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Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2100 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is Citrulline Malate?

Citrulline Malate is a compound made up of Citrulline, a non-essential amino acid that is primarily found in watermelons, and malate. This combination compound provides athletes a new and unique opportunity to fight muscle fatigue and improve sports performance while speeding up and enhancing muscle and energy recovery post intense exercise. The malate, or malic acid, is an apple derivative and enhances the positive effects of citrulline. Malic acid takes part in aerobic cellular respiration where oxygen and a carbon compound (acetyl Co-A) are used to produce immediate energy and CO2 in the mitochondria of the cell in what is called the Krebs cycle, a major producer of aerobic energy within the mitochondria. Malate is responsible in the process of recycling lactate and pyruvate to promote efficient energy production and protect muscles from fatigue. Citrulline Malate has several positive effects on aerobic exercise performance including: 1) increased aerobic production of energy; 2) Improved stamina and fatigue resistance, and; 3) improved recovery and energy levels.

Citrulline will assist you in training harder and longer during intense exercise sessions in a similar manner to the energy production of creatine, without any side effects of cramping, bloating or water retention. Recent research studies suggest that Citrulline is even more effective than arginine for enhancing overall plasma arginine levels. The reason for this is Citrulline's effects on endogenous arginine synthesis. This leads researchers to believe that Citrulline may indeed be more potent at nitric oxide (NO) production than supplementing with arginine and AAKG supplements. Citrulline has also been demonstrated to be very effective at growth hormone (GH), insulin, and creatine production. In studies of Citrulline Malate supplementation in the 6 gram dose range, that it is highly effective at increasing ATP production by 30%, significantly reducing muscle fatigue and a dramatic increase in phosphocreatine levels post exercise.

Citrulline functions to remove endotoxins to prevent lactic acid and ammonia build up, by acting as an intermediary in the Urea Cycle. These endotoxins impair overall exercise performance and are produced by the body in response to intense physical exercise, protein metabolism and catabolic states. Citrulline supplementation rapidly speeds up the removal of these lactic acid and ammonia waste products from your working muscles, resulting in a better performance from the working muscle tissue and allowing you to train harder and recover much faster with each and every workout.

Citrulline Malate's key function is it improves endurance and is widely used by many top athletes for that purpose alone. Citrulline Malate usually yields noticeable performance results in 15 days or less, but will immediately begin to work on clearing toxins from the body, increasing overall energy, and strengthening the immune system. Some users have reported noticeable results in as little as a week, but most will see results in no later than 15 days. In a human clinical study researchers examined the effects of supplementation with six grams of citrulline malate daily for 15 days. Results showed that citrulline malate supplementation led to a significant reduction in the sensation of fatigue following exercise, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise.

What is Citrulline Malate used for and who uses it?

Citrulline Malate is effective and beneficial to anyone involved in high intensity resistance and endurance exercise. This would include strength athletes, powerlifters, strongman competitors, bodybuilders, runners and sprinters and cyclists to name but a few people who will benefit from Citrulline supplementation. Anyone who is involved in aerobic exercise and who wants to enhance performance and recovery may benefit from citrulline malate supplementation. Since citrulline malate enhances the recovery process it may be useful for the recovery process of power athletes.

Citrulline malate improves aerobic performance and capacity in the athlete by influencing lactic acid metabolism and reducing fatigue. Studies in Europe, where citrulline malate has been used for over a decade, show significant reduction in mental and physical fatigue and exhaustion in geriatric and post-surgery patients. Clinical studies done on rats and microbes back the results seen in humans. Administration of citrulline malate to animals shielded the subjects from acidosis and ammonia poisoning. In a microbial model, malate significantly helped in eliminating ammonium and citrulline facilitated lactate metabolism. The results show a synergistic action of the complex.

The use and supplementation of citrulline malate to humans have shown promising results. French researchers reported in several human studies that blood lactate concentrations were significantly reduced and the elimination of ammonia was much faster after physical exertion. Rapid recovery from physical effort has a positive and direct correlation to the disappearance of lactate from blood after performance at a high level of acidosis, suggesting citrulline malate’s essential role in acid-base balance.

How pure is your Citrulline Malate?

This pharmaceutical grade amino acid L-Citrulline DL-Malate (commonly referred to as Citrulline Malate) is assayed by the manufacturer to be 99.6% product. You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents.

Overall, studies suggest that citrulline malate supplementation can boost athletic performance and enhance recovery by eliminating the amino acid breakdown products of protein metabolism and augmenting the detoxifying capacity of liver cells in removal of ammonium and lactate from the blood. If all you want are the health benefits and enhanced athletic performance made possible with Citrulline Malate, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of Citrulline Malate?

The effective dosages commonly seen and reported in scientific literature is three to four grams twice daily. For bodybuilders and performance athletes one level teaspoon will supply approximately 3239 milligrams, or just about 3 grams for the bulk density of this Citrulline Malate powder. You can see the full bulk density/volumetric conversion chart for Citrulline Malate here. For optimal results consume it in the morning and 45 minutes before your workout.

Recent anecdotal reports from the bodybuilders and strength athletes suggest that using Citrulline in conjunction with Beta Alanine and L-Histidine (which we both carry in our inventory) would be of great benefit to the user. Both of these substances work synergistically to increase carnosine levels within the muscles, resulting in a similar improved performance and increased Nitric Oxide production.

Potential side effects of Citrulline Malate

Citrulline Malate appears to be very safe and has no recorded side effects at all, primarily because Citrulline malate is both well tolerated and rapidly acting. It works so fast that in fact, clinical results have been reported by the third to fifth day after start of administration. However be cautious in using this in conjunction with other medications or supplements as adverse effects can come from drug interactions. Anyone considering supplementing with Citrulline who suffers with existing heart or psychiatric conditions should consult with their doctor prior to supplementing with any Citrulline based products.

Taste, solubility, and suggested preparation of Citrulline Malate

This product dissolves quickly in water and has a deliciously sour taste. Just mix your usual dose with water or juice and drink. For best results supplement with between 3 and 6 grams of Citrulline 35-45 minutes prior to intense exercise. If you already take a pre-workout shake then adding citrulline malate (if there isn't any there already) can make it even more effective.

Citrulline Malate is used in the following Proprietary Formulas

BSN NO-Xplode, Gaspari Nutrition SuperPump250, VPX NO Shotgun V.3, SciVation Xtend, MuscleTech Nitro-Tech Hardcore, NOW L-Citrulline, PrimaForce Citrulline Malate, Source Naturals L-Citrulline, Supplement Direct L-Citrulline Malate 2:1

References & Further Research

Citrulline malate promotes aerobic energy production in human exercising muscle
To investigate the effects of citrulline malate supplementation on muscle energetics. Eighteen men complaining of fatigue but with no documented disease were included in the study. A rest-exercise (finger flexions)-recovery protocol was performed twice before, three times during, and once after 15 days of oral supplementation with 6 g/day citrulline malate. Metabolic variables measured twice before citrulline malate ingestion showed no differences, indicating good reproducibility of measurements and no learning effect from repeating the exercise protocol. Citrulline malate ingestion resulted in a significant reduction in the sensation of fatigue, a 34% increase in the rate of oxidative ATP production during exercise, and a 20% increase in the rate of phosphocreatine recovery after exercise, indicating a larger contribution of oxidative ATP synthesis to energy production. The changes in muscle metabolism produced by citrulline malate treatment indicate that citrulline malate may promote aerobic energy production.

Watermelon consumption increases plasma arginine concentrations in adults
Watermelon is a rich source of citrulline. No detailed studies have been conducted to evaluate plasma arginine response in humans after long-term feeding of citrulline from natural plant sources. This study investigated if watermelon juice consumption increases fasting concentrations of plasma arginine, ornithine, and citrulline in healthy adult humans. Subjects consumed a controlled diet and 0 (control), 780, or 1560 g of watermelon juice per day for 3 weeks in a crossover design. The treatments provided 1 and 2 g of citrulline per day. Compared with the baseline, fasting plasma arginine concentrations increased 12% after 3 wk of the lower-dose watermelon treatment; arginine and ornithine concentrations increased 22% and 18%, respectively, after 3 wk of the higher-dose watermelon treatment. Fasting citrulline concentrations did not increase relative to the control but remained stable throughout the study. The increased fasting plasma concentrations of arginine and ornithine and stable concentrations of plasma citrulline in response to watermelon juice consumption indicated that the citrulline from this plant origin was effectively converted into arginine.

Citrulline Malate for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying Citrulline Malate Bulk or Wholesale

If you need Citrulline Malate in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!