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What is Phenylethylamine HCl?

Phenylethylamine HCL is also known by the name PEA and pronounced Pheyl-Ethyl-Amine. PEA is considered a neuromodulator (and monoamine), and has been widely known as the "Love Drug" because of its effect in triggering the transmission of dopamine and norepinephrine and because it is available abundantly in chocolate. As an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) neuro receptor stimulant, PEA is responsible in improving and increasing acetylcholine release through the glutamatergic system, thus acting as a mood enhancer. Unlike D-Phenylalanine which is a restricted drug, Phenylethylamine is perfectly legal for use as a nutritional supplement, although both has many similar characteristics and effects as many other such as which acts as a precursor for the natural physiological synthesis of Phenylethylamine in the brain. Low levels of Phenylethylamine in the brain have been found to be associated with ADHD (Attention Deficit Hyperactivity Disorder) and specific types of depression, whereas high levels of Phenylethylamine have been linked to schizophrenia. If you are undergoing treatment of depression with medications (especially MAO inhibitors) you should check with your prescribing physician before taking phenylethylamine.

Phenylethylamine HCL is the salt analog of phenylethylamine. Phenylethylamine in conjunction with hydrochloric acid is forms a crystallized salt which is a monoamine alkaloid with two stereoisomers. The basic form of phenylethylamine HCL can be derived naturally from dietary sources such as chocolate, however food sources such as this are metabolized too quickly to significantly affect the chemistry of the body. As a dietary supplement, Phenylethylamine is a monoamine alkaloid that works in the human brain either as a neuromodulator (a substance other than a neurotransmitter, conveying information that is released from a neuron at a synapse over a region of neurons) or a neurotransmitter (the brains chemicals that amplify, relay, and modulate electrical signals between a neuron and another cell). Phenylethylamine is a natural compound biosynthesized from the amino acid phenylalanine by enzymatic decarboxylation.

Once it permeates the blood brain barrier, phenylethylamine HCL has a unique and significant effect both neurologically and emotionally in humans. However, phenylethylamine HCL has a very short lifespan within humans once contact is initiated even before crossing the blood brain barrier. Five to 15 minutes is usually the half life that is observed within human beings as phenylethylamine HCL is very quickly processed and metabolized in the body by the monoamine oxidase A, monoamine oxidase B, aldehyde dehydrogenase and dopamine betahydroxylase enzymes present. The chemist Alexander Shulgin has been credited on the research of phenylethylamine HCL and the vast majority of its derivatives. The detailed research of phenylethylamine HCL and its derivatives are documented in Alexander Shulgin's book "PiHKAL," which was release in 1991. It is here where the similarities of phenylethylamine HCL to other substances, such as amphetamine, methamphetamine, and dopamine, are documented and discussed in detail, as well as their similar effects within the biochemistry of the human body.

Phenylethylamine is most notably found in chocolate, certain algae’s and is produced in the brain from the amino acid DL-Phenylalanine. PEA (phenylethylamine) is the substance present in chocolates which is believed responsible for its well known aphrodisiac effects. PEA has been referred to as the "love drug" because of its effect on beta endorphins, an opioid peptide responsible for pleasurable feelings, mimicking the brains chemistry when a person is in love. Phenylethylamine works very well to help trigger and keep mental alertness, focus, mood and concentration. Phenylethylamine acts as a neuromodulator of aminergic synapses while also increasing energy, and improving mood.

What is Phenylethylamine HCl used for and who uses it?

Phenylethylamine HCL or also called PEA is extremely effective in maintaining and promoting focus, mental alertness, mood and concentration by acting as a neurotransmitter and a neuromodulator. You can use Phenylethylamine in conjunction with any other energy or fat burning supplement to help enhance their specific function by working synergistically with them. In the human brain, phenylethylamine bio-synthesized and made from the amino acid phenylalanine may work as a neurotransmitter. Phenylalanine is an essential amino acid that is necessary and required for normal functioning of the central nervous system. It has been used with great success and a proven track record in helping control symptoms of depression and chronic pain, as well as other diseases linked to a malfunctioning central nervous system.

Phenylethylamine HCL functions by increasing dopamine levels within the brain while inhibiting the action of dopamine transmitters. This dual action effect results to a large accumulation of dopamine within the brain if exposure outside the blood brain barrier is not terminated or otherwise regulated. Those with attention deficit disorder have been shown to have lowered dopamine levels while patients with schizophrenia have been confirmed to have heightened dopamine levels. This fact reaffirms the huge significance and effect of phenylethylamine HCL beyond the blood brain barrier on human biochemistry.

Chocolate also has phenylethylamine, a substance related to amphetamines and increases blood pressure and blood glucose levels. This results to feeling more alert and getting a sense of well being and contentment. Its action is believed to operate by stimulating the brain to release b-endorphin, an opioid peptide which is the driving force behind the pleasurable effects. Phenethylamine, somewhat similar to amphetamine, works as a releasing agent of norepinephrine and dopamine. For this reason, it has been called the "body's endogenous amphetamine". Low concentrations of endogenous phenethylamine are found in those suffering from attention-deficit hyperactivity disorder (ADHD) and often in clinical depression, while levels are elevated in schizophrenia.

How pure is your Phenylethylamine HCl?

This pharmaceutical grade nutritional supplement Phenylethylamine HCL is assayed by the manufacturer to be 99.33% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 0.67% by weight are inactive byproducts of the extraction. Phenylethylamine is known as the "love drug" and is believed be the reason why chocolate is a potent aphrodisiac. Phenylethylamine is an endogenous neuroamine that has been linked to the regulation of physical energy, mood, and attention. For these reasons, one may opt to consider the benefits of Phenylethylamine HCl supplementation.

What is the daily suggested dose of Phenylethylamine HCl?

The commonly recommended dose for Phenylethylamine varies from 100-500 milligrams (mg) per dose, depending upon individual needs. One half level teaspoon will supply approximately 1487 milligrams, or just about 1.5 grams for the bulk density of this Phenylethylamine HCl powder. You can see the full bulk density/volumetric conversion chart for Phenylethylamine HCl here. Some people find that taking two or three doses per day of Phenylethylamine is optimally effective for them, whereas some people find that they can take Phenylethylamine only once per day with satisfactory results. Many health practice professionals consider doses larger than 500 milligrams per day to be unnecessarily large for most people because of the chance of overstimulation and occasional side effects of mania and/or euphoria.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Safety, Caution, and Potential side effects of Phenylethylamine HCl

Phenylethylamine should not to be taken with MAO (MonoAmine Oxidase) inhibitor drugs. MAO inhibitors are a potent class of medications used to treat depression. If you are pregnant or breastfeeding or are being treated for depression or other neurological conditions you should consult your health care professional before using this product. As with other medications and supplements, do not exceed the recommended dose, andif you have high blood pressure, or any other medical or emotional condition. Do not use if you are pregnant, nursing, or may become pregnant. Do not use if you are taking any prescription drugs. Discontinue use at once and seek medical attention if side effects occur.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Phenylethylamine HCl

This product dissolves quickly in water and has a markedly bitter taste. But with sufficient sweetening the bitterness can be moderated somewhat. Just mix your usual dose with water or juice and drink.

Phenylethylamine HCl is used in the following Proprietary Formulas

Universal Animal Cuts, VPX NO Shotgun, Nutrex Lipo 6 Black, Gaspari Nutrition Mitotropin, Nutrex Lipo 6x, Body Conditioning Solutions PEA, Cognitive Nutrition Phenylethylamine, Cognitive Nutrition Ultra Strength Phenylethylamine, PrimaForce Phenylethylamine, Supplement Direct Beta-Phenylethylamine HCL

References & Further Research

Evidence for the presence of m-tyramine, p-tyramine, tryptamine, and phenylethylamine in the rat brain and several areas of the human brain
Postmortem human brains have been obtained from four nonpsychiatric patients, aged 59-70 years. Regional analysis of the trace amines phenylethylamine, p-tyramine, m-tyramine, and tryptamine has indicated that the amines are distributed heterogeneously throughout the brain, but are most concentrated in the basal ganglia. Although the levels are very low, evidence obtained from animal studies has indicated that the trace amines have a very rapid turnover rate. Their presence in a brain synaptosomal fraction suggests a possible involvement in the process of neurotransmission. Postmortem changes in human brain amines are discussed in relation to those occurring postmortem in the rat brain, in which phenylethylamine, p-tyramine, and tryptamine have been shown to increase to levels greater than those prevailing in vivo.

Characterization of Beta-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study
In vivo microdialysis was used to investigate the effect of beta-phenylethylamine on extracellular levels of monoamines and their metabolites in the nucleus accumbens of conscious rats. The results suggest that beta-phenylethylamine increases the efflux of monoamines, preferentially dopamine, without affecting monoamine metabolism, in the nucleus accumbens.

Phenylethylamine modulation of affect: therapeutic and diagnostic implications
A review of the literature indicates that brain phenylethylamine (PEA) may be a neuromodulator of aminergic synapses and that it promotes energy, elevates mood, and favors aggression. Phenylacetic acid, the main metabolite of PEA, is decreased in the biological fluids of depressed subjects and schizophrenic subjects and is increased in schizoaffective subjects. The administration of PEA or of its precursor L-phenylalanine improves mood in depressed patients treated with a selective monoamine oxidase B inhibitor. The authors speculate that studies of PEA metabolism may have diagnostic value and that PEA administration may be therapeutic in selected depressed patients.

Phenylethylamine HCl for International Customers

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