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What is L-Arginine Malate?

L-Arginine Malate, also known as Di-Arginine Malate or Nitrous Malate, combines the power of Arginine—known for its ability to provide skin-stretching pumps and unbelievable improvements in body composition, with Malic Acid—a naturally occurring Krebs Cycle intermediate that plays a crucial role in our natural energy producing cycle. It basically has the same benefits of L-Arginine, with a much more efficient delivery system. L-Arginine L-Malate is a more bio-available analog of the free form L-Arginine Base amino acid with increased absorption, fewer side effects, and better taste. It is a form of Arginine used to stimulate nitric oxide known as nitrous malate. The combination of arginine and malic acid (malate) gives its user unbeatable insulin secretion, muscle pumps, vascularity, and energy production and recovery.

Many athletes consume malic acid combined with creatine in the form of Dicreatine Malate (which we also carry in our inventory) to increase the delivery of oxygen to muscle cells, thereby improving stamina and endurance. Potential health benefits of malic acid include restoring skin tone and alleviating muscle pain and arthritis discomfort. Malic acid is available as a supplement either as a standalone or as part of a complex. One of Malic Acid’s most significant benefits lies in its ability to stimulate metabolism and increase energy production. This stems from the integral role it plays in a process known as the Krebs cycle - the complex series of biochemical reactions taking place within the body's cells to transform proteins, fat and carbohydrates into water and energy. This process needs a constant supply of vitamins, enzymes and chemical agents such as malic acid, in order to maintain it to function properly 24 hours a day. The Krebs cycle is paramount importance to our very existence because without it, energy production would be virtually impossible. Therefore it is critical that there are sufficient supplies or stores of malic acid in order to promote the efficient functioning of this cycle or to make this cycle possible to begin with. Malic acid plays a huge part in improving overall muscle performance, reversing muscle fatigue following exercise, reducing tiredness and poor energy levels, as well as improving mental clarity.

L-arginine is a chemical building block called “an amino acid.” It can be derived from the diet and is necessary for the body to make proteins. L-arginine is found in red meat, poultry, fish, and dairy products. It can also be synthesized in a laboratory and used as medicine. L-arginine is converted in the body into a compound called nitric oxide. Nitric oxide causes blood vessels in a process called vasodilation to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances and hormones essential in the proper overall functioning of the body. Because of this L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain, high blood pressure, and coronary artery disease. L-arginine is also beneficial for recurrent pain in the legs due to blocked arteries (intermittent claudication), decreased mental capacity in the elderly (senile dementia), erectile dysfunction (ED), and male infertility. Some people use L-arginine for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.

Nitrous Malate is a significant development and advancement over regular L-Arginine. Nitrous Malate is a newly discovered bioavailable form of Arginine Alpha-Ketoglutarate (among the purest form available) that is crucial for increasing nitric oxide levels in the body. The more nitric oxide you have in your system, the more muscle you are able to build. You may have heard of positive nitrogen balance. When you are in positive nitrogen balance, your body is more capable at absorbing, utilizing, and converting protein into muscle mass. In essence, when you have greater nitrogen retention, your body is in a more anabolic and muscle-building state. You’ll build muscle and increase strength faster. Nitrous Malate works very well to increase and enhance nitrogen retention because once it enters the body it converts to nitric oxide, which is an essential component necessary for nitrogen retention. When nitric oxide levels in your body are elevated you’ll become much more vascular in just a matter of days because your red blood cell production will be increased due to having more nitric oxide in your body.

What is L-Arginine Malate used for and who uses it?

L-arginine is used in conjunction with a number of over-the-counter and prescription medications for numerous conditions. For example, L-arginine is used together with ibuprofen for migraines; with conventional chemotherapy drugs for treating breast cancer; with other amino acids for treating weight loss in people with AIDS; and with fish oil and other supplements for reducing infections, improving wound healing, and shortening recovery time after surgery. Some people topcally use L-arginine to the skin to speed wound healing and for increasing blood flow to cold hands and feet, especially in people with diabetes. It is also used to help treat sexual problems in both men and women.

Arginine is important in the repair of tissue as well as the formation of collagen and building of new bone and tendons. Di-Arginine Malate or L-Arginine Malate is two molecules of the amino acid Arginine bonded to one molecule of Malic Acid. It is extremely beneficial in strengthening the immune system. Di-Arginine has been demonstrated to help significantly in maintaining the nitrogen balance in the muscle. This can help improve and enhance the production of nitric oxide which, in turn, can help transport oxygen and other nutrients to the working muscle. The combination of Arginine and Malic Acid will improve its delivery rate resulting in advanced energy production and greater pumps to the muscle during and after training. It may also be used for weight control as it helps the increase of muscle mass, while reducing body fat.

What are other common effects and results that people anticipate while taking L-Arginine Malate?

L-Arginine Malate can help build lean, powerful muscle, burn fat, increase strength and power, maximize endurance, and promote recovery. L-Arginine Malate is also effective for improving recovery after surgery. Taking L-arginine with ribonucleic acid (RNA) and eicosapentaenoic acid (EPA) before surgery or afterwards seems to help reduce the recovery time, decrease the number of infections, and speed up wound healing after surgery. For congestive heart failure, taking L-arginine along with usual treatment seems to help eliminate extra fluids that are a problem in congestive heart failure. For chest pain associated with coronary artery disease (angina pectoris), taking L-arginine seems to decrease symptoms and improve exercise tolerance and quality of life in people with angina. For bladder inflammation, taking L-arginine seems to improve symptoms, but it may take as long as three months of use to see any remarkable improvement.

How pure is your L-Arginine Malate?

This pharmaceutical grade amino acid L-Arginine L-Malate assayed by the manufacturer to be 99.1% product. You will receive a sealed and labeled heavy-duty 4 mil polyethylene bag containing this white powder product. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product also has no additives, fillers or anti-caking agents included. For individuals that want the most L-Arginine for their money, or those who want to encapsulate their L-Arginine supplement, this pure bulk powder is among the most effective yet economical L-Arginine supplement available. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of L-Arginine Malate?

The commonly recommended dose for L-Arginine L-Malate varies in the published clinical and scientific literature from between 1 grams and 12 grams per day taken in divided doses between meals, depending upon individual needs.

• For congestive heart failure, suggested doses range from 6-20 grams per day, as three divided doses.
• For chest pain associated with coronary artery disease (angina pectoris), suggested doses range from 3-6 grams three times per day for up to one month.
• For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris), suggested dose is 700 mg four times daily.
• For organic erectile dysfunction (ED), suggested dose is 5 grams per day. Be advised taking lower doses might not be effective.
(Source: WebMD)

One level teaspoon will supply approximately 2501 milligrams, or just about 2.5 grams for the bulk density of this L-Arginine Malate powder. You can see the full bulk density/volumetric conversion chart for L-Arginine Malate here.

Potential side effects of L-Arginine Malate

L-arginine is safe for most people when taken appropriately by mouth short-term. Keep in mind though that higher doses of arginine can increase stomach acid, and as such, this can harm people with heartburn, ulcers, or who are already taking drugs that are harmful to the stomach. Arginine may change and affect potassium levels, especially in people with liver disease. People with kidney problems and those who take ACE inhibitors or potassium sparing diuretics should not use supplemental arginine unless they are under medical supervision from a qualified professional. If you decide to take L-arginine, use it with caution.

It is not advisable to take higher doses of arginine in pregnant and nursing women and children. Arginine cannot be suggested as a supplement during pregnancy or breastfeeding because there is not enough scientific information available.

Taste, solubility, and suggested preparation of L-Arginine Malate

This product dissolves quickly in hot water or somewhat slowly in cold water and has a slightly sour but agreeable taste. L-Arginine L-Malate has such a mildly sour taste that few people have trouble taking this pure bulk powder dissolved in hot or cold water with an added sweetener. Just mix your usual dose and sweetener hot water, stir until it is completely dissolved, and then cool with ice and drink, or add the cooled solution to citrus juice and drink.

L-Arginine Malate is used in the following Proprietary Formulas

Nitrocharge and Vasocharge (both from Primaforce), Syntrax, BSN NO-Xplode, Gaspari Nutrition SuperPump250, USPlabs Jack3d, Gaspari Nutrition SizeOn, MuscleTech NaNO Vapor, 4Ever Fit L-Arginine, AllMax Nutrition Arginine, Cheap Supplements Arginine, Higher Power AAKG Powder,Jarrow Formulas Arginine 1000, Natrol L-Arginine, NOW AAKG Powder, Shocker Nutrition N.O. Extreme, Syntrax Nitrous, Twinlab L-Arginine, Ultimate Nutrition Arginine Power

References & Further Research

Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males
"Twenty-two adult males participated in a 5 week progressive strength training program. One half the subjects received the amino acids L-arginine and L-ornithine and the other half, a placebo. The study used a double blind protocol so that subjects as well as investigators had no knowledge of which substances were being administered. Following the short term strength program using progressively high intensities, tests were taken for total strength (TS), lean body mass (LBM) and urinary hydroxyproline (UH). It was concluded that arginine and ornithine taken in prescribed doses can, in conjunction with a high intensity strength training program, increase TS (Total Strength) and LBM (Lean Body Mass) in a relatively short period of time. Arginine and ornithine also aid in recovery from chronic stress by quelling tissue breakdown as evidenced by lower UH levels."

Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism
The intake of arginine aspartate has been shown to increase anabolic hormones like human growth hormone (hGH) and glucagon. The aim of this study was to investigate whether daily intake of two different dosages of arginine asparate during four weeks affects selected parameters of overtraining syndrome like performance, metabolic and endocrine parameters.

A pilot study of l-arginine supplementation on functional capacity in peripheral arterial disease
Peripheral arterial disease (PAD) impairs walking capacity and is often associated with a profound endothelial vasodilator dysfunction, characterized by reduced bioactivity and/or synthesis of endothelium-derived nitric oxide (NO). The results showed there was no significant difference observed in absolute claudication distance between the groups. However, a trend was observed for a greater increase in walking distance in the group treated with 3 g L-arginine daily, and there was a trend for an improvement in walking speed in patients treated with L-arginine. This pilot study provided data for safety, for power calculation and for dosing for the larger definitive trial that is now underway.

L-Arginine Malate for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Arginine Malate Bulk or Wholesale

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