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Click to Enlarge Unit Weight: 1000 grams Unit Volume: 1750 cc Click to Enlarge Certificate of Analysis Click to Enlarge Volumetric Equivalents

What is L-Tyrosine?

L-Tyrosine, or simply Tyrosine, is one of the 20 non-essential amino acids that are used by cells to synthesize proteins. Tyrosine is an amino acid that has an important role in the structure of almost all the protein found in the human body. It is primarily used to enhance focus and alertness. Tyrosine, also called L Tyrosine, is not an essential amino acid since it can be made from phenylalanine which is another amino acid. Supplementation with both tyrosine and phenylalanine results to alertness and mental arousal. Tyrosine is the precursor of the thyroid hormones threonine and thyroxine, and the adrenal and growth hormones epinephrine, dopamine and norepinephrine. The function of the amino acid tyrosine is closely related with neurotransmitters and hormones in the body and is essential for normal mental functions. It is also used to create melanin the dark pigmentation in the skin which helps shield our body from the harmful UV rays of the sun. As with other amino acids, many vitamins and minerals improve tyrosine's absorption into the body. Dietary sources of tyrosine are principally derived from animal and vegetable proteins, which includes soy products, chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, and sesame seeds.

Tyrosine deficiency may cause a variety of conditions, including muscle loss, weakness, low protein levels, mood disorders and liver damage. Low levels have been linked to hypothyroidism (low thyroid function) and depression. Manifestations of tyrosine deficiency can also be evident through symptoms such as low blood pressure, low body temperature (such as cold hands and feet), and restless leg syndrome. Most people suffering by PKU (phenylketonuria, the inability to metabolize phenylalanine) are deficient in tyrosine. Tyrosine helps regulate mood and stimulates the nervous system. It can also boost the metabolism and treat conditions characterized by chronic fatigue. The body needs adequate supplies of tyrosine to make many important brain chemicals that help regulate appetite, pain sensitivity, and the body’s response to stress. It is also needed for proper functioning of the thyroid, pituitary, and adrenal glands, as low levels of tyrosine may lead to chronic fatigue and sluggish metabolism.

The body needs both tyrosine and the essential amino phenylalanine to make epinephrine, dopamine, and norepinephrine, three neurotransmitters that play an important role in the way you perceive and interact with your environment. Without adequate amounts of phenylalanine, the body can’t manufacture its own supply of tyrosine; without adequate amounts of tyrosine, the body cannot metabolize phenylalanine. A scarcity of either of these amino acids could make you more susceptible to a number of mental disorders, including anxiety, depression, low libido, and chronic fatigue. Tyrosine supplements, especially when combined with 5-HTP (5-hydroxy-tryptophan) supplements, have been utilized successfully to treat depression. Tyrosine supplementation has also been used for treatment of allergies, headaches, Parkinson’s disease, and drug withdrawal.

What is L-Tyrosine used for and who uses it?

L-tyrosine supplements have been used as a therapeutic supplement for those with phenylketonuria, depression, Parkinson's disease, and those who want to improve their memory. Tyrosine supplementation may be used in the treatment of Parkinson's disease, because tyrosine can make l-dopa which is used directly to treat Parkinson's disease. Several studies have also indicated that L-Tyrosine benefits people with Alzheimer’s disease, schizophrenia, and dementia. Tyrosine and tryptophan have been used successfully in the treatment of cocaine abuse. In another study, it was combined with the antidepressant Imipramine to treat chronic cocaine abuse where it was found out that the action of the two blocked the cocaine high and prevented the severe depression that accompanies withdrawal.

Aside from its obvious brain functions because of its link to dopamine as well as norepinephrine, Tyrosine is also helpful in suppressing the appetite and reducing body fat, producing the skin and hair pigment (melanin), and aiding in the proper functioning of the thyroid as well as the pituitary and adrenal gland. It is beneficial for stress reduction and may be beneficial in narcolepsy, fatigue, anxiety, depression, allergies, headaches as well as drug withdrawal. In one study with soldiers as subjects, tyrosine proved effective in alleviating stress and keeping them more alert. Other possible benefits of tyrosine include helping to calm the body, increasing energy, and enhancing libido. It is also converted into the skin pigment melanin that shields the skin from the harmful effects of UV rays.

L-tyrosine, through its effect on neurotransmitters, is used in mood enhancement, appetite suppression, and growth hormone stimulation. In addition, tyrosine also has an antioxidant effect, which may prevent cancer development, coronary heart disease, and slow down the signs of aging. Tyrosine appears to prevent the decline in various aspects of performance and mood associated with many kinds of acute stress by acting as an adaptogen, helping the body cope with the effects of physical or psychological stress, and may prove helpful in enhancing performance in situations where performance is compromised. Tyrosine is involved in the synthesis of enkephalins, compounds that have pain-relieving effects. When taken properly, l-tyrosine can help improve a sluggish thyroid and assist a person who is on diet in losing excess, unwanted pounds. At present, it is often used as a dietary supplement for relieving stress, depression and in promoting general well being. It is also being popularly used as a supplement for body building, weight loss, and promoting skin health.

How pure is your L-Tyrosine?

This pharmaceutical grade amino acid L-Tyrosine is assayed by the manufacturer to be 99.46% product. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag containing this white powder product. Even if tyrosine is non-essential and that tyrosine is largely available through tyrosine foods, some people have increased needs of tyrosine due to one or several factors, while other suffer from tyrosine deficiency. For example, people going through depression reportedly have low tyrosine levels, as with those who suffer from phenylketonuria. If you have extremely low levels of tyrosine, you will suffer from a variety of conditions, such as muscle weakness, muscle loss, mood disorders, low protein level and liver damage. If you are one of those who have increased tyrosine level need or suffer from deficiency of the amino acid, taking in tyrosine through natural tyrosine foods is not enough so you would need actual tyrosine supplementation. Due to the fact that our product is pharmaceutical grade, these are best utilized by the body, since they do not require digestion and are easily absorbed. Our product does not contain any fillers, additives or anti-caking agents. If all you want are the health benefits made possible with L-Tyrosine, buying this product in bulk is the best way to get there. Buying in bulk is also your best bet for saving money because for sure you’ll pay more at a local nutrition store. Bulk costs are cheaper in the long run and you will receive a great deal at or below wholesale prices for a high purity bulk quantity of this product.

What are some of the common effects of L-Tyrosine?

Tyrosine and the Brain: Tyrosine helps produce neurotransmitters. By virtue of this, L-tyrosine can also prove helpful in treating a variety of brain conditions including, Alzheimer's disease, Parkinson's disease, narcolepsy, chronic fatigue syndrome and dementia.

Tyrosine and Stress: If you are under a lot of stress often, you can benefit from tyrosine. During stressful situations, your brain may fail to produce sufficient amounts of tyrosine from phenylalanine. What could happen next is a neurotransmitter depletion rate higher than their rate of production. With L-tyrosine supplements, some of the negative effects that stress brings can be canceled out or neutralized.

Tyrosine and Depression: Tyrosine has also been demonstrated to have significant effects in fighting depression, as this amino acid has the ability to regulate moods.

Tyrosine and Thyroid: L-tyrosine is also closely linked to thyroid function. Tyrosine facilitates the production of the hormone thyroxin in the thyroid.

The effect of L-tyrosine on brain functions: Tyrosine helps regulate dopamine and serotonin levels in the brain. High serotonin levels translate to a deep sense of relaxation, while high dopamine levels produce sharpness, well-being and mental alertness. The benefits of L-tyrosine can be maximized with the combination of tyrosine and phenylalanine-rich food sources as well as supplements. However, care must be taken not to overdo or take too much as it has potential detrimental effects.

What is the daily suggested dose of L-Tyrosine?

The commonly recommended dose for L-Tyrosine varies between as little as 500 milligrams per day to as much as 4 grams per day depending upon individual needs and responses to this nutritional supplement. One level 1/2 teaspoon yields approximately 980 milligrams (0.98 grams), or just about 1 gram. Taking 1/2 level teaspoon two times per day will yield an approximate daily dose of 2 grams, or taken three times per day will yield a daily dose of approximately 3 grams. You can see the full bulk density/volumetric conversion chart for L-Tyrosine here.

You should consider that L-Tyrosine supplementation will take between 2 and 4 weeks at a given dose to give you a complete understanding of the dosage level you are taking. If you find you are being over stimulated by your L-Tyrosine dose you should cut your dose down and reevaluate your results after about two weeks at your new dose. Likewise, if you find you could use greater stimulation and mood enhancement you might try increasing your dose accordingly. L-tyrosine supplements should be taken before meals, preferably 30 minutes before, and divided into two or three doses daily.

Precautions and Potential Side Effects of L-Tyrosine

Side effects from L-Tyrosine use and overdose are uncommon when taken within the range of recommended dose, but can include restlessness, anxiety, euphoria and insomnia. The total amount of tyrosine dose taken in one day should not exceed 12,000 milligrams or 12 grams as it can lead to toxicity. Aside from those already mentioned, a few people have reported instances of overstimulation, heart palpitations and arrhythmia due to high doses of tyrosine. If you find that taking L-Tyrosine is over stimulating you should consider cutting back on your dose and find the level of dose right for your individual needs.

Anyone with high blood pressure or migraines should not take tyrosine or even eat foods high in this amino acid, as it may aggravate their condition. Anyone taking monoamine oxidase (MAO) inhibitors should not take tyrosine or phenylalanine supplements or even eat foods that contain significant amounts of these amino acids, as both have been shown to cause dangerous spikes in blood pressure when combined with these medications. Also, Tyrosine should not be taken at the same time as levodopa, a medication used to treat Parkinson's disease because levodopa may interfere with the absorption of tyrosine.

People with liver or kidney disease in general should not take this or any other amino acid supplement without first consulting their physician. Getting too much of any one amino acid can throw the citric acid cycle out of balance, which makes the liver and kidneys work harder to eliminate toxins.

Taste, solubility, and suggested preparation of L-Tyrosine

This product will dissolve slowly in hot water, but mixes thoroughly and suspends well in cold water and has virtually no taste. Just mix your usual dose with water or juice and drink. If prescribed with a tyrosine supplement, it is best to take it at bedtime, or with a high carbohydrate meal to prevent competition of absorption with other amino acids. Folic acid, copper and vitamin B6 is a good combination to have with this nutrient to maximize absorption and effectiveness.

L-Tyrosine is used in the following Proprietary Formulas

BSN NO-Xplode, Gaspari Nutrition SuperPump250, Universal Animal Cuts, VPX NO Shotgun, Gaspari Nutrition Mitotropin, 4Ever Fit L-Tyrosine, Country Life 7-KetoTrim, Country Life L-Tyrosine, Olympian Labs Calm, Olympian Labs Siesta, SNAC Vitalyze, Source Naturals Calm Thoughts

References & Further Research

Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria
The objective of this study was to characterize abnormalities of brain function in patients with phenylketonuria (PKU) who had relaxed or stopped the dietary regimen and to test whether oral high-dose tyrosine (Tyr) supplementation has a beneficial effect. Overall data suggests high-dose Tyr supplementation cannot be recommended as an “alternative” treatment for patients with PKU after relaxation or termination of strict dietary adherence.

In search of the action of anti-depressants, 5HTP, tyrosine mixtures in depression
For a long time antidepressants have been considered to act via enhancement of central monoaminergic activity (due to reuptake or MAO inhibition). An alternative hypothesis holds that their action is based on down-regulation of monoaminergic activity (due to decrease in density or sensitivity of certain receptor populations). In this paper the likelihood of both hypotheses is discussed and the conclusion reached that the first one is the most plausible. The following arguments are discussed: (1) the 5-HT precursor 5-HTP, which is transformed to 5-HT in the brain, has antidepressant properties; (2) there are indications that the same holds true for tyrosine, a catecholamine precursor transformed in the brain to DA and NA; and (3) evidence was found that the effects of 5-HTP in depression are potentiated by tyrosine. Since activation rather than suppression of monoaminergic activity seems to be linked to antidepressant activity, it seems likely that the signs of decreased monoamine metabolism that have been demonstrated in certain types of depression are the expression of a primary metabolic deficit rather than a phenomenon secondary to receptor hypersensitivity. Further clinical studies of 5-HT/CA precursor combinations in depression are justified.

L-Tyrosine for International Customers

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