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Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2800 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Isoleucine?

Isoleucine is an essential amino acid that is primarily used to help improve endurance, speed up healing and repair of muscle tissue, as well as stimulate clotting at the site of injury. This amino acid is particularly important to serious athletes and body builders because its main function in the body is to boost energy and help the body recover from strenuous physical activity. Being an essential amino acid, this means L-Isoleucine cannot be manufactured in the body and must be consumed through dietary sources to maintain proper health. Good sources of isoleucine include high-protein foods, such as nuts, almonds, seeds, meat, cashews, eggs, fish, chicken, liver, lentils, peas, soy protein, brown rice, and whole wheat bread products. In the human body Isoleucine is highly concentrated in the muscle tissues. For this reason people that exercise a lot or that have a low-protein diet should consider supplementation.

L-Isoleucine is the fourth most abundant amino acid in human skeletal muscles, and it comprises about 12% of all proteins in the human body. L-Isoleucine is typically taken by weight lifters and performance athletes wanting to reduce fat and maximize muscle mass. Blood levels of L-Isoleucine will fall significantly after strenuous exercise and will stay low until complete recovery. Supplementation with L-Isoleucine one hour before strenuous workouts can reduce the recovery time by increasing muscle protein synthesis and counteract catabolic processes. Isoleucine should always be taken together in conjunction with the other two branched-chain amino acids, leucine and valine. To make the most out of this supplement, the ideal balance is 2 milligrams of leucine and valine for every milligram of isoleucine.

Isoleucine is a branched-chain amino acid (BCAA). There are three branched-chain amino acids in the body, namely, isoleucine, valine, and leucine, and all of them are essential in helping encourage muscle recovery after exercise. Isoleucine in particular keeps energy levels stable by helping to regulate blood sugar and also helps increase energy level because Isoleucine can be broken down for energy within the muscle tissue. A deficiency of isoleucine manifests symptoms similar to those seen in hypoglycemic patients, and may include headaches, dizziness, fatigue, depression, confusion, and irritability.

BCAAs (branched chain amino acids) - L-leucine, L-isoleucine and L-valine - are undoubtedly the single most important group of amino acids for just about anyone, from world champion athletes to regular people. The body uses these to promote healing of injured tissues, to speed up recovery, and to protect against muscle tissue breakdown (catabolism) during exercise. BCAAs are one third of all the protein in muscles, therefore extremely important for developing and building muscles. Studies have shown BCAA to be helpful in other areas as well, due to what each ingredient does in its own right. For example, Leucine is necessary for wound recovery to skin and bones as well as helps protect muscles, Valine helps promote or maintain nitrogen balance (essential for muscular development), and Isoleucine helps boost energy and is necessary for forming hemoglobin.

What is L-Isoleucine used for and who uses it?

Some of the benefits of L-IsoLeucine include maintaining healthy and optimal levels of blood sugar in the body as well as energy levels, and it is also needed for the formation of hemoglobin. This amino acid plays a key role for muscle recovery after exercise, and is crucial in metabolism for producing energy because IsoLeucine is literally broken down within the muscle tissue to provide energy. L-IsoLeucine is also of critical importance for preventing muscle wasting or atrophy in individuals suffering debilitating illnesses and conditions. It is also essential for the manufacture and synthesis of body proteins, and is directly involved in blood clot formation. IsoLeucine is required for nitrogen balance in adults, and for the healthy, normal growth of infants.

IsoLeucine is probably best known for its ability in increasing endurance and helping heal and repair muscle tissue. Serious athletes and bodybuilders need this amino acid because it can boost energy levels and help the muscles recover from strenuous exercise and other physical activities. Strength and performance sports like weightlifting, bodybuilding, powerlifting, and other physically demanding sports require energy and endurance. By using IsoLeucine together with Valine and Leucine, the muscles are able to fully recover after exercise in a much shorter period.

Supplementing with L-leucine, L-isoleucine and L-valine, collectively known as BCAAs, can feed your body so that it doesn’t eat your own tissue. Aside from being required by the body, BCAAs can also be used to regenerate the skin of burn victims, because they aid in repair, growth, and development of muscle tissue, and to help treat kidney failure and liver disease as well. The combination of these three essential amino acids - L-leucine, L-isoleucine and L-valine makes up approximately 33% of skeletal muscle in the human body, and plays an important role in protein synthesis. BCAAs are currently used primarily for supplementation among strength athletes because it promotes protein synthesis in muscle. When taken during training, BCAAs have been shown to increase both growth hormone (GH) and insulin, thus increasing anabolism and anti-catabolism. Also, unlike other amino acids, BCAAs are used to provide energy and they have been shown to decrease post-workout soreness, which translates to faster recovery times even after intense and grueling trainings.

Since BCAAs are so crucial for the proper functioning of muscle tissue, they are very popular with endurance athletes, body builders, and others looking to simply stay healthy. BCAAs are metabolized in the muscle as opposed to the liver, and because of this many body builders and athletes use BCAA supplements while undergoing intense exercise. Even light exercise can cause BCAAs levels to drop quickly which leads to muscle breakdown (catabolism), fatigue, and a drop in testosterone levels. If you are in a building phase in any exercise routine or if you train for long periods of time, BCAAs are a good choice for you to ensure you do not use or burn the muscle you’ve worked so hard to build to get the energy you require in your strenuous activities.

How pure is your L-Isoleucine?

This pharmaceutical grade amino acid L-Isoleucine is assayed by the manufacturer to be 99.9% product. You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. For athletes or anyone who practices regular strenuous physical activity, IsoLeucine supplements are really beneficial. Although there are plenty of dietary sources that contain this amino acid, people who are extremely active and exercise heavily need more IsoLeucine in their bodies to repair and protect muscle tissues. If all you want are the health benefits and muscle mass gains made possible with L-Isoleucine, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because sure you’ll pay more for Isoleucine supplements found in your local health food store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of L-Isoleucine?

Isoleucine is also available in stand-alone supplemental form, but should always be taken together with the other two branched-chain amino acids, leucine and valine. The ideal balance is 2 milligrams of leucine and valine for every milligram of isoleucine. Combination supplements that provide all three of the BCAAs may be more convenient, but may not be in the right proportion or balance. The typically recommended dose for L-Isoleucine varies between 1 grams and 2 grams per single dose taken 1 or 2 times per day for a total combined daily dose of between 1 grams and 4 grams. One half level teaspoon (2.46 cc) of L-Isoleucine will be equivalent to about 1786 milligrams. You can see the full bulk density/volumetric conversion chart for L-Isoleucine here.

Deficiency symptoms, Precautions, and Potential side effects of L-Isoleucine

If one is taking a supplement of isoleucine, it should be taken in balance with the other two branched-chain-amino-acids leucine and valine in the ratio of 2 mg of leucine and valine for each 1 mg of isoleucine.

Deficiency of isoleucine is present in people whose diet is lacks in dietary protein. The symptoms may include headaches, dizziness, fatigue, depression, confusion as well as irritability. Symptoms of deficiency may resemble those of hypoglycemia. This nutrient has also been found to be lacking in people with mental and physical disorders, but more studies are still needed to confirm this.

Higher dosages of isoleucine does not produce any adverse effects for most of people but those with kidney or liver disease should not consume high amounts of amino acids without prescription or medical advise. People with impaired liver or kidney function should not take isoleucine without first consulting a physician, as large doses of amino acids may aggravate these conditions.

Taste, solubility, and suggested preparation of L-Isoleucine

Pure bulk L-Isoleucine powder is not easily soluble in water and has a bitter taste. The best way to take L-Isoleucine powder is mixed, or blended with and suspended within a protein shake.

L-Isoleucine is used in the following Proprietary Formulas

Nitrobol, MNT LeuceMine, AllMax Nutrition Leucine, AST BCAA 4500, Cheap Supplements BCAA, Cheap Supplements Leucine, Eclipse 2000 Deluxe BCAA, Optimum BCAA, Optimum Superior Amino 2222, PrimaForce L-Leucine, SciFit BCAA AKG 1000, Source Naturals L-Leucine, Supplement Direct L-Leucine, Ultimate Nutrition Branch Chain Amino Acids, 4Ever Fit 4Ever Whey Gainer, ASN Maxabol II, Champion AdreNOl8, Champion Amino Shooter Core+, Controlled Labs Golden Finish, Core Nutritionals Core ABC, Cytogenix Laboratories CYTOCELL, CytoSport Monster Amino, Dedicated Athlete Rapid Recharge, Dymatize BCAA Complex 2200, Gaspari Nutrition SuperPump250, LA Muscle LA Whey, Met-Rx Amped ECN NOS, MHP A-Bomb, Muscle Asylum Project Mass Impact, Muscle Pharm Combat Powder, MuscleTech Anabolic Halo, MuscleTech Cell-Tech Hardcore, Universal Torrent, Universal Uni-Liver, Vitol Russian Bear, VPX BANG!, Weider Amino 6000, Xero Limits EPO-Blast, Xtreme Formulations ICE

References & Further Research

Branched-Chain Amino Acid Enriched Supplements as Therapy for Liver Disease
Altered amino acid metabolism is a hallmark of liver disease, characterized by low levels of circulating BCAAs and elevated levels of circulating aromatic amino acids, and methionine. Although overwhelming evidence indicates that the incidence of complications of liver disease increases with malnutrition, the reported impact of nutritional therapy, specifically BCAA supplementation, on outcomes in patients with liver disease has varied with the indication. Both studies found improved nutritional status associated with BCAA supplementation. On balance, BCAA supplementation appears to be associated with decreased frequency of complications of cirrhosis and improved nutritional status when prescribed as maintenance therapy

Isoleucine infusion during "simulated" upper gastrointestinal bleeding improves liver and muscle protein synthesis in cirrhotic patients
Upper gastrointestinal (GI) bleeding in cirrhotic patients has a high incidence of mortality and morbidity. Postbleeding catabolism has been hypothesized to be partly due to the low biological value of hemoglobin, which lacks the essential amino acid isoleucine. The aims were to study the metabolic consequences of a "simulated" upper GI bleed in patients with cirrhosis of the liver and the effects of intravenous infusion of isoleucine. The present study investigated hepatic and portal drained viscera protein metabolism selectively in humans. The data show that hepatic and muscle protein synthesis is stimulated by improving the amino acid composition of the upper GI bleed by simultaneous intravenous isoleucine administration.

Isoleucine, a Blood Glucose-Lowering Amino Acid, Increases Glucose Uptake in Rat Skeletal Muscle in the Absence of Increases in AMP-Activated Protein Kinase Activity
Leucine and isoleucine were shown to stimulate insulin-independent glucose uptake in skeletal muscle cells in vitro. In this study, the effects of leucine and isoleucine on blood glucose in food-deprived rats and on glucose metabolism in skeletal muscle in vivo were examined. Oral administration of isoleucine, but not leucine, significantly decreased the plasma glucose concentration. This is the first report of isoleucine stimulating glucose uptake in rat skeletal muscle in vivo, and these results indicate that there might be a relation between the reduction in blood glucose and the increase in skeletal muscle glucose uptake that occur with isoleucine administration in rats. The alterations in glucose metabolism caused by isoleucine may result in an improvement of the availability of ATP in the absence of increases in AMP-activated protein kinase activity in skeletal muscle.

L-Isoleucine for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Isoleucine Bulk or Wholesale

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