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L-citrulline DL-malate

What is L-Citrulline?

The amino acid L-citrulline is fundamental to proper functioning of the urea cycle and detoxification of the liver. Citrulline eliminates endotoxins to prevent lactic acid and ammonia buildup and functions as an intermediary in the urea cycle (Wikipedia).

Lactic acid and ammonia are manufactured by the body in response to intense exertion and hamper overall exercise performance. Citrulline supplementation helps speed up their removal from working muscles, aiding both physical performance and recovery.

Citrulline is synthesized in the mitochondria, the power plants of cells. It is then moved to the cytoplasm to be transformed to arginine. The production of arginine is important to the body in a variety of ways. Arginine is used by the body for removing excess ammonia, protein synthesis and the secretion of essential hormones.

Arginine is also needed to produce nitric oxide, a component in cell communication and in vasodilation, the relaxation of blood vessels that allows increased blood flow.

Citrulline is found naturally in many common foods, including eggs, meat, fish, legumes, milk products and particularly in watermelon rinds.

Health Benefits of L-Citrulline

Citrulline is useful to those involved in high intensity resistance and endurance exercise, including strength athletes, powerlifters, strongman competitors, bodybuilders, runners, sprinters and cyclists.

Citrulline is effective in promoting nitric oxide (NO) production and supports the production of growth hormone, insulin and creatine.

Citrulline aids strength athletes in a manner similar to creatine, but without unwanted side effects like cramping, bloating or water retention.

Purity and Concentration of L-Citrulline

Purebulk's pharmaceutical-grade L-Citrulline contains no fillers, additives or anti-caking agents. L-Citrulline is a free-form base amino acid nutritional supplement without any additional chemical groups attached.

Suggested Use of L-Citrulline

The suggested serving size for L-citrulline is 3000 milligrams (3 grams) taken twice daily. You can see the full bulk density/volumetric conversion chart for L-citrulline here. A serving size of one level teaspoon is equal to 2765 milligrams. So, a slightly rounded teaspoon will provide about 3000 milligrams.

The body needs a supply of all the amino acids in order to effectively create and utilize proteins. Those supplementing any of the amino acids should have a balanced intake of all the others. Getting too much of any one amino acid can throw the citric acid cycle out of balance, which makes the liver and kidneys work harder to eliminate toxins.

Potential Side Effects of L-Citrulline

Citrulline should not be taken at the same time as glutamine or supplements that contain glutamine. It can, however, be consumed at a different time of the day.

Those with liver or kidney disease should not take L-citrulline, or any other amino acid supplement, without first consulting their physician. It is not recommended for women who are pregnant or nursing.

Mixing and Solubility of L-Citrulline

This product dissolves quickly in water and has a pleasantly sour taste. Mix with water or juice and drink. Citrulline should be taken 35-45 minutes prior to intense exercise. If you already take a pre-workout protein shake, adding citrulline can make it even more effective.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

Nutrition Journal: Watermelon consumption increases plasma arginine concentrations in adults

Wikipedia: Citrulline

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.