PureBulk

Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2200 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Arginine HCl?

L-arginine is a semi-essential amino acid that has been show to lower blood pressure, treat hypertension and promote wound healing. "Essential" has a slightly different meaning in nutrition. An essential nutrient is one that you must obtain somehow, either through diet or through supplements, because your body can't manufacture it on its own. L-arginine is described as semi-essential because usually the body produces enough L-arginine on its own. But in some cases, such as trauma or liver disease, people can develop deficiencies, and then an L-arginine supplement is called for. Athletes have also found L-Arginine to be useful for muscle recovery, especially after intense training sessions and competitions. The HCL analog molecules naturally produce a neutral pH and more palatable drink when mixed with water or juice.

L-Arginine is an important amino acid for both protein synthesis and production of other amino acids. It also assists the human body in getting rid of waste efficiently. L-arginine does not rank among the body’s nine essential amino acids, because it can generally be produced by the body. However, it can become essential and very useful when the body is under stress or experiences injury. Certain conditions such as severe burns, sepsis, jaundice, protein deficiencies, malnutrition, as well as dialysis, can affect your ability to produce L-arginine. People who don't have enough L-arginine may manifest symptoms including but not limited to constipation, alopecia (hair loss) and skin problems. Their wounds may take a much longer time to heal, and fat may have built up in their livers. Found naturally in red meat, poultry, fish, and dairy products, L-arginine has crucial roles in cell division, wound healing, ammonia removal, immune function, and the secretion of important hormones like insulin and growth hormone.

Arginine is a versatile amino acid in animal cells, serving as a precursor for manufacturing not only of proteins but also of nitric oxide, urea, glutamate, and creatine. What makes arginine interesting and unique is that it can be metabolized to nitric oxide (NO). NO is the most powerful chemical compound whose main function is to dilate and engorge blood vessels leading to various organs. This indicates arginine may help a great deal in the treatment of angina, atherosclerosis, coronary artery disease, intermittent claudication, erectile dysfunction, female impotence, migraine, congestive heart failure, and other conditions that are linked to reduced blood flow throughout the body.

What is L-Arginine HCl used for and who uses it?

L-arginine is best known for its effects and benefits on the vascular system. The body utilizes arginine to manufacture nitric oxide, which in turn helps to relax and keep blood vessels dilated, thus helping the heart receive adequate oxygen. L-arginine can also act as a natural blood thinner by lowering platelet aggregation and smooth muscle cell formation (common contributors to atherosclerosis and other degenerative heart conditions). L-arginine also has immune support and wound healing benefits, and it does this by supporting the production of immune cells like natural killer cells and lymphokine-activated-killer cells. L-arginine is also believed to help speed up wound healing through its role in supporting production of L-ornithine and L-proline. L-proline (together with vitamin C) is a key element in collagen synthesis. Additionally, L-arginine helps protect, detoxify, and regenerate the liver, which makes the immune system’s job easier.

In energy production and detoxification, L-arginine helps in these processes because it contributes to the production of:

• Human Growth Hormone – required for skeletal growth, cellular reproduction, and immune system stimulation
• Creatine – vital source of enery to muscles
• L-Glutamine – crucial to the body’s acid-base balance, energy production, along with immune support and recovery after intense workouts
• L-Proline – essential to healthy collagen and connective tissue production
• Glycogen and glucose – primary sugar energy sources

L-arginine is necessary for removing excess ammonia from the body because it is also required to generate urea. Our body needs L-arginine to be able to make urea, the waste product that we get rid of when we urinate. Urea is a byproduct created when our body breaks down proteins. Our body requires some nitrogen, but the breakdown of protein creates more than what we need. Making urea is a very efficient way for your body to get rid of excess nitrogen. L-arginine therefore is helpful in regulating wastes and certain chemical balances in the human body.

When it's administered as a medicine, L-arginine is a vasodilator -- that is, it dilates the blood vessels, allowing more blood to pass through at once. That has the effect of lowering blood pressure and, in some cases, helping the body counter the effects of arterial blockages that result from conditions such as atherosclerosis.

How pure is your L-Arginine HCl?

This pharmaceutical grade amino acid L-Arginine HCL assayed by the manufacturer to be 99.46% product. You will receive a sealed and labeled heavy-duty 4 mil polyethylene bag containing this white powder product. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product also has no additives, fillers or anti-caking agents included. For individuals that want the most L-Arginine for their money, or want to encapsulate their L-Arginine supplement, or for individuals that have no troubles with the bitter taste of this bulk powder, this pure bulk powder is the most potent and economical L-Arginine supplement available. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of L-Arginine HCl?

Recommended oral doses for L-Arginine HCL vary in the published scientific literature from as little as one to three grams per day to as much as 20 to 30 grams per day. Clinical studies confirming the beneficial effects for oral supplementation of L-Arginine have determined minimum beneficial doses to be in the range of 10 to 20 grams per day for a 75 kilogram (165 pound) human (L-Arginine HCL is approximately 83% L-Arginine and 17% Chloride). While L-Arginine HCL does have a slightly lower L-Arginine content than L-Arginine Base (83% versus 100% respectively), L-Arginine Base is not very palatable on its own and is seldom taken as a bulk powder (it is almost always taken in capsules). However, at the typical minimum beneficial doses recommended by researchers, taking 10 to 20 grams L-Arginine Base in capsules per day is both inconvenient and many times more expensive than L-Arginine HCL bulk powder. One level teaspoon will supply approximately 2968 milligrams, or just about 3 grams for the bulk density of this L-Arginine HCl powder. You can see the full bulk density/volumetric conversion chart for L-Arginine HCl here.

Potential side effects of L-Arginine HCl

Some people taking very large doses of more than 10 to 20 grams in a single dose occasionally report gastric upset, but few if any other side effects have been reported clinically even at high doses. L-arginine is not advisable for those people who recently had a heart-attack. Please contact your health care practitioner before starting on this supplement if that concerns you. L-arginine works synergistically with L-ornithine in the synthesis of growth hormone. If you are using lysine to treat herpes, L-arginine may counteract any potential benefit. For those with kidney or liver conditions should consult a health care practitioner before supplementing L-arginine. Those with herpes should not take L-arginine as it may stimulate virus replication and lead to further complications/make matters worse.

It is not advisable to take higher doses of arginine in pregnant and nursing women and children. Arginine cannot be suggested as a supplement during pregnancy or breastfeeding because there is not enough scientific information available.

Taste, solubility, and suggested preparation of L-Arginine HCl

This product dissolves quickly in water and has a slightly bitter taste, not as bitter as L-Arginine Base, and not as pleasing a sour taste as either AAKG or L-Arginine Pyroglutamate. L-Arginine HCL has a mildly bitter taste that most people do not have trouble getting accustomed to. Just mix your usual dose with water or citrus juice and drink.

L-Arginine HCl is used in the following Proprietary Formulas

Sargenor, Spedifen®, BSN NO-Xplode, Gaspari Nutrition SuperPump250, USPlabs Jack3d, Gaspari Nutrition SizeOn, MuscleTech NaNO Vapor, 4Ever Fit L-Arginine, AllMax Nutrition Arginine, Cheap Supplements Arginine, Higher Power AAKG Powder,Jarrow Formulas Arginine 1000, Natrol L-Arginine, NOW AAKG Powder, Shocker Nutrition N.O. Extreme, Syntrax Nitrous, Twinlab L-Arginine, Ultimate Nutrition Arginine Power

References & Further Research

L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways
Diabetes impairs wound healing and there are few therapeutic options to reverse it. Previous work has demonstrated the importance of nitric oxide for successful wound healing. In diabetes, NO synthesis is reduced in the wound milieu. The amino acid L-arginine is the only substrate for NO synthesis. The data demonstrate that the impaired NO synthesis in the diabetic wound milieu can at least partially be reversed by arginine supplementation. In view of previous results on the importance of NO for wound healing, the data suggest that arginine supplementation restores impaired healing in this acute wound model by normalizing the NO pathway but without affecting arginase activity.

Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism
The intake of arginine aspartate has been shown to increase anabolic hormones like human growth hormone (hGH) and glucagon. The aim of this study was to investigate whether daily intake of two different dosages of arginine asparate during four weeks affects selected parameters of overtraining syndrome like performance, metabolic and endocrine parameters.

A pilot study of l-arginine supplementation on functional capacity in peripheral arterial disease
Peripheral arterial disease (PAD) impairs walking capacity and is often associated with a profound endothelial vasodilator dysfunction, characterized by reduced bioactivity and/or synthesis of endothelium-derived nitric oxide (NO). The results showed there was no significant difference observed in absolute claudication distance between the groups. However, a trend was observed for a greater increase in walking distance in the group treated with 3 g L-arginine daily, and there was a trend for an improvement in walking speed in patients treated with L-arginine. This pilot study provided data for safety, for power calculation and for dosing for the larger definitive trial that is now underway.

L-Arginine HCl for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Arginine HCl Bulk or Wholesale

If you need L-Arginine HCl in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!