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Click to Enlarge Unit Weight: 100 grams Unit Volume: 220 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Ornithine HCl?

Ornithine is a non-essential amino acid synthesized and made from the breakdown of arginine during the citric acid cycle. It helps build muscle and decrease body fat, especially when taken together with the amino acids arginine and carnitine. Ornithine is also required for the formation of citrulline, proline, and glutamic acid, three amino acids that help supply energy to every cell in the body. Ornithine is an amino acid synthesized from arginine, and its role is closely related in the formation of urea. In the Krebs cycle, ornithine takes part in the synthesis of citrulline where ornithine reacts with carbamyl phosphate to form citrulline. Ornithine also plays an important role in the synthesis of proline and glutamic acid. Ornithine is a non-essential amino acid because it is manufactured by the body, and it helps build muscle and reduce body fat. Arginine is necessary for the production of ornithine and should be supplied in sufficient quantities to the body. Carnitine also increases the effect of this nutrient. The body can manufacture ornithine but can also be obtained from protein rich sources such as meat, fish, dairy, and eggs.

Ornithine is usually added with arginine and marketed to strength athletes and body builders as a muscle-building supplement. Laboratory studies have demonstrated that ornithine increases both insulin and growth hormone levels, which are of paramount importance to build and maintain muscle during intensive physical training. Aside from this use, in clinical studies on people hospitalized for surgery, generalized infections, cancer, trauma, or burns, supplementation with a derivative of L-Ornithine, ornithine alpha-ketoglutarate (OKG), has been reported to produce several beneficial effects including increased ability to heal, better appetite, weight gain, and improved quality of life compared with those who did not supplement with OKG. Preliminary trials using ornithine aspartate, another analog of ornithine, has been shown to aid people with brain abnormalities (hepatic encephalopathy) due to liver cirrhosis. Those taking ornithine had significant improvements in liver function and blood tests compared with those who did not. Other studies also suggest that ornithine can help those who have experienced severe burns. In a clinical trial, burn patients who used 10-30 grams of ornithine alpha-ketoglutarate per day observed an improved and faster healing which lead to shorter hospital stays.

What is L-Ornithine HCl used for and who uses it?

Ornithine is crucial since it triggers the release of growth hormone in the body, which in turn helps with fat metabolism. It is further necessary for a properly functioning immune system and liver and helps in ammonia detoxification and liver rejuvenation. It is also beneficial in healing and repairing skin and tissue and is found in both of these body parts. Ornithine assists in the elimination of toxic ammonia from the liver, and may reduce the effects of cirrhosis of the liver and disorders associated with liver malfunction.

Ornithine may also be of use in fighting the muscle loss that is a normal part of the aging process. As the body gets older, it becomes less efficient at synthesizing proteins and can’t regenerate muscle tissue as quickly as before, which leads to a decline in both strength and muscularity. By its action and attribute of being able elevate growth hormone levels, ornithine may help speed the production of muscle tissue and offset the effects of aging. Ornithine is also required for the manufacture of citrulline, proline, and glutamic acid, three amino acids that help bring energy to every cell in the body. It also helps to speed up the process of healing in cases of burns, trauma, improvement in appetite, weight gain and improvement in quality of life.

L-Ornithine by itself is used by athletes to improve performance as it increases both insulin and growth hormone levels needed to build and maintain muscle during intensive physical training. Supplementation with L-Ornithine hydrochloride supplies hydrochloric acid, a naturally occurring stomach acid that helps break up fats and proteins for quicker digestion in the small intestine. Stomach acid also helps make the absorption of nutrients through the walls of the intestines easier so it can go into the blood and delivered where it is needed. Gastric acid also aids in guarding the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach, which is 100,000-1,000,000 times more acidic than water, is sufficient to kill bacteria, but a low level increases the possibility and severity of some bacterial and parasitic intestinal infections.

Ornithine also assists in eliminating toxic ammonia from the liver, and may lower the harmful effects of cirrhosis of the liver and disorders associated with liver malfunction. In one study, participants taking 18 grams of ornithine aspartate for two weeks showed significant improvement in blood tests and liver function compared to the placebo group. Research has also shown that ornithine helps promote healing and tissue repair. Clinical studies reported that taking 10 grams of ornithine alpha-ketoglutarate (OKG) each day helped reduce the length of hospital stays for those recovering from surgery, generalized infections, cancer, trauma, and burns.

How pure is your L-Ornithine HCl?

This pharmaceutical grade amino acid L-Ornithine HCL assayed by the manufacturer to be 99.2% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder product. L-ornithine is a basic amino acid and is important in the formation of urea. Although it is a nonprotein amino acid which means that it does not occur in proteins, the body utilizes it in the biosynthesis of L-arginine, L-proline and polyamines. L-Ornithine may be very beneficial if you are trying to lose fat because it initiates the release of growth hormone in the body that can in turn help with fat metabolism. The liver and immune system also require ornithine to function properly. It assists in ammonia detoxification and liver rejuvenation. Ornithine can also help with healing and repairing skin and tissue for people recovering after surgery and athletes who experience trauma from training on a regular basis. Purebulk L-Ornithine HCl comes in a pure powder form with absolutely no additives or fillers, just pure active L-Ornithine HCl. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. If all you want are the health benefits and muscle mass gains made possible with Ornithine, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of L-Ornithine HCl

The typically recommended dose for L-Ornithine HCl varies between 1 gram and 3 grams per day in divided doses, depending upon individual needs. For bodybuilders and performance athletes one half level tablespoon will supply approximately 3914 milligrams, or just about 4 grams for the bulk density of this L-Ornithine HCl powder. You can see the full bulk density/volumetric conversion chart for L-Ornithine HCl here.

Deficiency Symptoms and Potential side effects of L-Ornithine HCl

Since the body can produce ornithine, a deficiency of this non-essential amino acid is rare. Few people are really deficient in ornithine, unless they are extremely malnourished or have a disorder that disrupts the citric acid cycle. There are no reported side effects from the use of ornithine, but children, pregnant or nursing mothers, or anybody suffering from schizophrenia should NOT take L-ornithine. No side effects have been reported with the use of ornithine, although gastrointestinal distress may develop with intakes over 10 grams per day. People recovering after surgery and athletes may benefit from this nutrient.

Taste, solubility, and suggested preparation of L-Ornithine HCl

This product dissolves somewhat quickly in hot water, somewhat slowly in cold water, and has mildly sour taste. Just mix your usual dose with water or your favorite citrus juice and drink.

L-Ornithine HCl is used in the following Proprietary Formulas

Fountain Of Youth HGH Complete, Universal GH Max, Ultimate Nutrition Arginine/Ornithine/Lysine, Universal NOX3, NOW Arginine & Ornithine, NOW L-Ornithine, Supplement Direct L-Ornithine HCL, Universal OKG, Country Life L-Arginine L-Ornithine Caps, Fusion Bodybuilding Shut-Eye, Healthy 'N Fit Advanced GH Enhancers, Healthy 'N Fit Advanced OKG 5000, Life Extension GH Pituitary Support Day Formula, Life Extension L-Ornithine HCL Powder, Magnum Nutraceuticals Serum, Neogenix CryoShock, Neogenix Vasospan, NOW Awe-Slim, NOW Pro-GH, NOW Tri-Amino, NRG-X Labs Anabolic Raptor, Olympian Labs Arginine & Ornithine, Twinlab L-Arginine/L-Ornithine, Universal Gain Fast 3100, Universal GH Max, Universal GH Stack

References & Further Research

Ornithine--Ketoglutarate (OKG) Supplementation Is More Effective than Its Component Salts in Traumatized Rats
Addition of an anabolic stimulus during nutritional support seems to be a reasonable adjunct to augment protein synthesis. Ornithine--ketoglutarate (OKG) has been used for this purpose in many pathological situations, but the mechanism of action is poorly understood. Overall research data suggest that the mechanism of OKG action may be associated with increases in growth hormone and insulin, as well as the production of metabolites of ORN and KG. OKG has better metabolic benefits than its two components given separately in the nutritional support of injured rats.

Ornithine alpha-ketoglutarate in nutritional support
Ornithine alpha-ketoglutarate (OKG) is a salt formed of two molecules of ornithine and one molecule of alpha-ketoglutarate. OKG has been successfully used by the enteral and parenteral route in burn, traumatized, and surgical patients and in chronically malnourished subjects. According to the metabolic situation, OKG treatment decreases muscle protein catabolism and/or increases synthesis. In addition, OKG promotes wound healing. The mechanism of action of OKG is not fully understood, but the secretion of anabolic hormones (insulin, human growth hormone) and the synthesis of metabolites (glutamine, polyamines, arginine, ketoacids) may be involved.

Growth retardation in children receiving long-term total parenteral nutrition: effects of ornithine alpha-ketoglutarate
The effect of ornithine ketoglutarate (OKG) in reversing abnormal growth in six prepubertal children receiving total parenteral nutrition (TPN) for 5-10 y were evaluated in this study. This study demonstrates that OKG is associated with statural growth acceleration and increased IGF1 concentrations.

L-Ornithine HCl for International Customers

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Buying L-Ornithine HCl Bulk or Wholesale

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