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What is L-Proline

Proline is a non-essential amino acid and a main component of collagen just like Lysine. Collagen, a major structural component of cells and animals, is the protein responsible in forming connective fibers in tissues such as skin, ligaments, cartilage, bones and teeth. Collagen also functions somewhat like an intracellular "glue" that provides support, shape and bulk to blood vessels, bones, and organs such as the heart, kidneys and liver. Collagen fibers keep bones and blood vessels strong, and assist in anchoring our teeth to our gums. Collagen is also needed for the repair of blood vessels, bruises, and broken bones. Since Proline is necessary to make collagen, Proline helps strengthen cardiac muscle, improves skin texture, and reduces the loss of collagen through the aging process. It can be derived from animal products such as dairy products, eggs, beef and poultry.

Proline — along with the amino acid lysine and Vitamin C — is essential for the formation of healthy collagen and cartilage. It maintains the flexibility of both muscles and joints, and helps reduce sagging and wrinkling that accompany UV exposure and normal aging of the skin. Proline is also beneficial in the formation of bone, skin and cartilage and it is of paramount importance for the proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles and is helpful in tissue repair after injury, or for any type of wound healing. Proline also participates in energy production. Since meat, dairy, and eggs are the best natural sources of proline, vegetarians or those with a low-protein diet should seriously consider a combination amino acid supplement containing, among other amino acids, proline.

Proline supplements are available by itself in both capsules and tablets, but this amino acid is more often than not included in supplements marketed for treatment of specific conditions, such as herpes (in combination with lysine), arthritis, or back pain, or in supplements or sports drinks made especially for hard training people like body builders and performance athletes. Proline may also be included in supplements and medications used to maintain or achieve cardiovascular health, usually in conjunction with vitamin C. Our body is continuously synthesizing collagen with the use of Proline, Lysine, and Vitamin C to maintain and repair connective tissues lost to daily wear and tear. Without vitamin C, the formation of collagen is disrupted, and this yields to a wide range of problems throughout the body. Scurvy, the disease caused by vitamin C deficiency, is really a process that disrupts the body's ability to manufacture collagen and connective tissues.

Proline is also very important in the process of reversing atherosclerotic deposits so people can avoid open heart surgery and angioplasty. Linus Pauling, the eminent American scientist and two-time Nobel Prize winner, announced in 1989 a breakthrough in how we view and treat heart disease. In "A Unified Theory of Human Cardiovascular Disease," Linus Pauling said that the root cause of heart disease is a long-term vitamin C deficiency, not the plaque deposits present in atherosclerosis, According to him, these plaque deposits were actually the result of our bodies trying to repair the damage caused by long-term vitamin C deficiency. In essence, Pauling believed that heart disease is a form of scurvy, and plaque is the body's attempt to reinforce and patch weakened blood vessels and arteries that would otherwise rupture. Pauling also demonstrated that heart disease can be prevented or treated by taking vitamin C and other supplements.

A significant number of animal studies have been found to back up Pauling's theory. Research conducted with animals that cannot manufacture their own vitamin C found that when vitamin C levels are decreased, collagen production reduces as well making blood vessels thinner and weaker. Additional studies also confirm that when animals are deprived of vitamin C, their bodies respond by forming plaque deposits to strengthen arteries and prevent vessel. In essence, collagen can prevent atherosclerosis because it melts plaque and it keeps arteries open. In addition to taking vitamin C to prevent atherosclerosis, Pauling suggested a combination of vitamin C and the amino acids lysine and proline to help remove existing plaque while strengthening weak and damaged arteries.

What is L-Proline used for and who uses it?

L-Proline is an amino acid that plays an important role in the synthesis of collagen, the most abundant protein in human body. Collagen is the principal protein and building block for the construction of all human connective tissues including skin, tendons, ligaments, cartilage, joints, bone, as well as blood vessels, arteries, veins, and lymph vessels. Supplementation with L-Proline can significantly improve the body's ability to synthesize vitally important connective tissues that can often fall into disrepair as we age. L-Proline can be a very beneficial supplement for individuals suffering from joint and connective tissue problems. Although L-Proline is synthesized by the human body, at times the amount produced may be inadequate for maintaining joint health and a healthy musculoskeletal system. Vegetarians are more likely to be deficient in L-Proline and with respect to this they stand to benefit greatly with L-Proline supplementation.

People recovering from traumatic injury, especially skin injuries such as severe burns, may want to supplement this amino acid. People with pain caused by inadequate cartilage or collagen formation could benefit from supplementary proline in their diet as well. Proline may be in supplements used to promote cardiovascular health, usually in conjunction with vitamin C. Reduction in proline levels have been observed in prolonged endurance runners and others following prolonged exercise. Serious athletes that undergo frequent, strenuous workouts may want to take a supplement containing proline in order to prevent loosing lean muscle mass in the process. This is because it is a known fact that the body begins to cannibalize its muscle for energy when glucose supplies run low.

Proline assists in the body’s task of breaking down proteins for use in creating healthy cells in the body. It is absolutely necessary to the development and maintenance of healthy skin and connective tissues, especially at the site of traumatic tissue injury. Proline and lysine (an amino acid which we carry in our inventory as well that is critical to protein synthesis) are both required to make hydroxyproline and hydroxylysine, two amino acids that form collagen. Collagen helps to heal cartilage and to bolster the joints and vertebrae. For this reason, proline supplementation may prove helpful in treating conditions such as osteoarthritis, persistent soft tissue strains, and chronic back pain.

How pure is your L-Proline

This pharmaceutical grade amino acid L-Proline is assayed by the manufacturer to be 99.7% product (normal range 98.5 to 101.0%). You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder product. This L- Proline powder is a free form of the amino acid L- Proline meaning that it is the most basic form without any additional chemical groups attached. This free form L- Proline is therefore somewhat more potent and concentrated with L- Proline than all other L- Proline analog molecules. It also has no additives, fillers or anti-caking agents included. The remaining 0.3% by weight are inactive byproducts of the extraction.

What is the daily suggested dose of L-Proline

Depending upon individual needs, the commonly recommended dose for L-Proline varies between as little as 500 milligrams to as much as 5 grams daily in divided doses between meals, in combination with vitamin C. A level 1/2 teaspoon of this pure bulk L-Proline powder is approximately 1213 milligrams. Taking 1/2 level teaspoon three times per day will yield a total daily dose of approximately 3.6 grams. You may want to adjust your dose higher or lower to suit your individual needs. You can see the full bulk density/volumetric conversion chart for L-Proline here.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of L-Proline

There are no known side effects or symptoms of overuse of L-Proline published in the scientific, clinical or medical literature. However, people with liver or kidney disease should not take this or any other amino acid supplement without first consulting their physician. Getting too much of any one amino acid can throw the citric acid cycle out of balance, which makes the liver and kidneys work harder to eliminate toxins.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of L-Proline

This product dissolves somewhat slowly in cold water, but faster in hot water, and has a somewhat sweet and characteristic taste, but not bad tasting. Just mix your usual dose with water or juice and drink. One point to keep in mind is that the body needs a supply of all the amino acids in order to effectively create and utilize proteins so if you intend to supplement any of the amino acids it is of paramount importance that you have a balanced intake of all the other amino acids. Being deficient in even one amino acid will lower the efficiency of all the other amino acids in your body.

L-Proline is used in the following Proprietary Formulas

Solgar L-Proline, Source Naturals L-Proline Powder, NOW Foods L-Proline, Roex L-Lysine and L-Proline, Swanson Health Products Swanson Premium L-Proline

References & Further Research

The relationship between the free pool of proline and collagen content in human liver cirrhosis
The free proline, free glutamic acid, and total collagen contents of the livers of cirrhotic and noncirrhotic patients were determined. The amounts of free proline in the sera of the patients were also determined. The average proline concentration in sera of cirrhotic patients was not higher than that of non cirrhotic patients, suggesting that the metabolic alteration noted above is a local event in the liver related to fibrogenesis. These and other results suggest that the pool size of free proline may play a prime role in regulation of collagen biosynthesis in liver cirrhosis.

Reducing the Risk for Cardiovascular Disease with Nutritional Supplements
Reducing the risk for cardiovascular disease (CVD) is a primary goal of any health care system in the industrialized world. The success of this world-wide effort will largely depend on the proper understanding of the mechanisms responsible for development of this disease. The therapeutic use of the amino acids L-lysine and L-proline could prevent further buildup of lipoprotein-a accumulation in the vascular wall. More importantly, optimum concentrations of L-lysine and L-proline could release deposited lipoprotein-a but also other atherogenic lipoproteins from the vascular wall.

L-Proline for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Proline Bulk or Wholesale

If you need L-Proline in bulk or wholesale quantities, please feel free to contact us with sourcing/shipping/fulfilment questions. If you have any questions about shipping or would like to arrange a shipment to an excluded country please use the contact page!