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Supplement Facts
Serving Size: 100 milligramsServings Per Container: Varies
| Amount Per Serving | % Daily Value* |
|---|---|
| Thiamine TTFD (Terahydrofurfuryl Disulfide) 100mg | † |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡
These supplement facts may vary from the product you receive. Please call for exact numbers.
Other Ingredients: None
Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.
Directions: As a dietary supplement, take 100 mg daily or as directed by a physician. An accurate gram weight scale is recommended.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.
Tested By Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
What is Fursultiamine (TTFD)?
Fursultiamine is the common name for thiamine tetrahydrofurfuryl disulfide (TTFD). It is a synthetic derivative of thiamine (vitamin B1) designed for superior absorption and cellular uptake. Unlike water-soluble thiamine salts, fursultiamine is fat-soluble, allowing it to cross cell membranes and the blood-brain barrier more efficiently. It helps to restore thiamine-dependent enzymatic activity in the mitochondria, particularly in conditions that impair thiamine transport or metabolism.
Fursultiamine bypasses normal intestinal transport mechanisms, making it more bioavailable than thiamine hydrochloride or thiamine mononitrate. It enters cells via passive diffusion and rapidly converts into active thiamine within the mitochondria, where it contributes to adenosine triphosphate (ATP) production for energy and nervous system function.
Potential Fursultiamine (Thiamine) Benefits
Supports Cellular Energy Production
TTFD is critical for metabolizing carbohydrates and generating ATP, the primary molecule for storing and
transferring
energy in cells. It also enhances pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase activity. These
thiamine-dependent enzymes are crucial for cellular metabolism.
Promotes Nervous System and Brain Function
Fursultiamine helps support neurological health, reduce mental fatigue, and improve cognitive clarity,
especially in individuals with low thiamine status. Unlike regular thiamine, fursultiamine can easily cross the
blood-brain barrier to provide direct brain support.
May Support Metabolic and Mitochondrial Health
Fursultiamine supports metabolic and mitochondrial health by enhancing thiamine availability and
mitochondrial respiration. Thiamine is a crucial co-factor for various metabolic enzymes that facilitate energy
production. Additionally, fursultiamine acts as an antioxidant, reducing oxidative stress and boosting overall
cellular resilience.
What Causes Thiamine Deficiency?
- Chronic alcohol consumption – Alcohol interferes with thiamine absorption and utilization.
- High carbohydrate intake – Increases thiamine demand.
- Certain medications – Diuretics, metformin, and chemotherapy drugs can deplete thiamine.
- Gastrointestinal disorders – Celiac, Crohn’s, and bariatric surgery can impair nutrient absorption.
- Prolonged stress or illness – Increases metabolic demand for thiamine.
Thiamine deficiency can result from several causes, including:
Thiamine Deficiency Symptoms
Thiamine deficiency may present as:
- Fatigue or low energy
- Irritability and brain fog
- Muscle weakness
- Peripheral neuropathy (tingling, numbness)
- Poor coordination (ataxia)
- Memory and concentration issues
- In severe cases, beriberi or Wernicke’s encephalopathy
Potential Fursultiamine (Thiamine) Side Effects
Most individuals tolerate fursultiamine well, especially compared to high doses of oral thiamine salts. However, some individuals may experience:
- Mild gastrointestinal discomfort (e.g., nausea)
- Headache
- Garlic-like body odor due to sulfur-containing metabolites
- Skin irritation or allergic reactions (rare)
Individuals taking medications or with other health conditions should always consult their physician before starting any new supplements.
References & Research
- https://www.sciencedirect.com/science/article/abs/pii/S0149291816306567
- https://pubmed.ncbi.nlm.nih.gov/15328496
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6073388
- https://pubmed.ncbi.nlm.nih.gov/27707509
- https://pubmed.ncbi.nlm.nih.gov/8815393
- https://www.mdpi.com/1422-0067/22/11/5418
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7594589
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8533091
- https://pubmed.ncbi.nlm.nih.gov/34679662
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