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What is Nattokinase

Nattokinase is a potent fibrinolytic enzyme extracted and highly purified from a Japanese food called Natto. Natto is a cheese-like food made from fermented soybeans which is a typical and popular soybean food in the Japanese diet where it is eaten with rice. Nattokinase was first discovered during the mid 80s by Dr. Hiroyuki Sumi while researching in Chicago, Illinois, U.S.A. It was he who named the enzyme "nattokinase". It is believed by many to be an important tool in lowering the likelihood of developing heart and vascular diseases. The Japanese had long viewed natto as being 'good for the heart' but it wasn't until recently when a researcher identified the nattokinase enzyme and verified its benefits that these health claims gained some legitimacy.

Natto is produced by fermentation by adding the beneficial bacteria Bacillus natto to boiled soybeans. The nattokinase enzyme product is made when the bacterium acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that possesses the unique nattokinase enzyme. Nattokinase is regarded in the alternative medicine community as a clot-buster and blood thinner, and is sometimes prescribed as a substitute for daily aspirin treatment. In terms of catalyzing other enzyme activity, its effects go far beyond that.

Nattokinase is a fibrionolytic enzyme, which in simpler terms mean nattokinase is able to dissolve the protein (known as fibrin) that thickens blood and initiates the formation of a blood clot. Because it acts directly on the fibrin itself, nattokinase is a newer, healthier type of 'blood thinner' similar to blood thinning drugs like coumadin. A major difference between nattokinase and blood thinning drugs is that the drugs interfere with the production of fibrin and due to this interference, blood thinning drugs have significant side-effects. Nattokinase works upon the fibrin itself, which is a metabolic end-product. Nattokinase is promising for certain types of circulatory problems but those with such disorders should check with their physician first to ensure and ascertain the appropriateness of nattokinase to their needs.

What is Nattokinase used for and who uses it?

Nattokinase is a profibrinolytic serine protease extracted and purified from natto, a traditional fermented soybean food popular in Japan. Nattokinase increases the fibrinolytic or clot dissolving activities of blood in animals and human volunteers and that it inhibits clot formation and promotes clot resolution in animals. Current research demonstrates nattokinase’s usefulness in the maintenance and enhancement of normal healthy endogenous fibrinolysis, the dissolution of the essential portion of the blood clot of thrombus. Maintenance of optimum functioning of the body’s fibrinolytic/ thrombolytic systems may offer decreased risk of dangerous blood clots that contribute to a variety of conditions involving particularly the brain and cardiovascular systems.

Nattokinase is said to help dissolve abnormal blood clots and have similar clot-dissolving abilities as does plasmin, a natural enzyme in blood that functions as our natural defense mechanism to dissolve unwanted blood clots. Abnormal blood clots can be the direct cause of heart attacks and strokes, and also conditions such as phlebitis, pulmonary embolism, or deep vein thrombosis. The clot dissolving agents used in clinical medicine (tPA or tissue plasminogen activator, streptokinase, urokinase, etc) to neutralize and eliminate blood clots that have led to heart attacks, strokes, pulmonary embolism or deep vein thrombosis, all work through strengthening plasmin's action. Nattokinase works by dissolving the tiny fibers (fibrin) that form the strong mesh in blood clots. Streptokinase and urokinase, drugs given via IV following a heart attack or stroke, work similarly. Nattokinase, however, is absorbable orally and believed to be longer-acting.

People combatting longterm Thrombus will benefit from Nattokinase taken every 12 hours. Due to the thromobolytic ability of nattokinase, nattokinase helps with lowering of blood pressure. The viscosity of blood will be lowered, therefore blood pressure will also be reduced correspondingly. This mechanism will make the person less susceptible to cardiovascular diseases. It also is a potent antioxidant. The antioxidatal function of nattokinase is especially useful to shielding the prostate gland. The prostaglandin, secreted from prostate gland, is a crucial mechanism for blood thinning. The antioxidant function is also key for eliminating free radicals. Additionally nattokinase may help mitigate or solve the symptoms of the pains in the loins and the back.

Purity and daily suggested dose of Nattokinase

Our pure, isolated Nattokinase supplement contains about 20,000 fibrinolytic units per gram. An average dose amount for a person would be about 250mg of Nattokinase. This would be comparable to eating about 100 grams of Natto per day. You can see the full bulk density/volumetric conversion chart for Nattokinase here.

The traditional Japanese food Natto has been used safely for over 1000 years. The potent fibrinolytic enzyme nattokinase appears to be safe based upon the long-term traditional use of this food. Nattokinase has many benefits including convenience of oral administration, confirmed efficacy, prolonged effects, cost effectiveness, and can be used preventatively. It is a naturally occurring, food based dietary supplement that has demonstrated stability in the gastrointestinal tract, as well as to changes in pH and temperature. With meticulous fermentation control and further purification and concentration steps, high purity and bio-activity purebulk nattokinase is produced.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Safety, Precautions, and Potential side effects of Nattokinase

The traditional Japanese food Natto has been used safely for over 1000 years. It is a naturally occurring, food based dietary supplement that has demonstrated stability in the gastrointestinal tract, as well as to changes in pH and temperature. The potent fibrinolytic enzyme nattokinase appears to be safe based upon the long-term traditional use of this food. Aside from the already mentioned health benefits, Nattokinase has other advantages this time in usage and administration itself including convenience of oral administration, confirmed efficacy, prolonged effects, cost effectiveness, and it can also be used preventatively.

Just to be on the safe side, Nattokinase should only be used under the guidance of a health care provider. Discuss with your health care professional before nattokinase use, especially if you are taking anti-coagulants, aspirin, coumadin or other medicines or herbs that thin the blood. Combining nattokinase and an anticoagulant, such as aspirin, may lead to internal bleeding in some patients. Because of this, Nattokinase shouldn't be used by people with bleeding disorders, by people who are taking Coumadin (warfarin), prescription vitamin K, heparin, aspirin, diuretics, ACE inhibitors, beta blockers, any other drug that influences blood clotting (unless under doctor's supervision), or if you are pregnant, may become pregnant, or breastfeeding.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Nattokinase is used in the following Proprietary Formulas

DOCTOR'S BEST Best Nattokinase, JARROW NattoMax, NATURALLY VITAMINS Nattokinase, NOW Nattokinase, NUTRICOLOGY NattoZyme, NUTRICOLOGY NattoZyme, SOLARAY Nattokinase, SOURCE NATURALS Nattokinase, Vitamin Shoppe Nattokinase

References & Further Research

Effects of nattokinase on blood pressure: a randomized, controlled trial
The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Overall data showed nattokinase supplementation resulted in a reduction in systolic blood pressure and diastolic blood pressure. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Dietary supplementation with fermented soybeans suppresses intimal thickening
Although soy foods have been consumed for more than 1000 years, it is only in the past 20 y that they have made inroads into Western diets. We investigated the effect of dietary supplementation with natto extracts produced from fermented soybeans on intimal thickening of arteries after vessel endothelial denudation. Natto extracts include nattokinase, a potent fibrinolytic enzyme having four times greater fibrinolytic activity than plasmin. Nattokinase supplementation suppressed intimal thickening compared with the control group. Nattokinase shortened euglobulin clot lysis time, suggesting that their thrombolytic activities were enhanced. These findings suggest that nattokinase, because of its thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation.

Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat
Nattokinase is a new fibrinolytic enzyme which cleaves directly cross-linked fibrin in vitro. In this study, we investigated the thrombolytic effect of nattokinase on a thrombus in the common carotid artery of rat in which the endothelial cells of the vessel wall were injured by acetic acid. On a molar basis, the recovery of the arterial blood flow with nattokinase, plasmin and elastase were 62%, 15% and 0%, respectively. The results indicate that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo.

Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase
It was confirmed that oral administration of nattokinase (or natto) produced a mild and frequent enhancement of the fibrinolytic activity in the plasma, as indicated by the fibrinolytic parameters, and the production of tissue plasminogen activator. The results obtained suggest that nattokinase represents a possible substance for use not only in the treatment of embolism but also in the prevention of the disease, since nattokinase has a proven safety and can be mass produced.

Nattokinase for International Customers

We have the most economical shipping costs & labeling practices for International orders. You can see our shipping costs here. Also, please note, that anything in a 1.5kg package can be shipped within a single flat rate envelope, however our shopping cart mistakenly displays 2 envelopes. Go ahead and ship the order, and you will notice that it only charges you the cost of 1 anyway. Look at the shipping costs tab above to see for yourself how you can calculate these charges.

Buying Nattokinase Bulk or Wholesale

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