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What is Magnesium Gluconate?

Magnesium Gluconate is a salt of Magnesium and Gluconic Acid (Gluconic Acid is the hexonic acid derived from the oxidation of the six-carbon monosaccharide glucose and a carboxyl group, the univalent radical COOH characteristic of all organic acids). Magnesium Gluconate is commonly used as a dietary Magnesium supplement and is often prescribed to help treat Hypomagnesemia, and Restless Leg Syndrome or Jumpy Leg Syndrome. Magnesium Gluconate is considered to have a higher bioavailability as a Magnesium supplement than the more common (and less expensive) Magnesium Carbonate or Magnesium Citrate. Magnesium is an essential and naturally occurring mineral crucial for many systems in the body, especially the muscles and nerves. Magnesium gluconate is among the best supplements that can help maintain adequate magnesium in the body.

Magnesium plays an integral role in more than 300 metabolic reactions in the body. Magnesium is required in protein, fat and nucleic acid synthesis. It also helps the body use glucose, and it is a key player in the body's energy transport system. Magnesium is also necessary in inhibiting muscle contractions and blood clotting. Because of this, Magnesium Gluconate can be used as a muscle relaxant. Magnesium is also helpful in maintaining tooth enamel, and it is of paramount importance to the proper functioning of the immune system. Additionally, Magnesium is also important to heart function. People who do not have enough magnesium manifest noticeable changes in the walls of their arteries and capillaries, which choke and compress in the absence of the mineral. This can result to increased blood pressure which could later on develop as a full blown cardiovascular disease. As such, supplements of Magnesium Gluconate can prevent hypertension and heart disease. Food sources of magnesium include nuts, whole grains, legumes, tofu, green leafy vegetables, wheat bran, soybean flour, almonds, cashews, pine nuts, and black walnuts, and seafood. In the average diet, these foods are often not consumed in adequate amounts to meet the body's need for magnesium. In such cases of deficiencies, taking supplements of Magnesium Gluconate are warranted, especially when conditions related to magnesium deficiency are present. These conditions may have symptoms such as muscle weakness, mitral valve proplapse, ADHD, depression, anxiety, constipation, and asthma.

Magnesium Gluconate may also be a beneficial and welcome addition in the supplement regimen for specific groups that are at risk of magnesium deficiency, particularly the elderly, diabetics, and those who rely on diuretics. Women who use oral contraceptives may benefit from extra magnesium as well. In addition, symptoms of premenstrual syndrome (PMS) respond to supplements of Magnesium Gluconate because of the mineral's calming effect on the body. Because calcium and magnesium work synergistically, Magnesium Gluconate supplements should be taken in doses that equal a one to two (1:2) ratio of magnesium to calcium respectively. For example, an individual taking 500 mg of Magnesium Gluconate should take a corresponding 1000 mg of calcium. Magnesium Gluconate functions as a mild laxative as well. While this is often the desired outcome, it can also be an unwanted side effect of taking Magnesium Gluconate supplements. Taking adequate amounts of calcium in addition to Magnesium Gluconate can counter this effect.

What is Magnesium Gluconate used for and who uses it?

Oral Magnesium Gluconate is used to treat low amounts of Magnesium in the blood, emptying of the bowel, indigestion, and incomplete or irregular bowel movements. It is also crucial in energy metabolism and protein synthesis. Magnesium Gluconate is used to clean stool from the intestines before surgery or certain bowel procedures such as colonoscopy, radiography, etc. It may also be used for relief from constipation. Magnesium in general keeps normal muscle and nerve function, maintains and stabilizes heart rhythm, and strengthens bones.

Magnesium has been used as a treatment for other conditions as well, including Raynaud's disease, skeletal muscle spasm from injury or trauma, gangrene, epilepsy, spastic colon, dry skin, nervous irritability, and lead toxicity. Magnesium supplementation may be indicated for persons with alcoholism. This is because low blood levels of magnesium occur in 30% to 60% of alcoholics, and in nearly 90% of patients experiencing alcohol withdrawal. Others who need supplemental magnesium are individuals with chronic malabsorptive problems such as Crohn's disease, gluten sensitive enteropathy, regional enteritis, and intestinal surgery may lose magnesium through diarrhea and fat malabsorption. Also, individuals with chronically low blood levels of potassium and calcium may have an underlying problem with magnesium deficiency. With the help of Magnesium supplements, the potassium and calcium deficiencies can be restored to normal and optimal levels. Older adults also need supplemental magnesium since they are at an increased risk for magnesium deficiency. Add to that the fact that seniors are more likely to be taking drugs that interact with magnesium, this combination of factors makes older adults more susceptible to magnesium deficiency. As such it is very important for older adults to consume recommended amounts of dietary magnesium.

How pure is your Magnesium Gluconate?

This Magnesium Gluconate bulk powder contains 5.4% elemental Magnesium. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this salt of Magnesium and Gluconic Acid. It contains no fillers, taste additives, or anti-caking agents. Magnesium Gluconate is a mineral supplement used to prevent and treat low amounts of magnesium in the blood. Magnesium is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of magnesium. However, certain situations cause your body to lose magnesium faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (e.g. severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes). Magnesium is not only one of the key nutrients required in both calcium utilization and protein synthesis, but it also plays a tremendous role in virtually every enzymatic reaction in our body. For these reasons, it must be supplied either from the diet or from supplementation.

What are some of the common effects and benefits of Magnesium Gluconate?

Magnesium has been found effective in preventing formation of blood clots, lowering blood pressure, preventing diabetes-related complications, maintaining bone strength, and contributing to longer and healthier life by reducing the risk of heart disease and by limiting the effects of free radical damage. Magnesium is also a mineral essential to a wide variety of body processes, including energy production, protein formation, DNA production, and nerve conduction. It maintains normal levels of potassium, phosphorus, calcium, adrenaline and insulin, and also helps in keeping the bones and the heart strong and healthy.

Magnesium stabilizes and relaxes the heart muscles to maintain a regular heartbeat, thus preventing sudden spikes in blood pressure. In fact, magnesium can be used to treat high blood pressure, angina, and arrhythmia. If given right away after a heart attack and for the succeeding weeks, magnesium has been demonstrated to speed recovery by decreasing the incidence of dangerous arrhythmias. Magnesium also protects the heart by raising HDL (good) cholesterol levels and also by inhibiting the aggregation (clumping) of red blood cells, which can lead to the formation of blood clots.

Magnesium is essential for the development and maintenance of healthy bones. If taken in relatively high amounts, it works synergistically with calcium and vitamin D to strengthen bones and prevent osteoporosis. Magnesium is also sometimes prescribed for treatment of migraines, asthma, and diabetes. Individuals with poorly controlled diabetes may benefit from magnesium supplements because of increased magnesium loss in urine associated with hyperglycemia. People with diabetes often have low magnesium levels, and there's some evidence that 200 to 300 milligrams of magnesium each day could help prevent and treat this disease. To help dissolve kidney stones, Magnesium is usually taken in combination with vitamin B6 (pyridoxine).

What is the daily suggested dose of Magnesium Gluconate?

The commonly recommended dose for Magnesium Gluconate varies from as little as 500 milligrams to as much as 2 grams or more per day, depending upon the recommendations of your physician. But because this Magnesium Gluconate bulk powder contains 5.4% elemental Magnesium it will be necessary for you to consider this fact if you are attempting to dose this product according to your elemental Magnesium supplementation needs. Most physicians, however, recommend that regardless of your daily dose requirements for Magnesium Gluconate you should not take more than 1000 milligrams Magnesium Gluconate in a single dose, and without the advice and/or consent of your physician you should not take more than 4 grams Magnesium Gluconate per day. Because high single doses of Magnesium Gluconate can have a laxative effect, or can occasionally induce diarrhea, it is always better to take daily doses larger than 1000 milligrams divided in multiple doses two, three, or sometimes 4 times per day.

Because Magnesium Gluconate is 5.4% elemental magnesium, taking 1 gram (also 1000 milligrams) of Magnesium Gluconate powder in a single dose will net approximately 54 milligrams elemental magnesium. You can see the full bulk density/volumetric conversion chart for Magnesium Gluconate here. Taking 1 gram three times per day, therefore, will net a total daily dose of 162 milligrams elemental Magnesium. For the treatment of specific medical conditions some physicians will occasionally recommend much higher doses than this so before you consider taking higher doses you should talk to your physician or pharmacist about Magnesium Gluconate dosing and consider their guidance before taking larger doses of this product.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of Magnesium Gluconate

Dietary magnesium does not pose a health risk, however very high doses of magnesium supplements, which may be added to laxatives, can promote adverse effects such as diarrhea. Magnesium toxicity is more often associated with kidney failure, when the kidney loses the ability to remove excess magnesium. The elderly are especially at risk of magnesium toxicity because kidney function declines with age and they are more likely to take magnesium-containing laxatives and antacids. Signs of excess magnesium can be similar to magnesium deficiency and include mental status changes, nausea, diarrhea, appetite loss, muscle weakness, difficulty breathing, extremely low blood pressure, and irregular heartbeat.

Certain antibiotics should not be taken at the same time as magnesium gluconate because they may not be absorbed as well by your body. If you are taking an antibiotic, avoid taking it within 2 hours before or after you take magnesium gluconate. Before taking magnesium gluconate, tell your doctor if you are allergic to anything, or if you have have kidney disease. If you have any of these conditions, you may not be able to use magnesium gluconate, or you may need a dosage adjustment during treatment.

To reduce and lessen the likelihood of stomach upset and diarrhea from occurring, taking this product with a meal helps. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Magnesium Gluconate

Purebulk Magnesium Gluconate is a white powder that is odorless, tasteless, freely soluble in water, very slightly soluble in alcohol and insoluble in ether. To help your body to better absorb magnesium gluconate, take this supplement with a full glass of water with a meal or just after eating. Measure the liquid form of magnesium gluconate with a special dose-measuring spoon or cup, not a regular table spoon. Keep in mind as well to store magnesium gluconate at room temperature away from moisture, heat, and light.

Magnesium Gluconate is used in the following Proprietary Formulas

Magonate, EAS Myoplex, Citrate of Magnesia, Citroma, Citroma Cherry, Citroma Lemon, NOW Magnesium Citrate, Solgar Magnesium Citrate, Universal Animal Pak, Optimum Opti-Men, Universal Animal Stak, AST Multi Pro 32X, NOW ADAM, Doctor's Best High Absorption Magnesium, Natural Vitality Natural Calm, NOW Magnesium Caps, NOW Magnesium Malate, Olympian Labs Magnesium Citrate, Twinlab Magnesium Caps

References & Further Research

Magnesium in cardiovascular and other disorders
The physiological role and metabolism of magnesium, the causes of magnesium deficiency, clinical data on the benefits of magnesium supplementation, and the management of magnesium deficiency are discussed.

Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study
Hypomagnesemia has been hypothesized to play a role in coronary heart disease (CHD), but few prospective epidemiologic studies have been conducted. Overall data and findings fom the research method suggest that low magnesium concentration may contribute to the pathogenesis of coronary atherosclerosis or acute thrombosis.

Effects of Oral Magnesium Therapy on Exercise Tolerance, Exercise-Induced Chest Pain, and Quality of Life in Patients With Coronary Artery Disease
Previous studies have demonstrated that magnesium supplementation improves endothelial function in patients with coronary artery disease (CAD). However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, has not been established. In a multicenter, multinational, prospective, randomized, double-blind and placebo-controlled trial, 187 patients with CAD were randomized to receive either oral magnesium 15 mmol twice daily Overall data and findings suggest that oral magnesium supplementation in patients with CAD for 6 months results in a significant improvement in exercise tolerance, exercise-induced chest pain, and quality of life, suggesting a potential mechanism whereby magnesium could beneficially alter outcomes in patients with CAD.

Magnesium Gluconate for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

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