PureBulk, Inc.

DHEA + Pregnenolone

$19.25
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Container: Capsules
Size: 120ct 125mg Veg. Caps
52 items left

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Pregnenolone 100 mg †
DHEA (Micronized) 25 mg †

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: Cellulose Capsule

Contains:

Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.

Directions: As a dietary supplement, take one capsule daily with water alongside a meal containing healthy fats for maximum absorption or as directed by a physician.

Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS OR WOMEN. Consult a physician before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased estrogen levels. Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Keep out of reach of children.

Tested By Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found  here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • Supports adrenal gland function and stress response
  • Provides foundational steroid hormone precursors
  • Promotes neurosteroid balance and cognitive support
  • Supports healthy aging and endocrine flexibility
  • Helps maintain energy and mood regulation
  • Designed to support the body’s natural hormone pathways

What is DHEA?

Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone primarily produced by the adrenal glands, with smaller amounts synthesized in the gonads and brain. It functions as a key precursor to both androgenic and estrogenic hormones, including testosterone and estradiol.

DHEA levels peak in early adulthood and gradually decline with age. Research indicates that this age-related reduction leads to changes in energy levels, body composition, immune regulation, and cognitive function. Widely known as a foundational building block of the endocrine system, DHEA plays a central role in the synthesis of steroid hormones.

In addition to serving as a hormone precursor, DHEA also acts as a neurosteroid, meaning it is synthesized in the brain and influences neurotransmitter signaling, stress response, and neuronal resilience. It drives the brain's ability to adapt, maintain, and recover functional capacity despite experiencing stress, trauma, or adversity.

What is Pregnenolone?

Pregnenolone is often referred to as the mother hormone because it is the first steroid hormone synthesized from cholesterol and serves as the upstream precursor to nearly all other steroid hormones, including DHEA, progesterone, cortisol, aldosterone, testosterone, and estrogen.

The adrenal glands, gonads, and brain produce pregnenolone, where it also functions as a neurosteroid. It helps regulate cognitive processes, memory formation, stress adaptation, and nervous system signaling.

Adequate pregnenolone levels are essential for hormonal balance, as they serve as the primary starting point for the entire steroidogenesis cascade. Supporting pregnenolone availability allows the endocrine system to respond dynamically to physical and mental stress.

Potential DHEA and Pregnenolone Benefits

Supports Adrenal Function and Stress Adaptation

DHEA and pregnenolone are integral components of adrenal hormone production. Together, they support the adrenal glands’ role in responding to physical and psychological stress by providing essential precursors for cortisol and related steroid hormones involved in stress regulation.

Promotes Hormone Precursor Balance

Rather than supplying downstream hormones directly, DHEA and pregnenolone provide raw materials for the body to synthesize hormones as needed. Taking a precursor-based approach supports endogenous hormone regulation and flexibility within the endocrine system.

Supports Cognitive Function and Neurosteroid Activity

Both DHEA and pregnenolone function as neurosteroids that influence synaptic plasticity, memory formation, and neurotransmitter balance. Research shows that these compounds may support mental clarity, focus, and age-related cognitive resilience by modulating GABAergic and glutamatergic signaling pathways.

Supports Healthy Aging

Age-related declines in DHEA and pregnenolone trigger significant changes in metabolism, immune function, and neurological health. Supplementation may help support physiological processes that naturally diminish over time, contributing to long-term vitality and well-being.

May Support Energy and Mood Regulation

DHEA and pregnenolone can indirectly influence perceived energy levels, motivation, and mood stability—particularly in individuals experiencing age-related hormonal decline. They achieve this by supporting adrenal hormone production and neurosteroid balance.

Potential DHEA and Pregnenolone Side Effects

Most individuals tolerate DHEA and pregnenolone supplements well when taken in appropriate serving sizes. However, because these supplements influence hormone pathways, some individuals may experience side effects, including:

    • Acne or oily skin
    • Irritability
    • Headache or mild gastrointestinal discomfort
    • Altered sleep patterns
    • Hormonal changes (e.g., changes in libido)

Individuals who are pregnant, breastfeeding, have hormone-sensitive conditions, or are taking medications that affect hormone levels should consult a qualified healthcare professional before use. Additionally, a healthcare provider should monitor long-term use.

References

Solubility: Fat-soluble.

When to Take: Take in the morning or early afternoon
to align with natural adrenal and cortisol rhythms.

What to take with: Take DHEA + Pregnenolone capsules
with water alongside a meal containing healthy fats for maximum absorption.

Spoon Set or Scale Needed?

DHEA + Pregnenolone supplement is a pre-measured product in
capsule form and does not require measuring tools.