PureBulk

Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2800 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Valine?

L-Valine is an essential amino acid that is required for the smooth functioning of the nervous system and the brain. It is one of the three Branched Chain Amino Acids (BCAAs), together with the other two being L-leucine and L-isoleucine. L-Valine cannot be manufactured by the body and must be taken through food or supplements. Amino acids are of paramount importance for everyday body functions, as well as for maintaining muscle and regulation of the immune system. L-Valine is not processed by the liver; rather, it is actively taken up by muscles. Since Valine and the other BCAAs can escape liver metabolism as they are metabolized in the muscle as opposed to the liver, this means they can directly and significantly influence muscle-protein metabolism and thus improve disorders of the muscles and help it recover faster from intense activity. Aside from this, Valine also influences brain uptake of other neurotransmitter precursors (tryptophan, phenylalanine, and tryosine). Some natural sources and food products that contain L-Valine include meat, leafy vegetables, mushrooms, peanuts, soy protein, kidney beans, poultry and milk.

Valine is an amino acid obtained by hydrolysis of proteins and was first derived by the German chemist Emil Fischer in 1901 from casein. Together with isoleucine and leucine, Valine is found in high concentration in the muscles and the three BCAAs constitute about 70 to 80 percent of the amino acids in the body proteins. As such, their importance in the formation and maintenance of structural and functional integrity in humans is immeasurable. Supplemental valine should always be combined with isoleucine and leucine (which we both carry in our inventory) at a milligram ratio of 2:1:2 respectively. Aside from promoting normal growth, repairing tissues, regulating blood sugar, and providing the body with energy, Valine also helps stimulate the central nervous system to ensure proper mental functioning.

Valine helps prevent catabolism or the breakdown of muscle by supplying the muscles with extra glucose for energy production during intense physical activity. Valine also helps eliminate potentially toxic excess nitrogen from the liver, and is beneficial in transporting nitrogen to other parts of the boy where it is needed. Because of this Valine may help treat liver and gallbladder disease, as well as alleviate the damage brought to these tissues and organs caused by alcoholism and drug abuse. Valine may also help treat or even reverse hepatic encephalopathy, or alcohol-related brain damage. People who train or exercise frequently, have a low-protein diet, or are seriously trying to build muscle mass should consider valine supplementation. Although Valine is available in stand-alone supplemental form, it should always be taken together with the other two branched-chain amino acids, isoleucine and leucine. To make the most out of this supplement, again as mentioned above the perfect balance is at two parts L-Valine for every two parts L-Leucine and for every one part of L-Isoleucine.

BCAAs (branched chain amino acids) - L-leucine, L-isoleucine and L-valine - are undoubtedly the single most important group of amino acids for just about anyone, from world champion athletes to regular people. The body uses these to promote healing of injured tissues, to speed up recovery, and to protect against muscle tissue breakdown (catabolism) during exercise. BCAAs are one third of all the protein in muscles, therefore extremely important for developing and building muscles. Studies have shown BCAA to be helpful in other areas as well, due to what each ingredient does in its own right. For example, Leucine is necessary for wound recovery to skin and bones as well as helps protect muscles, Valine helps promote or maintain nitrogen balance (essential for muscular development), and Isoleucine helps boost energy and is necessary for forming hemoglobin.

What is L-Valine used for and who uses it?

Valine is needed for muscle metabolism, tissue repair, and the maintenance of a proper nitrogen balance in the body. As one of the branched-chain amino acids found in high concentrations in muscle tissue, this means it can be used as an energy source by muscles, and in doing so preserves the use of glucose. Also, it may prove useful in treating liver and gallbladder disease, and it can correct the type of severe amino acid deficiencies that can be caused by drug addiction. It may also be beneficial to help treat or reverse the symptoms of hepatic encephalopathy, or alcohol related brain damage, as well as degenerative neurological conditions. L-Valine is typically taken (with the other BCAAs) by weight lifters and performance athletes wanting to reduce fat and maximize muscle mass. Blood levels of L-Valine will fall significantly after strenuous exercise and will stay low until complete recovery. Supplementation with L-Valine one hour before strenuous workouts can reduce the recovery time by increasing muscle protein synthesis and counteract catabolic processes.

Valine is often used by bodybuilders, (in conjunction with leucine and isoleucine), to promote muscle growth, tissue repair and as an energizer, although more studies are still needed to support these claims. Studies have however shown that these three substances might help restore muscle mass in people suffering from liver disease, injuries, or those who have undergone surgery. For this to work though, the three branched-chain amino acids should always be taken in balance at two parts L-Leucine for every two parts L-Valine and for every one part of L-Isoleucine. Other benefits of L-Valine include improvement in insomnia and nervousness. It has also been demonstrated to improve the regulation of the immune system, and is effective as an appetite suppressant. Valine also plays an integral role in the detoxification of ammonia and works along with alpha-ketoglutarate. It may be a vital amino acid to prevent muscle wasting in diabetes and in the prevention of ammonia toxicity in individuals who belong to the older-aged group who are hospitalized. As beneficial as it is in helping treat certain illnesses, perhaps the biggest benefits are those experienced by athletes who perform long distance sports and bodybuilding. This is because L-Valine is essential for muscle tissue repair and muscle metabolism, and also increases exercise endurance.

Supplementing with L-leucine, L-isoleucine and L-valine, collectively known as BCAAs, can feed your body so that it doesn’t eat your own tissue. Aside from being required by the body, BCAAs can also be used to regenerate the skin of burn victims, because they aid in repair, growth, and development of muscle tissue, and to help treat kidney failure and liver disease as well. The combination of these three essential amino acids - L-leucine, L-isoleucine and L-valine makes up approximately 33% of skeletal muscle in the human body, and plays an important role in protein synthesis. BCAAs are currently used primarily for supplementation among strength athletes because it promotes protein synthesis in muscle. When taken during training, BCAAs have been shown to increase both growth hormone (GH) and insulin, thus increasing anabolism and anti-catabolism. Also, unlike other amino acids, BCAAs are used to provide energy and they have been shown to decrease post-workout soreness, which translates to faster recovery times even after intense and grueling trainings.

Since BCAAs are so crucial for the proper functioning of muscle tissue, they are very popular with endurance athletes, body builders, and others looking to simply stay healthy. BCAAs are metabolized in the muscle as opposed to the liver, and because of this many body builders and athletes use BCAA supplements while undergoing intense exercise. Even light exercise can cause BCAAs levels to drop quickly which leads to muscle breakdown (catabolism), fatigue, and a drop in testosterone levels. If you are in a building phase in any exercise routine or if you train for long periods of time, BCAAs are a good choice for you to ensure you do not use or burn the muscle you’ve worked so hard to build to get the energy you require in your strenuous activities.

How pure is your L-Valine?

This pharmaceutical grade amino acid L-Valine is assayed by the manufacturer to be 99.9% product. You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. This is one of the most important amino acids for hard training individuals and athletes. Valine, as well as the other branched chain amino acids (BCAAs) Leucine and IsoLeucine, is metabolized in the muscle as opposed to the liver, and since they can escape liver metabolism, this means they can directly and significantly influence muscle-protein metabolism. Dietary valine functions and helps by acting as a substrate for muscle metabolism during times of cellular energy depletion especially during intense and grueling exercise, thus sparing critical contractile and enzyme muscle protein from being depleted to supply Valine requirements. Because of this, for athletes or anyone who practices regular strenuous physical activity, Valine supplements are really beneficial. Although there are plenty of dietary sources that contain this amino acid, most athletes don't get enough L-Valine for muscle support through the foods they eat. As such, taking supplements is highly recommended to repair and protect muscle tissues especially for people who are extremely active. If all you want are the health benefits and muscle mass gains made possible with Valine, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because sure you’ll pay more for Valine supplements found in your local health food store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of L-Valine?

The typically recommended dose for L-Valine varies upon individual needs between 1 gram and 2 grams per single dose taken 1 or 2 times per day for a total combined daily dose of between 1 grams and 4 grams. One level teaspoon (5 cc) of L-Valine will be equivalent to about 3 grams. For bodybuilders and performance athletes one half level tablespoon will supply approximately 4946 mg milligrams, or just about 5 grams for the bulk density of this L-Valine powder. You can see the full bulk density/volumetric conversion chart for L-Valine here. Again, keep in mind that to get the most out of supplementing with L-Valine, it should be dosed at two parts L-Leucine for every two parts L-Valine and for every one part of L-Isoleucine.

Potential side effects of L-Valine

An excessively high intake of valine may cause a skin crawling sensation and even hallucinations. Too much valine in the diet can also disrupt liver and kidney function by increasing the amount of ammonia in the body. People with impaired liver or kidney function should not take isoleucine without first consulting a physician, as large doses of amino acids may aggravate these.

Taste, solubility, and suggested preparation of L-Valine

Pure bulk L-Valine powder is not easily soluble in water and has a bitter taste. The best way to take L-Valine powder is mixed, or blended with and suspended within a protein shake. As discussed above, all supplements of L- Valine should ideally be balanced with supplements of L-isoleucine and L-leucine at the same time. It cannot be stressed enough that the dosage of the amino acid supplements must always be complemented by taking a combination supplement containing the other branched side chain amino acids in the ratio - one part L-isoleucine, two parts L-leucine and two parts of L-valine.

L-Valine is used in the following Proprietary Formulas

Universal Animal Pak, Gaspari Nutrition SuperPump250, VPX NO Shotgun, Optimum Opti-Men, SciVation Xtend Nitrobol, MNT LeuceMine, AllMax Nutrition Leucine, AST BCAA 4500, Cheap Supplements BCAA, Cheap Supplements Leucine, Eclipse 2000 Deluxe BCAA, Optimum BCAA, Optimum Superior Amino 2222, PrimaForce L-Leucine, SciFit BCAA AKG 1000, Source Naturals L-Leucine, Supplement Direct L-Leucine, Ultimate Nutrition Branch Chain Amino Acids, 4Ever Fit 4Ever Whey Gainer, ASN Maxabol II, Champion AdreNOl8, Champion Amino Shooter Core+, Controlled Labs Golden Finish, Core Nutritionals Core ABC, Cytogenix Laboratories CYTOCELL, CytoSport Monster Amino, Dedicated Athlete Rapid Recharge, Dymatize BCAA Complex 2200, Gaspari Nutrition SuperPump250, LA Muscle LA Whey, Met-Rx Amped ECN NOS, MHP A-Bomb, Muscle Asylum Project Mass Impact, Muscle Pharm Combat Powder, MuscleTech Anabolic Halo, MuscleTech Cell-Tech Hardcore, Universal Torrent, Universal Uni-Liver, Vitol Russian Bear, VPX BANG!, Weider Amino 6000, Xero Limits EPO-Blast, Xtreme Formulations ICE

References & Further Research

Branched-Chain Amino Acid Enriched Supplements as Therapy for Liver Disease
Altered amino acid metabolism is a hallmark of liver disease, characterized by low levels of circulating BCAAs and elevated levels of circulating aromatic amino acids, and methionine. Although overwhelming evidence indicates that the incidence of complications of liver disease increases with malnutrition, the reported impact of nutritional therapy, specifically BCAA supplementation, on outcomes in patients with liver disease has varied with the indication. Both studies found improved nutritional status associated with BCAA supplementation. On balance, BCAA supplementation appears to be associated with decreased frequency of complications of cirrhosis and improved nutritional status when prescribed as maintenance therapy

Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial
The role of oral supplementation with branched-chain amino acids (BCAA) in advanced cirrhosis is far from settled. A nutritional approach might prevent progressive liver failure and improve nutritional parameters and quality of life. This study found that in advanced cirrhosis, long-term nutritional supplementation with oral BCAA is useful to prevent progressive hepatic failure and to improve surrogate markers and perceived health status.

Effects of exercise training and amino-acid supplementation on body composition and physical performance in untrained women
The purpose of this study was to determine the effects of 6 wk of essential amino acid (EAA) supplementation on body composition and exercise performance in untrained women The total weight lifted at the subject’s maximum 12 repetitions did not significantly change in either EAA or placebo group. In previously untrained individuals, the ingestion of EAAs combined with aerobic and heavy-resistance training for 6 wk did not have a significant effect on body composition or muscular strength; however, aerobic muscular endurance increased significantly.

L-Valine for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying L-Valine Bulk or Wholesale

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