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Click to Enlarge Unit Weight: 1500 grams Unit Volume: 2750 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is Gamma Aminobutyric Acid (GABA)?

GABA is another name for the nonessential amino, Gamma-Amino Butyric Acid. First discovered in 1883 in Berlin, GABA is formed from glutamic acid with the help of vitamin B6, and is the most important and widespread inhibitory neurotransmitter in the brain since is found in almost every region of it. In human physiology, a neurotransmitter is characterized as a substance that facilitates the network of communication between nerve cells in the central nervous system (CNS). Just like the amino acids aspartate, glutamate, and glycine, GABA is also another amino acid that is critical in brain functioning. With respect to brain chemistry and brain health, GABA may be among the most important of all nonessential nutrients.

GABA is synthesized in the body from another amino acid, glutamic acid. Through the action of the enzyme glutamic acid decarboxylase (GAD), which catalyzes the formation of GABA from glutamic acid, GABA is formed. GAD requires vitamin B6 (pyridoxal phosphate) as a coenzyme, which can be utilized to control and manage the levels of GABA. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system responsible for blocking the transmission of an impulse from one cell to another.

Simply put, GABA’s main purpose is to prevent the over-firing of the nerve cells and to decrease overall neuron activities occurring within the CNS. It is also utilized by the brain to stimulate calmness and tranquility via brain metabolism. This may prove extremely beneficial as compared to other medications due to the addictive attributes of many prescribed “tranquilizing” drugs (benzodiazepines), to those suffering from certain forms of restlessness and/or anxiety. It is also equally critical in mediating muscle activities, and in the triggering of certain glands located throughout the body. GABA can help promote normal brain function by helping to block stress-related messages from reaching receptor sites in the central nervous system. GABA helps minimize feelings of anxiety, and may be beneficial in alleviating and ultimately treating treatment of disorders linked to emotional stress, such as reduced sex drive and hypertension.

The production and synthesis of GABA is limited and controlled by B-vitamin compounds, particularly B6. In line with this, to ensure adequate GABA levels, anyone who needs it should strive for various food sources high in both protein and vitamin B6. This will ensure a sufficient supply of nutrients required to manufacture this vital amino acid. Due to its many chemical reactions in the brain, GABA is often times viewed by scientists more as a neurotransmitter rather than as an amino acid. GABA is abundant in several food sources, with the richest concentrations being in fish (particularly. mackerel) and wheat bran.

What is Gamma Aminobutyric Acid (GABA) used for and who uses it?

There have been numerous clinical studies done on GABA to reveal its therapeutic effects in relation to human physiology. Supplementation with GABA has demonstrated promise in promoting relaxation and sleep. Other studies have shown GABA supplementation to be beneficial in assisting with chronic pain and preventing seizures. This nonessential amino has also been tested and studied for enhancing exercise tolerance, reducing body fat, and keeping blood pressure within healthy limits. Many prescribed and commercial sleep medications aim at GABA receptors in the brain. Because of this, these medications pose a problem that stems from dependency that may develop as a direct result of the misuse and abuse of such drugs. Research and trials confirm that GABA is often recommended by physicians because it has been proven to be non-habit forming. Although GABA does not promote sleep by causing drowsiness by itself, the reduction in anxiety that it provides may make it easier for sleep sufferers to rest.

GABA functions as a neurotransmitter in the central nervous system, controlling neuron activity thus preventing and inhibiting them from overfiring. With niacinamide (B3) and inositol, GABA is essential for brain metabolism, and it prevents anxiety and stress-related messages from reaching the motor centers of the brain. This blockage of anxiety and stress related impulses (stressors) from getting near the motor centers results to mood-elevating effects. This is especially critical because a continued stress factor may be a main factor in the development of clinical depression. In relation to stress, chronic pain may also be directly attributed to lower levels of GABA. Because of its natural anti-stress attributes, GABA may reduce the intensity of pain and also be crucial in alleviating pain-related nerve impulses.

GABA has been used in treating clinical depression, manic-depressive (bipolar) disorder, seizures, premenstrual dysphoric (feeling depressed) disorder, and anxiety. As an inhibitory neurotransmitter that blocks the transmission of an impulse from one cell to another in the central nervous system, GABA also serves in improving sleep cycles which yields to more restful sleeping and better health. GABA also has powerful stabilizing effects on blood pressure, and is a very effective analgesic, eliminating pain from chronic conditions such as arthritis and lower back pain.

GABA has been used in the treatment of both epilepsy and hypertension where it is believed to induce tranquility in individuals who have a high activity of manic behavior and acute agitation. GABA brain levels may affect seizure activity in individuals with epilepsy because GABA appears to prevent nerve cells in the brain from firing and setting off seizures. In the United States, GABA analog gabapentin has been approved for the treatment of epileptic seizures and post-herpetic neuralgia. GABA supplementation may also be beneficial for people suffering from Attention Deficit Hyperactivity Disorder (ADHD), PMS in women, and a depressed sex drive in both sexes. Current findings are promising, although more research is still needed to ascertain and substantiate these claims.

How pure is your Gamma Aminobutyric Acid (GABA)?

This pharmaceutical grade pure bulk powder amino acid GABA (Gamma-AminoButyric-Acid) is assayed by the manufacturer to be 99.89% product. You will receive a sealed and labeled heavy-duty 4 mil polyethylene bag containing this fine white powder product. GABA in essence functions as a tranquilizer in the body, with effects similar to those of prescription drugs such as Valium and other tranquilizers minus the side effects. Because GABA helps to subdue the firing of nerve cells in the brain, it may be useful for treatment of disorders thought to be linked to over stimulation of the brain's motor centers, such as epilepsy and attention deficit disorder. Studies also suggest that it may help treat alcoholism by minimizing alcohol cravings. GABA can benefit individuals with enlarged prostate glands as well, as this amino acid plays a key role in balancing and regulating levels of sex hormones in the body. Research have also confirmed that GABA actually increases human growth hormone (HGH) levels in the body, which consequently leads to increased muscle mass and decrease in overall body fat. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health and therapeutic benefits made possible with Gamma Aminobutyric Acid (GABA), buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What is the daily suggested dose of Gamma Aminobutyric Acid (GABA)?

Recommended daily allowances (RDAs) are defined as the levels of intake of essential nutrients that the Food and Nutrition Board judges to be adequate to meet the known nutrient needs of most healthy persons. Specific recommendations for each vitamin depend on age, gender, and other factors (such as pregnancy). However, an RDA (Recommended Daily Allowance) has not been established for GABA. The usual recommended dosage for GABA is 3 to 5 grams. You can see the full bulk density/volumetric conversion chart for Gamma Aminobutyric Acid (GABA) here. Although some studies have used doses as high as 18 grams, you should proceed with caution when taking large doses of GABA. Most people start by taking about 1/2 gram per dose 3 times per day for a week and then increase their dose to 1 to 8 grams per dose thereafter. Too much GABA may actually increase feelings of anxiety, and has been reported to cause numbness, tingling, and shortness of breath. In addition, abnormal levels of GABA may also induce seizure activity in some individuals.

Some doctors recommend GABA in the amount of 2 grams four times daily. Doses of GABA as high as 5 grams per dose are recommended within hard-core bodybuilding circles to stimulate spikes in plasma growth hormone levels, but smaller doses of 1-2 grams are probably more realistic. One teaspoon will supply approximately 2866 milligrams, or just about 3 grams for the bulk density of this GABA powder. Again you can see the full bulk density/volumetric conversion chart for Gamma Aminobutyric Acid (GABA) here. Doses are typically taken on an empty stomach prior to sleep. Getting a good night's sleep and obtaining more rest while increasing fat loss and promoting muscle growth with the help of GABA can lead to more energy and vigor throughout the day.

What kind of results do people anticipate while taking Gamma Aminobutyric Acid (GABA)?

The main purpose of GABA is to induce and trigger relaxation, analgesia, and sleep. Excitation in the brain must be countered and balanced with inhibition, as too much excitation can result to restlessness, irritability, insomnia, and even seizures. It is through this mechanism that barbiturates and benzodiazepines are able to induce relaxation, by stimulating GABA receptors. Several neurological disorders, such as epilepsy, sleep disorders, and Parkinson’s disease are directly influenced by this neurotransmitter. In addition, GABA can also trigger and stimulate fat loss by promoting the synthesis of Human Growth Hormone (HGH). HGH, through its powerful muscle-building effects, has been found in studies to facilitate the metabolism of fats in the body.

Deficiency, Precautions, Toxicities, and Potential side effects of Gamma Aminobutyric Acid (GABA)

A deficiency of GABA has also been linked to depression. Some people with anxiety and panic disorders may not manufacture sufficient levels of GABA. GABA appears to be safe at recommended doses, and there are no negative side effects possible with the use of GABA. However, at high doses, GABA can actually increase anxiety and insomnia. It may also cause numbness around the mouth and tingling in the extremities, mild nausea, a slight shortness of breath that lasts for a few minutes and temporary tingling of the skin. In extreme cases, GABA may cause a chemical imbalance in the brain, resulting in seizures. Toxicities, however, remain extremely rare.

One point to keep in mind is that the body needs a supply of all the amino acids in order to effectively create and utilize proteins so if you intend to supplement any of the amino acids it is of paramount importance that you have a balanced intake of all the other amino acids. Being deficient in even one amino acid will lower the efficiency of all the other amino acids in your body. People with liver or kidney disease should not take this or any other amino acid supplement without first consulting their physician. Getting too much of any one amino acid can throw the citric acid cycle out of balance, which makes the liver and kidneys work harder to eliminate toxins.

Taste, solubility, and suggested preparation of Gamma Aminobutyric Acid (GABA)

This product dissolves quickly in water and has almost no taste. Just mix your usual dose with water or juice and drink. If you haven't taken GABA previously, consult your physician or health practice professional before taking. You may feel a slight tingling effect after taking but this is normal.

Gamma Aminobutyric Acid (GABA) is used in the following Proprietary Formulas

Controlled Labs White Flood, Fountain Of Youth HGH Complete, Goliath Labs Ejaculoid, Muscle Pharm Bullet Proof, Controlled Labs REDuction PM , AST GABA, Dymatize GABA, Higher Power GABA Powder, NOW GABA, Supplement Direct GABA, Ultimate Nutrition GABA, Ageless Foundation UltraMAX Gold, BigNutrition PowerTrip, Brain Pharma Happy Dreams, Champion Sleep Aid, Controlled Labs REDuction

References & Further Research

Relaxation and immunity enhancement effects of gamma-aminobutyric acid administration in humans
The effect of orally administrated gamma-aminobutyric acid on relaxation and immunity during stress has been investigated in humans. Two studies were conducted. The first evaluated the effect of GABA intake by 13 subjects on their brain waves. After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to see the role of relaxant and anxiolytic effects of GABA intake on immunity in stressed volunteers. Overall data showed GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.

Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
We investigated the blood-pressure-lowering effects of gamma-aminobutyric acid and a GABA-enriched fermented milk product (FMG) by low-dose oral administration to spontaneously hypertensive (SHR/Izm) and normotensive Wistar-Kyoto (WKY/Izm) rats. A single oral dose of GABA or FMG (5 ml/kg; 0.5 mg GABA/kg) significantly decreased the blood pressure of SHR/Izm from 4 to 8 h after administration, but did not increase that of WKY/Izm rats. The hypotensive activity of GABA was dose-dependent from 0.05 to 5 mg/kg in SHR/Izm. During the chronic administration of experimental diets to SHR/Izm, a significantly slower increase in blood pressure with respect to the control group was observed at 1 or 2 weeks after the start of feeding with the GABA or FMG diet respectively and this difference was maintained throughout the period of feeding. The present results suggest that low-dose oral GABA has a hypotensive effect in SHR/Izm and that the hypotensive effect of FMG is due to GABA.

A role for GABA mechanisms in the motivational effects of alcohol
Low doses of ethanol have been hypothesized to act directly via proteins that form ligand-gated receptor channels, such as the gamma-aminobutyric acid (GABA) receptor complex, to allosterically alter function, particularly in specific brain areas such as those hypothesized to be involved in ethanol reinforcement. At the pharmacological level, one can antagonize the effects of ethanol with GABA antagonists, particularly its sedative, anxiolytic-like and acute reinforcing actions. Brain sites involved in the GABA ergic component of ethanol reinforcement include the ventral tegmental area, elements of the extended amygdala (including the central nucleus of the amygdala), and the globus pallidus. Chronic administration of ethanol sufficient to produce dependence and increased ethanol intake are associated with increased GABA release in the amygdala and increased sensitivity to GABA agonists. A hypothesis is proposed that GABA ergic interactions with the brain stress neurotransmitter corticotropin-releasing factor in specific elements of the extended amygdala may be an important component for the motivation for excessive drinking associated with the transition from social drinking to addiction.

Gamma Aminobutyric Acid (GABA) for International Customers

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