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Betaine Anhydrous (TMG)


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Betaine Anhydrous (TMG) versus Betaine Hydrochloride Purebulk sells both Betaine Anhydrous and Betaine HCl. While both are taken as a nutritional supplement in treatment of high homocysteine levels, betaine hydrochloric acid is also sold as a digestive aid and as a supplemental source of hydrochloric acid for people who have a deficiency of stomach acid production; the anhydrous form does not include this benefit. The HCl form also has an extremely sour taste while the anhydrous has a mild, pleasant taste.

What is Betaine Anhydrous (TMG)?

Betaine anhydrous, also called trimethylglycine, is an important nutrient derived from choline. Betaine carries and donates methyl molecules in the body to help make chemical processes work.

Betaine anhydrous takes its name from the vegetable in which it was first discovered: sugar beets. It is also found in a variety of plant and animal sources. The best dietary sources of betaine anhydrous include green leafy vegetables, cereal grains, seafood, legumes, wine and sugar beets.

Studies have been conducted on whether TMG (trimethylglycine) may help reduce high levels of the amino acid homocysteine (Wikipedia) in the blood. Scientists are working to determine if a high homocysteine level has a direct negative effect on cardiovascular health or if it is simply a risk factor.

Betaine anhydrous also plays a role in the manufacture of carnitine and helps protect the kidneys.

In humans, betaine is essential to the maintenance of intestinal function and cell production.

As a nutritional aid, betaine anhydrous promotes the oxidization of lipids. This is the result of enhancing the production of carnitine. Optimal levels of carnitine in the body contribute to overall physical fitness as fat is efficiently used to fuel the body.

Performance athletes who engage in serious strength training, especially creatine non-responders, may find it beneficial to take TMG together in combination with Creatine Monohydrate, for muscle mass gains.

Betaine Anhydrous is also known by the following names:

Trimethylglycine (TMG), Methanaminium1-carboxy-N,N,N-trimethyl-, inner salt, 2-(Trimethylammonio) ethanoic acid hydroxide, inner salt, (Carboxymethyl) trimethylammonium hydroxide inner salt, Trimethylammonioacetate, Glycine Betaine, Trimethylbetaine, Trimethylglycocoll, Abromine, Glycylbetaine, Oxyneurine.

Purity and Concentration of Betaine Anhydrous (TMG)

This food-grade betaine anhydrous (TMG) contains no fillers, additives or anti-caking agents.

Potential Side Effects of Betaine Anhydrous (TMG)

Possible adverse side effects of TMG can include diarrhea, stomach upset, and nausea. This product is not recommended for diabetics and pregnant or nursing women without medical consultation.

Bioavailability, Mixing and Solubility of Betaine Anhydrous (TMG)

This food-grade betaine anhydrous powder has a mildly tart taste but mixes and dissolves readily with hot water. Please note: there is a significant difference in taste between the mild betaine anhydrous and Betaine HCL, which is quite sour.

References & Further Research

University of Maryland Medical Center: Betaine

Pubmed: Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women

The information at is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.

Tested by Accredited 3rd Party Labs

This PureBulk product is manufactured in a cGMP registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.


Supplement Facts

Serving Size: 750 milligrams 
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Trimethylglycine (TMG) (Betaine Anhydrous) 750mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established 
‡ These supplement facts may vary from the product you receive.    Please call for exact numbers.

Other Ingredients: None

Free of:  Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.

Directions:  As a dietary supplement, take 750 mg up to two times daily, or as directed by a physician. Accurate gram weight scale recommended.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place.

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