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Product Details

What is L-Serine?

L-serine is a nonessential amino acid important to overall physical and mental health. It is needed for proper functioning of the brain and central nervous system.

L-serine helps build the phospholipids required to produce cells in the body. It is also involved in muscle formation, RNA and DNA function, fat and fatty acid metabolism and the maintenance of a healthy immune system.

Serine is synthesized from glycine and helps produce cysteine in the body from homocysteine.

It is one of three amino acids that is usually phosphorylated during cell signaling in eukaryotes (Wikipedia). Phosphorylated serine residues are referred to as phosphoserine. Serine proteases are a common type of protease. Serine has sugar-producing qualities and is very reactive in the body. It is highly concentrated in all cell membranes, helping manufacture immunoglobulins and antibodies.

Serine can be made in the body from either glycine or threonine, but its production is dependent on sufficient levels of vitamin B3, vitamin B6 and folic acid.

Serine is crucial in metabolism because it participates in the biosynthesis of purines and pyrimidines, cysteine, tryptophan (in bacteria), in the formation of cell membranes and in creatine synthesis and absorption.

Tryptophan is an amino acid the body uses to manufacture serotonin, a brain chemical. Serotonin levels play a key role in the regulation of mood, appetite, sexual behavior and aggression.

Creatine is an energy source used in the body to develop strength and stimulate muscle growth. It helps build and maintain all the muscles in the body, including the heart.

Serine is an integral component of brain proteins and nerve sheaths, important in the production of cell membranes and in muscle tissue synthesis. It helps make the immunoglobulins and antibodies that support a strong immune system.

Serine is also a constituent of phospholipids that help seal in moisture. It is included as a natural moisturizing agent in numerous skin care products.

Purity and Concentration of L-Serine

This pharmaceutical grade L-serine (more commonly referred to as serine) contains no fillers, taste additives or anti-caking agents.

Potential Side Effects of L-Serine

Side effects are generally rare but can include nausea, indigestion and insomnia. Very high serine levels may cause immune suppression and psychological symptoms such as cerebral allergies. This product is not recommended for women who are pregnant or nursing.

Bioavailability, Mixing and Solubility of L-Serine

Serine has almost no taste and dissolves quickly in water. Mix with water or juice and drink.

How should I store it?

You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.

References & Further Research

Official Journal of the American Journal of Sports Medicine: Effects of phosphatidylserine on exercise capacity during cycling in active males

Wikipedia: Serine

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits. To learn more about DSHEA, visit the FDA Web site.

Tested by Accredited 3rd Party Labs

This PureBulk product is manufactured in a cGMP certified and registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

Supplement Facts & Directions

Supplement Facts

Serving Size: 2000 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
L-Serine 2000mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you recieve.    Please call for exact numbers.

Other Ingredients: None


Free of:  Sugar, Soy, Dairy, Yeast, Gluten & Additives.

Directions:  As a dietary supplement, take 2000mg (level unpacked 1/2 tsp) daily, or as directed by a physician.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.