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REPRESENTATIVE DOCUMENTS
COA
*(Documents above may vary from batch received. Click here to request batch-specific documents)
Note: This product is concentrated Cyanocobalamin (not for individual use). However, we do offer a 1% Cyanocobalamin and 99% Mannitol blended product as well.
Restricted Product
Because of the potential for personal harm, injury or death associated with the use or misuse of certain products, PureBulk, Inc., requires that you demonstrate that you possess the required instrumentation, analytical skills, and knowledge to accurately measure and deliver a safe serving size for these products.
Vitamin B12 is a water-soluble essential B vitamin that contains the mineral Cobalt. Vitamin B12 is a cofactor for several enzymes that are critical for several metabolic processes, including methionine synthase and l-methyl-malonyl-CoA mutase. Vitamin B12 is also essential for energy production and DNA synthesis.
The body can’t produce vitamin B12, so individuals obtain it through food and supplements. Most vitamin B12-rich foods come from animals, such as eggs, meats, and milk. As a result, vegans may struggle to meet their B12 dietary needs without supplementation.
B12 is a member of the cobalt-containing compounds collectively known as cobalamins. Cobalamin vitamers have similar chemical structures that exert B12 vitamin activity when the body is in a B12-deficient state. Cobalamin exists in several forms, including cyanocobalamin, hydroxocobalamin, methylcobalamin, and adenosylcobalamin.
Cyanocobalamin forms when a cyanide molecule replaces the adenosyl ligand in vitamin B12. Cyanocobalamin is the most common form of vitamin B12, as it is the most stable. Once ingested, it converts into one of the active forms of vitamin B12, adenosylcobalamin or methylcobalamin.
Cyanocobalamin plays a pivotal role in red blood cell production. Low vitamin B12 can cause the malformation of red blood cells, making them bloated and oval-shaped rather than small and round. Oddly shaped red blood cells have difficulty entering the bloodstream and transporting oxygen to the organs. Without sufficient blood cells, the body is prone to fatigue and weakness.
Vitamin B12 supplements may support strong bones as well. Adults that don’t have sufficient B12 levels experience lower than normal bone density, an effect that is particularly prominent in women. Over time, bones can become fragile and weak.
Like most B vitamins, cyanocobalamin supports energy production. While vitamin B12 doesn’t innately provide energy, it’s a cofactor for energy-producing enzymes and supports energy metabolism.
Cognitive health relies on sufficient levels of vitamin B12. Low vitamin B12 levels can reduce the synthesis of methionine and S-adenosylmethionine (SAM), which are essential for methylation reactions. These reactions play a significant role in synthesizing components of the myelin sheath and neurotransmitters.
Vitamin B12 supplements have several other interesting properties that may help balance moods, support heart health, and promote eye health.
B12 insufficiency and deficiency are prevalent problems across the globe. Up to 20% of adults over the age of 60 in the US and UK have insufficient vitamin B12 levels, while 6% have a true B12 deficiency. Certain groups are more likely to experience a B12 deficiency, including the elderly, people with gastrointestinal disorders, individuals taking proton pump inhibitors, and vegans. Certain autoimmune conditions can affect B12 absorption as well.
The following are several signs that may indicate a B12 insufficiency or deficiency:
As an essential vitamin, individuals typically tolerate vitamin B12 well. As a water-soluble vitamin, the body excretes any excess B12 that it doesn’t need. However, taking excessively large doses can cause headaches, nausea, tingling sensations, weakness, or diarrhea.
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
