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Pyridoxal-5-Phosphate

What is Pyridoxine HCl (Vitamin B6)?

Pyrodoxine is vitamin B6, a very important B vitamin for most people, and especially vital for women. It seems to be directly related and connected to hormone balance and water shifts in women.

Vitamin B6 is made up of three related compounds, all of which can be found in food - pyridoxine, pyridoxal and pyridoxamine. The predominant biologically active form is pyridoxal. Pyridoxine is the form used in vitamin supplements because it is the least expensive to produce commercially.

Vitamin B6 is stable in acid and is fairly easily destroyed with ultraviolet light, for example sunlight, and during the processing of food. It is also lost in cooking or refining, as well as with improper food storage.

Pyridoxine is readily absorbed from the small intestine and utilized throughout the body in a wide array of functions. Diets which focus on fasting and reducing usually deplete the vitamin B6 supply unless it is supplemented. Usually within eight hours, much of the excess is excreted through the urine, while some B6 is stored in muscle.

The best dietary sources of vitamin B6 are meats, particularly organ meats such as liver, and the whole grains, especially wheat and wheat germ. It is also synthesized by the intestinal bacteria. Aside from meat, other excellent protein sources of B6 include fish, poultry, egg yolk, soybeans and other dried beans, peanuts and walnuts. Bananas, prunes, potatoes, cauliflower, cabbage and avocados top the list for vegetable and fruit sources.

Benefits of Pyridoxine HCl

Pyridoxine and its coenzyme form, pyridoxal-5-phosphate, are involved in a multitude of metabolic functions in the body, especially in amino acid metabolism (Wikipedia) and in the central nervous system, where they support production of gamma-aminobutyric acid (GABA).

The pyridoxal group is beneficial in the utilization of food sources for energy and in facilitating the release of glycogen (stored energy) from the liver and muscles. It assists in the production of antibodies and red blood cells, and in the synthesis and functioning of both DNA and RNA.

By helping manage the balance of sodium and potassium in the body, vitamin B6 is crucial in fluid balance regulation and the electrical functioning of the nerves, heart and musculoskeletal system.

Pyridoxine is especially important with respect to protein metabolism. Many physiological reactions rely on vitamin B6 to help get amino acids across the intestinal mucosa into the blood and from the blood into cells. By itself and with other enzymes, pyridoxine helps build and break down amino acids as well as change one to another and it is especially related to the production and metabolism of choline, methionine, serine, cysteine, tryptophan, and niacin.

Deficiency is a big concern with vitamin B6, as it is with all the B vitamins. Symptoms include muscle weakness, nervousness and irritability. Many of the symptoms are similar to those of both niacin and riboflavin deficiencies.

Purity and Concentration of Pyridoxine HCl

Pyridoxine hydrochloride contains no fillers, taste additives or anti-caking agents.

Suggested Use of Pyridoxine HCl (Vitamin B6)

The suggested serving size for pyridoxine HCl is 50 milligrams per day, depending on individual needs. You can see the full bulk density/volumetric conversion chart for Pyridoxine HCl here. As the suggested amounts are so small, PureBulk recommends a milligram weight scale for precision measuring.

The FDA recommends a daily intake value (DV) of 2 milligrams Vitamin B6 per day for adults. Pyridoxine HCl yields 82% actual Vitamin B6. Thus, a 50 mg serving yields 41.1 mg Vitamin B6, which is 2057% of the daily value. Do not use more than 125 milligrams per day.

Potential Side Effects of Pyridoxine HCl (Vitamin B6)

Pyridoxine is safe at suggested serving sizes. Vitamin B6 overuse can cause neurological disorders, such as loss of sensation in legs and imbalance, when taken in high quantities (200 milligrams or more per day) over a long period of time. Symptoms of too much pyridoxine may include poor coordination, staggering, numbness, and decreased sensation to touch, temperature, and vibration.

Bioavailability, Mixing and Solubility of Pyridoxine HCL (Vitamin B6)

Pyridoxine hydrochloride dissolves quickly in warm or hot water, but rather slowly in cold water. Mix with water or juice and drink.

How should I store it?

You will receive this powder in a resealable bag. Store it in a cool, dry, dark location. Reseal tightly between uses.

References & Further Research

University of Maryland Medical Center: Vitamin B6

Linus Pauling Institute, Micronutrient Information Center

NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-label­ing standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.