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L-Histidine Base

What is L-Histidine HCl?

L-histidine HCl is an analog of L-histidine with hydrochloric acid, a naturally occurring stomach acid that promotes digestion.

L-histidine is an essential amino acid that must be consumed in food or as a dietary supplement to maintain proper health.

Because increased supplementation of L-histidine causes the secretion and elimination of zinc in the body to increase, many researchers suggest supplementing with zinc when taking L-histidine.

Histidine is one of the most common of all naturally occurring amino acids. It is found in large concentrations in skeletal muscle.

The dipeptides found in muscle (anserine and carnosine) are both comprised of one part L-histamine and one part beta alanine.

Health Benefits of Histidine

Histidine helps the body grow and repair tissues. It serves as the primary amino acid responsible for maintaining myelin sheaths that coat and safeguard delicate nerve cells and ensure the transmission of messages from the brain to various parts of the body.

This amino also plays a crucial role in many fundamental human metabolic processes. It aids in the production of red and white blood cells, helps to regulate and stabilize blood pressure and assists in ridding the body of metallic toxins via the circulatory system. Histidine is the precursor to histamine (Wikipedia) biosynthesis and is the substance released by the immune system in response to an allergic or inflammatory reaction.

Histidine is an important component of many enzymes that affect neurotransmitter function. It is present in many high-protein foods like meat and dairy products as well as grains such as rice, wheat, and rye.

L-histidine hydrochloride increases stomach acid and helps make the absorption of nutrients through the walls of the intestines easier. Gastric acid also aids in guarding the gastrointestinal tract from harmful bacteria. Research suggests that histidine acts as a natural detoxifier as well.

Studies suggest using L-histidine together with Beta Alanine to increase Carnosine in the muscles. Carnosine is a natural substrate for the production of nitric oxide (Wikipedia), which increases blood flow in the body. Carnosine has antioxidant properties that protect cell membranes. It also protects muscle from becoming too acidic during exercise, providing support for longer workouts.

Purity and Concentration of Histidine

This pharmaceutical grade amino acid L-Histidine HCL contains no fillers, additives or anti-caking agents. The molecule is the histidine analog with hydrochloride attached.

Suggested Use of Histidine

As a dietary supplement, take 500 milligrams (scant 1/8 tsp) daily (or as directed by physician.) Servings greater than 1 gram are not recommended.

You can see the full bulk density/volumetric conversion chart for L-Histidine HCl here. A serving size of 1/8 teaspoon is equal to 672 milligrams, so a scant 1//8 tsp is approximately 500 mg. Or more accurately, a serving size of 1/32 teaspoon is equal to 168 mg, so 3/32 tsp is 504 milligrams.

Potential Side Effects of Histidine

Histidine is generally safe at suggested serving sizes. Too much histidine can cause constipation, which can be overcome by taking zinc in the form of primrose, borage or black currant oil. People suffering from schizophrenia, bipolar disorder and liver or kidney disorders should not take histidine without consulting a physician. This product is not intended for women who are pregnant or nursing.

Mixing and Solubility of Histidine

Histidine HCL powder is easily soluble in hot water, dissolves slowly in cold water and has a mildly sour and bitter taste. Dissolve in water or blend into a favorite protein shake.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

Wikipedia: Histidine

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.