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COA (Griffonia Seed)
COA (Fermented)
*(Documents above may vary from batch received. Click here to request batch-specific documents)

Supplement Facts & Directions

Supplement Facts

Serving Size: 300 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
5-Hydroxytryptophan (Griffonia simplicifolia) Extract 300mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: None


Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.

Directions: As a dietary supplement, take 300 mg (1/8 tsp) daily with meals or as directed by a physician.

Warning: If you are pregnant, nursing, taking any medications (including medication for depression, migraines, Parkinson's disease, or psychiatric disorders), or have any medical conditions consult your physician before use. DO NOT use with other supplements containing L-tryptophan or 5-HTP. It may cause drowsiness. Keep out of reach of children.

Product Details

What is 5-HTP (5-Hydroxytryptophan)?

5-HTP (5-Hydroxytryptophan) is an amino acid and a precursor to serotonin, a neurotransmitter that regulates mood, cognition, appetite, and sleep. The body uses tryptophan to synthesize 5-HTP, which then converts to serotonin. However, chronic stress, hormones, and imbalanced gut microbes can reduce serotonin production. Low serotonin levels can cause a multitude of health problems, including weight gain, problems sleeping, emotional unease, and more.

Taking 5-HTP supplements can help bridge the gap when external factors reduce serotonin production. The seeds of the Griffonia simplicifolia shrub are the primary dietary source of 5-HTP and can contain up to 20% 5-HTP by weight. 5-HTP supplements offer the benefits of Griffonia simplicifolia with more reliable results, as individuals have control over the dosage.

Potential 5-HTP Benefits

5-HTP and Appetite

Many individuals notice an uptick in hunger when they first begin dieting. However, a reduced calorie intake isn’t solely to blame. The body responds to a restricted calorie intake by producing hormones that increase hunger and drive food-seeking behavior. 5-HTP supplements help offset this by counteracting hunger, reducing calorie intake, and improving satiety.

5-HTP and GABA

GABA promotes relaxation and synergizes with 5-HTP to improve both supplements’ sleep-enhancing benefits.

5-HTP for Sleep

5-HTP supplements may facilitate better sleep by boosting serotonin levels, which then convert to melatonin. One study noted 5-HTP’s effects on sleep dramatically improved when paired with GABA. The combination of 5-HTP and GABA helped reduce sleep latency, enhance sleep quality, and increase sleep duration.

Other 5-HTP Uses

Imbalanced serotonin can cause emotional distress and low moods. 5-HTP supplement may improve mood by restoring serotonin levels. It may also reduce the negative effects of romantic and emotional stress.

Potential 5-HTP Side Effects

5-HTP supplements may cause digestive side effects, including heartburn, nausea, upset stomach, or diarrhea. Individuals can reduce the likelihood of 5-HTP side effects by splitting their dose and taking it twice per day instead of one larger dose. Individuals taking MAOIs, SSRIs, or other tryptophan supplements should not take 5-HTP supplements, as they also increase serotonin levels. Individuals should always consult with a physician before taking new supplements.


Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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