PureBulk

Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2200 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Arginine-HCL L-Ornithine-HCL?

L-Arginine and L-Ornithine are two amino acids that work synergistically to promote nitric oxide synthesis by the hepatic and systemic enzyme, nitric oxide Synthase (NOS). For this blended product the base forms of these amino acids have been modified to include a small HCL (hydrochloride, sometimes abbreviated HCl). The addition of this HCl group to both amino acids reduces that pH of that amino acid in solution and significantly improves the taste of the bulk powder.

The amino acid L-Arginine (hydrochloride), has several nutritional uses including the promoting of synthesis of nitric oxide by the enzymes eNOS, iNOS, and nNOS (endothelial Nitric Oxide Synthase, inducible Nitric Oxide Synthase, and neural Nitric Oxide Synthase). Other important benefits of L-Arginine supplementation include the promotion protein synthesis as well as the promotion of healthy immune function. Arginine is a conditionally “essential” amino acid which means during heavy training cycles inadequate amounts are synthesized in the liver from other amino acids. As such Arginine must be supplied to the body from crude proteins and supplements. Arginine has a known role in natural Growth Hormone production, sperm production and motility and natural creatine production. Arginine also acts as a precursor to Nitric Oxide NO2. Nitric Oxide (NO2) is a very powerful vasodilator that increases the intensity and duration of the "pump" which is gained when working out (usually after heavy weights). Most AAKG users experience a visible increase in vascularity and pump.

Ornithine is a non-essential amino acid synthesized and made from the breakdown of arginine during the citric acid cycle. It helps build muscle and decrease body fat, especially when taken together with the amino acids arginine and carnitine. Ornithine is also required for the formation of citrulline, proline, and glutamic acid, three amino acids that help supply energy to every cell in the body. An amino acid synthesized from arginine, Ornithine’s role is closely related in the formation of urea. In the Krebs cycle, ornithine takes part in the synthesis of citrulline where ornithine reacts with carbamyl phosphate to form citrulline. Ornithine also plays an important role in the synthesis of proline and glutamic acid. Ornithine is a non-essential amino acid because it is manufactured by the body, and it helps build muscle and reduce body fat. Arginine is necessary for the production of ornithine and should be supplied in sufficient quantities to the body. Carnitine also increases the effect of this nutrient. The body can manufacture ornithine but can also be obtained from protein rich sources such as meat, fish, dairy, and eggs.

L-Ornithine (hydrochloride) has many nutritional benefits and used including its serving as a feedback inhibitor of the hepatic and systemic enzyme arginase. Supplementation with L-Ornithine can significantly increase blood levels of L-Arginine through the feed-back inhibition of arginase. Arginase is a major metabolic pathway for the conversion of L-Arginine to L-Ornithine and because of the physiological feedback inhibition increased blood levels of L-Ornithine can significantly reduce metabolic activity of arginase allowing L-Arginase blood levels to rise significantly higher than would otherwise be possible without L-Ornithine supplementation. But L-Ornithine supplementation is believed to have many benefits other than merely boosting L-Arginine blood levels. L-Ornithine supplementation is believed by researchers to reduce the ammonia accumulation during strenuous exercise and also helps to reduce brain ammonia levels. When taken at bedtime L-Ornithine promotes ease of sleep onset and enhances sleep quality and rested state awareness upon arousal.

What is L-Arginine-HCL L-Ornithine-HCL used for and who uses it?

Because L-Arginine- HCL L-Ornithine- HCL seems to be involved in amino acid synthesis and protein availability, many athletes supplement with this as a way to increase muscle mass, hormone levels and strength. Taking L-Arginine- HCL L-Ornithine- HCL decreases muscle protein catabolism (breakdown) and increases protein synthesis, in addition to promoting wound healing. L-Arginine- HCL L-Ornithine- HCL fulfills these functions by encouraging the secretion of insulin and human growth hormone, and by up regulating glutamine and arginine production. When given to trauma patients, there are notable improvements in both IGF-1 and growth hormone levels.

L-Arginine- HCL L-Ornithine- HCL is a potent anabolic muscle building food. It enhances and improves energy, endurance and muscle mass while at the same time inhibiting muscle breakdown, fatigue, and the build up of fat. L-Arginine- HCL L-Ornithine- HCL also has the ability to speed up recovery time which is why it has become a popular choice among many athletes. L-Ornithine L-Arginine work synergistically in L-Arginine- HCL L-Ornithine- HCL to create a conducive environment for growth and development from most exercise and training regimens, by regulating glutamine levels. L-Glutamine is a primary source of cellular fuel, which makes metabolic processes possible.

L-Arginine-HCL L-Ornithine- HCL also stimulates the growth-promoting action of insulin, which encourages muscle growth and increases strength. It provides the amino acid arginine which triggers your pituitary gland to create and release Growth Hormone (GH). This hormone boosts the metabolism of body fat while at the same time protecting your muscle tissue from being broken down for energy, which results in a leaner appearance. By encouraging the excretion of ammonia (released during exercise), L-Arginine- HCL L-Ornithine- HCL also prevents the build up of lactic acid - known to accumulate with ammonia - which causes muscle fatigue, soreness and poor stamina.

This amino acid plays several roles in the body, such as in wound healing, removing excess ammonia from the body, stimulating immune function, and promoting secretion of certain hormones, including glucagon, insulin, and growth hormone. Severe burns, infections, and injuries can decrease the body’s supply of arginine. It is used in hospitals as a supplement for the immune system to speed up especially for patients coming from intensive care. Arginine can also be used to avert colds, asthma, kidney failure, and improve recovery from illness and injury. This amino acid also helps in the synthesis of proteins synthesis, which consequently leads to an increase in cellular replication. As such, arginine may help people with inadequate numbers of certain cells. In line with this, studies have shown that men with low sperm counts experienced an increase in the number of sperm when they supplemented with arginine.

Some evidence has also shown arginine may significantly help in regulating the cholesterol levels. By reducing platelet aggregation, it makes the blood thin and by increasing the protein synthesis in the body, it helps in the wound healing. Arginine is used to help treat conditions such as congestive heart failure, impotence, sexual dysfunction in women, intermittent claudication and interstitial cystitis as well. Among other functions, Arginine acts as a chemical messenger that is necessary for good memory and learning, as well as in the regulation of the sleep-wake cycle.

How pure is your L-Arginine-HCL L-Ornithine-HCL?

These blended pharmaceutical grade amino acids, L-Arginine HCL and L-Ornithine HCL, are assayed by the manufacturer to be 99.46% product and 99.2% product respectively. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this blended white powder product consisting of 1000 grams L-Arginine HCL and 500 grams L-Ornithine HCL (representing a 2 parts L-Arginine HCL to 1 part L-Ornithine HCL blend which is the standard blend ratio for these products). It contains no fillers, taste additives, or anti-caking agents.

What are some of the common effects of L-Arginine-HCL L-Ornithine-HCL?

Arginine is directly involved in a myriad of hormonal processes in the body. It supports and triggers the pancreas to release insulin, is used to manufacture the pituitary hormone vasopressin, and controls the production of growth hormone, to name a few. In fact, the FDA has given the green light in using intravenous (IV) arginine to evaluate those with suspected growth hormone deficiency. Some researchers suggest and believe that delayed sexual maturity may be one of the direct results of arginine deficiency. It is also theorized that arginine may help treat sterility in men, because of the fact that the seminal fluid of healthy men normally contains large amounts of arginine. Boosting arginine levels may help bolster the activity of sperm as well. Ornithine is usually added with arginine and marketed to strength athletes and body builders as a muscle-building supplement. Laboratory studies have demonstrated that ornithine increases both insulin and growth hormone levels, which are of paramount importance to build and maintain muscle during intensive physical training.

Arginine stimulates and strengthens the immune system by increasing the production of T lymphocytes (T- cells) from the thymus gland. Recent studies home in on the potential of arginine as a treatment for AIDS, cancer, and other diseases linked to a weak immune system. Arginine supports in detoxifying the liver by neutralizing the effects of ammonia and other toxic substances in the body. Research has shown that this type of amino acid may significantly improve circulation and treat impotence and heart disease. Also, it is essential for the generation of urea, which is needed to remove toxic ammonia from the body during urination.

The body requires arginine to manufacture nitric oxide, a chemical that causes blood vessel relaxation (vasodilation). Arginine is also a precursor to nitric oxide, and because of this both of these two compounds work together to ensure blood vessels are dilated so that the heart can receive adequate oxygen. Preliminary studies indicate that arginine may help a great deal in the treatment of angina, atherosclerosis, coronary artery disease, intermittent claudication, erectile dysfunction, female impotence, migraine, congestive heart failure, and other conditions that are linked to reduced blood flow throughout the body.

What is the daily suggested dose of L-Arginine-HCL L-Ornithine-HCL?

The typical recommended dose for this product varies from 1-5 grams per day, depending upon your nutritional needs and goals. For healthy heart and cardiovascular health a dose of about 3 grams per day should be sufficient for most people. You may elect to divide your dose in 2 or 3 doses taken per day. Athletes involved in performance sports will usually find that that the optimal daily dose will be 5 grams per day. You can see the full bulk density/volumetric conversion chart for L-Arginine-HCL L-Ornithine-HCL here. Taking 1 level teaspoon will supply a total dose of 2926 mg or about 3 grams. As with all types of intended uses for this supplement, dividing your dose into 2 or three doses per day will help to maximize your benefit and minimize the occasional side effects.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Potential side effects of L-Arginine-HCL L-Ornithine-HCL

Symptoms and/or side effects from Arginine-Ornithine overuse may include gastric upset (stomach ache), restlessness and insomnia. Some individuals will occasionally experience one or more of these side effects when taking higher than recommended doses, and occasionally these symptoms may be experienced with dosing within the recommended ranges. If you experience any of these symptoms or side-effects following ingestion of this product you should reduce your dose or stop taking this product and consult your physician about your symptoms. The effectiveness of these amino acids are slightly improved when taken while fasting, however, symptoms and side effects should they occur may be more pronounced when fasting.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of L-Arginine-HCL L-Ornithine-HCL

This product dissolves quickly in water and has a slightly sour taste, but not bad at all! Just mix your usual dose with water or juice and drink.

Quantitative Analysis:

L-Arginine Monohydrochloride: CAS# 1119-34-2, Molecular Weight = 210.66 g/mol
L-Ornithine Monohydrochloride: CAS#: 3184-13-2, Molecular Weight = 168.62 g/mol
L-Arginine Base: CAS# 74-79-3, Molecular Weight: 174.20 g/mol
L-Ornithine Base: CAS# 70-26-8, Molecular Weight: 132.16 g/mol
Monohydrochloride: Molecular Weight: 36.46 g/mol
As a total percent of L-Arginine-HCL and L-Ornithine-HCL (2:1) blended product:
L-Arginine-HCL and L-Ornithine-HCL (2:1): 100%
L-Arginine Monohydrochloride: 66.7%
L-Ornithine Monohydrochloride: 33.3%
L-Arginine Base: 55.1%
L-Ornithine Base: 26.1%
Monohydrochloride: 18.8%

L-Arginine-HCL L-Ornithine-HCL is used in the following Proprietary Formulas

Sargenor, Spedifen®, BSN NO-Xplode, Gaspari Nutrition SuperPump250, USPlabs Jack3d, Gaspari Nutrition SizeOn, MuscleTech NaNO Vapor, 4Ever Fit L-Arginine, AllMax Nutrition Arginine, Cheap Supplements Arginine, Higher Power AAKG Powder,Jarrow Formulas Arginine 1000, Natrol L-Arginine, NOW AAKG Powder, Shocker Nutrition N.O. Extreme, Syntrax Nitrous, Twinlab L-Arginine, Ultimate Nutrition Arginine Power

References & Further Research

Ornithine--Ketoglutarate (OKG) Supplementation Is More Effective than Its Component Salts in Traumatized Rats
Addition of an anabolic stimulus during nutritional support seems to be a reasonable adjunct to augment protein synthesis. Ornithine--ketoglutarate (OKG) has been used for this purpose in many pathological situations, but the mechanism of action is poorly understood. Overall research data suggest that the mechanism of OKG action may be associated with increases in growth hormone and insulin, as well as the production of metabolites of ORN and KG. OKG has better metabolic benefits than its two components given separately in the nutritional support of injured rats.

Ornithine alpha-ketoglutarate in nutritional support
Ornithine alpha-ketoglutarate (OKG) is a salt formed of two molecules of ornithine and one molecule of alpha-ketoglutarate. OKG has been successfully used by the enteral and parenteral route in burn, traumatized, and surgical patients and in chronically malnourished subjects. According to the metabolic situation, OKG treatment decreases muscle protein catabolism and/or increases synthesis. In addition, OKG promotes wound healing. The mechanism of action of OKG is not fully understood, but the secretion of anabolic hormones (insulin, human growth hormone) and the synthesis of metabolites (glutamine, polyamines, arginine, ketoacids) may be involved.

Growth retardation in children receiving long-term total parenteral nutrition: effects of ornithine alpha-ketoglutarate
The effect of ornithine ketoglutarate (OKG) in reversing abnormal growth in six prepubertal children receiving total parenteral nutrition (TPN) for 5-10 y were evaluated in this study. This study demonstrates that OKG is associated with statural growth acceleration and increased IGF1 concentrations.

A pilot study of l-arginine supplementation on functional capacity in peripheral arterial disease
Peripheral arterial disease (PAD) impairs walking capacity and is often associated with a profound endothelial vasodilator dysfunction, characterized by reduced bioactivity and/or synthesis of endothelium-derived nitric oxide (NO). The results showed there was no significant difference observed in absolute claudication distance between the groups. However, a trend was observed for a greater increase in walking distance in the group treated with 3 g L-arginine daily, and there was a trend for an improvement in walking speed in patients treated with L-arginine. This pilot study provided data for safety, for power calculation and for dosing for the larger definitive trial that is now underway.

L-Arginine-HCL L-Ornithine-HCL for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Arginine-HCL L-Ornithine-HCL Bulk or Wholesale

If you need L-Arginine-HCL L-Ornithine-HCL in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!