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What is Choline Bitartrate?

Choline Bitartrate is a water-soluble B vitamin that's categorized as a lipotropic, which means it functions by helping the liver transport and eliminate fat. Lipotropics like Choline Bitartrate support overall function and health of the liver by converting the transported fat for additional energy. A member of the Vitamin B complex and classified as a lipotropic, or fat emulsifier, choline may be beneficial in strengthening the liver and also in keeping cholesterol buildup at bay, and aiding the treatment of memory loss and Alzheimer's. Additionally, it works with the body to synthesize numerous substances and compounds that are essential for the well-being of cell membranes. Although can be produced in the human body, natural quantities are often insufficient making choline supplementation necessary. Choline (especially in lecithin form) is a basic dietary component and is present in many fat and protein-containing foods which include egg yolk, legumes, wheat germ, peanuts, and organ meats. Bitartrate is coupled with choline to speed up and significantly improve the absorption rate within the human body. This component of food is usually found in the fatty portion of the cell membrane (phospholipids).

Choline works closely with B-vitamins in helping with brain and memory development. It is found as phosphatidylcholine (lecithin) in cell membranes and the covering of nerve fibers (myelin sheath), and it is believed to influence for muscle contractions, coordination and movement. Eggs, legumes, liver, cauliflower, spinach, soybeans, lettuce, wheat germ, butter, banana, oranges, potatoes, tomatoes, sesame seeds and peanuts are the excellent natural sources of Choline. Even though it can be obtained in some foods and our body can produce some choline we should still take dietary supplements to maintain the normal function of the cell activity, liver function and transporting nutrients throughout the body because we don't always get adequate amounts of Choline from our diet. Experts recommend taking Choline supplements at the right time and right amount to help the nervous system stimulates muscle cells. Bitartrate is added to the Choline for fast absorption within our body.

Aside from helping the liver transport lipids, Choline Bitartrate prevents the liver from collecting excessive cholesterol and fats that can pose a threat to our systems and overall health. Choline Bitartrate works with the central nervous system to enhance nerve impulse transmissions, cell communications and help manage optimal muscle functioning. Choline Bitartrate is of paramount importance in brain and nerve functions, as it plays a crucial role in producing the neurotransmitter acetylcholine, which in turn is responsible for things such as appetite, behavior, memory and mood. Furthermore, it contains antioxidant properties that trigger and stimulate the growth, development, repair and preservation of our glands, organs and tissue. Since Choline Bitartrate helps to protect the liver, it can decrease a person's risk of degenerative kidney disease and cirrhosis. It's also thought to be of value when it comes to preventing conditions like Alzheimer's, Huntington's and Tardive dyskinesia.

What is Choline Bitartrate used for and who uses it?

Studies show that Choline Bitartrate is a memory enhancer that helps you in analytical reasoning and creativity, maintains normal function of cell activity, breaks down fats, can increase physical endurance, promotes the production of acetylcholine, amino acids and proteins, improves cognitive function and proven to support the nervous system activity. It has been used experimentally to help improve neuromuscular function in Alzheimer's disease. It also improves the effectiveness of lithium in the treatment of manic depression. If the amount of your Choline level is far too low you must take Choline Bitartrate supplement especially if you are running a marathon or if you exercise for more than 2 hours to maintain proper health because Choline deficiency has been co-related to stress, fatigue, insomnia, poor ability of the kidneys to concentrate urine, problems with memory, and nerve-muscle imbalances. Since it came from B vitamin family, deficiency in Choline can cause deficiency of another B-vitamin (an essential nutrient).

Choline is an essential nutrient required by the body to make several important compounds necessary for healthy cell membranes. This nutrient helps form phosphatidylcholine, the primary phospholipid of cell membranes. Choline is also the precursor and an integral part of acetylcholine, a stimulatory neurotransmitter and one of the crucial brain chemicals involved in memory essential for proper functioning of the nervous system as it aids the flow of electric current. Choline is also used to assist fat and cholesterol emulsification and transport, and it also helps in the production of lipotropic agents which converts fats into useful products and aids in the production of HDL (good) cholesterol. A major use of choline in the body is the formation of betaine, an important methyl donor. Furthermore, choline helps transport of lipids from the liver. This choline supplement is pharmaceutical grade choline bound to tartaric acid, making it easier to absorb.

How pure is your Choline Bitartrate?

This Purebulk Choline Bitartrate is measured by the manufacturer to be 99.83% pure. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing a white crystalline powder product. It contains no fillers, taste additives, or anti-caking agents. Choline bitartrate is a B vitamin that is soluble in water produced by the body in very low quantities, therefore, should be obtained through diet or supplements. Foods that contain choline bitartrate include egg yolks, peanuts, wheat germ, legumes and organ meats. Choline bitartrate is known to benefit circulation and coordination, as well as higher-level brain functions such as thought, the intellect and memory. It is also essential for the structural integrity of cell walls, and aids in the production of amino acids and proteins. Choline Bitartrate benefits body weight loss as well as it aids in the metabolism of fats, and it can also help treat Parkinson's disease, Alzheimer's disease, and manic depression. Although the human body creates choline, you must take extra or additional amounts to ensure you get the most out of this nutrient.

How important is Choline Bitartrate?

Choline deficiency may contribute to liver degeneration and hardening of the arteries. Choline is not technically a vitamin B, but it is often included in the family of B vitamins, because it works intimately with other B vitamins, particularly folic acid (vitamin B9) and cobalamin (vitamin B12) to treat fat and keep the heart and brain healthy. Choline is also necessary for improving the gallbladder and liver functions, the formation of lecithin, production of hormones, and central nervous system regulation as well.

Choline produces acetylcholine, an important neurotransmitter critical for brain and memory functions. In fact, scientists are now looking into the potential of choline in aiding the treatment and even prevention of diseases that affect the brain and central nervous system such as Parkinson's and Alzheimer's (people of Alzheimer's typically have low levels of acetylcholine in the brain). Recent studies also indicate that is also important to the proper functioning and brain health of the newborns. Choline keeps the liver healthy by excreting or transporting fat from the liver to body cells. Choline produces PC (phosphatidylcholine), which is essential for the manufacture of the fatty substance that is used to form cell membranes and phosphatidylcholine may in turn be used by the body as a source of choline (in Germany, doctors sometimes administer phosphatidycholine to treat hepatitis or liver damage).

What are some of the common effects of Choline Bitartrate?

Choline is used to make acetylcholine, a neurotransmitter essential for normal muscle function. Prolonged exercise will deplete choline levels which in turn, results to a weakened state and lower physical output. Several studies have demonstrated that choline supplementation is of particular use to endurance based athletes, especially those who may exercise for 2 or more hours. Choline has numerous other functions in the human body ranging from promoting the structural integrity of cell walls, up to the synthesis of amino acids and proteins. Choline is also closely linked to neurological function and can help improve movement, coordination, and muscle contraction.

Choline Bitartrate is also known to help in the metabolism of fat by increasing the mobilization of fatty acids, which in turn results to weight and body fat loss. It is widely used as part of a weight control program, and also controls fat and cholesterol build up in the body. Choline Bitartrate prevents fat accumulation in the liver, and helps move fats in the body cells. As a fat emulsifier that "melts" cholesterol so that it doesn't cling to arterial walls, Choline Bitartrate works as a lipotropic fat burner that helps the body eliminate fat in areas that are normally hard to lose weight, such as the hips, stomach and thighs.

Taste, solubility, and daily suggested dose of Choline Bitartrate

There is no Recommended Dietary Allowance (RDA) for choline since a lot of people obtain this from dietary sources ranging between 300 to 1000 mg per day of food, which seems to be sufficient to prevent deficiency. Adequate daily intake is 425 mg for adult women (450 mg during pregnancy and 550 mg if nursing), and 550 mg for adult men. Because choline has been associated with brain development in newborns, all pregnant women and nursing must be sure to get plenty of choline in their diet by eating lots of foods rich in lecithin, such as rice, eggs, red meat, liver, cabbage, cauliflower, soybeans, chickpeas, lentils, beans, peas, and soy lecithin. Lecithin is also a common food additive used in ice cream, margarine, mayonnaise and chocolate bars to help bind the fat in these foods with water.

This pure bulk nutritional powder is soluble in water and slightly soluble in alcohol. A level teaspoon of Choline Bitartrate is approximately 2.65 grams and a slightly rounded teaspoon will be roughly 3 grams. You can see the full bulk density/volumetric conversion chart for Choline Bitartrate here. For both strength and endurance athletes during intense training periods, 1000 mg of choline daily is recommended.

The best way to prepare this Choline Bitartrate powder is to mix 1/3 level teaspoon one to three times daily on your favorite juice drink or in other beverage. To get the right amount of Choline Bitartrate you must only take the daily recommended dosage to maintain good health.

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

What kind of results do people anticipate while taking Choline Bitartrate?

Choline is a dietary component available in a wide variety of protein and fat containing sources. It works as a cell-signaling molecule, as a precursor of acetylcholine, and adds structural integrity of cell membranes. Very similar to tyrosine, choline diet is an effective neurotransmitter precursor and is also responsible for the production of another neurotransmitter, acetylcholine. Acetylcholine is released into the brain and the neuromuscular junction and is responsible for many physiologically important events.

In trained endurance athletes, plasma choline concentrations can decrease by as much as 40% during training or competition. These reductions in blood choline could lead to a decline in the synthesis of acetylcholine (as indicated above) and therefore focus, memory and performance will all be negatively affected. Choline supplementation can replenish these reduced concentrations of choline in the blood.

Thanks to its effects on brain levels of acetylcholine, choline supplementation may improve memory in healthy subjects and in rats. Additionally, choline, together with supplements that help maximize and extend the effects of acetylcholine at the neuromuscular junction, may improve neuromuscular transmission. Since dietary lecithin can increase plasma choline concentrations and is better tolerated than choline, an alternative is to supplement with lecithin rather than choline itself.

Precautions and Potential side effects of Choline Bitartrate

Typical side effects of ingested choline include an increase body temperature and sweating. Nausea and loss of appetite may result from very high doses. Most people notice that they focus more and more active, while others report a more positive side effect of choline for its help with erectile dysfunction. Supplementation for healthy pregnant and breastfeeding women is NOT recommended. While Choline supplements are available at health-food stores, if you suspect you have poor liver function make sure you are under medical care and discuss these supplements with your doctor before taking them.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Choline Bitartrate is used in the following Proprietary Formulas

You can find choline as part of phosphatidyl choline (lecithin), choline chloride, CDP-Choline, choline bitartrate, choline inositol combination, etc., and in common brand names such as Diet Rx, Optimum Opti-Men, Universal Animal Pak, Universal Uni-Liver, NOW ADAM, BrainQuicken BodyQuick, Absolute Nutrition Thyroid T-3, ASN Affinity Complete, Bayer HealthCare Flintstones Complete, Beverly Int. Lean Out, Biochem Ultimate Fat Metabolizer, BrainQuicken BodyQuick, Cardio Fire Cardio Fire 2Go, Eclipse 2000 Natural Mass Pack, Eight Ball Nutrition VitaEDGE SPORT, Enyotics Health Science Focus Fast, Enzymatic Therapy Liv-A-Tox, Everlast Focus, Factor Nutrition Labs ACAIfactor, Femme Slender Couture Curves, Get Diesel JP8, Health Plus Blood Cleanse, Healthy 'N Fit Advanced Fat Metabolizing Nutrients, KAL Coenzyme B-Complex, MuscleTech Hydroxycut Hardcore X RTD, NOW B-100 Caps, NOW Choline & Inositol, Schiff Vitamin B Complex, Solaray Lecithin Granules, Twinlab Amino Fuel Liquid, Ultimate Nutrition Super Vitamin B-Complex, Universal Animal Pak, Universal Uni-Liver

References & Further Research

Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally
The synthesis of brain phosphatidyl choline may utilize three circulating precursors: choline; a pyrimidine (e.g., uridine, converted via UTP to brain CTP); and a PUFA (e.g., docosahexaenoic acid); phosphatidylethanolamine may utilize two of these, a pyrimidine and a PUFA. We observe that consuming these precursors can substantially increase membrane phosphatide and synaptic protein levels in gerbil brains. Alzheimer's disease brains contain fewer and smaller synapses and reduced levels of synaptic proteins, membrane phosphatides, choline and DHA. The three phosphatide precursors might thus be useful in treating this disease.

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
ackground: Elevated concentrations of homocysteine in blood may be an independent risk factor for the development of atherosclerosis. Elevated homocysteine concentrations can be caused by decreased methylation of homocysteine to form methionine, as occurs in folate deficiency. A parallel pathway exists for methylation of homocysteine, in which choline, by way of betaine, is the methyl donor. Objective: Our goal was to determine whether choline deficiency results in a decreased capacity to methylate homocysteine. Conclusion: These results suggest that choline, like folate, plays an important role in the metabolism of homocysteine in humans and that response to a methionine load may be useful when assessing choline nutriture.

Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study
A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction. The patients included also suffered from moderate to mild disturbances of consciousness, and all were admitted within 14 days of the ictus. Patients were allocated randomly to treatment with either CDP-choline (1,000 mg/day i.v. once daily for 14 days) or with placebo (physiological saline). One hundred thirty-three patients received CDP-choline treatment, and 139 received placebo. The group treated with CDP-choline showed significant improvements in level of consciousness compared with the placebo-treated group, and CDP-choline was an entirely safe treatment.

Choline in the treatment of rapid-cycling bipolar disorder: clinical and neurochemical findings in lithium-treated patients
This study examined choline augmentation of lithium for rapid-cycling bipolar disorder. Choline bitartrate was given openly to 6 consecutive lithium-treated outpatients with rapid-cycling bipolar disorder. Five patients also underwent brain proton magnetic resonance spectroscopy. Five of 6 rapid-cycling patients had a substantial reduction in manic symptoms, and 4 patients had a marked reduction in all mood symptoms during choline therapy. The patients who responded to choline all exhibited a substantial rise in the basal ganglia concentration of choline-containing compounds. Choline was well tolerated in all cases. Choline, in the presence of lithium, was a safe and effective treatment for 4 of 6 rapid-cycling patients in our series. A hypothesis is suggested to explain both lithium refractoriness in patients with bipolar disorder and the action of choline in mania, which involves the interaction between phosphatidylinositol and phosphatidylcholine second-messenger systems.

Choline Bitartrate for International Customers

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