What is GPR109A?
The KEY to unlocking our understanding of how to prevent along with revert disease, promote health forward, even “anti-age,” and so much more, may lie in GPR109A, a G-protein-coupled receptor spanning all tissues of the body. Specific to each cell, the receptor is meant to remain in direct communication with niacin (the only vitamin B3 in higher life forms: unmodified, immediate release nicotinic acid) – as catalyzed by what have been identified as being folic acid (the sole bioavailable folate representing vitamin B9, contrary to methyl-folates) and N-acetyl-L-glutamine (the precursor for proper exogenous delivery of glutamine, providing acetylation to protect the heat-labile free form of l-glutamine to be available for the body to use) – through the level of its expression reflecting the magnitude of excess, unusable energy (e.g., free radical electrons, inflammation, esterified cholesterol/fats, toxins, heavy metals, xenobiotics, pathogens, reactive oxygen & nitrogen species, cellular debris) and/or the corresponding bioenergetic requirement, for the concurring amount of niacin to bind to and activate it.
By activating GPR109A, harnessed more completely with matching amounts of folic acid and N-acetyl-L-glutamine, a cascade of exergonic reactions is triggered intracellularly in which niacin serving as reactant is anabolized into more complex coenzyme products, the syntheses of which continuing sufficient supply of specifically these three nutrients are responsible, namely nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) – each focal in regulating the balance between energy production and consumption (also known as redox balance) and furthermore the latter in furnishing glutathione for antioxidation – as well as nicotinic acid adenine dinucleotide (NAADP+) for autophagy and phagocytosis in developing endo-lysosomes. Notwithstanding their essentiality for virtually all biochemical reactions involved in fundamental operations such as energy metabolism, anti-inflammation, immune modulation, pathogenic clearance, the manufacture and repair of DNA & RNA, gene signaling & circuitry, circadian rhythm, thermoregulation, and the processing of biochemically vital precursors including folic acid and N-acetyl-L-glutamine (recursively fueling their respective assembly from niacin as precursor), a persistent lack of counter to the evidently age- and illness-related decline in the availability of NAD+, NADP+, and NAADP+ consequently causes impairment in cellular function to compound.
In this fashion, the biosynthesis of these regulatory coenzymes is contingent on preserving GPR109A modulation, or analogously, in tune with ample folic acid and N-acetyl-L-glutamine, how adequate niacin remains in its agonism of GPR109A and in turn GPR109A does in its expression to niacin forward. Niacin directly binding to GPR109A leading to bigger coenzyme molecules producing bestows the host with potential energy at no cost, i.e., without investment for such work as would alternatively be the case with for instance, engagement in physical activity. Subsequently, this energy resulting from niacin executing these exergonic moves via GPR109A activation can be coupled chemically to enhance the efficiency and capacity of cellular bioenergetics by enabling cells to use less substrates while generate more ATP (the universal energy currency), and/or simultaneously, it can be utilized as a proton-motive force to power extinguishment and release out the body of excess, unusable energy, an action which is tangibly experienced as the harmless and in fact therapeutic red flush sensation and as would be expected, most prominently upon each of the first few doses given the greatest accruement of exergy incoming to commencing supplementation, provided single dose sizes are high enough (typically at least 500 mg of niacin, or two GPR109A capsules, for average-sized adults) to reach concentrations in the body for niacin to start activating its GPR109A receptor.
Excessive energy accumulating throughout the nooks and crannies of the body places intensifying strain on how favorably ATP can be formulated and with this, governs progression in the deterioration of cells. Because they have repeatedly been shown to be determined independently by the levels of intake in niacin, folic acid, and N-acetyl-L-glutamine, what are colloquially termed biomarkers into health conditions and chronic diseases may just represent the myriads of combinations of clinical manifestations emerging and evolving as engrained functions of progressively unaddressed, growing voids in particularly these three nutrients over the life course. Rather than permitting the accruement in bioenergetic dysfunction that unravels as a result, the course of diseases potentially in their entirety can be averted and even turned around readily. Accordingly, the biological process of aging itself now has the opportunity to be reversed. By promoting more efficient utilization and disposal of energy dynamically transferred in, out, and through the body, maintaining ubiquitous equilibrium in the expression and activation of GPR109A might literally embody the instruction manual for attaining and sustaining homeostatic function and peak performance in a living organism system.
Considering that the growing body of relevant literature as of more recently has elucidated the impossibility for diet to provide adequate quantities of exclusively niacin, folic acid (note: required along with these two others for its conversions to active folates, most especially among individuals with associated genetic variations), and N-acetyl-L-glutamine to retain steady state in the regulation of GPR109A over aging or in the face and aftermath of health challenges, the insufficiencies of other micronutrients are likely occurring downstream in addition to disruptions in the metabolism of macronutrients, ergo replenished by intervening appropriately, of course once having disentangled this temporality. No epidemiologically comparable influence exists for alternative remedies ranging from but not confined to supplements, homeopathies, over-the-counter or prescription medications, and diet plans outside of a well-balanced diet and clean (preferably distilled) water. Instead, with greater or more prolonged insufficiency in niacin, folic acid, and N-acetyl-L-glutamine, administering foreign agents often has been documented to induce harm whilst hindering the mechanisms of GPR109A and exasperating the requirement for the three nutrients that do appear to be obligatory for supplementation. Taking into further account the distinct yet complementary roles evidenced solely for these three nutrients ideally at stoichiometrically-determined ratio together in modulating GPR109A and their collaborative ability to fine-tune energy homeostasis along with the associated benefits, our GPR109A product not only synthesizes but aims to advance fusion of such significant science with high impact by premiering a blend intending to offer precise combination of the three nutrients indispensable to supplement daily for supporting the restoration into maintenance thereafter of optimal health and functioning.
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GPR109A is not just a product. It blossomed from a critical mission for society. Proceeds from every bottle purchased go to aiding HOM3OSTASIS.com, an up-and-coming 501(c)(3)-registered nonprofit public charity organization that seeks to educate and empower communities to take charge of their wellness by accompanying the donations of our supporters with site membership to keep patrons dynamically equipped with valid and consistent dissemination of health-related information. HOM3OSTASIS offers a unique and focused approach in guiding our members by combining cutting-edge research, personalized communication, and community support.
Dmitry Kats, Ph.D., M.P.H.
As founder and CEO, Dr. Dmitry Kats (scholar.google.com/citations?user=oRnx2NUAAAAJ), comes as a highly accomplished epidemiologist, biostatistician, mathematician, and physical chemist with a genuine desire for transitioning his skills into maximizing the health of individuals and populations. Dmitry holds a Ph.D. in Epidemiology from the University of North Carolina at Chapel Hill and a M.P.H. in Biostatistics from the University of South Florida, as well as degrees in Mathematics from Xavier University in Cincinnati, Ohio (to where he and his brother with classical autism emigrated from the Soviet Union) and Physical Chemistry from Tulane University.
Dr. Kats’ Journey
While leading interdisciplinary teams through influential public health projects, Dr. Kats has published various papers into top peer-reviewed medical journals on important topics in aging, leading to his groundbreaking implementation of exceedingly advanced statistical models designed to permit unbiased, causal inference equipped with only observational assessment across decades in aging adults, which culminated into unearthing the thermodynamic nature underlying the etiology and governing the pathologic development of disease and the construct of unhealthy aging. Interwoven in all this was identification of a causative intersection for primarily niacin ultimately into the promise of its pharmacologic application to mitigate these disabling processes. Despite working under the pressure of a global pandemic unfolding that since mid-2020 made it mandatory for Dr. Kats to wear a digital clinician-like hat for reliable data, these dedicated tracking efforts led to the development of trajectory reports in perhaps millions of individuals across the world that are still being collected and incorporated into analyses to this day.
As profound and consistent of a punch niacin threw in at least 95% of the population for the remainder of 2020, the baseline deficiency in grew unaddressed with each consecutively incoming cohort thereafter. Per continued surveillance, it became imperative to confirm what components may be and were indeed needed to supplement alongside niacin to maximize its performance through GPR109A or, as in worse cases who at the time were likely mirroring corresponding degrees of downregulation in the expression of GPR109A, what very same components had depleted and eventually exhausted in proportion to the compounding void in niacin, all of which thereby as a whole, once identified and affirmed, became absolutely necessary to restore for the expression of GPR109A for niacin and not to mention, for the recovery to utmost health of countless globally. Operating at accelerated and intensified pace over these last few years, investigations fortunately eventually gave rise to folic acid and N-acetyl-L-glutamine, the missing pieces in harmony with niacin in activation of GPR109A to complete the puzzle.
Dr. Kats treasures having acquired multifaceted skills and insights from his elite scientific training and extensive experience in research, collaboration, product design, teaching, and outreach service. Having already established himself as a pioneer in the health sciences, Dmitry persists ambitiously humble while boldly passionate in his commitment towards advancing knowledge, understanding, and successful application stemming from the veracity of his discoveries to as many people as possible into making a truly everlasting difference.
For this reason, Dr. Kats has partnered with PureBulk, a leading manufacturer and supplier of the verified finest-quality, commercially and internationally available, pure nutrient supplements, to release GPR109A as a convenient, all-in-one product, delivering niacin precisely fused with relevant amounts of folic acid and N-acetyl-L-glutamine to uphold modulation of the GPR109A receptor, after which it was named, in the fine-tuning of energy metabolism to reap its gifts. Like Dmitry, PureBulk prides itself on providing you the truth and nothing else, ensuring no fillers and that all product is produced in a cGMP & FDA registered facility and undergoes meticulous third-party laboratory testing for compliance, safety, and purity before being sold.
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