L-Serine
| Name/Weight | Volume | Price | |
|---|---|---|---|
L-Serine 100g |
260cc | $15.50 | |
L-Serine 250g |
525cc | $33.00 | |
L-Serine 500g |
950cc | $60.00 | |
L-Serine 1kg |
1800cc | $108.00 | |
L-Serine 1.5kg |
2650cc | $155.00 |
|
)
)
)
What is L-Serine?
Serine is a nonessential amino acid synthesized from glycine, and it also helps derive cysteine from homocysteine. It is one of three amino acids that is usually phosphorylated during cell signaling in eukaryotes. Phosphorylated serine residues are referred to as phosphoserine. Serine proteases are a common type of protease. Serine has sugar-producing qualities, and is very reactive in the body. It is highly concentrated in all cell membranes, helping in the manufacture of immunoglobulins and antibodies.Serine can be made in the body from either glycine or threonine (making it nonessential), but its production is dependent on sufficient levels of B3, B6, and folic acid. Serine is crucial in metabolism because it participates in the biosynthesis of purines and pyrimidines, cysteine, tryptophan (in bacteria), in the formation of cell membranes, and in creatine synthesis. Serine is also necessary for fat and fatty acid metabolism, muscle growth, and a healthy immune system. It is vital in the production of immunoglobulins and antibodies, and is an integral component of brain proteins and nerve sheaths. It is thus important in the production of cell membranes, as well as in muscle tissue synthesis.
What is L-Serine used for and who uses it?
Serine is important to overall physical and mental health, and is especially important to proper functioning of the brain and central nervous system because it helps build the phospholipids required to make every single cell in your body. It is also involved in RNA and DNA function, fat and fatty acid metabolism, muscle formation, and the maintenance of a healthy immune system. The proteins used to form the brain, as well as the protective myelin sheaths that protect the nerves, contain serine. Without serine, the myelin sheaths could become less effective at transmitting messages between the brain and nerve endings in the body, thus short circuiting mental function.Serine is also required to synthesize tryptophan, an amino acid that is used to manufacture serotonin, a mood-determining brain chemical. Low levels of serotonin and tryptophan have been directly linked to depression, insomnia, confusion, and anxiety. Research indicates that shortages of serine may also contribute or lead to chronic fatigue syndrome (CFS) and fibromyalgia (FM). Serine helps make immunoglobulins and antibodies for a strong immune system, and also aids in creatine absorption, a substance made from amino acids that helps build and maintain all the muscles in the body, including the heart. Serine as a constituent of phospholipids also help seal in moisture, and for this reason it is also often included as a natural moisturizing agent in numerous skin care products.
How pure is your L-Serine?
This pharmaceutical grade L-Serine (more commonly referred to as Serine) is assayed by the manufacturer as 99.7% pure product (normal range 98.5 to 101.0%). You will receive a double sealed and labeled bulk polyethylene bag containing this white crystalline powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 0.3% by weight are inactive byproducts of the extraction. Meat and soy foods, dairy products, wheat gluten, and peanuts are all good natural sources of serine, but today’s diet includes so much processed fast food. For this reason, amino acid supplementation may be needed more to ensure adequate intake. All persons in good health can benefit from supplementing with Serine, but athletes and the elderly especially can benefit from Serine supplementation because of the benefits described above.What is the daily suggested dose of L-Serine?
Since Serine is a nonessential amino acid, meaning this is an amino acid that can be produced in our body, there is no established RDA. However, 500mg daily has been proven beneficial in numerous clinical studies. You can see the full bulk density/volumetric conversion chart for Serine here.As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.
Precautions and Potential side effects of L-Serine
Side effects are generally rare but can include nausea, indigestion and insomnia. Although toxicity has not been established it has been found that very elevated serine levels may cause immune suppression and psychological symptoms such as cerebral allergies. Do not take Serine if you are a child, are pregnant or are nursing.The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
Taste, solubility, and suggested preparation of L-Serine
Serine has almost no taste and dissolves quickly in water. As a dietary supplement, you can add your dose to water, stir and drink, or you can add your Serine dose to juice or smoothies.L-Serine is used in the following Proprietary Formulas
MuscleTech Hydroxycut Advanced, NOW Phosphatidyl Serine, Biochem Neuro-PS, John Scott's Nitro Burn Extreme PM, NOW Brain ElevateReferences & Further Research
Effects of phosphatidylserine on exercise capacity during cycling in active malesThe purpose of the study was to investigate the effects of 750 mg of soybean-derived phosphatidylserine, administered daily for 10 d, on exercise capacity, oxygen uptake kinetic response, neuroendocrine function, and feeling states during exhaustive intermittent exercise. This is the first study to report improved exercise capacity following phosphatidylserine supplementation. These findings suggest that phosphatidylserine might possess potential ergogenic properties.
Safety of soy-derived phosphatidylserine in elderly people
Phosphatidylserine is a phospholipid which has been claimed to enhance neuronal membrane function, and can be derived from several sources. Earlier studies used brain cortex derived phosphatidylserine, of which the human tolerability of 300mg daily in 130 patients has been shown. The human tolerability of phosphatidylserine derived from soybean has not been reported, although it is widely sold as a nutritional supplement which may improve cognitive function in the elderly. We report the results of a study of the safety of two dosages of soy-phosphatidylserine in elderly. Subjects were 120 elderly of both sexes who fulfilled the more stringent criteria for age-associated memory impairment; some also fulfilled the criteria for age-associated cognitive decline. In conclusion, overall data indicate soy derived phosphatidylserine is a safe nutritional supplement for older persons if taken up to a dosage of 200 mg three times daily.
The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor
There have been previous reports that supplements of phosphatidylserine blunted the release of cortisol in response to exercise stress and that it improved mood. The present study extended these observations by considering whether phosphatidylserine supplementation influenced subjective feelings of stress and the change in heart rate when a stressful mental arithmetic task was performed. In young adults, with neuroticism scores above rather than below the median, the taking of 300mg phosphatidylserine each day for a month was associated with feeling less stressed and having a better mood. The study for the first time reports an improvement in mood following phosphatidylserine supplementation in a sub-group of young healthy adults.
