What is SAMe (S-Adenosyl Methionine)?
S-Adenosyl Methionine (SAMe), sometimes called ademetionine, occurs when the amino acid methionine binds to an adenosine triphosphate (ATP) molecule. It acts as a methyl donor and regulates numerous cellular functions, including the synthesis of neurotransmitters, proteins, hormones, and phospholipids. As a methyl donor, SAMe accelerates certain metabolic reactions. It also plays a role in the immune and inflammatory response and is critical for repairing and growing cells. Studies have linked low levels of SAMe to several health conditions, including joint problems and low moods.
Potential SAMe Benefits
S-Adenosyl Methionine has significant potential to relieve joint pain. Clinical studies examining more than 20,000 participants noted that SAMe outperformed NSAIDs and other pain relievers when it came to reducing joint pain and improving joint function. SAMe also has anti-inflammatory properties, which help reduce swelling around joints. SAMe caused fewer side effects compared to long-term NSAID use.
SAMe supplements may help regulate moods. Individuals with mood imbalances tend to have high levels of homocysteine. Individuals with vitamin B12 and folate deficiencies also have elevated homocysteine levels and lower levels of serotonin and norepinephrine (the neurotransmitters involved in regulating mood). Excessive homocysteine and reduced mood-regulating neurotransmitters can cause lethargy, difficulty concentrating, and poor moods. SAMe supplements can help to balance moods within a few days. S-Adenosyl Methionine also helps relieve the cognitive impacts of low moods, such as memory recall.
SAMe may convey some antioxidant benefits. It helps combat oxidative stress and excess free radicals, which damage cells and overall health. SAMe also increases glutathione production, one of the most powerful and potent antioxidants found in the body. Glutathione protects cells from damaging free radicals, heavy metals, peroxides, and more.
Potential SAMe Side Effects
SAMe supplements are generally safe for most adults. Some individuals may experience nausea or mild digestive problems. Taking SAMe supplements with a meal may relieve digestive side effects.
SAMe may increase the risk of mania in individuals with bipolar disorder. SAMe may interact with medications that increase serotonin. Consult with a physician before taking SAMe supplements.
How to Store SAMe Supplements
SAMe loses its potency when exposed to excess moisture in the air. Store SAMe supplements in a cool, dry location. PureBulk ships SAMe in a resealable bag. Securely reseal SAMe supplement powder after each use to maximize its shelf life.
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