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What is Pyridoxine Hydrochloride (Vitamin B6)?

Vitamin B6 (Pyridoxine) is a very important B vitamin for most people, but it is especially vital for women. It seems to be directly related and connected to hormone balance and water shifts in women. Vitamin B6 is made up of three related compounds, all of which can be found in food, namely pyridoxine, pyridoxal, and pyridoxamine. The predominant biologically active form is Pyridoxal. However, pyridoxine is the form used in vitamin supplements because it is the least expensive to produce commercially. Vitamin B6 is stable in acid, and is fairly easily destroyed with ultraviolet light, for example sunlight, and during the processing of food. It is also lost in cooking or refining, as well as with improper food storage.

Pyridoxine is readily absorbed from the small intestine and utilized throughout the body in a wide array of functions. Diets which focus on fasting and reducing usually deplete the vitamin B6 supply unless it is supplemented. Usually within eight hours, much of the excess is excreted through the urine, while some B6 is stored in muscle. The best dietary sources of vitamin B6 are meats, particularly organ meats, such as liver, and the whole grains, especially wheat and wheat germ. It is also synthesized by the intestinal bacteria. Aside from meat, other excellent protein sources of B6 include fish, poultry, egg yolk, soybeans and other dried beans, peanuts, and walnuts, while bananas, prunes, potatoes, cauliflower, cabbage, and avocados top the list for vegetable and fruit sources.

Pyridoxine and its coenzyme form, pyridoxal-5-phosphate, have a multitude of metabolic functions in the body, especially in amino acid metabolism and in the central nervous system, where it supports production of gamma-aminobutyric acid (GABA). Many reactions, including the conversion of tryptophan to niacin and arachidonic acid to prostaglandin E2, need vitamin B6. The pyridoxal group is beneficial in the utilization of all food sources for energy and in facilitating the release of glycogen (stored energy) from the liver and muscles. It assists as well in the production of antibody and red blood cell (hemoglobin synthesis) as well, and in the synthesis and functioning of both DNA and RNA. By helping manage the balance of sodium and potassium in the body, vitamin B6 is crucial in the fluid balance regulation and the electrical functioning of the nerves, heart, and musculoskeletal system.

Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid metabolism: the main biologically active form is pyridoxal 5-phosphate. Pyridoxine has been used as an antidote in acute intoxications, including isoniazid overdose, Gyromitra mushroom or false morrel (monomethylhydrazine) poisoning and hydrazine exposure. It is also recommended as a co-factor to improve the conversion of glyoxylic acid into glycine in ethylene glycol poisoning. Other indications are recommended by some sources (for example crimidine poisoning, zipeprol and theophylline-induced seizures, adjunct to d-penicillamine chelation), without significant supporting data.

Pyridoxine is especially important with respect to protein metabolism. Many amino acid reactions rely on vitamin B6 to help get amino acids across the intestinal mucosa into the blood and from the blood into cells. By itself and with other enzymes, pyridoxal-5-phosphate helps build amino acids, break them down, and change one to another and is especially related to the production and metabolism of choline, methionine, serine, cysteine, tryptophan, and niacin. During pregnancy, the body has a high requirement for vitamin B6. It is important for maintaining hormonal and fluid balance of the mother and for the developing nervous system of the baby. Pyridoxine may somehow be related to the development and health of the myelin covering of the nerves, which allows them to conduct impulses properly.

What is Pyridoxine Hydrochloride (Vitamin B6) used for and who uses it?

With its many functions, there is also a wide range of clinical uses of vitamin B6, being most beneficial when symptoms and diseases are related to a pyridoxine/pyridoxal-5-phosphate depletion or deficiency. Recently there has been widespread use of higher doses of B6, usually from 50-200 mg. per day (though some studies use 500 mg. per day of pyridoxine in time-release form) for premenstrual symptoms, especially water retention, which can lead to breast soreness and emotional tension. Pyridoxine has been very helpful in this role, probably because of its diuretic effect through its influence on sodium-potassium balance and its mysterious influence on the hormonal system. Vitamin B6 also helps with the acne that often develops premenstrually, as well as with dysmenorrheal, or menstrual pain; magnesium is usually used as well in all of these menstrual-related problems. In pregnancy, B6 has been helpful in many women for controlling the nausea and vomiting of morning sickness, which some authorities feel is highly related to vitamin B6 deficiency.

It seems that whenever there are increased levels of estrogen in the body, more B6 is required. This occurs not only in pregnancy but also for women who take birth control pills and those postmenopausal women on estrogen treatment as well. It is likely that some of the emotional symptoms experienced by many women on the pill, such as fatigue, mood swings, depression, and loss of sex drive, may be related to a deficiency of B6 and thereby helped by supplementation.

Vitamin B6 is used for people with stress conditions, fatigue, headaches, nervous disorders, anemia, and low blood sugar or diabetes, and in men for prostatitis, low sex drive, or hair loss. Pyridoxal-5-phosphate (P5P) is occasionally used in formulas or as an individual supplement for certain conditions. As the active coenzyme of pyridoxine, P5P can go more directly into the metabolic cycles and does not have to be converted; thus, it may be more helpful than pyridoxine alone in such problems as fatigue, allergies, viral disease, chemical sensitivities, mental illness, and cancer. Pyridoxine supplementation is also used for a variety of skin problems--dandruff, eczema, dermatitis, and psoriasis. In regard to the nervous system, vitamin B6 has been supportive in cases of epilepsy, Parkinson's disease, multiple sclerosis, and neuritis. Vitamin B6 therapy, from 100-300 mg. daily for 8-12 weeks, appears to reduce carpal tunnel syndrome and increase the ability to use the hands in most patients.

How pure is your Pyridoxine Hydrochloride (Vitamin B6)?

Pyridoxine Hydrochloride is also commonly referred to as Pyridoxine, or Vitamin B6, and is assayed by the manufacturer to be 99.35% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder. Vitamin B6 in its several forms is widely available in nature, though not many foods have very high amounts. Since it is lost in cooking and in the refining or processing of foods, it is not the easiest B vitamin to obtain in sufficient amounts from the diet, especially if we eat much processed food, as it is not one of the vitamins replaced in "enriched" flour products such as cereals and pastries. As examples of how easily vitamin B6 is lost in the processing of food, raw sugar cane has a good amount, while refined sugar has none; whole wheat flour contains nearly 0.5 mg. of pyridoxine (wheat germ and wheat flakes have much more), while refined wheat flour has almost none, and even whole wheat bread has lost nearly all of its vitamin B6. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits made possible with Pyridoxine Hydrochloride (Vitamin B6), buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What are some of the common effects of Pyridoxine Hydrochloride (Vitamin B6)?

Pyridoxine is a natural diuretic and is often helpful not only for the previously mentioned premenstrual problems but also in overweight and fluid-retaining people and as an adjunct to blood pressure control. Vitamin B6 (along with magnesium) has received some note in regard to preventing the formation of kidney stones or the recurrence of stones in those who have had them. The B6-magnesium combination also helps in some hyperactive kids and those with fits or problems of autism. Vitamin B6 is a water-soluble vitamin which helps the body make proteins, which are then used to make body cells. It also helps convert tryptophan (an amino acid) into niacin and serotonin (a brain chemical). Vitamin B6 also helps produce other body chemicals such as insulin, hemoglobin and antibodies to fight infection. Pyridoxine in fairly large doses will stimulate dream activity as well as reduce the potential toxicity of barbiturate drugs, carbon monoxide and some other chemical exposures, and irradiation. Vitamin B6 works best when taken with magnesium, zinc, riboflavin, and brewer's yeast or the other B vitamins.

Pyridoxine, probably more than the other B vitamins except folic acid, is supportive of healthy immune function. B6 deficiency can produce immune weakness, and B6 treatment may be helpful against infections and cancer. Recent studies have shown that pyridoxine can inhibit the growth of some cancer cells, specifically mice and human melanoma cells. Further research with B6 will likely find an even wider range of uses.

What is the daily suggested dose of Pyridoxine Hydrochloride (Vitamin B6)?

The common daily recommended dose for Pyridoxine Hydrochloride Powder usually ranges from less than 1 milligram to as much as 200 milligrams per day, depending upon individual needs. Vitamin B6 intake, though based on many factors, is determined primarily by protein intake, because it is so important to protein metabolism. The RDA for adults is a minimum of 2 mg. of B6 per 100 grams of protein consumed. In children, it ranges from 0.6-1.2 mg. per 100 grams of protein. You can see the full bulk density/volumetric conversion chart for Pyridoxine HCl here.

However, the need for vitamin B6 increases in a variety of situations. During pregnancy and lactation and with birth control pill or estrogen use, higher levels are required. For those who eat a high-sugar or processed-food diet or a high-protein diet, requirements for B6 are greater and deficiencies or depletion are more common. When there is impairment of the digestive system, cardiac failure, or radiation use, or even just the aging process, needs for vitamin B6 are increased. Drugs that influence needs for B6 are oral contraceptives, isoniazid (for tuberculosis), hydralazine (for high blood pressure), amphetamines, reserpine (for high blood pressure), and some antibiotics. More B6 is utilized with an increased intake of the amino acid methionine. Adequate magnesium in the body is important to the functions of vitamin B6. A safe, basic intake for vitamin B6 is probably 10-15 mg. per day, though much higher daily amounts are easily tolerated. B6 should also be taken along with other B vitamins to prevent metabolic imbalance.

What kind of results do people anticipate while taking Pyridoxine Hydrochloride (Vitamin B6)?

Pyridoxine Hydrochloride (Vitamin B6) is a water soluble vitamin that is readily expelled from the body through the urine and when taken internally must be consumed regularly on a daily basis, two to three times per day for optimal nutritional benefit. Pyridoxine is an essential Vitamin and nutrient that promotes normal metabolic function and processes in human physiology. Pyridoxine is an especially important vitamin for maintaining healthy nerve and muscle cells and it aids in the production of DNA and RNA, the body's genetic material. It is necessary for proper absorption of vitamin B12 and for the production of red blood cells and cells of the immune system. Pyridoxine has also been called the "woman's vitamin" because it may help relieve symptoms of premenstrual syndrome (PMS). In addition to other B complex vitamins, pyridoxine is considered an "anti-stress" vitamin because it is believed to enhance the activity of the immune system and improve the body's ability to withstand stressful conditions.

Potential side effects of Pyridoxine Hydrochloride (Vitamin B6)

Thiamin Mononitrate Powder (Vitamin B6) supplementation at doses up to 200 mg per day is considered safe and is usually free of side effects in adults. However, Vitamin B6 overuse and/or overdose can cause neurological disorders, such as loss of sensation in legs and imbalance, when taken in high doses (200 mg or more per day) over a long period of time. Thiamin Mononitrate Powder (Vitamin B6) toxicity can damage sensory nerves, leading to numbness in the hands and feet as well as difficulty walking. Symptoms of a pyridoxine overdose may include poor coordination, staggering, numbness, decreased sensation to touch, temperature, and vibration, and tiredness for up to six months.

Deficiency, as usual, is a bigger concern with vitamin B6, as it is with all the B vitamins. So many functions are performed by pyridoxine that its deficiency affects the whole body. Most of these deficiency symptoms are fairly vague. Muscle weakness, nervousness, irritability, and depression are not uncommon. Many of the symptoms are similar to those of both niacin and riboflavin deficiencies; depression is common in all of them. Overall, vitamin B6 deficiency can cause a variety of nervous symptoms, skin problems, and amino acid/protein metabolic abnormalities. These can lead to the more common expressions--headache, dizziness, inability to concentrate, irritability and epileptic-type activity, labile depression, and weakness. Water retention is common. Nausea, vomiting, and dry skin, especially extensive dandruff and a cracked sore mouth and tongue are also more likely with vitamin B6 deficiency.

Taste, solubility, and suggested preparation of Pyridoxine Hydrochloride (Vitamin B6)

Pyridoxine Hydrochloride powder has a somewhat characteristic taste and dissolves quickly in warm or hot water, but rather slowly in cold water. Just measure and stir your usual dose into water or juice and drink.

Pyridoxine Hydrochloride (Vitamin B6) is used in the following Proprietary Formulas

Finest Vitamin B6, Nature's Way Vitamin B6, Nature Made Super B-Complex Supplement Tablets, Meijer Melatonin with Vitamin B6, Nature Made Stress B-Complex Supplement, Natrol Melatonin 5 mg TR with Vitamin B6, Natures Way PMS with Vitamin B6 and 5-HTP, Integrative Therapeutics Vitamin B6

References & Further Research

Efficacy of vitamin B6 and magnesium in the treatment of autism: A methodology review and summary of outcomes
Pauling's orthomolecular hypothesis appeared in 1968, stating that some forms of mental illness and disease are related to biochemical errors in the body. Vitamin therapy is believed to be a means of compensating for such errors. There have been few empirical studies on vitamin therapy in individuals with autism. This article presents a critical analysis of the 12 published studies located through an extensive computerized search. Studies were systematically evaluated to provide an objective assessment of empirical evidence supporting the efficacy of vitamin treatment. The majority of studies report a favorable response to vitamin treatment. However, interpretation of these positive findings needs to be tempered because of methodological shortcomings inherent in many of the studies. For example, a number of studies employed imprecise outcome measures, were based on small samples and possible repeat use of the same subjects in more than one study, did not adjust for regression effects in measuring improvement, and omitted collecting long-term follow-up data. Recommendations are offered to assist researchers in designing future investigations.

Inherited disorders of neurotransmitters in children and adults
Inherited disorders of neurotransmitters are a group of neurometabolic syndromes attributable to a primary disturbance of neurotransmitter metabolism or transport. This is an enlarging group of recognized disorders requiring specialized diagnostic procedures for detection. This review considers clinical disorders of biopterin, catecholamines, serotonin, glycine, pyridoxine, and GABA metabolism. Overall data suggest both pyridoxine and pyridoxal-5-phosphate dependency need to be considered in refractory neonatal seizures.

Pyridoxine Hydrochloride (Vitamin B6) for International Customers

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