PureBulk

What is Melatonin?

Melatonin is a hormone synthesized and secreted by the pineal gland each night that affects the body's circadia rhythm (sleep pattern).

The pineal gland functions as the timekeeper of the brain, helping manage the sleep-wake cycle. Melatonin production in the body is triggered by darkness and inhibited by light, helping the body manage its natural sleep rhythm.

Discovered in the 1950s as a neurohormone (N-acetyl-5 methoxytryptamine) produced in the brain by the pineal gland from the amino acid tryptophan, melatonin became available as a dietary supplement in 1994.

The precursor of melatonin, tryptophan (L-tryptophan), is an essential amino acid synthesized from proteins during digestion via the action of proteolytic enzymes. During the day. it is converted to serotonin (a brain chemical involved with mood) before being converted to melatonin.

Health Benefits of Melatonin

Melatonin plays a key role in the sleep-wake cycle, or circadian rhythm, an internal 24-hour timekeeping system that plays an important role in sleeping and waking.

Melatonin has also been demonstrated to have powerful antioxidant properties, protecting cells from damage caused by free radical molecules.

Purity and Concentration of Melatonin

This pharmaceutical-grade melatonin contains no fillers, taste additives or anti-caking agents.

Suggested Use of Melatonin

The suggested serving size for melatonin ranges between 1 milligram and 3 milligrams taken before bedtime, depending on individual needs. For accurate measurement use only a milligram analytical scale.

Potential Side Effects of Melatonin

Due to the extreme potency and the small serving sizes required of this product we are restricting sales to qualified health practice professionals only. Please email store@purebulk.com to prequalify your purchase of this product.

Melatonin should not be taken by people using certain antidepressants, such as Prozac (a serotonin inhibitor) or Nardil (a monoamine oxidase inhibitor). Interaction between melatonin and these types of antidepressants can cause a stroke or heart attack. Preliminary symptoms include confusion, sweating, shaking, fever, lack of coordination, elevated blood pressure, diarrhea and convulsions.

Melatonin should only be taken before sleep. Vivid dreams and morning grogginess are common melatonin side effects on daily serving sizes greater than 0.5 milligrams. People taking blood thinners, antiseizure drugs, blood pressure medications, diabetes medications or hormone replacements should avoid melatonin supplements, as they may interfere with the effectiveness of these medications. This product is not recommended for pregnant or nursing women.

References & Further Research

University of Maryland Medical Center: Melatonin

WebMD: Melatonin

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.