What is D-Ribose?
D-ribose is an aldopentose sugar with a five-carbon ring structure. It is essential for gene expression and
regulation and to code and decode genes. It forms the structural backbone of RNA and DNA. The body needs
d-ribose to synthesize several adenine nucleotides, including adenosine monophosphate (AMP), adenosine
triphosphate (ATP), and adenosine diphosphate (ADP). All three molecules are critical for energy storage and
transfer. However, ATP has the greatest molecular unit of currency when it comes to energy. It stores and
releases energy to cells to catalyze several bodily processes, including nerve impulse propagation and
muscle contractions. ATP is also an essential component to synthesize RNA.
Potential D-Ribose Benefits
D-Ribose for Energy
D-Ribose may be able to reduce fatigue due to its integral role in synthesizing ATP. One study noted that
chronically fatigued participants taking d-ribose supplements experienced significant improvements in their
energy levels. The same study reported notable improvements in participants’ sleep, mental clarity, and
mood. D-Ribose is also a limiting factor to synthesize ATP. For example, certain pathological conditions and
intense exercise deplete ATP to meet the body’s demand for energy. However, the availability of d-ribose
limits how much ATP the body can synthesize. By replenishing d-ribose stores, the body can produce more ATP
to boost energy.
D-Ribose and Heart Health
D-ribose supplements may support heart health by boosting energy availability in heart muscle, improving
heart metabolism, and increasing the heart’s ability to tolerate exercise. Several studies have noted that
d-ribose helps improve heart function and quality of life for individuals with heart conditions.
D-Ribose and Pain
D-Ribose may improve pain symptoms by improving energy metabolism. A pilot study reported that d-ribose
supplements improved the intensity of the participants’ subjective pain levels. Another all-female study
noted that d-ribose improved the participants’ pain levels. Researchers believe d-ribose supplements help
attenuate pain by altering how muscles metabolize adenine nucleotides.
D-Ribose and Exercise Performance
D-ribose may enhance exercise performance by replenishing ATP for muscle energy. One study found that
d-ribose outperformed a placebo sugar when restoring ATP after intense exercise. Researchers hypothesized
that increased ATP synthesis may reduce soreness and exercise recovery. Another study reported that
improvements in exercise performance are particularly notable in individuals with lower fitness levels.
Participants with a lower VO2 max were able to sustain their exercise performance with a reduced perceived
rate of exertion.
Potential D-Ribose Side Effects
Most individuals tolerate d-ribose supplements without experiencing side effects. Some individuals may
experience mild gastrointestinal side effects, such as nausea, upset stomach, or diarrhea. Individuals with
diabetes should not take d-ribose supplements without consulting their physician, as it may lower blood
sugar. Individuals with upcoming surgical procedures should abstain from taking d-ribose supplements for at
least two weeks before their surgery to avoid problems with maintaining blood sugar.
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity
and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.