|Amount Per Serving||% Daily Value*|
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.
Other Ingredients: None
Free of: Soy, Dairy, Yeast, Gluten & Additives.
Directions: As a dietary supplement, take 700 mg (3/16 tsp) up to three
times daily on an empty stomach, or as directed by a physician. Accurate gram weight scale recommended.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. DO NOT use if you are taking MAO's, blood pressure or erectile dysfunction medication (such as Viagra). DO NOT use if you have a herpes infection or cold sores. Keep out of reach of children.
L-arginine base powder is a free form of L-arginine, an amino acid that is a component in many proteins. It is a central part of the urea cycle, a process that allows the body to dispose of excess ammonia. Arginine is also the precursor to creatine, glutamate (the precursor to glutamine), and proline. Arginine is usually a non-essential amino acid, as the body can synthesize it from citrulline. However, it can become semi-essential while recovering from injuries or in individuals with kidney or intestinal disorders.
PureBulk derives this l-arginine base powder from glucose via molasses sugar. It is vegan- and vegetarian-friendly.
Ammonia is a toxic substance that the body must eliminate by converting it into glutamine via glutamate or through the urea cycle. Arginine plays a key role regardless, as it’s a precursor to glutamate and actively participates in the urea cycle.
Ammonia must first convert into carbamoyl phosphate before it can enter the cycle. The carbamoyl phosphate then transfers a phosphate group to ornithine to convert into citrulline. From there, the citrulline converts into argininosuccinate, which produces arginine when broken down. Arginase enzymes begin the last step of the cycle by cleaving arginine to form ornithine and urea. The ornithine can then return to the start of the cycle while the body excretes the urea through the urine.
The body uses arginine to make nitric oxide. Nitric oxide produces a vasodilation effect, which relaxes blood vessels, widens arteries, and improves blood flow. Wider, more relaxed blood vessels may enhance exercise performance and support heart health.
Numerous scientific studies have examined l-arginine and l-citrulline’s roles as nitric oxide boosters. The body can make nitric oxide by using citrulline to produce arginine. Unfortunately, nitric oxide has an incredibly short half-life, which limits its ability to exert benefits. However, research shows that citrulline and reduced glutathione synergize to sustain nitric oxide levels for longer.
PureBulk carries numerous nitric oxide boosters. These include:
Nitric oxide plays an important role in exercise. It helps deliver nutrients and oxygen to muscles during intense exercise by improving blood flow. A clinical trial found that arginine supplements produced dramatic increases in nitric oxide, allowing participants to exercise for much longer than the placebo group. Another study examined arginine’s effects on athletes over a six-week period. The participants taking arginine supplements performed significantly better than the placebo group.
Improving nitric oxide goes beyond enhancing athletic performance. It can also support heart health by improving circulation. It also helps to reduce pressure in blood vessels by relaxing them. Research also shows that arginine helps reduce chest pain.
Arginine has several interactions with the immune system. It helps develop T-cells, a type of white blood cell that protects the body from infections by attacking antigens directly. T-cells also direct the humoral immune response to help B-cells eliminate invading pathogens by creating antibodies. Arginine also promotes rapid lymphocyte production for faster wound healing.
Research shows that doses up to 20g of arginine are likely safe; however, this far exceeds the recommended 600mg. Doses in excess of 10g may cause an upset stomach or diarrhea. Some individuals may experience mild gastrointestinal side effects from standard doses, such as bloating, stomach pain, or nausea. Arginine may interact with certain medications and medical conditions. Individuals with kidney or liver disease or those taking blood pressure medication should consult a physician before taking arginine supplements. Individuals recovering from a recent heart attack should not take arginine supplements.
Vegan l-arginine supplement has a slight ammonia smell when first opening the container. However, the odor dissipates quickly. The product is not breaking down and is safe to consume.
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.