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What is Niacinamide?

Niacinamide, also called nicotinamide, Vitamin B3 and/or Nicotinic Acid Amide, is a water soluble member of the family of B vitamins. There are two commonly used forms of Vitamin B3, Niacin and this form, Niacinamide. The chemical difference between these form is that this Niacinamide form has an amide group attached to the basic Niacin form. But there are additional differences in these forms regarding their nutritional use. Whereas the more basic Niacin form is typically used in lowering blood lipid levels (including LDL Cholesterol), this amide form is commonly taken and has been demonstrated clinically to help reduce lipid accumulations from arterial walls and it is also helpful in stabilizing blood sugar levels of type I diabetics. Additional benefits of Niacinamide supplementation include cognitive improvement in the elderly, treating acne, and helping to reduce fatigue in some individuals.

Vitamin B3 or Niacinamide, a water-soluble vitamin whose analogs such as NADH play key roles in energy metabolism in living organisms, is also called by other names such as niacin, nicotinic acid, nicotinamide, antipellagra vitamin, and niacinamide. Niacin is one of the most stable of the B vitamins owing to the fact that it is resistant to the effects of heat, light, air, acid, and alkali. Niacin and niacinamide is a white crystalline substance that is soluble in both water and alcohol as they are both readily absorbed from the small intestine. Small amounts may be kept in the liver, while most of the excess is excreted in the urine.

Vitamin B3 or Niacinamide works with vitamin B1, riboflavin (vitamin B2), pyridoxine (vitamin B6), pantothenic acid, and biotin to break down and convert the carbohydrates, fats, and proteins in food into energy. As such, vitamin B3 is crucial in metabolizing carbohydrates, fats, and proteins to produce energy. Involvement of Niacin, an essential B vitamin, in cellular energy production means that it is of paramount importance for healthy cardiovascular function, nervous system function, and immune function. It is also helpful in the synthesis of hydrochloric acid, which is required for proper digestion. Additionally, vitamin B3 enhances the body's ability to eliminate toxins. The name niacin is taken from NIcotinic ACid + (IN). When the properties of niacin were first known, it was thought wise to choose a common name other than nicotinic acid, for fear that it might be associated with nicotine, which may lead to notions that either smoking provided vitamins or that wholesome food contained a poison.

Niacinamide plays a key role in clearing the body of toxic and harmful chemicals. It also helps the body synthesize numerous sex and stress-related hormones in the adrenal glands and other parts of the body. Vitamin B3 is needed for the action of many enzymes in the body. Enzymes are special substances that catalyze or speed up chemical reactions in the body. These enzymes are responsible for generating energy in the body, breaking down dietary fats, the creation of certain hormones and cholesterol, the processing of genetic material (DNA) and the growth and maturation of the cells in the body. Niacin is potent in enhancing circulation and lowering cholesterol levels in the blood. Niacin needs can be met partially by incorporating high protein foods in the diet because the human body is able to convert tryptophan, an amino acid, into niacin. Niacin, through its analogs, is involved in a variety of metabolic and biological processes, including energy production, fatty acid synthesis, cholesterol and steroids, signal transduction, the management of gene expression and the maintenance of genomic integrity. Nicotinic acid, in clinical and pharmacological applications, is used as an antihyperlipidemic agent. Niacinamide is also helpful in treating osteoarthritis, rheumatoid arthritis, insomnia, migraine headaches, and insulin-dependent diabetes. Vitamin B3 (Niacin) heightens good cholesterol (HDL) while lowering bad cholesterol (LDL), and can also enhance the effectiveness of some medications prescribed to lower cholesterol.

What is Niacinamide used for and who uses it?

Niacin and niacinamide are both forms of vitamin B3, and they can be used interchangeably in daily doses of 100 mg or less. However, each form has specific health applications when used in higher doses. Niacin is often taken to support healthy levels of cholesterol (both LDL and HDL), while niacinamide is used to help promote a healthy insulin response, as well as to help maintain joint health. Niacinamide, or vitamin B3, works with other B vitamins to produce energy in the cells, and to control circulation, hormones, glucose, and hydrochloric acid in the body. Niacin also works intimately with riboflavin (vitamin B2) and pyridoxine (vitamin B6) to maintain healthy skin, and ensure the smooth operation of the nervous and digestive systems. Niacin is also useful in treating dizziness and ringing in the ears, Raynauds syndrome, PMS, headaches, cramps, and circulation problems. Niacin is a vasodilator meaning it makes your blood vessels widen, which in turn leads to improved circulation.

Niacinamide when taken in sufficiently large doses (but not to exceed 500mg in a single dose) blocks the breakdown of fats and can have a dramatic lowering effect on blood lipid levels. Niacinamide is occasionally prescribed by physicians and taken for the treatment of hyperlipidemia because oral Niacin can reduce blood levels of VLDL (very-low-density lipoprotein) which are the precursors for LDL (the bad cholesterol). Because niacin blocks the breakdown of fats it can cause a decrease in free fatty acids in the blood, and thereby lead to decreased hepatic (liver) secretion of VLDL. When lowering VLDL blood levels niacin also has the effect of increasing the level of HDL (high density lipoproteins which is the good cholesterol). If you have high cholesterol or elevated blood lipid levels and are currently taking prescription drugs to treat your condition you should consult your prescribing physician before taking this product.

Niacinamide has been clinically demonstrated to help reduce and prevent the onset of Type I Diabetes in experimental subjects. Niacinamide enhances and protects insulin sensitivity and secretion, by helping to pancreas beta cell function and metabolism. Topical gels and creams using 4% Niacinamide (by weight) are commonly available and have been demonstrated effective as acne treatments in clinical trials when applied regularly over a minimum of 4 to 8 weeks. Since Niacinamide is readily water soluble you can mix about 1.1 grams Niacinamide per ounce of aloe vera gel or cream base to yield approximately 4% niacinamide.

In relatively high doses Niacinamide has been proven effective in the treatment of both osteoarthritis and rheumatoid arthritis. Studies have determined the therapeutic amount of Niacinamide to be 250 mg per dose taken between 4 and 16 times per day, although because of the potential for liver inflammation with doses exceeding 2 grams per day, doses greater than 1 gram per day should only be taken under the care and supervision of a physician. For effective treatment and the reduction of symptoms associated with arthritis it can take 8 to 12 weeks of 250 mg doses taken 4 times per day. Consult your physician if you have arthritis and wish to take oral Niacinamide as a treatment for your condition.

How pure is your Niacinamide?

This Niacinamide USP is a pharmaceutical grade form of Vitamin B3 that is manufactured in strict compliance to the United States Pharmacopeia standards (USP28) and is assayed by the manufacturer to be 99.91% product. You will receive a double sealed labeled bulk polyethylene bag containing this white powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 0.09% by weight are inactive byproducts of the extraction.

Because of its unique relationship with energy production, vitamin B3 or Niacinamide deficiency is often associated with general weakness, muscular weakness, and lack of appetite, as well as a bright red rash resembling sunburn, irritation of the mouth, inflammation and ulceration of the tongue, nausea and vomiting, insomnia, depression, headache dizziness, delusions, hallucinations and anemia. The most common symptoms of niacin deficiency involve the skin, digestive system, and the nervous system. Skin infections and digestive problems can also be attributed to niacin deficiency. For these reasons, it must be supplied either from the diet or from supplementation.

What is the daily suggested dose of Niacinamide?

Recommended doses for Niacinamide vary from as little as the daily allowance to as much as 250 milligrams three or four times per day (totaling 750 to 1000 milligrams per day). Since Niacinamide is also Vitamin B3, the daily allowance is 2-12 milligrams for children, 14 milligrams for women, 16 milligrams for men, and 18 milligrams for pregnant or breast-feeding women. One eighth level teaspoon will supply approximately 377 milligrams, or just about 0.4 grams for the bulk density of this Niacinamide. You can see the full bulk density/volumetric conversion chart for Niacinamide here here. Since Niacinamide can also increase stomach acid production it is best taken with meals. Do not exceed 1 gram per day without the advice and supervision of your physician.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions, Drug Interactions, and Potential Side Effects of Niacinamide

Do not take oral Niacinamide if you are currently taking anticonvulsant drugs such as carbamazepine or primidone. Large doses of niacin can cause liver damage, peptic ulcers, and skin rashes. In the high doses used for controlling cholesterol levels (anything above 100mg/day), nicotinic acid can cause skin flushing and skin itching as well as headaches, lightheadedness and low blood pressure. Consult your prescribing physician if you are currently taking any anticonvulsant drug.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Niacinamide

This product dissolves quickly in water and has a sour taste that is only slightly bitter. Just mix your usual dose with water or juice and drink.

Niacinamide is used in the following Proprietary Formulas

Powerade Zero Grape, Propel, Olay ProX Professional Anti-Aging Skin Care Line, Universal Animal Pak, Controlled Labs Purple Wraath, NOW ADAM, BrainQuicken BodyQuick, I Force Hemavol, AOR Niacin No-Flush, Maximum Nutrients Niacin Flush Free, Natrol Niacin TR, Nature's Science Niacin 500, NOW Niacin, Schiff Flush Free Niacin, Twinlab No-Flush Niacin

References & Further Research

Use of Niacin in the Prevention and Management of Hyperlipidemia
Niacin is an inexpensive drug useful in treating various forms of hyperlipidemia. Cardiac doses of niacin are effective in lowering serum triglyceride, low density lipoprotein, and lipoprotein-a levels and in elevating high density lipoprotein levels. Adverse reactions to niacin are varied and dose-dependent and range from annoying cutaneous flushing to hepatic toxicity. Patients advised to use the drug should be carefully screened and monitored. This paper reviews the pathologic and pharmacologic basis for niacin as an antilipemic agent. The biochemical and physiologic effects of the drug and its mechanisms of action are discussed

Treatment of hyperlipidemia with combined niacin-statin regimens
Combined use of niacin with a statin is an attractive option, since these types of medication have the best records in clinical trials for reduction in cardiovascular events and improvement in progression/regression of coronary lesions. The niacin-statin treatment regimens gave augmented low-density lipoprotein (LDL)-cholesterol reduction along with favorable changes in high-density lipoprotein (HDL) cholesterol, lipoprotein(a), and triglycerides.

Effect of Two Aspirin Pretreatment Regimens on Niacin-Induced Cutaneous Reactions
The objective of this study is to compare the effects of pretreatment with two aspirin regimens and placebo on niacin-induced cutaneous reactions. Using a randomized, double-blind, placebo-controlled, crossover study, overall data revealed an aspirin regimen of 325 mg is effective in suppressing niacin-induced cutaneous reactions. Increasing the dose to 650 mg does not provide additional benefit.

Niacinamide for International Customers

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