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What is N,N-Dimethyl Glycine HCL (DMG)

N,N Dimethylglycine, or DMG, is an N,N-dimethylated form of the amino acid Glycine with a chemical structure just like choline. It functions similarly as a methyl donor, very much like Betaine Anhydrous, which we also carry in our directory. Some compounds considered to be methyl donors include DMG, TMG, SAM-e, and DMAE, together with the B vitamins folic acid and B12. Methyl donors are helpful in the synthesis of several brain chemicals and thus have an influence on sexual enjoyment, mood, energy, wellbeing, alertness, concentration, and visual clarity. DMG (dimethylglycine) in essence is the amino acid glycine attached to two methyl groups. DMG is a normal physiologically active nutrient available in low amount in such foods as cereal grains, liver, and beans. Humans also naturally produce DMG in small amounts. As a nutritional supplement, DMG functions as a building block for the synthesis of many important substances such as choline, SAM-e, the amino acid methionine, several hormones, neurotransmitters, and DNA. TMG (trimethylglycine), otherwise known as betaine, is essentially the amino acid glycine bound to three methyl groups. Simply put, TMG has one more methyl group than DMG.

Dimethyl Glycine is also known as Vitamin B15 or Pangamic Acid. It helps to optimize oxygen uptake and therefore quicker recovery time from strenuous exercise. As an analog of the amino acid Glycine, it is also an energy Booster, and can help to maintain acid balance and minimize the muscle fatiguing effects of strenuous activity. Glycine is one of the non-essential amino acids and is beneficial in creating muscle tissue and changing glucose into energy. It is also of paramount importance to maintaining healthy central nervous and digestive systems, and has recently been shown to provide protection via antioxidants from some types of cancer. Dimethylglycine is an intermediary metabolite and amino acid found in low levels in many foods, and is produced in the body from choline. DMG is an endogenous compound and an enzyme system in the body effectively converts the substance into metabolites that are either used by the body or are safely excreted from the body.

Glycine is utilized in the body to help form normal DNA and RNA strands—the genetic material necessary for proper cellular function and formation. It helps prevent the breakdown of muscle by boosting the body’s levels of creatine, a compound that helps build muscle mass. High concentrations of glycine are found both in the muscles, and in the skin and other connective tissues as well. Almost one-third of collagen, responsible in keeping the skin and connective tissue firm and flexible, is made up of glycine. Without glycine the body would not be able to repair damaged tissues, making the skin loose or baggy as it succumbed to UV rays, oxidation, and free radical damage, and wounds would never heal.

Glycine helps supply the body with glucose needed for energy. For this reason, Glycine is considered a glucogenic amino acid. It helps manage healthy and optimal blood sugar levels, and thus glycine supplementation may be helpful in treating symptoms manifested by low energy and fatigue, such as hypoglycemia, anemia, and Chronic Fatigue Syndrome (CFS). Glycine is also essential for a healthy, normally functioning digestive system. It helps control the synthesis of the bile acid used to digest fats, and is included in many commercial gastric antacid agents.

Owing to the fact that Dimethylglycine is an amino acid (dimethylated form of Glycine), it is a building block for protein. It is found in the body in very small amounts and for only a few seconds at a time. People use dimethylglycine to make medicine for attention deficit-hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory disorders, pain and swelling (inflammation), cancer, alcoholism, and drug addiction. It is also used to improve speech and behavior in autism, nervous system function, liver function, the body’s use of oxygen, and athletic performance. Some people use it to reduce stress and the effects of aging, as well as boost the immune system’s defenses against infection. Dimethylglycine is also used to lower blood cholesterol and triglycerides, and to help restore blood pressure and blood sugar into normal range.

What is N,N-Dimethyl Glycine HCL (DMG) used for and who uses it?

Glycine is very important for central nervous system function. Research has demonstrated that this amino acid can help prevent the neurotransmitters that cause seizure activity, hyperactivity, and manic (bipolar) depression. Glycine can also be changed as needed to another neurotransmitter, serine, which in turn may be beneficial in controlling schizophrenia. In one study, twenty-two schizophrenic patients, who were non-responsive to traditional treatments, added glycine to their ongoing antipsychotic medication and found that it significantly reduced their symptoms. More research concerning the effects of glycine on schizophrenia is still needed though. Studies have also shown that glycine also helps improve memory retrieval loss in those that suffer from a wide variety of sleep-depriving conditions, including schizophrenia, Parkinson’s disease, Huntington’s disease, jet lag, and overwork.

N,N Dimethylglycine (DMG), a derivative of Glycine, can boost the immune system, can improve cellular oxygen utilization, and can act as an antioxidant by stimulating the proliferation of lymphocytes and thereby boosting interferon production. Because DMG can significantly increase cellular oxygen utilization it can also neutralize lactic acid build-up in muscle tissues at a much faster rate following strenuous exercise and physical workouts. In line with this benefit, DMG can greatly help many athletes in various sports perform longer with increased endurance and decreased recovery times following strenuous physical activity. As a methyl donor, DMG is needed in the conversion of homocysteine to methionine which in turn converts to SAMe. DMG has recently been revealed to have positive results in the treatment of adults and children with autism, and DMG has also been used to treat children with ADD (Attention Deficit Disorder), improving speech and tolerance to frustration within 24 to 48 hours following DMG supplementation.

Results from preliminary studies of glycine as a possible treatment for cancer have been promising, and suggest that it can help offset the development of cancerous tumors and melanoma. In laboratory mice, dietary glycine prevented tumor growth by inhibiting angiogenesis, the process by which tumors develop their own blood supply. Glycine also plays an important role in maintaining the prostate’s health. In one study, overall data revealed glycine can help reduce the symptoms of prostatic hyperplasia in men.

How pure is your N,N-Dimethyl Glycine HCL (DMG)?

This food grade N,N Dimethylglycine is a bulk powder product consisting of very fine white granular crystals. You will receive a labeled heavy-duty 4 mil polyethylene bag containing this bulk powder product. Proponents of DMG claim that it can improve eye contact, frustration tolerance, speech and interest in interacting socially, as well as decreasing aggressive behavior toward self and others in severe cases. It also improves immune functioning and boosts athletic performance. Behavioral effects generally occur in less than a week, but experts recommend trying the supplement for three or four weeks as benefits may occasionally take longer to manifest. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits made possible with N,N-Dimethyl Glycine HCL (DMG), buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of N,N-Dimethyl Glycine HCL (DMG)?

The commonly recommended dose for N,N Dimethylglycine (DMG) varies from as little as 100 milligrams 1 to 3 times per day to as much as 500 milligrams or more taken 1 to 3 times per day. On level 1/8 teaspoon contains about 355 milligrams DMG and can be taken two to three times per day for best results. You can see the full bulk density/volumetric conversion chart for N,N-Dimethyl Glycine HCL (DMG) here.

Potential side effects of N,N-Dimethyl Glycine HCL (DMG)

Dimethylglycine (DMG), also known as Dimethyl Glycine, Calcium Pangamate, Pangamatic Acid, Pangamic Acid and Vitamin B15, provides benefits for many individuals with autistic spectrum disorders. DMG is relatively safe, with no known serious side effects. A few parents have reported hyperactivity or agitation after giving their children DMG. Taking a folic acid supplement reduces the likelihood of this symptom occurring and may even increase the effectiveness of the DMG itself.

Taste, solubility, and suggested preparation of N,N-Dimethyl Glycine HCL (DMG)

This HCL analog of DMG is extremely sour tasting. Unlike other products that can be simply taken with water it would be best to add your DMG dose to juice or smoothies to mask the sour taste. It can be taken with orange juice but it still tastes very sour, so some people might find that encapsulating works best.

N,N-Dimethyl Glycine HCL (DMG) is used in the following Proprietary Formulas

Equimins DMG (Dimethyl Glycine HCL - pure), Nature’s Hospital Pure DMG, NOW DMG, 1FAST400 DMG, ATRI-DMG PLUS, Vita-Flex DMG, Gaines Nutrition DMG, Kirkman DMG

References & Further Research

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial of Low Dose Dimethylglycine in Patients with Autistic Disorder
As the treatability of the syndrome of autism becomes more possible there is a great deal more interest in the effectiveness of various therapies. Although the very influential nonmedical literature cited in the Autism Research Review International Newsletter finds that dimethylglycine (DMG) is regarded as more effective than the usual psychopharmacologic drugs, there have been no studies of DMG using the currently accepted research methodology. Overall data revealed no statistically significant differences, and parent reports were equally distributed. The major methodologic weaknesses of the study are thought to be the low dosage of DMG and the small sample size.

Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder
N,N-dimethylglycine, a dietary supplement, has been reported to be beneficial in children with autism and pervasive developmental disorder. We examined the effectiveness of dimethylglycine in children with autism and pervasive developmental disorder in a double-blind, placebo-controlled study. Thirty-seven children between 3 and 11 years of age with a diagnosis of autism and/or pervasive developmental disorder were gender and age matched and randomly assigned to receive either placebo or dimethylglycine for 4 weeks. An overall improvement on all behavioral measures was observed for both the placebo and the dimethylglycine groups. However, the improvement among the children who received dimethylglycine was not statistically different from the improvement observed among the children who received the placebo. Some children appeared to respond positively to the dimethylglycine, and there was a smaller proportion of negative changes in the dimethylglycine group, but the quantitative changes in the dimethylglycine behavioral assessments were not significantly different from what was observed among children who received placebo.

Other Names:

Dimethylglycine HCl, (Dimethylamino)acetic Acid, DMG, DMG HCl, N,N-dimethylaminoacetic Acid, N,N-dimethylglycine, N,N Dimethylglycine HCl, N-methylsarcosine, Dimethyl Glycine, Calcium Pangamate, Pangamatic Acid, Pangamic Acid, and Vitamin B15

N,N-Dimethyl Glycine HCL (DMG) for International Customers

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