researchers suggest and believe that delayed sexual maturity may be one of the direct results of arginine deficiency. It is also theorized that arginine may help treat sterility in men, because of the fact that the seminal fluid of healthy men normally contains large amounts of arginine. Boosting arginine levels may help bolster the activity of sperm as well.

The body requires arginine to manufacture nitric oxide, a chemical that causes blood vessel relaxation (vasodilation). Because of this, these two compounds work synergistically to ensure blood vessels are dilated so that the heart can receive adequate oxygen. Preliminary studies indicate that arginine may help a great deal in the treatment of angina, atherosclerosis, coronary artery disease, intermittent claudication, erectile dysfunction, female impotence, migraine, congestive heart failure, and other conditions that are linked to reduced blood flow throughout the body.

What is L-Arginine used for and who uses it?

Because the body manufactures its own arginine, there is no need for most people to take arginine supplements. Many common foods, such as chocolate, coconut, dairy products, brown rice, raisins, almonds, barley, cashews, cereals, chicken, gelatin, meat, oats, peanuts, soybeans, walnuts, white flour, wheat, and wheat germ, contain large amounts of arginine. However, arginine supplements may be required for those combating infection, burns, undergoing dialysis, experiencing rapid growth, or those with trouble processing urea. Anyone wanting to lose weight, build muscle, or strengthen the immune system also may want to consider supplementation. Typically, 2 to 3 grams of arginine is used daily to supplement the diet, although it can go as high up as 15 grams in clinical trials studying the effects of arginine on congestive heart failure.

Large concentrations of arginine are found in the skin, and this amino acid plays a key role in the health of all the body’s connective tissues, particularly the muscles. Arginine assists the body process both creatine, a natural substance which is a by product of metabolism that helps build muscle mass, and nitrogen, a chemical needed for muscle metabolism. Laboratory research and clinical studies suggest that arginine may help reduce body fat and speed up weight loss. Arginine has also been demonstrated to help heal and repair damaged tissues faster, and thus may be beneficial to both athletes and those suffering from arthritis. People with angina pectoris and low blood pressure may need higher dosages of arginine, but in doing so, the increased intake of arginine must be under medical supervision. Higher dosages of arginine can also help in people with erectile problems but keep in mind that again the guidance of physician is necessary. Some have also suggested that the supplements can improve the function of blood vessels, enhance coronary blood flow, and higher intakes may also be needed during times of unusual stress including infections, burns, and injury.

This amino acid plays several roles in the body, such as in wound healing, removing excess ammonia from the body, stimulating immune function, and promoting secretion of certain hormones, including glucagon, insulin, and growth hormone. Severe burns, infections, and injuries can decrease the body’s supply of arginine. It is used in hospitals as a supplement for the immune system to speed up especially for patients coming from intensive care. Arginine can also be used to avert colds, asthma, kidney failure, and improve recovery from illness and injury. This amino acid also helps in the synthesis of proteins synthesis, which consequently leads to an increase in cellular replication. As such, arginine may help people with inadequate numbers of certain cells. In line with this, studies have shown that men with low sperm counts experienced an increase in the number of sperm when they supplemented with arginine.

Some evidence has also shown arginine may significantly help in regulating the cholesterol levels. By reducing platelet aggregation, it makes the blood thin and by increasing the protein synthesis in the body, it helps in the wound healing. Arginine is used to help treat conditions such as congestive heart failure, impotence, sexual dysfunction in women, intermittent claudication and interstitial cystitis as well. Among other functions, Arginine acts as a chemical messenger that is necessary for good memory and learning, as well as in the regulation of the sleep-wake cycle.

How pure is your L-Arginine?

This purebulk L-Arginine Base powder is assayed by the manufacturer to be 99.69% product. You will receive a sealed and labeled heavy-duty 4 mil polyethylene bag containing this white powder product. It contains no fillers, taste additives, or anti-caking agents. This L-Arginine Base powder is a free form of the amino acid L-Arginine meaning it is the most basic form without any additional chemical groups attached. This free form L-Arginine Base is therefore somewhat more potent and concentrated with L-Arginine than all other L-Arginine analog molecules. For individuals that want the most L-Arginine for their money, or want to encapsulate their L-Arginine supplement, or for those who have no troubles with the bitter taste of this product, this pure bulk powder is among the most potent and economical L-Arginine supplements available.

What are some of the common effects of L-Arginine?

Although it has been first isolated way back in 1886, it was only in 1932 when scientists learned that L-arginine is needed to create urea, a waste product that is necessary for toxic ammonia to be removed from the body. In 1939, researchers discovered that L-arginine is also necessary to manufacture creatine. Creatine supplements and aids athletes in increasing muscle mass significantly, improving high-energy sports performance, increasing energy levels and speeding up recovery. Arginine helps inhibit creatine breaking down into creatinine at a constant rate, so that people who train can use this creatine in their intense training sessions and benefit from this top supplement by developing strength and stimulating muscle growth instead of it being cleared from the body by the kidneys,

Arginine changes into nitric oxide, which causes blood vessel relaxation (vasodilation). Early evidence shows arginine may be beneficial in treating medical conditions that improve with vasodilation, such as chest pain, clogged arteries (called atherosclerosis), coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and blood vessel swelling that causes headaches (vascular headaches). Arginine also stimulates the body to make protein and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of muscle wasting (atrophy) in people with critical illnesses.

What is the daily suggested dose of L-Arginine?

A typical dosage of arginine is 2 to 3 g of arginine per day. One fourth level teaspoon will supply approximately 1005 milligrams, or just about 1 gram for the bulk density of this Arginine powder. You can see the full bulk density/volumetric conversion chart for Arginine here. While some people with serious infections, burns, or other trauma should take arginine, a physician must first be consulted to determine appropriate amounts. Clinical studies confirming the beneficial effects for oral supplementation of L-Arginine have determined minimum beneficial doses ranging from 10 to 20 grams per day for a 75 kilogram (165 pound) human.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Potential side effects of L-Arginine

When taking arginine up to moderate doses of 2 to 3 g per day, arginine is free of side effects except for minor digestive disturbances which rarely occur. Keep in mind though that higher doses of arginine can increase stomach acid, and as such, this can harm people with heartburn, ulcers, or who are already taking drugs that are harmful to the stomach. Arginine may change and affect potassium levels, especially in people with liver disease. People with kidney problems and those who take ACE inhibitors or potassium sparing diuretics should not use supplemental arginine unless they are under medical supervision from a qualified professional. It is not advisable to take higher doses of arginine in pregnant and nursing women and children, and cannot be suggested as a supplement during pregnancy or breastfeeding.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of L-Arginine

This product dissolves quickly in hot water and somewhat more slowly in cold water. L-Arginine Base has a characteristically bad and bitter taste, not as bitter as it is bad tasting. The bitter taste of L-Arginine Base makes it difficult for most people to take this product as a bulk powder. For some people encapsulation of L-Arginine Base powder in gel or vegi caps is the best way to take this nutritional supplement. When taking L-Arginine Base as a plain powder it is best to mix your usual dose with strongly flavored beverage or citrus juice before drinking.

Synonyms/Terms

2-amino-5-guanidinopentanoic acid, Arg, arginine, arginine hydrochloride (intravenous formulation), dipeptide arginyl aspartate, HeartBars, ibuprofen-arginate, L-arg, L-arginine, NG-monomethyl-L-arginine,

L-Arginine is used in the following Proprietary Formulas

Sargenor, Spedifen®, BSN NO-Xplode, Gaspari Nutrition SuperPump250, USPlabs Jack3d, Gaspari Nutrition SizeOn, MuscleTech NaNO Vapor, 4Ever Fit L-Arginine, AllMax Nutrition Arginine, Cheap Supplements Arginine, Higher Power AAKG Powder,Jarrow Formulas Arginine 1000, Natrol L-Arginine, NOW AAKG Powder, Shocker Nutrition N.O. Extreme, Syntrax Nitrous, Twinlab L-Arginine, Ultimate Nutrition Arginine Power

References & Further Research

Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism
The intake of arginine aspartate has been shown to increase anabolic hormones like human growth hormone (hGH) and glucagon. The aim of this study was to investigate whether daily intake of two different dosages of arginine asparate during four weeks affects selected parameters of overtraining syndrome like performance, metabolic and endocrine parameters.

A pilot study of l-arginine supplementation on functional capacity in peripheral arterial disease
Peripheral arterial disease (PAD) impairs walking capacity and is often associated with a profound endothelial vasodilator dysfunction, characterized by reduced bioactivity and/or synthesis of endothelium-derived nitric oxide (NO). The results showed there was no significant difference observed in absolute claudication distance between the groups. However, a trend was observed for a greater increase in walking distance in the group treated with 3 g L-arginine daily, and there was a trend for an improvement in walking speed in patients treated with L-arginine. This pilot study provided data for safety, for power calculation and for dosing for the larger definitive trial that is now underway.

L-Arginine for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Arginine Bulk or Wholesale

If you need L-Arginine in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!