What is Niacinamide?
Niacinamide, also called nicotinamide, Vitamin B3, or nicotinic acid amide, is a water-soluble member of the family of B vitamins. Vitamin B3 is commercially available in two forms: niacin and niacinamide. The chemical difference between the two forms is that niacinamide has an amide group attached to the basic niacin form.
Both are readily absorbed from the small intestine but have different effects on the body. Both compounds can convert into the enzyme nicotinamide adenine dinucleotide (NAD) and subsequently NADH. NADH is the reduced form of this enzyme, and it plays a key role in energy production. NAD helps add and remove electrons from various molecules to help transfer energy, repair DNA, protect cells from damage, and regulate inflammation.
Niacinamide vs. Niacin
In small amounts (less than 100 mg), niacin and niacinamide can be used interchangeably. However, they do produce different actions on the body in larger amounts. Niacin is important in the balance of good (HDL) and bad (LDL) cholesterol in the bloodstream. Niacinamide acts more to promote a healthy insulin response and to maintain joint health. Unlike niacin, niacinamide doesn’t have vasodilating effects, meaning it doesn’t cause skin flushing. As such, some prefer to take niacinamide supplements to avoid this potential niacin side effect.
Potential Niacinamide Benefits
Niacinamide Supplements for Energy
Vitamin B3 or niacinamide works with vitamin B1, riboflavin (vitamin B2) , pyridoxine (vitamin B6), pantothenic acid, and biotin to break down and convert the carbohydrates, fats, and proteins in food into energy. Vitamin B3 is also helpful in the synthesis of hydrochloric acid, which is necessary for proper digestion. Vitamin B3 catalyzes REDOX reactions in the body to generate energy, break down dietary fats, create certain hormones, process genetic material (DNA), and for the growth and maturation of cells.
Niacinamide as an Antioxidant
Niacinamide plays a key role in clearing the body of toxic and harmful chemicals. It also provides antioxidant benefits by increasing NAD production. With a boosted supply of NAD, the body can repair and protect cells from oxidative stress and damage.
Niacinamide for Skin
Niacinamide is a prominent component in many skin care products, as its nonirritating and highly stable in cosmetics. It may improve the smoothness of skin by reducing inflammation, diminishing the appearance of wrinkles, and improving skin elasticity. Niacinamide may relieve redness and acne symptoms as well. Its skin clearing benefits are more notable in individuals with oily skin. It also helps protect the skin from harmful UV rays, and it can repair the damage caused by UV rays.
How to Make a Hydrating 10% Niacinamide Serum
Niacinamide serums are popular skin care products, but they can be pricey. It’s also difficult to know the purity of niacinamide serums, as not all companies provide a certificate of analysis (COA). Niacinamide pairs well with hyaluronic acid, which acts as a moisturizer and gelling ingredient. You will need the following to make 15g of 10% niacinamide serum:
- A digital milligram scale 0.01g
- 50ml glass beaker
- 12g distilled water
- 1.5g niacinamide powder
- 0.3g vegetable glycerin
- 0.6 grams 1, 3, propanediol
- .07g preservative*
- 0.3g calendula extract
- 0.15g hyaluronic acid powder
- A glass dropper bottle or glass pump bottle
* All water-based serums require a preservative to prevent bacterial growth. Some commercially sold serums include Germall® Plus, Optiphen™, and Gluconolactone & Sodium Benzoate.
- Place the beaker on the milligram scale and add 12g of distilled water.
- Add the 1.5g of niacinamide powder and mix thoroughly. Allow the mixture to sit until the niacinamide completely dissolves. The water should be clear.
- Add the 0.3g of vegetable glycerin; 0.6 grams 1, 3, propanediol; and 0.3g calendula extract. Stir thoroughly to combine all the ingredients
- Add 0.15g hyaluronic acid powder. Hyaluronic acid is extremely hygroscopic, and it can hold up to 1000 times its weight in water. It will clump initially but mix in the hyaluronic acid powder as well as possible. Cover the serum with aluminum foil and allow it to sit overnight.
- The serum should be clear and gel-like. Pour it into the glass dropper bottle or glass pump bottle for optimum storage. Using a dropper or pump bottle helps prevent contamination.
After cleansing your face, apply 2-3 drops of the hyaluronic acid + niacinamide serum to damp skin.
Purity and Concentration of Niacinamide
PureBulk’s niacinamide USP powder is a pharmaceutical-grade form of vitamin B3 manufactured in strict compliance with United States Pharmacopeia standards (USP28). It contains no fillers, taste additives, or anti-caking agents.
Potential Niacinamide Side Effects
Niacinamide is safe at suggested serving sizes. Do not take oral niacinamide if you are currently taking anticonvulsant drugs, such as carbamazepine or primidone. Excessive doses of vitamin B3 can cause liver damage, peptic ulcers, and skin rashes. Consult with a physician before taking niacinamide supplements.
Bioavailability, Mixing, and Solubility of Niacinamide Powder
This product dissolves quickly in water and has a sour, slightly bitter taste. Mix niacinamide powder with water or juice.
References & Further Research
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity
and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.