| Amount Per Serving | % Daily Value* |
|---|---|
| Calcium D-Glucarate 1500 mg | † |
| Calcium (from Calcium D-Glucarate) 183 mg | 18% |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.
Other Ingredients: None
Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.
Directions: As a dietary supplement, take 1500 mg (3/8 tsp) with meals or as directed by a physician.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.
Calcium D-Glucarate, also known as calcium saccharate and saccharated lime, is a calcium salt combined with glucaric acid. The addition of glucaric acid dramatically improves the calcium’s oral bioavailability. Once ingested, stomach acids break down calcium D-glucarate into calcium and D-glucaric acid. Calcium is an essential mineral and electrolyte that the body needs to maintain the circulatory, digestive, and muscular systems. It is also critical for bone formation, blood cell function, muscle contractions, and nerve conduction.
Glucaric acid occurs naturally in many fruits and vegetables, including apples, grapefruits, oranges, and cruciferous vegetables like broccoli. D-glucarate has antioxidant and anti-inflammatory properties that help rid the body of toxins and support the body’s natural defense systems. Glucaric acid also helps remove excess estrogen. Additionally, calcium D-glucarate exerts beneficial effects on cholesterol levels.
Calcium D-glucarate may support liver health due to its detoxification properties. The liver goes through two phases of detoxing harmful substances. The first phase can sometimes produce metabolites that are more noxious than the original compounds. The second phase targets these metabolites for elimination in a process known as glucuronidation. Phase II detoxification also processes harmful metabolic byproducts, hormones, and medications.
Glucuronidation neutralizes these toxins by binding them to glucuronic acid. The body can then excrete them through the gut or kidneys via bile, bowel movements, and urine. However, beta-glucuronidase enzymes found in the gut can reverse glucuronidation and cause the body to reabsorb the toxins the liver tried to eliminate. Calcium D-glucarate inhibits beta-glucuronidase activity, which may help attenuate a buildup of toxins in the body.
The body needs beta-glucuronidase to metabolize carbohydrates and produces the enzymes via colon bacteria. However, high-fat diets, processed foods, excess sugar consumption, and insufficient fiber intake can cause an imbalance of beta-glucuronidase in the gut. As mentioned above, beta-glucuronidase can unbind excess hormones packaged via glucuronidation before the body can eliminate them. Numerous scientific studies support the connection between the gut and sex hormones. Calcium D-glucarate can help restore gut health by blocking beta-glucuronidase enzymes and preserving glucuronidation.
Excess estrogen can lead to numerous health problems in men and women alike. An imbalance of estrogen and testosterone in women can cause breast tenderness, low sex drive, mood swings, irregular periods, worse PMS symptoms, weight gain, weight loss resistance, hair loss, headaches, endometriosis, polycystic ovarian syndrome (PCOS), and thyroid disorders. Long-term estrogen elevation also has strong ties to breast, ovarian, and uterine cancers, as these malignancies rely on estrogen to grow and proliferate. Men with too much estrogen may experience fertility problems due to low sperm count, erectile dysfunction, breast growth, and reduced libido. Men with high estrogen may also have a higher risk of developing breast cancer.
D-glucarate supplements show significant potential for balancing cholesterol levels. Animal trials reported a 12-15% decrease in total cholesterol and a 30-35% decrease in LDL (bad) cholesterol. Preliminary research shows D-glucarate has similar effects on humans and reduces total cholesterol by up to 12%, LDL cholesterol by up to 28%, and triglycerides (another type of fat found in the blood) by up to 43%. Researchers believe that calcium D-glucarate exerts these effects by reducing beta-glucuronidase production, which provides better liver circulation. Enhancing liver circulation helps lower cholesterol levels by increasing bile acid secretion and reducing cholesterol synthesis.
Calcium D-glucarate may support weight loss efforts due to its interactions with hormones. Excess estrogen can cause weight gain and make it difficult to lose weight. Balancing the estrogen gut microbiome may alleviate these problems.
The body needs ample calcium to develop and maintain strong bones and teeth, and eating a calcium-rich diet can promote long-term bone health. Calcium intake is particularly important for the elderly to prevent bone loss, maintain bone strength, and sustain bone mineral density. Elderly individuals are less likely to experience bone fractures when taking calcium supplements with . Vitamin D helps the body absorb calcium, and vitamin D deficiencies tend to presage calcium deficiencies.
Current studies report no significant side effects from taking calcium D-glucarate. However, calcium D-glucarate may interact with other medications broken down by the liver. Taking calcium D-glucarate with alcohol may reduce its effectiveness. Calcium D-glucarate may reduce the effectiveness of the antibiotic kanamycin.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.