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What is L-Histidine HCl

L-Histidine HCL, synonymously referred to as L-Histidine Hydrochloride, is commonly referred to as an essential amino acid because it cannot be synthesized in human physiology but must be consumed in food or as a dietary supplement to maintain proper health. Because increased supplementation of L-Histidine causes secretion and elimination of zinc from the human body to significantly increase, many researchers suggest supplementing with zinc when taking L-Histidine. Histidine is one of the most common of all naturally occurring amino acids, and it is found in large concentrations in skeletal muscle. The dipeptides found in muscle (anserine and carnosine) are both comprised of one part L-Histamine, and one part beta-alanine. Histidine’s primary responsibility lies within its ability to aid the human body with the growth and repair of tissues. It also serves as the primary amino acid responsible for maintaining the myelin sheaths that coat and safeguard delicate nerve cells to ensure the transmission of messages from the brain to various parts of the body. This amino also plays a crucial role in many fundamental human metabolic processes. It aids in the production of red and white blood cells, increases sexual functioning in adults, helps to regulate and stabilize blood pressure, and assists in ridding the body of (metallic) toxins via the circulatory system. Histidine is also the precursor to histamine biosynthesis. Histamine is the substance released by the immune system in response to an allergic or inflammatory reaction.

By virtue of its role in the myelin sheaths, Histidine is an important component of many enzymes that affect neurotransmitter function. In line with this, it may be helpful in treating mental disorders as well as certain types of sexual dysfunction. Just like other amino acids, histidine can be derived and obtained from many high-protein foods, such as meat and dairy products, as well as grains such as rice, wheat, and rye. Histidine is also available in capsule and powder forms, as well as in combination amino acid formulas. It is not yet clear and exact if histidine is an essential or non-essential amino acid because most health nutrition and experts agree that, although the body makes its own histidine, it is quite easy for natural supplies to run short. The chronically ill, post-surgery, or arthritic individual are the prime candidates to benefit from supplementing with this amino acid.

The amount of Histidine in the body must be balanced, not too much or too little, to promote good mental and physical health. Excessive levels of this amino acid have been linked to help cause psychological disorders such as anxiety and schizophrenia, while low levels of histidine are believed to contribute to the development of rheumatoid arthritis and the type of deafness that results from nerve damage. With respect to this taking histidine supplements may help relieve symptoms of rheumatoid arthritis. Histidine is also important to normal sexual functioning, because it gets converted into histamine, a chemical needed to stimulate sexual arousal. When consumed in conjunction with vitamin B3 (niacin) and vitamin B6 (pyridoxine), histidine can enhance sexual pleasure by boosting histamine levels in the body. Histamine is required by the body to help the immune system when the person is experiencing an allergic reaction, and for the production of stomach enzymes and juices needed for proper digestion.

L- Histidine hydrochloride supplies hydrochloric acid, a naturally occurring stomach acid that helps break up fats and proteins for quicker digestion in the small intestine. Stomach acid also helps make the absorption of nutrients through the walls of the intestines easier so it can go into the blood and delivered where it is needed. Gastric acid also aids in guarding the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach, which is 100,000-1,000,000 times more acidic than water, is sufficient to kill bacteria, but a low level increases the possibility and severity of some bacterial and parasitic intestinal infections. Research suggests that histidine acts as a natural detoxifier as well, protecting against radiation damage, and removing heavy metals from the system. It may even help prevent the onset of AIDS owing to the fact that histidine is essential to the production of both red and white blood cells.

What is Histidine used for and who uses it?

Histidine is a precursor of histamine, a chemical compound released by immune system cells when a person experiences an allergic reaction. It is required for the growth and repair of tissue, as well as the maintenance of the myelin sheaths that act as shield for nerve cells. It is also necessary for the synthesis and manufacture of both red and white blood cells, and assists in protecting the body from damage caused by radiation and to detoxify, chelate, and remove harmful metals and free radicals from the body. In the digestive tract, histidine is also needed in producing gastric juices, and because of this people with deficiency of gastric juices or suffering from indigestion, may greatly benefit from this nutrient.

Histidine also functions to help enhance sexual arousal and enjoyment. Men and women having problems achieving orgasms may be find help with this through histidine supplementation, because this may result in increased histamine levels in the sexual tract, which in turn may make orgasms and ejaculations easier. The reason for this is because for the most part, it is histamines that regulate ejaculations and orgasms. Men who suffer from premature ejaculations often manifest increased histamine activity. Another amino acid, namely methionine, can help in this situation because it can counteract the formation of histamine from histidine or the activity of histamine.

Also, studies suggest using L-Histidine together with Beta Alanine to increase muscle Carnosine. Carnosine, a naturally-occurring dipeptide first discovered in Russia in 1900 and made up of amino acids Beta-Alanine and L-Histidine, is a natural substrate for the production of Nitric Oxide. Carnosine has antioxidant, buffering, free radical scavenging and even neurotransmitter properties attributed to itself. Carnosine also increases your ability to work harder by preventing your muscle from becoming too acidic during times of stress and more Carnosine in muscle means you can keep muscle acid at bay so you can train harder and longer.

How pure is your Histidine?

This pharmaceutical grade amino acid L-Histidine HCL (commonly referred to as Histidine) is assayed by the manufacturer to be 98.31% product. You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. It does not contain any fillers, additives or anti-caking agents. To ensure good mental and physical health, Histidine levels in the body must be stable. Because of this, it must be supplied either from the diet or from supplementation.

What are some of the common effects of Histidine?

As beneficial and effective as it may be, Carnosine biosynthesis and bioavailability is largely dependent on the presence of both Beta-Alanine and L-Histidine. Carnosine averts muscular injuries and shortens recovery times in sports. Carnosine fights these free radicals produced through high intensity muscular activity and oxidative stress in the muscles if there is enough of it in the body. Oral supplementation of Carnosine can lead to increased concentrations of Carnosine, however, supplementation with L-Histidine may prove to be a more effective way for getting the benefits of elevated levels of Carnosine like increased athletic performance and more.

It is also believed that histidine may be beneficial to people suffering from arthritis and nerve deafness. Histidine is used as a supplement for sufferers of rheumatoid arthritis, since it has been determined and demonstrated that in these patients, histidine levels are low. And last but not least, histidine is, like many other amino acids, important for growth and general tissue repair. For this reason alone, it has made its way in many of the popular bodybuilding supplements available in the market both as a standalone supplement and in combination amino acid formulas as well.

What is the daily suggested dose of Histidine?

The commonly recommended dose for L-Histidine HCL varies from as little as 500 milligrams per single dose taken 1 time per day to as much as 1000 milligrams taken up to 3 times per day for a total combined daily dose of between 500 milligrams and 3 grams. Large single doses of L-Histidine greater than 1 gram are not commonly recommended.

One half level teaspoon will supply approximately 2688 milligrams, or just about 2.7 grams for the bulk density of this L-Histidine HCl powder. You can see the full bulk density/volumetric conversion chart for L-Histidine HCl here. As you can see you don’t need to consume that much to meet the daily requirements recommended, which gives you real value for your money, because our product is pharmaceutical grade and we never use cutters, fillers, dyes, taste additives, or anti-caking agents.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of Histidine

Too much histidine will actually cause constipation, and this is overcome by taking zinc and GLA in the form of primrose, borage, or black current oil. There are no reported side effects in using histidine within the suggested amounts, but too high levels of histidine may lead to stress and mental disorders such as anxiety, and people with schizophrenia have been found to have high levels of histidine. People suffering from schizophrenia or bipolar (manic) depression should not take a histidine supplement without first consulting their physician. Anyone with liver or kidney disorders should not take histidine without first consulting with a licensed health care provider. Taking any one amino acid supplement may cause levels of nitrogen in the body to become imbalanced, as well as disrupt the Krebs cycle by which toxins are eliminated from the liver and kidneys.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Histidine

Pure bulk Histidine HCL powder is easily soluble in hot water, dissolves slowly in cold water, and has a mildly sour and bitter taste, but not too bad. You can take L-Histidine HCL powder dissolved in water or blended into your favorite protein shake.

Histidine is used in the following Proprietary Formulas

GU Energy Gel, L-Histidine (Supplement Direct), Nitro Fire (Prolab), 3-XL (iSatori), Body Octane (MAN), MuscleON (NxLabs), Vassive-EA8 (Optimum), Threshold (Optimum), Muscle Blast (SNI), Armageddon (StarChem Labs), IntraVol (MuscleTech), N.O.-TapouT Pre-Workout (TapouT Sports Nutrition), N.O. Plasmacore (Muscle Asylum Project), Anabolic Halo (MuscleTech), NO-Xplode (BSN), Advanced Holistics - Virility For Men (Pure Essence)

References & Further Research

Evidence that histidine is an essential amino acid in normal and chronically uremic man
The requirement for dietary histidine was investigated in four normal and three chronically uremic men. After administration of the histidine-repletion diet, nitrogen balance became positive in six subjects; serum albumin increased in five cases; plasma and muscle histidine rose; serum iron fell abruptly; a reticulocytosis ensued; and the hematocrit rose. The clinical symptoms and skin lesions disappeared. These observations indicate that histidine is an essential amino acid in normal and chronically uremic man. The absence of dietary histidine is associated with failure of normal erythropoiesis.

The Role of Histidine in the Anemia of Folate Deficiency
The amino acid histidine is metabolized to glutamic acid in mammalian tissue. In normal subjects, histidine is excreted much more in the urine than other essential amino acids are. Hemoglobin protein contains 10% histidine. Under normal conditions, dietary histidine can supply sufficient histidine to prevent anemia. When the dietary intake is diminished or the urinary excretion is greatly increased, anemia results. It is concluded that folate deficiency causes histidine depletion through increased urinary excretion of this amino acid. Feeding histidine replenishes tissue levels of histidine, resulting in hemoglobin regeneration. Folic acid administration results in return of histidine to normal urinary levels. Thus, a combination of folic acid histidine would be beneficial for folate deficient individuals.

Histidine for International Customers

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