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What is L-Methionine?

Amino acids are off paramount importance for human metabolism, ensuring most of the processes in the human body occur and function properly for good health. The human body, without water, is comprised of 75 percent amino acids. All of the neurotransmitters, except for one, are made up of amino acids and 95 percent of hormones are amino acids. L-Methionine is an essential amino acid meaning that it must be consumed in the diet and it must be supplied to the body through protein intake because it is not produced in the human body in significant amounts. L-Methionine is required by the body to synthesize SAMe (pronounced "Sammy" or S-adenosylmethionine). The body integrates L-Methionine with ATP, which in turn produces SAMe. SAMe is active and required in 40 biochemical processes and involved indirectly in many more.

SAMe is made within the body and is present in almost every tissue, and it has been shown to be effective as a treatment for osteoarthritis and associated joint pain, stiffness, and inflammation. SAMe has also been shown to be beneficial for most types of depression. Many studies have confirmed that SAMe is as effective as other commercial antidepressant drugs, working more quickly with fewer side effects by boosting the activity of several brain chemicals involved in mood, such as norepinephrine, dopamine, andserotonin. SAMe enhances and stabilizes liver function. In many places including Europe, SAMe is used in the treatment of cirrhosis and liver damage caused by alcohol. SAMe has been proven effective in the treatment of fibromyalgia, AIDS-related myelopathy, and attention deficit-hyperactivity disorder (ADHD) in adults. SAMe also aids the body in manufacturing a wide range of compounds, including neurotransmitters such as serotonin and dopamine, as well as cartilage components such as glycosaminoglycans.

The body also requires more than adequate methionine supplies to produce two other sulfur-containing amino acids, cysteine and taurine, which enhances the body's natural ability to eliminate of toxins, builds strong, healthy tissues, and supports cardiovascular health. The body utilizes sulfur to develop hair follicles and promote healthy hair, skin, and nail growth. Sulfur improves the production of lecithin in the liver, which reduces cholesterol, reduces liver fat, protects the kidneys, reduces bladder irritation by regulating the formation of ammonia in the urine, and helps the body to excrete heavy metals. Methionine is a lipotropic, or a chemical agent that assists the liver process fats (lipids) more efficiently. Other lipotropics include choline, inositol, and betaine (trimethylglycine), all of which help ensure normal liver function, which is essential for the elimination of toxins from the body. Methionine also supports liver function by maintaining healthy glutathione supplies, and glutathione in turn neutralizes toxins in the liver.

It is also one of the three amino acids the body needs to manufacture creatine monohydrate, a compound essential and used for energy production and muscle building. Creatine is a nutrient naturally found primarily in muscle tissue that provides the energy our muscles need to move, and has been found to boost athletic performance during short, intense workouts. Creatine is necessary for all muscular function, and thus supports normal functioning of the heart and circulatory system. High levels of methionine can be found in sesame seeds, Brazil nuts, fish, eggs, beans, garlic, lentils, yogurt, onions, meats, and some other plant seeds.

What is Methionine used for and who uses it?

L-Methionine is an amino acid that is beneficial in reducing the toxicity of radiation. It also helps speed healing wounds after a surgical operation. L-Methionine also helps regulate the availability of folic acid, which is necessary during pregnancy. Other benefits of L-Methionine include its use in treating clinical depression, liver disease, alcoholism as well as reducing asthma symptoms. Methionine has been proven effective in reducing fat and lowering cholesterol. It does this by aiding in reducing liver fat, and increasing the body's metabolism. Because of its ability to remove and transport fat out of the body, it can be used for weight loss. Methionine also improves the body’s ability to synthesize muscle protein. Methionine is also a source of sulfur that is required for the synthesis of other substances that are important for the efficient production of energy in the body such as choline, creatine and carnitine.

It assists in the breakdown of fats and thus impedes the build-up of fat in the arteries, as well as supports the digestive system and eliminates the heavy metals from the body since it can be converted to cysteine, which is a precursor to glutathione, a crucial ingredient in detoxifying the liver. The amino acid methionine is also a great antioxidant as the sulfur it supplies intercepts and wards off free radicals. It may also be used to treat depression, arthritis pain as well as chronic liver, and some studies have also indicated that methionine might improve memory recall.

Methionine is used to treat acetaminophen (paracetamol e.g. Tylenol) poisoning to prevent liver damage by deactivating the breakdown products of acetaminophen from damaging the liver thus aiding in the body's detoxification process. The detoxification process requires a great deal of essential amino acids. In times of stress such as illness or trauma, the essential amino acid requirements are even higher. If the digestive system does not produce the necessary amounts of essential amino acids for the liver, it will result to toxin overload in the tissues. Methionine, essential for the production of glutathione, has a protective effect on it and prevents its depletion during toxic overload, which can protect the liver from the damaging effects of toxic compounds. L-Methionine also benefits those suffering from arthritis, fibromyalgia and depression - a condition that is often accompanied by chronic pain conditions.

Methionine levels help determine and regulate the liver's concentration of sulfur-containing compounds and SAMe improves and normalizes liver function. SAMe is used in the treatment of cirrhosis and damage caused by alcohol. Alzheimer's and Parkinson's patients have very low levels of SAMe, and methionine may help treat some symptoms of Parkinson's disease. SAMe has been used in clinical studies to treat anxiety, schizophrenia, demyelination diseases, and dementia. Methionine in combination with several antioxidants can reduce pain and recurrences of attacks of pancreatitis (inflammation of the pancreas). SAMe can also treat some symptoms of fibromyalgia patients, who suffer from chronic muscle pain, non-restorative sleep, and profound fatigue.

How pure is your Methionine?

This essential amino acid L-Methionine is assayed by the manufacturer to be 99.6% pure bulk nutritional powder. You will receive a sealed and labeled heavy duty 4 mil polyethylene bag of this white powder product. It does not contain any fillers, additives or anti-caking agents. Methionine supplements are often recommended by alternative medical practitioners, especially for those who are not getting a proper diet, such as vegetarians who might not be getting a balance of complete protein, athletes, people under severe stress, and anyone whose alcohol intake level is moderate to high. Since it is a powerful antioxidant that assists in the breakdown of fats and helps inactivate free radicals, and because it is an essential amino acid, it must be supplied either from the diet or from supplementation.

What is the daily suggested dose of Methionine?

The typically recommended dose for L-Methionine varies between 250 and 1000 milligrams per dose taken from 2 to 4 times per day, not to exceed 4 grams per day, depending upon individual needs. One half level tablespoon will supply approximately 4007 milligrams, or just about 4 grams for the bulk density of this L-Methionine powder. You can see the full bulk density/volumetric conversion chart for L-Methionine here. For acetaminophen (Tylenol) poisoning, as backed by scientific research, 2.5 grams of methionine every 4 hours for 4 doses is required to prevent liver damage and death. If you are considering taking a methionine supplement, it is best to balance it with choline and inositol

As always, if you have concerns or questions, consult a physician or a health care professional before taking any supplements. Before taking any kind of medicine, check with your doctor to ensure that the supplement you want to take is right for you. You may be allergic or you may have a sensitive stomach which may raise the need for special instruction as far as dosage goes.

What kind of results do people anticipate while taking Methionine?

L-Methionine is an essential amino acid that aids in the body's detoxification process. Amino acids catalyzes the production of various neurotransmitters and enzymes critically needed in brain metabolism. Amino acids allow smooth, balanced cognition and fluid transition from thought to disciplined action and thus aids in the reduction of stress, frustration and cognitive overload. As such diets deficient in this essential amino acid may result in a destructive breakdown and metabolism of protein. Signs of deficiency include apathy, edema, lethargy, liver damage, muscle and/or fat loss and weakness.

Methionine is a powerful anti-oxidant and an excellent source of sulfur, which prevents disorders of the hair, skin, and nails. It also assists in the breakdown of fats, thus keeping the buildup of fat in the liver and arteries in check so as to not obstruct blood flow to the brain, heart, and kidneys. It is helpful in detoxifying harmful agents such as lead and other heavy metals. In essence, it helps diminish muscle weakness (by helping the body create creatine), prevents brittle hair, and protects against the affects of radiation (by helping create sulfur-containing amino acids). It also reduces the level of histamine in the body which can cause the brain to relay wrong messages, thus helping individuals suffering from schizophrenia.

Precautions and Potential side effects of Methionine

Studies have not found any drug interactions associated with methionine, and although there appears to be no toxic dosage of this amino acid, excessive or undiagnosed use may cause side effects such as nausea, vomiting, drowsiness, and irritability. Women who are expecting or breastfeeding should consult with their doctors before using any kind of supplement. In general people who are healthy and eat a well-balanced diet should not require methionine supplementation.

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Taste, solubility, and preparation of Methionine

L-Methionine has a somewhat mild flavor, slightly sweet and slightly bitter, but not bad. L-Methionine dissolves quickly in hot water, but will not dissolve readily in cold water. It is advisable to place your usual dose (1 gram once or twice per day is sufficient for most people) in 4 ounces hot water and then add your favorite sweetener (we recommend sweetening with 1 teaspoon Xylitol powder or instead use a tiny amount of Stevia powder).

Methionine is used in the following Proprietary Formulas

TriCardia, Universal Animal Pak, Optimum Superior Amino 2222, Controlled Labs Purple Wraath, MuscleTech Anabolic Halo, MuscleTech IntraVol

References & Further Research

S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease
The objective of this report was to conduct a search of the published literature on the use of S-adenosyl-L-methionine (SAMe) for the treatment of osteoarthritis, depression, and liver disease; and, on the basis of that search, to evaluate the evidence for the efficacy of SAMe

Efficacy of the dietary supplement S-adenosyl-L-methionine
Several reviews and at least two meta-analyses have examined the available evidence surrounding SAMe in the therapy of depression for trials completed prior to 1994 and concluded that SAMe was superior to placebo in treating depressive disorders and approximately as effective as standard tricyclic antidepressants.

L-Methionine for International Customers

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Terms:

Methionine, L-Methionine, L-Methionine, L-2-amino-4-(methylthio)butyric acid