|Amount Per Serving||% Daily Value*|
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.
Other Ingredients: None
Free of: Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.
Directions: As a dietary supplement, take 3000 mg (3/4 tsp) twice daily, or as directed by a physician.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.
L-Citrulline, also truncated to citrulline, is an amino acid named after the Latin word Citrullus, meaning watermelon. Doctors named and described the compound as early as the late 19th century, but researchers didn’t isolate citrulline until 1914. They obtained the culture from a watermelon, hence its name.
Citrulline didn’t garner much attention until 1930, when scientists established it as an α-amino-δ-carbamidovaleric acid. By 1932, researchers discovered citrulline is a critical component of the urea cycle, facilitating the excretion of ammonia by converting it into urea. The cycle starts with arginase enzymes converting l-arginine into ornithine. Ornithine enzymes use carbamoyl phosphate as a cofactor to synthesize l-citrulline. The enzymes use ammonia to complete this process, thereby decreasing ammonia while increasing urea.
Citrulline also plays a role in the nitric oxide cycle. The body can recycle citrulline to create more arginine. Citrulline binds to l-aspartate to produce arginosuccinate, which enzymes break down into fumarate and arginine. Nitric oxide synthase enzymes catalyze this process to produce more nitric oxide.
Citrulline’s efficiency at increasing arginine bioavailability and synthesizing nitric oxide often outperforms direct arginine supplementation. Nitric oxide is a vasodilator that also possesses antioxidant and anti-inflammatory properties. It relaxes blood vessels to increase blood flow and the delivery of nutrients and oxygen to muscle tissue. Nitric oxide also plays a role in protein synthesis and building lean muscle. Nitric oxide is critical for men’s sexual function, but its production and bioavailability decrease with age. Boosting nitric oxide levels may support sexual health in men.
Blood vessels need nitric oxide to help smooth muscles relax. Nitric oxide also widens blood vessels for improved blood flow. Vasodilation has a strong correlation with enhanced exercise performance. It also supports heart health by reducing arterial resistance.
Citrulline may help improve exercise performance and reduce muscle soreness after exercising. It fuels muscles by boosting nitric oxide production to increase blood flow for greater oxygen and nutrient delivery. Muscles work more effectively when oxygenated and replenished. Taking NO boosting supplements like citrulline may allow individuals to work out harder for longer. Citrulline also helps build lean muscle by stimulating protein synthesis and preventing the breakdown of amino acids that also help build muscle. Citrulline also clears away waste products that contribute to muscle fatigue. Studies have noted that citrulline supplements effectively reduced the participants’ rate of perceived exertion during workouts. One study reported that citrulline supplements reduced the participants’ muscle soreness by 40%.
Citrulline malate is citrulline combined with malic acid. Malate is a critical component of the citric acid cycle (CAC). CAC is a critical pathway that connects the metabolism of carbohydrates, fats, and proteins. It produces adenosine triphosphate (ATP), the primary source of energy that powers all cellular processes.
Most individuals can take citrulline supplements without experiencing side effects. Studies using doses as high as 15g reported no adverse effects. However, excessively high doses don’t yield better results, and there are no studies on the long-term effects of ingesting such high amounts of citrulline supplements. Citrulline may interact with certain medications. Individuals taking medications for heart conditions or erectile dysfunction should not take citrulline supplements. Consult with a physician before taking any new supplements.
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.