Cyanocobalamin 1% (Mannitol 99%) (Vitamin B12)



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Supplement Facts & Directions

Supplement Facts

Serving Size: : at 1% 200 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Vitamin B12 (Cyanocobalamin) 2000 mcg 83333%

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: Mannitol


Free of: Soy, Dairy, Yeast, & Gluten.

Directions: As a dietary supplement, take 200 mg (1/16 tsp) once daily, or as directed by physician. Accurate gram weight scale recommended.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Potentially toxic in higher amounts. Use extreme care when measuring. Keep out of reach of children.

Product Details

What is Cyanocobalamin 1%?

Vitamin B12, also known as cyanocobalamin or cobalamin, is a water-soluble vitamin stored in the liver that works with other B vitamins to turn food into energy. To dilute its concentration this product is blended with mannitol, a sugar alcohol that has only 1.6 calories per gram.

High levels of vitamin B12 are stored in the liver, kidney and other body tissues.

The vitamin is part of a group of cobalt-containing compounds called corrinoids (Wikipedia). Vitamin B12 is also known as cobalamin because a major constituent is the metal cobalt. The major cobalamins include cyanocobalamin, hydroxocobalamin and the coenzyme analogs of vitamin B12, methylcobalamin and 5-deoxyadenosylcobalamin (adenosylcobalamin).

Cyanocobalamin is the common form of the vitamin used as an additive in the fortification of foods and in nutritional supplements.

Cyanocobalamin is considered the most potent vitamin. It is combined in the body with a substance called gastric intrinsic factor (IF), which is then absorbed by the intestinal tract. Intrinsic factor is secreted by the stomach lining, tightly binding vitamin B12 to help it pass through the intestinal lining and into the blood. Any abnormal production or shortage of this intrinsic factor can result in vitamin B12 deficiency.

Vitamin B12 is important for normal nerve cell activity, DNA replication and production of the mood-affecting substance S-adenosyl-L-methionine (SAM) (Wikipedia).

Vitamin B12 also works intimately with vitamin B9 (folate) to regulate the formation of red blood cells, helping iron function better in the body and preventing anemia. Vitamin B12 is needed for the action of certain enzymes within calls that control fat, amino acid and carbohydrate metabolism. Vitamin B12 as well as folate is essential in the synthesis of DNA and RNA, the genetic material in the body.

Vitamin B12 is found naturally in food sources (primarily animal products) in protein-bound forms. Excellent dietary sources of vitamin B12 include liver, tuna, cottage cheese, yogurt and eggs. The only reliable unfortified sources of vitamin B12 are meat, dairy products and eggs. Since Vitamin B12 is bound to the protein in many of these foods, it must be released during digestion. Persons with low levels of gastric acid may be unable to properly process these sources. Most standard multivitamin supplements are formulated with the recommended daily allowance of vitamin B12.

Vitamin B12's main functions are in the formation of red blood cells and the maintenance of a healthy nervous system. Vitamin B12 helps maintain nerve cells and aids production of DNA and RNA, the body's genetic material. Cyanocobalamin aids normal growth and development, helps with certain types of nerve damage. Pernicious anemia is a condition in which the body lacks Vitamin B12, and thus cannot produce enough healthy red blood cells.

Nerves are surrounded by an insulating fatty sheath comprised of a complex protein called myelin. B12 plays a vital role in the metabolism of fatty acids essential for the maintenance of myelin. Prolonged B12 deficiency can lead to nerve degeneration and irreversible neurological damage.

Those with vitamin B12 deficiency show irregular destruction of the myelin sheaths, which eventually causes paralysis and death. Vitamin B12 levels decrease with age and various measures of cognitive impairment are associated with reduced B12 status.

Vitamin B9 (folate) and vitamin B12 are critical to a process that clears homocysteine (Wikipedia) from the blood. Vitamins B12, B6, and B9 (folate) work closely together to control blood levels of homocysteine, an amino acid. Elevated plasma homocysteine concentrations are considered to be a risk factor for vascular disease and birth defects such as neural tube defects.

Purity and Concentration of Cyanocobalamin 1%

Purebulk's cyanocobalamin 1% powder contains no taste additives or anti-caking agents. Pure cyanocobalamin is mixed with 99% mannitol to produce the 1% concentration. Store in a cool, dry area protected from light. Reseal after each use.

This PureBulk product is manufactured in a cGmp certified and registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found form.

Potential Side Effects of Cyanocobalamin

Vitamin B12 is considered safe and nontoxic in recommended serving sizes. However, cyanocobalamin can be toxic if taken in excess! Use extreme care when measuring!

What is vitamin B12 deficiency?

Vitamin B12 deficiency (Web MD) occurs when there is an abnormally low level of the vitamin absorbed in the body. It can be a factor in a variety of different health conditions and disorders. B12 deficiency inhibits the body’s ability to produce blood, increases blood cell destruction and is harmful to the nervous system. Characteristic signs of B12 deficiency include fatigue, weakness, nausea, constipation, flatulence, loss of appetite and weight loss. Symptoms of severe vitamin B12 deficiency (regardless of the cause) may include a burning feeling on the tongue, fatigue, weakness, loss of appetite, intermittent constipation and diarrhea, abdominal pain, weight loss, menstrual problems, psychological symptoms and nervous system problems such as numbness and tingling in the feet and hands.

Vitamin B12 absorption occurs in the small intestine and requires a secretion from the stomach known as gastric intrinsic factor. If intrinsic factor is deficient, absorption of vitamin B12 is severely diminished.

Vitamin B12 is not usually present in plant food sources, and it is likely that a vegetarian will not consume enough of this vitamin in their diet. Elderly people should also be aware of possible deficiency symptoms since cobalamin levels decline with age. Deficiencies in the elderly are usually caused by malabsorption of the vitamin. Symptoms of B12 deficiency may not show themselves for five to six years until the body's reserves are completely depleted and a supplement should be considered.

References & Further Research

National Institutes of Health, Office of Dietary Supplements: Vitamin B12

University of Maryland Medical Center: Vitamin B12 Overview

Linus Pauling Institute: Vitamin B12

The information at is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.

Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.