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Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2675 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is Betaine Anhydrous (TMG)?

Betaine Anhydrous, also called Trimethylglycine, is a vitamin derived from choline. Dietary sources of Betaine Anhydrous include spinach, cereal grains, wine, seafood, and sugar beets. Betaine Anhydrous (Trimethylglycine) is very important to proper liver function, cellular replication, and detoxification reactions. Betaine also plays a role in the manufacture of carnitine and serves to protect the kidneys from damage. Additionally Betaine has also been found to play a critical part in reducing blood levels of homocysteine, a toxic breakdown product of amino acid metabolism that is one of the main causes of atherosclerosis and osteoporosis. Although folic acid, vitamin B6, and vitamin B12 are the main nutrients involved in controlling homocysteine levels, TMG has been reported to be helpful in some individuals whose elevated homocysteine levels did not improve even after taking these other nutrients. Dietary sources with highest concentrations of Betaine Anhydrous include green leafy vegetables, spinach, cereal grains, seafood, legumes, wine and sugar beets. TMG (trimethylglycine) or anhydrous betaine is found in a variety of plant and animal sources and is used in the conversion of homocysteine to methionine. Maintaining normal homocysteine levels is important for the health of the cardiovascular system. In animal studies, Betaine has also been shown to help protect the liver and raise S-adenosylmethionine (SAM-e) levels.

What is Betaine Anhydrous (TMG) used for and who uses it?

Betaine Anhydrous is a versatile vitamin that is used by the body for a wide variety of physiological purposes. Anyone free from medical complication and in good health, including athletes and members of the general population, can benefit from supplementing with betaine into their overall health regimen. This is also useful in times of stress, as stock betaine levels may not be enough to support optimal immune system function. Those who need to incorporate it into their health management strategy out of necessity manifest symptoms of deficiency which can include compromised gastrointestinal and liver function, decreased immunity, and abnormally high or unstable homocysteine levels.

Betaine Anhydrous is used primarily for people who need to lower abnormally high homocysteine levels in their blood. Homocysteine is a potentially toxic substance that results from meat digestion. By lowering or controlling homocysteine levels, betaine reduces ones risk of this. In humans, betaine is essential to the maintenance of intestinal function and cell production, and it serves to protect DNA and DNA formation. Betaine has also been shown to increase low plasma methionine and S-adenosylmethionine (SAM) levels under certain conditions.

As a nutritional aide, betaine anhydrous has been shown to be lipotropic - i.e. fat loss causing - by promoting the oxidization of lipids. It has also been noted to increase appetite, and in animals it has been shown to promote lean mass. The action of betaine is potentiated in the presence of choline (its precursor), folic acid, and vitamins B6 and B12. In some circumstances, betaine anhydrous can be used as a substitute for methionine and choline chloride.

Athletes who engage in serious strength trainings like powerlifters, strongman competitors, bodybuilders and other performance athletes who don’t get much results out of their creatine intake (Creatine non-responders) find it beneficial to take TMG together with Glycocyamine (a non-methylated precursor of the amino acid Creatine) to get the most out of their intense trainings by increasing lean muscle mass and enhancing performance.

How pure is your Betaine Anhydrous (TMG)?

This food grade Betaine Anhydrous (TMG) is assayed by the manufacturer as 97.4% pure product (normal range 95.0% and up). You will receive a double sealed labeled bulk polyethylene bag containing this very fine white granular powder product. It contains no fillers, taste additives, or anti-caking agents. The remaining 2.6% by weight are inactive byproducts of the extraction. Although TMG is a naturally occurring phytonutrient found in a variety of plants and animals, it can be difficult to eat enough of these foods to provide the body with sufficient amounts of TMG so supplementation may be necessary.

What are some of the common effects of Betaine Anhydrous (TMG)?

As a nutritional aide, betaine anhydrous has been shown to be effective to cause significant fat loss by promoting the oxidization of lipids. It has also been noted to increase appetite, and promote lean mass.

What is the daily suggested or recommended dose of Betaine Anhydrous (TMG)?

Dosage guidelines depend on factors like age and medical fitness, as well as individual needs. As a general rule of thumb in TMG dosage, children and adults can take two 3 gram doses daily, for a total of 6 grams per day. You can see the full bulk density/volumetric conversion chart for Betaine Anhydrous (TMG) here.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

What kind of results do people anticipate while taking Betaine Anhydrous (TMG)?

TMG supplementation has been shown in clinical and non-clinical studies to support a healthy homocysteine level, which in turn supports healthy cardiovascular function. Bodybuilders and performance athletes frequently use TMG in combination with the amino acids Creatine Mono, Creatine Ethyl Ester, Creatine Ethyl Ester Malate, and especially with Glycocyamine for superior muscle mass gains. Also, Betaine Anhydrous is clinically proven to be effective in enhancing the human production of the amino acid Carnitine, a nutrient that helps the body turn fat into energy (or, more technically, it helps your cells metabolize ATP). Optimal levels of carnitine in the body leads to overall physical fitness, as any intake of fat will be efficiently used to fuel the functions of the body, which in turn translates to more energy.

Betaine Hydrochloride versus Betaine Anhydrous (TMG)

Betaine hydrochloride is an acidic form of betaine and is used as a digestive aid. It is particularly helpful in persons with insufficient acid production in the stomach. While both are given as a nutritional supplement used for the treatment of high homocysteine levels, Betaine hydrochloric acid is sold as a digestive aid and as a supplemental source of hydrochloric acid for people who have a deficiency of stomach acid production. Betaine is also called trimethylglycine or TMG. The HCl form has an extremely sour taste while the anhydrous has a mild, pleasant taste. Besides the taste, HCl may be used as a digestive aid for people with low stomach acid because of its high acidity while the anhydrous form does not include this benefit.

Betaine lowers homocysteine levels. Higher intakes of dietary choline and betaine are related to lower homocysteine concentrations independent of other determinants, including folate and other B vitamins. Those with a high dietary choline and betaine intake have lower concentrations of inflammatory markers such as C-reactive protein, interleukin-6, and tumor necrosis factor. Betaine has also been found to protect liver cells from toxins, and Betaine is a nutrient that leads to a significant biochemical and histological improvement in patients with nonalcoholic steatohepatitis (NASH).

Precautions and Potential side effects of Betaine Anhydrous (TMG)

Possible side effects of TMG can include diarrhea, stomach upset (gastrointestinal irritation) and nausea. Although this product has no known interactions with medications, prior to intake users should still consult with a physician. This product is not recommended for diabetics, as well as for pregnant or nursing women unless they consult a physician prior to TMG administration.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and suggested preparation of Betaine Anhydrous (TMG)

This food grade Betaine Anhydrous powder is made for human consumption and has a mildly tart taste but mixes and dissolves readily with hot water. Betaine HCL is essentially the same as this Anhydrous Betaine except with an added HCL group. The difference in taste between the Anhydrous and the HCL is tremendous! Whereas the HCL has an extremely sour taste and is highly acidic (often used as a digestive aid), this Anhydrous Betaine has a fairly mild taste that is far less acidic (not suitable as a digestive aid). Betaine Anhydrous will readily dissolve in hot water, and has a pleasantly mild, almost sweet, taste. As a dietary supplement, take 1/2 teaspoon in juice or water 1 to 4 times daily, preferably with meals.

Betaine Anhydrous (TMG) is used in the following Proprietary Formulas

BSN NO-Xplode, MuscleTech Cell-Tech Hardcore, Controlled Labs Purple Wraath, LG Sciences Lipotropic Protein, MRI Black Powder.

Betaine Anhydrous is also known by the following names:

Trimethylglycine (TMG), Methanaminium1-carboxy-N,N,N-trimethyl-, inner salt, 2-(Trimethylammonio) ethanoic acid hydroxide, inner salt, (Carboxymethyl) trimethylammonium hydroxide inner salt, Trimethylammonioacetate, Glycine Betaine, Trimethylbetaine, Trimethylglycocoll, Abromine, Glycylbetaine, Oxyneurine.

References & Further Research

Effects of betaine intake on plasma homocysteine concentrations and consequences for health
High plasma concentrations of homocysteine may increase risk of cardiovascular disease. Betaine in high doses (6 g/d and higher) is used as homocysteine-lowering therapy for people with hyperhomocysteinemia due to inborn errors in the homocysteine metabolism. Studies in healthy volunteers with plasma homocysteine concentrations in the normal range show that betaine supplementation lowers plasma fasting homocysteine dose-dependently to up to 20% for a dose of 6 g/d of betaine. Moreover, betaine acutely reduces the increase in homocysteine after methionine loading by up to 50%, whereas folic acid has no effect. Betaine doses in the range of dietary intake also lower homocysteine. This implies that betaine can be an important food component that attenuates homocysteine rises after meals. If homocysteine plays a causal role in the development of cardiovascular disease, a diet rich in betaine or choline might benefit cardiovascular health through its homocysteine-lowering effects.

Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations
Remethylation of homocysteine to methionine can occur through either the folate-dependent methionine synthase pathway or the betaine-dependent betaine-homocysteine methyltransferase pathway. The relevance of betaine as a determinant of fasting total homocysteine (tHcy) is not known, nor is it known how the 2 remethylation pathways are interrelated. The objectives of the study were to examine the relation between plasma betaine concentration and fasting plasma homocysteine concentrations and to assess the effect of folic acid supplementation on betaine concentrations in healthy subjects. The plasma betaine concentration is a significant determinant of fasting homocysteine concentrations in healthy humans. Overall data indicated folic acid supplementation increases the betaine concentration, which indicates that the 2 remethylation pathways are interrelated.

Betaine in human nutrition
Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary sources include seafood, especially marine invertebrates; wheat germ or bran; and spinach. The principal physiologic role of betaine is as an osmolyte and methyl donor (transmethylation). As an osmolyte, betaine protects cells, proteins, and enzymes from environmental stress (eg, low water, high salinity, or extreme temperature). Databases of betaine content in food are being developed for correlation with population health studies. The growing body of evidence shows that betaine is an important nutrient for the prevention of chronic disease.

Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women
High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is approximately 0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma homocysteine concentrations in healthy adults. Overall data indicate a betaine -rich diet might therefore lower cardiovascular disease risk.

Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects
Betaine is found in several tissues in humans. Betaine is involved in homocysteine metabolism as an alternative methyl donor and is used in the treatment of homocystinuria in humans. In pigs, betaine decreases the amount of adipose tissue. The aim of the study was to examine the effect of betaine supplementation on body weight, body composition, plasma homocysteine concentrations, blood pressure, and serum total and lipoprotein lipids. Overall data showed a hypoenergetic diet with betaine supplementation (6 g daily for 12 wk) decreased the plasma homocysteine concentration but did not affect body composition more than a hypoenergetic diet without betaine supplementation did.

Betaine supplementation decreases plasma homocysteine concentrations
The aim of the study was to examine the effect of betaine supplementation on body weight, body composition, plasmahomocysteine concentrations, blood pressure, and serum total and lipoprotein lipids. Results showed a hypoenergetic diet with betaine supplementation (6 g daily for 12 wk) decreased the plasma homocysteine concentration but did not affect body composition more than a hypoenergetic diet without betaine supplementation did.

Betaine Anhydrous (TMG) for International Customers

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