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What is Resveratrol?

Resveratrol is a polyphenol and a protective compound found and produced in the skin of red grapes, certain berries, and other plants in response to environmental stresses. Studies have demonstrated that resveratrol has potent antioxidant activity and also has the ability to inhibit platelet aggregation. These actions may help prevent free radical damage throughout the body and provide protective support to the cardiovascular system. Resveratrol, especially when combined with other polyphenols, is known for its youthful sustaining properties. Red wine has about 1.5 to 3 milligrams of resveratrol per liter (a liter is almost 34 ounces).

Resveratrol has been in the news a great deal. Recent headlines have been talking about the health benefits of red wine, most notably that it lowers your risk of cancer and heart disease. Research studies continue to find more interesting benefits from this red wine compound, including potential anti-cancer and anti-aging activity. Scientists discovered the link between red wine consumption and better health while studying what they call the French paradox: Why do the French have less heart disease and cancer, when the typical French diet and lifestyle often includes high-fat foods as well as cigarettes? Their studies showed that, surprisingly, it was the French habit of drinking a glass or two of red wine each day that protected them from developing these chronic diseases.

Yet how can drinking alcohol actually improve anyone’s health when it is a well-established fact that alcohol inhibits the body’s absorption of all vitamins, and can, when consumed regularly, lead to liver damage, dementia, and a host of other nasty disorders? Researchers found the answer to this question when they discovered resveratrol, an antioxidant, anti-inflammatory substance found in red wine. Further studies of resveratrol revealed that it helps prevent blood clots by keeping blood vessels open and pliable.

Resveratrol helps lower cholesterol, and is as much as 10 to 20 times more potent than vitamin E in protecting against LDL oxidation, a process that has been linked to the development of cardiovascular disease. It is also thought to discourage tumor growth by blocking the action of Cox-2, an enzyme that researchers believe contributes to the development of colon cancer. Additional studies suggest that resveratrol may be useful in both preventing and treating cancer.

Resveratrol is found in the stems, leaves, and skins of grapes. As red wine is a rich source of resveratrol, many sources will reference resveratrol as "red wine polyphenols," "red-wine extract," etc. Although a glass or two of red wine each day may lower the risk of heart disease, one recent study shows that alcohol-free red wine works just as well. Resveratrol is also present in purple grape juice, red or purple grapes, and peanuts. However, because of the fermenting process, resveratrol levels are higher in red wine than other natural sources—red wine has about three times as much resveratrol as grape juice.

What is Resveratrol used for and who uses it?

This natural supplement can cause large and permanent weight loss. Resveratrol acts to improve the metabolism on a cellular level, which results in the more efficient burning of fat. The compound also aids for the regulation of the blood sugar levels. In this way the nutritional chemical substances that we receive with the food are processed more efficiently. As a result you will feel more energetic despite the slimming process taking place. Furthermore, the appetite is more balanced, which will reduce the natural craving for food. The chemical substance also provides for the improvement of the work of the cardiovascular system. The levels of cholesterol in the body are sufficiently lowered and the risk of high blood pressure and heart diseases is reduced.

One of the most highly appreciated effects of Resveratrol is its anti-aging effects most evident on the skin. Resveratrol activates a cell's survival defense enzyme, which prolongs the time cells have to repair their broken DNA. With the improved production of elastin and collagen cells the skin becomes softer and more elastic. The appearance of wrinkles is prevented or if they have appeared they are naturally diminished and softened. The overall result is a fresher and rejuvenated look. The substance also acts to prevent the dying of cells in all bodily organs and the more efficient production of new ones. This means that the risk of various diseases that occur mainly due to the poorer work of the different systems in the body is substantially reduced.

Most importantly, Resveratrol can affect positively even the most essential and sensitive of organs specifically those of the nervous system. It can efficiently slow the dying and the loss of neurons, which is a naturally occurring process, the rate of which increases with aging. In turn the neuronal functioning of the brain is significantly improved and the risk of disease of the nervous system is reduced through the intake of sufficient amounts of Resveratrol. The compound can successfully prevent serious medical conditions such as Sclerosis and Alzheimer. The combined positive effects of the chemical substance on the nervous and cardiovascular systems can slow the aging process. Resveratrol has and anti-cancer action as well. When taken regularly and in optimal dosages it can prevent the formation of tumor cells in all organs of the body. To determine with certainty whether the systematic intake of the compound can effectively prevent the formation of carcinomas, tests and studies are still being conducted. Positive results were observed on the treatment of breast, skin, colon and gastric cancer and leukemia cells.

Resveratrol acts on the human body by activating a gene called Sirtuin1 or SIRT1. As a result the work of the mitochondria in the cells is improved. The mitochondria are responsible for the processing of energy and the regulation of metabolism on a cellular level. The effect on the body that is achieved is similar to the one occurring when the person is on a very restricted calorie diet. Put more simply, by taking resveratrol your body can burn fat more actively creating a slimming effect, reduce bad cholesterol levels thus lowering high blood pressure, and regulate blood sugar levels to provide extra energy.

How pure is your Resveratrol?

This natural grade Trans-Resveratrol 99% is a powdered extraction from the Polygonum cuspidatum plant root. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag of this slightly off-white powdered product. It contains no fillers, taste additives, or anti-caking agents. The remaining 2% by weight are inactive byproducts of the extraction.

Apart from those benefits already mentioned, Resveratrol thins the blood more effectively than aspirin. Resveratrol can interfere with the development of cancer in three ways: by blocking the action of cancer-causing agents, by inhibiting the development and growth of tumors, and by causing precancerous cells to revert to normal. As such Resveratrol has been found to inhibit the proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic and thyroid cancers. For these reasons, supplementation may be necessary to ensure adequate intake and good health.

What is the daily suggested dose of Resveratrol?

The commonly recommended dose for Trans-Resveratrol varies from 500-2000 milligrams (2 grams) per day in divided doses. With animal studies (mice) the effective Trans-Resveratrol dose inferred from these studies would be equivalent to a human dose of between 500mg and 1.5 grams per day taken in divided doses (3 doses per day minimum are recommended). Taking one level 1/4 teaspoon (about 399mg) of this Trans-Resveratrol 99% powder three times per day will yield a total Trans-Resveratrol dose of approximately 1.2 grams (1,200 milligrams). You can see the full bulk density/volumetric conversion chart for Resveratrol here. To increase the bioavailability of the Trans-resveratrol powder you should consider taking it with meals, high-fat foods, or with wine.

Resveratrol supplements work best when combined with grape extracts or other antioxidants. Since researchers are just beginning to explore the benefits of resveratrol, there is no strict Recommended Dietary Allowance (RDA) for this substance. Researchers believe that 500 milligrams daily is the minimum amount of resveratrol needed to protect against cancer. A glass of red wine contains approximately 640 micrograms of resveratrol, and a handful of peanuts supplies nearly 75 micrograms.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

Precautions and Potential side effects of Resveratrol

To date, no serious side effects, toxic symptoms, or drug interactions have been reported in connection with resveratrol consumption. The adverse effects, in rare occasions, include stomach cramps and diarrhea, nausea, loss of appetite and numbness in the limbs. Most of these people, however, seem to have taken inappropriate dosages. Some have used products that are of poor quality, which usually tend to cause problems. Others admit that they have previously suffered from these symptoms and that they have not been enhanced by the intake of the supplement. For all these reasons it is best to take Resveratrol in the optimal dosage. Children, pregnant women and those who are breastfeeding are also recommended not to use the product. People suffering from serious medical conditions should discuss taking Resveratrol with their general health care provider or a specialist before they start using it.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Resveratrol

Trans-Resveratrol Powder is only very slightly soluble in water. In an ethanol and water solution Trans-Resveratrol is soluble to about 50mg per liter at 20°C. This natural powdered extraction is of the highest purity tested and assayed by HPLC to be greater than 99% Trans-Resveratrol. In product testing Trans-resveratrol-3-O-glucoside, Cis-resveratrol, Cis-resveratrol-3-O-glucoside and Emodin were undetectable. Unlike the Trans-Resveratrol 30% or 50% powdered extractions that we also sell, this 99% pure product has almost no taste and is very easy to take orally with foods or wine.

Resveratrol is used in the following Proprietary Formulas

S.A.N. MyoTEST, NOW Natural Resveratrol, Nutrabolics Vitabolic, Olympian Labs Clinical Resveratrol, Country Life Resveratrol Plus, Nature's Science Trans-Resveratrol 650, Ageless Foundation UltraMAX GOLD Rejuvenation Spray, Anabolic Addiction Mass Addiction, Anabolic Addiction ResverAcai, Biotivia Bio Shape, Biotivia Bioforte Resveratrol, Doctor's Best Best Resveratrol, Jarrow Formulas Resveratrol, KAL Fizz C Energy W/ ALA & Resveratrol, KAL Resveratrol, Life Extension Optimized Resveratrol

References & Further Research

Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
Beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of Alzheimer's disease. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease, an additional neuroprotective effect has been postulated for resveratrol. The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Abeta-induced neurotoxicity. The neuroprotective capacity against Abeta-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances. Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. Our findings suggest that red wine may be neuroprotective through the actions of resveratrol.

Resveratrol improves health and survival of mice on a high-calorie diet
Resveratrol extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) activity, increased mitochondrial number, and improved motor function. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways.

Fungicidal effect of resveratrol on human infectious fungi
Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 microg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on Candida albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
Besides cardioprotective effects, resveratrol exhibits anticancer properties, as suggested by its ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; multiple myeloma; cancers of the breast, prostate, stomach, colon, pancreas, and thyroid; melanoma; head and neck squamous cell carcinoma; ovarian carcinoma; and cervical carcinoma. Phamacokinetic studies revealed that the target organs of resveratrol are liver and kidney, where it is concentrated after absorption and is mainly converted to a sulfated form and a glucuronide conjugate. In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression. Besides chemopreventive effects, resveratrol appears to exhibit therapeutic effects against cancer. Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer.

Resveratrol for International Customers

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