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Supplement Facts & Directions

Supplement Facts

Serving Size: 200 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
  (from S-Adenosyl-L-Methionine Disulfate Tosylate) 106 mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: None


Free of: Soy, Dairy, Gluten & Additives.

Directions: Take 200 mg 2-4 times daily as a dietary supplement, preferably on an empty stomach. An accurate gram weight scale is recommended. Refrigeration is recommended after opening.

Warning: For adults only. Individuals with bipolar depression, anxiety disorders, or taking antidepressant medications should not take SAMe unless under professional medical supervision. If you are pregnant, nursing, taking any medications, or have any medical conditions consult your physician before use. Keep out of reach of children.

Product Details

What is SAMe (S-Adenosyl Methionine)?

S-Adenosyl Methionine (SAMe), sometimes called ademetionine, occurs when the amino acid methionine binds to an adenosine triphosphate (ATP) molecule. It acts as a methyl donor and regulates numerous cellular functions, including the synthesis of neurotransmitters, proteins, hormones, and phospholipids. As a methyl donor, SAMe accelerates certain metabolic reactions. It also plays a role in the immune and inflammatory response and is critical for repairing and growing cells. Studies have linked low levels of SAMe to several health conditions, including joint problems and low moods.

Potential SAMe Benefits

S-Adenosyl Methionine has significant potential to relieve joint pain. Clinical studies examining more than 20,000 participants noted that SAMe outperformed NSAIDs and other pain relievers when it came to reducing joint pain and improving joint function. SAMe also has anti-inflammatory properties, which help reduce swelling around joints. SAMe caused fewer side effects compared to long-term NSAID use.

SAMe supplements may help regulate moods. Individuals with mood imbalances tend to have high levels of homocysteine. Individuals with vitamin B12 and folate deficiencies also have elevated homocysteine levels and lower levels of serotonin and norepinephrine (the neurotransmitters involved in regulating mood). Excessive homocysteine and reduced mood-regulating neurotransmitters can cause lethargy, difficulty concentrating, and poor moods. SAMe supplements can help to balance moods within a few days. S-Adenosyl Methionine also helps relieve the cognitive impacts of low moods, such as memory recall.

SAMe may convey some antioxidant benefits. It helps combat oxidative stress and excess free radicals, which damage cells and overall health. SAMe also increases glutathione production, one of the most powerful and potent antioxidants found in the body. Glutathione protects cells from damaging free radicals, heavy metals, peroxides, and more.

Potential SAMe Side Effects

SAMe supplements are generally safe for most adults. Some individuals may experience nausea or mild digestive problems. Taking SAMe supplements with a meal may relieve digestive side effects.

SAMe may increase the risk of mania in individuals with bipolar disorder. SAMe may interact with medications that increase serotonin. Consult with a physician before taking SAMe supplements.

How to Store SAMe Supplements

SAMe loses its potency when exposed to excess moisture in the air. Store SAMe supplements in a cool, dry location. PureBulk ships SAMe in a resealable bag. Securely reseal SAMe supplement powder after each use to maximize its shelf life.


Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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