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Click to Enlarge Unit Weight: 1500 grams Unit Volume: 1900 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is Glutamine?

Glutamine is one of the twenty amino acids generally found in animal proteins. Of these amino acids, Glutamine is the most abundant in the human body. Over 61% of skeletal muscle tissue is glutamine. Glutamine is involved in more metabolic processes than any other amino acid because it is the main fuel utilized by both the digestive and immune systems, and it is also the primary conductor of nitrogen to the muscles, owing to the fact that 19 percent of a Glutamine molecule is made up of nitrogen. It is available in high concentrations in the brain, muscles, gut lining, lungs, heart, kidney, and liver where it has multiple and critical functions.

Glutamine is a non-essential amino acid (can be made by the body) and is found in large amounts in the muscles of the body. Since it can easily penetrate the blood-brain barrier, it is also known as a superb brain fuel. For this reason some people actually refer to it as a “smart-vitamin” – although in fact it is actually not a vitamin at all. It is considered to be nature's "Brain food" by improving mental capacities; and is used in the treatment of depression, fatigue, alcoholism, epilepsy, muscular dystrophy, mental retardation, and schizophrenia. Glutamine can easily bypass the blood-brain barrier and by doing so, it increases the amount of glutamic acid and GABA; thereby enhancing normal nervous system function. As amino acids chemically change in the process of being used up, ammonia is released. Glutamine plays a role in eliminating this toxic ammonia from the brain.

In instances wherein the body requires more glucose as an energy source, Glutamine is converted to glucose. This conversion can provide fuel for athletes, thus enhancing athletic endurance, and prevent muscle catabolism. Glutamine also aids in maintaining the proper acid/alkaline balance in the body, and is of paramount importance for the synthesis of RNA and DNA. Glutamine can also stave off the craving for sweets and sugar, which is beneficial to people wishing to lose weight. L-Glutamine is typically taken by weight lifters and performance athletes wanting to reduce fat and maximize muscle mass. Blood levels of L-Glutamine will fall significantly after strenuous exercise and will stay low until complete recovery. Supplementation with L-Glutamine can reduce the recovery time following your demanding workouts by increasing muscle protein synthesis and counteracting catabolic processes. L-Glutamine availability by supplementation is a key factor in muscle growth and the anterior pituitary gland secretion of human growth hormone, also essential for building muscle mass.

What is Glutamine used for?

Glutamine is an amino acid that helps build and maintain the muscles of the body. It is also useful in eliminating toxic substances such as ammonia from the liver and helps maintain a healthy central nervous system. Glutamine deficiency is common in today's busy lifestyle, making its supplementation increasingly popular both in sports as well as in medical practice. During periods of extreme stress, trauma or simply intense sports training, Glutamine deficiency takes place and it becomes increasingly evident as manifested by decreased strength, stamina and recovery, which takes anywhere up to six days to return to normal levels. Studies have shown that intense resistance training and stress can significantly reduce Glutamine levels by up to 50%. As such, Glutamine can be very beneficial for people who perform any type of serious workout, for those who are going through any type of stressful event, and even for those who are just trying to fight off the cold or flu.

Glutamine is essential for several bodily functions. It assists with blood sugar control, plays a major role in synthesizing muscle protein and cell-volumizing, enhances mental function by promoting the synthesis of GABA, keeps the intestinal lining intact, and it is also a primary source of energy for the immune system. Supplemental L-glutamine is also used therapeutically for arthritis, autoimmune diseases, developmental disabilities, and for tissue damage from cancer radiation treatments. Glutamine has also been shown to help manage alcoholism, speed up the healing and recovery from ulcers, and alleviate fatigue, depression, and impotence. It has also been reported successful in treating schizophrenia and senility. Food sources of glutamic acid include meat, poultry, fish, eggs, and dairy products, as well as some high-protein plant varieties.

Glutamine is converted to glutamic acid in the brain, which is essential for cerebral functions, and increases the amount of GABA (gamma-aminobutyric acid), an amino acid that acts as a neurotransmitter in the body required for brain functioning and mental activity. It is required in the muscles to synthesize muscle proteins, and is beneficial for the treatment of wasting muscles or atrophy after illness or post-operative care. Although the body requires nitrogen, free nitrogen in the body can be harmful since it forms ammonia – especially toxic to the brain. The liver naturally converts ammonia to urea, excreted in the urine – but glutamic acid attaches itself to nitrogen and forms glutamic acid, while removing ammonia from the brain. This glutamic acid formed is further utilized in the body to balance and stabilize healthy acid/alkaline levels, and is also the basis of RNA and DNA. Additionally, it serves as a fuel source for cells in the digestive tract, and it is also used by white blood cells and is important for immune function.

Glutamic acid is a vital excitatory neurotransmitter, and glutamic acid is also useful in the metabolism of sugars and fats. It helps move potassium across the blood-brain barrier, although it does not pass this barrier that easily. It also shows promise in the future treatment of neurological conditions, ulcers, hypoglycemic come, muscular dystrophy, epilepsy, Parkinson's, and mental retardation. Glutamic acid can be used as fuel in the brain, and can attach itself to nitrogen atoms in the process of forming glutamine, which rids the body of ammonia. This action is unique to Glutamic acid, and it is very important because it is the only way by which the brain can be detoxified from ammonia. The fluid produced by the prostate gland also contains significant amounts of glutamic acid, and may help in the normal function of the prostate.

How pure is your Glutamine?

This pharmaceutical grade amino acid L-Glutamine is assayed by the manufacturer to be 99.9% product (normal range 98.0 to 102.0%). You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. It does not contain any fillers, additives or anti-caking agents. Athletes who spend a lot of their time training in the gym like powerlifters and bodybuilders have the most to gain from the intake of glutamine because they are most susceptible to overtraining. Since such strength athletes use a lot of their glutamine during training, they are more likely to have health related problems, as the immune system relies heavily on this amino acid.

Catabolism or muscle breakdown/wasting can occur if the body takes glutamine from the muscles for use somewhere else, such as nitrogen transport or maintaining the immune system. When supplemented, Glutamine helps athletes engaged in serious strength training, like strongman competitors, powerlifters, and body builders, reduce the amount of muscle deterioration that occurs and thus promote muscle sparing because other tissues that need glutamine will not deplete the glutamine stored in the muscle cells.

Deficiency of this nutrient is rare, since it can be manufactured by the body but deficiencies can develop during periods of fasting, starvation, strict dieting, cirrhosis, and weight loss associated with AIDS and cancer. Vegans or vegetarians may be at a higher risk of deficiency because Glutamine is mostly found in many high protein foods, such as fish, meat, beans, and dairy. For individuals who want the most L-Glutamine for their money, or want to encapsulate their L- Glutamine supplement, this pure bulk powder ranks high among the most potent and economical L-Glutamine supplements available.

What are some of the common effects of Glutamine?

Glutamine is an anti-catabolic agent. This means that when it’s taken after a workout, the stimulus from training will not break down the muscle and will instead yield the desired growth in new muscle tissue because Glutamine can help counteract and repair muscle damage. Glutamine has also been clinically proven to have a positive effect on the immune system. When you’re training intensely your immune system may be weakened due to the stress put on your muscles and on your central nervous system (CNS). Glutamine can help boost the immune system and prevent you from getting sick, allowing you to continue training harder and longer.

Bodybuilders need to supplement on glutamine as they burn lots of glutamine while exercising. Glutamine will help repair muscles, provide energy, and maintain muscle cell volume and hydration. Glutamine can be likened to the multi-talented decathlete, because it is a multi-faceted supplement. Glutamine helps regulate muscle mass, is involved in the immune system, affects the synthesis of glucose and can even improve insulin metabolism. Glutamine seems to be involved in a little bit of everything and is arguably one of the most, if not the most, important amino acid for athletes from any physically demanding sport.

What is the daily suggested or recommended dose of Glutamine?

The amount of Glutamine you take really depends on how intense you train and what kinds of food are in your diet. Since Glutamine is found in raw parsley and spinach, you don't need as much glutamine if you eat a lot of these. We recommend that you take between 5 - 15 grams per day. Alternatively, L-Glutamine can be taken between 2 grams and 5 grams per single dose taken 2 or 3 times per day for a total combined daily dose of between 4 grams and 15 grams. One level teaspoon of L-Glutamine will supply approximately 3100 milligrams, or just about 3 grams for the bulk density of this Glutamine powder. You can see the full bulk density/volumetric conversion chart for Glutamine here. Glutamine can be taken at any time of day, although most people prefer to use glutamine immediately after their training session.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

What are the kind of results do people anticipate while taking Glutamine?

Studies have shown that glutamine supplementation can increase protein synthesis (which leads to increased muscle mass), increase nitrogen retention, decrease muscle breakdown, decrease recovery time needed after a workout, and enhance immune functions.

Precautions and Potential side effects of Glutamine

There are no known side effects to supplementing with glutamine since the body is already very familiar with it owing to the fact that Glutamine is the most abundant amino acid in our body. Unlike other sports supplements, glutamine does not interfere with the processes and the levels of other hormones in our body. If large quantities of glutamine are ingested, the person may experience nothing more than an upset stomach. When this occurs, just revert to smaller doses. As long as you stay within the recommended dosage, there should not be any negative side effects to glutamine supplementation for body building.

People with kidney problems, people with cirrhosis of the liver, pregnant women, women who are breast feeding, and anyone who is under any medication or with any medical condition should NOT be taking Glutamine Powder. Before taking any dietary supplement always consult with your doctor. Anyone with liver or kidney problems, Reye’s syndrome, or any type of disorder that can result in an accumulation of ammonia in the blood should not take glutamine, as it may aggravate these conditions.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Glutamine

This product dissolves quickly in water and has very little taste. Just mix your usual dose with water or juice and drink. The extremely popular amino acid L-Glutamine can be found in protein powders, beans, meats, fish, poultry, dairy products, and L-Glutamine supplements.

Glutamine is used in the following Proprietary Formulas

Gaspari Nutrition SuperPump250, MuscleTech Nitro-Tech Hardcore, BSN CellMass, SciVation Xtend, MuscleTech Cell-Tech Hardcore, MHP Glutamine-SR, Optimum Nutrition Glutamine Powder, Optimum Nutrition Glycomaize, EAS L-Glutamine, Ultra Fuel Powder, Prolab Glutamine Powder

References & Further Research

Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia
The objective of this study is to determine the effects of orally administered glutamine on the resting energy expenditure (REE) and nutritional status of children and adolescents with sickle cell anemia. After 24 weeks of orally administered glutamine, children and adolescents with sickle cell anemia had a decrease in REE and improvement in nutritional parameters. Those who were underweight had a greater decrease in REE than those of normal body weight. Lowering REE may be an effective way to improve the growth of these children and adolescents.

Effects of an oral mixture containing glycine, glutamine and niacin on memory, HGH and IGF-I secretion in middle-aged and elderly subjects
Aging is associated with declining activity of the growth hormone-insulin-like growth factor-I (GH-IGF-I) axis and with a decrease in cognitive function. The stimulatory effect of an orally administered nutritional supplement, mainly containing glycine, glutamine and niacin on the GH-IGF-I axis and on mood and cognition was investigated. It is concluded that an oral mixture of glycine, glutamine and niacin can enhance GH secretion in healthy middle-aged and elderly subjects.

Glutamine supplementation in serious illness: A systematic review of the evidence
The objective of this study was to examine the relationship between glutamine supplementation and hospital length of stay, complication rates, and mortality in patients undergoing surgery and experiencing critical illness. After the trials and the research they found out high-dose glutamine supplementation lead to a reduction in infectious complication rates and a shorter hospital stay even for critically ill patients.

Glutamine prevents downregulation of myosin heavy chain synthesis and muscle atrophy from glucocorticoids
The aims of this study were to determine whether glutamine infusion prevents the decline in protein synthesis and muscle wasting associated with repeated glucocorticoid treatment. In conclusion, the data showed glutamine infusion is effective therapy in counteracting glucocorticoid-induced muscle atrophy. Atrophy attenuation appears related to maintaining muscle glutamine levels.

Glutamine for International Customers

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Buying Glutamine Bulk or Wholesale

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