What is Coenzyme Q10 (COQ10)?
Coenzyme Q10 (or CoQ10) is a quinone, a substance that aids in providing energy to cells in all oxygen-breathing organisms. Researchers first discovered CoQ10 in 1957, naming it ubiquinone - the quinone found in every cell of the body (ubi = everywhere). Ubiquinones are lipophilic, water-insoluble substances that deliver electrical charges to the mitochondria, or powerhouses of the cells, so that they can produce energy and sustain life.
Coenzyme Q10, essentially a vitamin-like substance, acts as a coenzyme in the body and has a variety of critical functions. CoQ10 is crucial in the synthesis of a vital molecule known as adenosine triphosphate (ATP) (Wikipedia) which serves as the cell's major energy source. ATP drives a number of biological processes including muscle contraction and the production of protein. Coenzyme Q10 plays an important role as the co-enzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell.
Reindeer, beef and pork hearts are the richest sources of CoQ10, followed by oily fish. About a hundred different food sources can provide CoQ10, but it is difficult to get a significant serving with some of the more appetizing ones.
Coenzyme Q10 is a naturally occurring nutrient found in each cell of the body. It was first identified by University of Wisconsin researchers in 1957. Coenzyme Q10 increases energy via efficient ATP production, strengthens the immune system and provides the benefits of an antioxidant. It also functions as a coenzyme for numerous key enzymatic steps in the energy production within the cell.
Coenzyme Q10 may be used either internally as a nutritional supplement or applied topically as a component in facial or skin creams.
Coenzyme Q10 improves circulation throughout the body and helps mitochondria process fat and cholesterol more efficiently. It heightens the levels of blood and oxygen available for the heart to use. Taking CoQ10 with at least 600-800 IU of vitamin E daily, along with vitamin C, niacin, helps to optimize its usefulness.
CoQ10 is also a powerful antioxidant and protects the body from free radicals, compounds that can damage cell membranes. As we age, particularly after age 30, CoQ10 levels begin to drop, leaving the body more susceptible to free radical damage.
Purity and Concentration of Coenzyme Q10 (COQ10)
This Coenzyme Q10 is a pharmaceutical-grade pure bulk nutritional powder. It contains no fillers or additives. This PureBulk product is manufactured in a cGmp certified and registered facility PureBulk's supplements are tested by accredited third party laboratories in the USA to ensure their identity, purity and potency. To receive a copy of these results or the results for any other PureBulk supplement please fill out the COA request form found here. Please use the comment box provided for any additional document requests.
Potential Side Effects of Coenzyme Q10 (COQ10)
Coenzyme Q10 appears to be generally safe with no significant side effects. No serious toxicity associated with the use of coenzyme Q10 has been reported.
Coenzyme Q10 may interact with some blood pressure medications and some blood thinners. Customers taking medication to lower blood pressure or thin the blood should consult their physician before taking CoQ10.
Caution: Do not exceed 800 mg per day.
Certain medications appear to deplete the body stores of CoQ10. These medications include statins, fibric acid derivatives, beta blockers, and tricyclic antidepressants. Individuals taking these types of medications should talk to their doctor about whether Coenzyme Q10 supplementation is right for them.
Many countries (including Japan, Italy, Sweden, Denmark, Israel, and Canada) classify CoQ10 as a prescription drug. In the United States, CoQ10 is considered a natural supplement and is a main constituent of many supplements that are available over the counter. CoQ10 is featured in many forms including capsules, tablets, skin creams, and combination supplements.
Bioavailability, Mixing, and Solubility of Coenzyme Q10 (COQ10)
Coenzyme Q 10 is a very large molecule with some chemical properties that affect the rate in which the body can use it (hydrophobic). Very little is absorbed if it is just taken directly in powder form ( or as a powder in capsules). The assimilation and absorption of Coenzyme Q-10 may be improved if taken with a fatty substance such as oil, peanut butter, or olive oil. Subsequently, Coenzyme Q10 oral supplements are commonly sold as gel caps dissolved in soybean oil. While this delivery method is somewhat better, Purebulk suggests the following recipe to increase the bioavailability/absorption of Coenzyme Q10.
Coconut Q10 (Coenzyme Q10 & Coconut Oil Recipe for Increased Bioavailability)
1) Heat 16 fluid ounces coconut oil to between 150°F (65°C) and 158°F (70°C) in a sauce pan on the stove.
2) Add 25 grams Coenzyme Q10 powder. The powder will melt instantly and dissolve into the hot oil.
3) Stir for one minute.
4) Remove from heat and allow to cool to between 80°F (27°C) and 90°F (32°C).
5) Pour mixture into a rigid plastic or glass resealable food storage container and allow to cool to room temperature.
6) At below 76°F (24.4°C) coconut oil will turn solid, but that's alright.
7) The blended oil should be kept sealed but refrigeration is optional.
8) A level half teaspoon of this oil, liquid or solid, will net approximately 130 milligrams Co-enzyme Q10, which is in the usual range of a commonly recommended serving size for this most bio-available form of CoQ10.
9) Do not exceed a serving size of 1 level teaspoon (260 milligrams) of the blended Coenzyme Q10 coconut oil per day, except under the care and supervision of a physician.
10) Take your CoQ10 preferably with a fatty food at meal time. You may spread it on toast, or add it to any food like you would as if it were butter.
This 16 fluid ounce recipe will net 96 level teaspoons, or 192 level 1/2-teaspoons, enough highly bio-available coconut oil dissolved Coenzyme-Q10 for more than a 6 month supply.
Recommended Storage of Coenzyme-Q10
In its crystalline form, Coenzyme-Q10 is extremely susceptible to oxidation, a chemical reaction with the oxygen in air. If kept in contact with air, CoQ10 will change from its usual bright orange color to a dark brown color., and will lose potency.
The best way to keep Coenzyme-Q10 from oxidizing is to solubilize the powder (see the Coenzyme Q10 & Coconut Oil recipe above). Coconut oil usually contains up to 40% medium chain triglycerides - natural antioxidant oils that protect Coenzyme Q10 from oxidation.
References & Further Research
University of Maryland: Coenzyme Q10
Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics.
The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.
Tested by Accredited 3rd Party Labs
This PureBulk product is manufactured in a cGMP certified and registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.