What is CDG (Calcium D-Glucarate)?
Calcium D-Glucarate, also known as calcium saccharate and saccharated lime, is a calcium salt combined with
glucaric acid. The addition of glucaric acid dramatically improves the calcium’s oral bioavailability. Once
ingested, stomach acids break down calcium D-glucarate into calcium and D-glucaric acid. Calcium is an
essential mineral and electrolyte that the body needs to maintain the circulatory, digestive, and muscular
systems. It is also critical for bone formation, blood cell function, muscle contractions, and nerve
Glucaric acid occurs naturally in many fruits and vegetables, including apples, grapefruits, oranges, and
cruciferous vegetables like broccoli. D-glucarate has antioxidant and anti-inflammatory properties that help
rid the body of toxins and support the body’s natural defense systems. Glucaric acid also helps remove
excess estrogen. Additionally, calcium D-glucarate exerts beneficial effects on cholesterol levels.
Potential Calcium D-Glucarate Benefits
Calcium D-Glucarate + Liver Health
Calcium D-glucarate may support liver health due to its detoxification properties. The liver goes through two
phases of detoxing harmful substances. The first phase can sometimes produce metabolites that are more
noxious than the original compounds. The second phase targets these metabolites for elimination in a process
known as glucuronidation. Phase II detoxification also processes harmful metabolic byproducts, hormones, and
Glucuronidation neutralizes these toxins by binding them to glucuronic acid. The body can then excrete them
through the gut or kidneys via bile, bowel movements, and urine. However, beta-glucuronidase enzymes found
in the gut can reverse glucuronidation and cause the body to reabsorb the toxins the liver tried to
eliminate. Calcium D-glucarate inhibits beta-glucuronidase activity, which may help attenuate a buildup of
toxins in the body.
Calcium D-Glucarate and Resveratrol Antioxidants
Calcium D-glucarate shows significant synergy with resveratrol
by boosting its antioxidant properties.
Calcium D-Glucarate + Estrogen
The body needs beta-glucuronidase to metabolize carbohydrates and produces the enzymes via colon bacteria.
However, high-fat diets, processed foods, excess sugar consumption, and insufficient fiber intake can cause
an imbalance of beta-glucuronidase in the gut. As mentioned above, beta-glucuronidase can unbind excess
hormones packaged via glucuronidation before the body can eliminate them. Numerous scientific studies
support the connection between the gut and sex hormones. Calcium D-glucarate can help restore gut health by
blocking beta-glucuronidase enzymes and preserving glucuronidation.
Excess estrogen can lead to numerous health problems in men and women alike. An imbalance of estrogen and
testosterone in women can cause breast tenderness, low sex drive, mood swings, irregular periods, worse PMS
symptoms, weight gain, weight loss resistance, hair loss, headaches, endometriosis, polycystic ovarian
syndrome (PCOS), and thyroid disorders. Long-term estrogen elevation also has strong ties to breast,
ovarian, and uterine cancers, as these malignancies rely on estrogen to grow and proliferate. Men with too
much estrogen may experience fertility problems due to low sperm count, erectile dysfunction, breast growth,
and reduced libido. Men with high estrogen may also have a higher risk of developing breast cancer.
Calcium D-Glucarate + Cholesterol
D-glucarate supplements show significant potential for balancing cholesterol levels. Animal trials reported a
12-15% decrease in total cholesterol and a 30-35% decrease in LDL (bad) cholesterol. Preliminary research
shows D-glucarate has similar effects on humans and reduces total cholesterol by up to 12%, LDL cholesterol
by up to 28%, and triglycerides (another type of fat found in the blood) by up to 43%. Researchers believe
that calcium D-glucarate exerts these effects by reducing beta-glucuronidase production, which provides
better liver circulation. Enhancing liver circulation helps lower cholesterol levels by increasing bile acid
secretion and reducing cholesterol synthesis.
Calcium D-Glucarate + Weight Loss
Calcium D-glucarate may support weight loss efforts due to its interactions with hormones. Excess estrogen
can cause weight gain and make it difficult to lose weight. Balancing the estrogen gut microbiome may
alleviate these problems.
Calcium D-Glucarate + Bones
The body needs ample calcium to develop and maintain strong bones and teeth, and eating a calcium-rich diet
can promote long-term bone health. Calcium intake is particularly important for the elderly to prevent bone
loss, maintain bone strength, and sustain bone mineral density. Elderly individuals are less likely to
experience bone fractures when taking calcium supplements with . Vitamin D helps the body absorb calcium,
and vitamin D deficiencies tend to presage calcium deficiencies.
Potential Calcium D-Glucarate Side Effects
Current studies report no significant side effects from taking calcium D-glucarate. However, calcium
D-glucarate may interact with other medications broken down by the liver. Taking calcium D-glucarate with
alcohol may reduce its effectiveness. Calcium D-glucarate may reduce the effectiveness of the antibiotic
Resources and References